Analysis of the Broad’s Avana CRISPR (Broad Institute Cancer Dependency Map 2018, Meyers et al. 2017) and the Broad and Dana-Farber Cancer Institite’s Achilles shRNA (MacFarland et al. 2018, Data Science 2018).

The Avana screen produced results using CERES (Meyers et al. 2017) (GitHub), which generates gene dependency scores from sgRNA depletion scores from gene essentiality screens and eliminates bias arising from the effect of copy number variation on Cas9 DNA cleavage. The lower the CERES score, the higher the likelihood that the gene is essential in the associated cell line. Scores are scaled per cell line such that a score of 0 is the median effect of nonessential genes and -1 is the median effect of common core essential genes.

All annotation files (copy number, mutation status, and gene expression) (Consortium and Consortium 2015, Barretina et al. 2012) were downloaded from the DepMap Data Portal.

1 Set up

library(bsselectR)
library(data.table)
library(ggpubr)
library(ggsignif)
library(htmlwidgets)
library(kableExtra)
library(plotly)
library(reshape2)
library(scales)
library(tidyverse)

2 Functions

2.1 Significance thresholding

adj_signif <- function(df) {
  # Takes df from compare_means and creates a signif code column for adjusted p-vals
  df$p.signif <- ifelse(df$p.signif == "ns", NA, df$p.signif)
  df$p.signif.adj <- ifelse(df$p.adj <= 0.0001, "****",
                     ifelse(df$p.adj <= 0.001, "***",
                     ifelse(df$p.adj <= 0.01, "**",
                     ifelse(df$p.adj <= 0.05, "*", NA))))
  df$p.short <- formatC(df$p, format = "g", digits =  2)
  df$p.adj.short <- formatC(df$p.adj, format = "g", digits =  2)
  
  return(df)
}

2.2 Wilcoxon tests by drug

WilcoxonByDrug <- function(drug, dataset, data_name, grouping_var) {
  if(grouping_var == "lineage") {
    grouper <- c("Hugo_Symbol", "group_general_lineage_name")
  }
  else if(grouping_var == "gene") {
    grouper <- "Hugo_Symbol"
  }
  use_data <- filter(dataset, Drug == drug)
  sig <- compare_means(AUC ~ Mutation_Status_Nonsilent, group.by = grouper, data = use_data, method = "wilcox.test", p.adjust.method = "BH")
  sig <- adj_signif(sig)
  sig <- sig[order(sig$p),]
  sig$Drug <- drug
  sig$Dataset <- toupper(data_name)
  return(sig)
}


WilcoxonByDrugAllGenes <- function(melt_file, grid_file, data_name) {
  druglist <- as.character(unique(melt_file$Drug))
  sig_df <- NULL
  for(i in 1:length(druglist)) {
    print(paste0("Current drug in process: ", druglist[i], " (drug ", i, " of ", length(druglist), ")."))
    flush.console()
    melted <- filter(melt_file, Drug == druglist[i])
    use_data <- merge(grid_file, melted, by = "accession_id", all.x = TRUE)
    use_data <- merge(use_data, ccl_converter, by = "accession_id", all.x = TRUE)
    use_data <- merge(use_data, maf_df, by = c("Hugo_Symbol", "CCLE_Name", "Broad_ID"), all.x = TRUE)
    use_data$Mutation_Status_Nonsilent <- ifelse(is.na(use_data$Mutation_Status_Nonsilent), "Other", use_data$Mutation_Status_Nonsilent)
    use_data$Hugo_Symbol <- factor(use_data$Hugo_Symbol)
    use_data$AUC <- as.numeric(use_data$AUC)
    use_data <- filter(use_data, !is.na(use_data$AUC))
    use_data$Drug_Gene <- paste0(use_data$Drug, "_", use_data$Hugo_Symbol)
    use_data_ptmuts <- filter(use_data, Reference_Allele_Length == 1 | Reference_Allele_Length == 0 | is.na(Reference_Allele_Length))
    use_data_ptmuts$Keep_PtMut_Tests <- ifelse(use_data_ptmuts$Reference_Allele_Length == 1 | is.na(use_data_ptmuts$Reference_Allele_Length), TRUE, ifelse(use_data_ptmuts$Tumor_Seq_Allele1_Length == 1, TRUE, FALSE))
    use_data_ptmuts <- filter(use_data_ptmuts, Keep_PtMut_Tests == TRUE)
    
    sig <- compare_means(AUC ~ Mutation_Status_Nonsilent, group.by = "Hugo_Symbol", data = use_data_ptmuts, method = "wilcox.test", p.adjust.method = "BH")
    sig <- adj_signif(sig)
    sig <- sig[order(sig$p),]
    sig <- filter(sig, p <= 0.05)
    sig$Drug <- druglist[i]
    sig$Dataset <- toupper(data_name)
    sig_df <- rbind(sig_df, sig)
  }
  return(sig_df)
}

2.3 Save widget to new directory

saveWidgetFix <- function (widget , file, ...) {
  ## A wrapper to saveWidget which compensates for arguable BUG in
  ## saveWidget which requires `file` to be in current working
  ## directory.
  wd <- getwd()
  on.exit(setwd(wd))
  outDir <- dirname(file)
  file <- basename(file)
  setwd(outDir);
  saveWidget(widget, file = file,...)
}

2.4 Make per-drug boxplots

makeDrugBoxplots <- function(drug, dataset) {
  if(dataset == "CCLE" | dataset == "ccle") {
    use_data <- filter(ccle_data_g2p_genesfilt, Drug == drug)
    use_color <- as.character(use_data$Color_Nonsilent)
    names(use_color) <- use_data$Mutation_Status_Nonsilent
    sig <- ccle_signif_g2p_ByDrug[[drug]]
    label_text <- data.frame(p.signif = sig$p.signif, p.signif.adj = sig$p.signif.adj, Hugo_Symbol = sig$Hugo_Symbol)
    label_text$Hugo_Symbol <- factor(label_text$Hugo_Symbol, levels = g2p_genes)
  }
  else if(dataset == "CTRP" | dataset == "ctrp") {
    use_data <- filter(ctrp_data_g2p_genesfilt, Drug == drug)
    use_color <- as.character(use_data$Color_Nonsilent)
    names(use_color) <- use_data$Mutation_Status_Nonsilent
    sig <- ctrp_signif_g2p_ByDrug[[drug]]
    label_text <- data.frame(p.signif = sig$p.signif, p.signif.adj = sig$p.signif.adj, Hugo_Symbol = sig$Hugo_Symbol)
    label_text$Hugo_Symbol <- factor(label_text$Hugo_Symbol, levels = g2p_genes)
  }
  else if(dataset == "GDSC" | dataset == "gdsc") {
    use_data <- filter(gdsc_data_g2p_genesfilt, Drug == drug)
    use_color <- as.character(use_data$Color_Nonsilent)
    names(use_color) <- use_data$Mutation_Status_Nonsilent
    sig <- gdsc_signif_g2p_ByDrug[[drug]]
    label_text <- data.frame(p.signif = sig$p.signif, p.signif.adj = sig$p.signif.adj, Hugo_Symbol = sig$Hugo_Symbol)
    label_text$Hugo_Symbol <- factor(label_text$Hugo_Symbol, levels = g2p_genes)
  }
  else { return("Error: Invalid dataset.") }
    
  plot <- ggplot(data = use_data, aes(x = Mutation_Status_Nonsilent, y = AUC)) +
    facet_wrap(~ Hugo_Symbol, drop = FALSE, nrow = 1) +
    geom_boxplot(mapping = aes(fill = Mutation_Status_Nonsilent), position = position_dodge(0.85), outlier.shape = 3, outlier.size = 0.5) +
    scale_fill_manual(values = use_color) +
    guides(color = FALSE) +
    geom_text(data = label_text, mapping = aes(x = 1.5, y = max(use_data$AUC), label = p.signif), nudge_y = 0.2) +
    theme(strip.text.x = element_text(size = 10, angle = 45), legend.position = "top", axis.ticks.x = element_blank(), axis.text.x = element_blank(), axis.title.x = element_blank()) +
    labs(fill = "Mutation Status", y = "AUC", x = "Mutation Status", title = paste0(toupper(dataset), ": ", drug))
  return(plot)
}

2.5 Make G2P lineage plotly

make_G2Plineage_plotly <- function(lineage_name) {
  use_data <- filter(g2p_druggenelin_all_summ, group_general_lineage_name == lineage_name)
  use_data$Dataset <- factor(use_data$Dataset, levels = c("CCLE", "CTRP", "GDSC"))
  ticker <- 0
  
  use_data_ccle <- filter(use_data, Dataset == "CCLE")
  use_data_ccle_summ <- use_data_ccle %>% count(InG2P)
  if(nrow(use_data_ccle_summ) <= 1) {
    ccle_lin_p_ttest_res <-  NA
    ticker <- ticker + 1
    }
  else if(use_data_ccle_summ[use_data_ccle_summ$InG2P == "Yes",]$nn < 2) { ccle_lin_p_ttest_res <-  NA }
  else if(use_data_ccle_summ[use_data_ccle_summ$InG2P == "Yes",]$nn >= 2) {
    ccle_lin_p_ttest <- t.test(use_data_ccle$p ~ use_data_ccle$InG2P)
    ccle_lin_p_ttest_res <- paste0("t = ", round(ccle_lin_p_ttest$statistic, 3), ", df = ", round(ccle_lin_p_ttest$parameter, 3), ", p = ", round(ccle_lin_p_ttest$p.value, 3))
  }
  
  use_data_ctrp <- filter(use_data, Dataset == "CTRP")
  use_data_ctrp_summ <- use_data_ctrp %>% count(InG2P)
  if(nrow(use_data_ctrp_summ) <= 1) {
    ctrp_lin_p_ttest_res <-  NA
    ticker <- ticker + 1
    }
  else if(use_data_ctrp_summ[use_data_ctrp_summ$InG2P == "Yes",]$nn < 2) { ctrp_lin_p_ttest_res <-  NA }
  else if(use_data_ctrp_summ[use_data_ctrp_summ$InG2P == "Yes",]$nn >= 2) {
    ctrp_lin_p_ttest <- t.test(use_data_ctrp$p ~ use_data_ctrp$InG2P)
    ctrp_lin_p_ttest_res <- paste0("t = ", round(ctrp_lin_p_ttest$statistic, 3), ", df = ", round(ctrp_lin_p_ttest$parameter, 3), ", p = ", round(ctrp_lin_p_ttest$p.value, 3))
  }
  
  use_data_gdsc <- filter(use_data, Dataset == "GDSC")
  use_data_gdsc_summ <- use_data_gdsc %>% count(InG2P)
  if(nrow(use_data_gdsc_summ) <= 1) {
    gdsc_lin_p_ttest_res <-  NA
    ticker <- ticker + 1
    }
  else if(use_data_gdsc_summ[use_data_gdsc_summ$InG2P == "Yes",]$nn < 2) { gdsc_lin_p_ttest_res <-  NA }
  else if(use_data_gdsc_summ[use_data_gdsc_summ$InG2P == "Yes",]$nn >= 2) {
    gdsc_lin_p_ttest <- t.test(use_data_gdsc$p ~ use_data_gdsc$InG2P)
    gdsc_lin_p_ttest_res <- paste0("t = ", round(gdsc_lin_p_ttest$statistic, 3), ", df = ", round(gdsc_lin_p_ttest$parameter, 3), ", p = ", round(gdsc_lin_p_ttest$p.value, 3))
  }
  
  y_value <- ifelse(ticker == 3, 10, max(use_data$n) + 1)

  g2p_druggenelin_all_summ_text <- data.frame(Dataset = c("CCLE", "CTRP", "GDSC"), Test_Results_p = c(ccle_lin_p_ttest_res, ctrp_lin_p_ttest_res, gdsc_lin_p_ttest_res))
  

  plot_p_point <- ggplot(data = use_data) +
    facet_wrap(~ Dataset, drop = FALSE) +
    coord_cartesian(xlim = c(0, 1), ylim = c(0, y_value)) +
    scale_x_continuous(breaks = seq(0, 1, by = 0.1), labels = seq(0, 1, by = 0.1)) +
    scale_y_continuous(breaks = pretty_breaks()) +
    geom_point(mapping = aes(label = Drug_Gene, color = InG2P, x = p, y = n), alpha = 0.5, position = position_jitter(width = 0, height = 0.15)) +
    geom_text(data = g2p_druggenelin_all_summ_text, mapping = aes(x = 0.5, y = y_value, label = Test_Results_p), nudge_y = 0.1) +
    labs(x = "Gene-drug association p-value between mutation groups", y = "Number of level A G2P associations", color = "Does the gene-drug combination have level A G2P indication?") +
    theme(legend.position = "none", plot.margin = unit(c(0.05, 0.5, 0.5, 0.5), "cm"), strip.background = element_blank(), strip.text.x = element_blank())

  plot_p_box <- ggplot(data = use_data) +
    facet_wrap(~ Dataset, drop = FALSE) +
    coord_cartesian(ylim = c(0, 1)) +
    scale_y_continuous(breaks = seq(0, 1, by = 0.1), labels = seq(0, 1, by = 0.1)) +
    geom_violin(mapping = aes(color = InG2P, y = p, x = InG2P), alpha = 0.5) +
    geom_boxplot(mapping = aes(color = InG2P, y = p, x = InG2P), alpha = 0.75, width = 0.25) +
    coord_flip() +
    labs(x = "Level A G2P\nassociation") +
    theme(legend.position = "none", axis.title.x = element_blank(), axis.text.x = element_blank(), axis.ticks.x = element_blank(), plot.margin = unit(c(0.5, 0.5, 0.05, 0.5), "cm"))

  plot <- subplot(plot_p_box, plot_p_point, nrows = 2, titleX = TRUE, titleY = TRUE) %>% layout(title = lineage_name, margin = list(t = 75, l = 75), xaxis5 = list(title = "Gene-drug association p-value between mutation groups"), yaxis = list(title = "Level A G2P\nassociation", domain = c(0.8, 1)), yaxis2 = list(title = "Number of level A G2P associations", domain = c(0, 0.79)))

  saveWidgetFix(widget = plot, file = paste0("./plots_18Q3/manuscript/plotlys_by_lineage/", lineage_name, "_g2p_evidence_plotly.html"))
}

3 Data management

3.1 D. Charytonowicz cell line converter

This comprehensive cancer cell line information curated by Daniel Charytonowicz.

ccl_converter <- read.delim("./data_munging/cell_line_database_v1_20180911.tsv", row.names = 1, sep = "\t", header = TRUE)
lineage_converter <- unique(ccl_converter[, c("grouped_general_doid", "group_general_lineage_name")])

3.2 DepMap cell line metadata

ccl_info <- read.delim("./data_munging/DepMap-2018q3-celllines.csv", sep = ",", header = TRUE, na.strings = c("", NA))
ccl_info$Primary.Disease <- gsub("\\\\", "", ccl_info$Primary.Disease)
ccl_info$Primary.Disease <- gsub("Ewings", "Ewing's", ccl_info$Primary.Disease)

# From figshare
crispr_meta <- read.delim("./data_munging/sample_info_18Q3_crispr.csv", sep = ",", header = TRUE, na.strings = c("", NA))
colnames(crispr_meta)[7] <- "CCLE_Name"

3.3 Genomic annotations

3.3.1 CCLE MAF file

For mutation calling, get paired gene name and cell line fields in a data frame. For this analysis, we don’t care about how many mutations there are per gene or what type of mutations there are, so I didn’t save more information. I took unique gene-cell line combinations since we only cared about mutation presence/absence. Add a Mutation_Status column denoting all entries in MAF files as mutations present in the associated cell lines.

maf_raw <- read.delim("./data_munging/CCLE_DepMap_18q3_maf_20180718.txt.gz", header = TRUE, sep = "\t")
# Filter for cell lines in CRISPR screen
maf_raw <- filter(maf_raw, Broad_ID %in% unique(crispr_meta$Broad_ID))
colnames(maf_raw)[colnames(maf_raw) == "Tumor_Sample_Barcode"] <- "CCLE_Name"

# Select columns
maf_df <- subset(maf_raw, select = c("Hugo_Symbol", "CCLE_Name", "Broad_ID", "Variant_Classification", "Reference_Allele", "Tumor_Seq_Allele1"))
maf_df$Reference_Allele_Length <- ifelse(maf_df$Reference_Allele == "-", 0, nchar(as.character(maf_df$Reference_Allele)))
maf_df$Tumor_Seq_Allele1_Length <- nchar(as.character(maf_df$Tumor_Seq_Allele1))

# Add Mutation_Status column
maf_df$Mutation_Status_Nonsilent <- ifelse(maf_df$Variant_Classification == "Silent", "Other", "Mutant")
maf_df <- unique(subset(maf_df, select = c("Hugo_Symbol", "CCLE_Name", "Broad_ID", "Mutation_Status_Nonsilent", "Reference_Allele_Length", "Tumor_Seq_Allele1_Length")))

3.3.2 CCLE copy number file

cn <- read.delim("./data_munging/public_18Q3_gene_cn_v2.csv.gz", sep = ",", check.names = FALSE, header = TRUE)

# Convert log2 ratios (log2(CN/2)) to CN
cn[2:ncol(cn)] <- lapply(cn[2:ncol(cn)], function(x) 2 * (2 ^ x))

# Remove Entrez gene IDs from colnames
colnames(cn) <- gsub(" .*", "", colnames(cn))
colnames(cn)[1] <- "Broad_ID"

# Melt
cn_melt <- melt(data = cn, id.vars = "Broad_ID", measure.vars = colnames(cn[2:ncol(cn)]), variable.name = "Hugo_Symbol", value.name = "Copy_Number")

saveRDS(cn_melt, "./data_munging/rds/cn_melt_18Q3.rds", compress = "xz")
cn_melt <- readRDS("./data_munging/rds/cn_melt_18Q3.rds")

3.3.3 CCLE gene expression file

Gene expression data (Reads Per Kilobase of transcript, per Million mapped reads, RPKM).

ge <- read.delim("./../crispr_lineages_giant_files/CCLE_DepMap_18q3_RNAseq_RPKM_20180718.gct.gz", skip = 2, header = TRUE, sep = "\t", check.names = FALSE)

# Edit columns
ge$Name <- NULL
colnames(ge)[1] <- "Hugo_Symbol"

# Melt
ge_melt <- melt(data = ge, id.vars = "Hugo_Symbol", measure.vars = colnames(ge[2:ncol(ge)]), value.name = "RPKM")
## Split variable column
ge_melt <- with(ge_melt, cbind(Hugo_Symbol, colsplit(variable, pattern = " ", names = c("CCLE_Name", "Broad_ID")), RPKM))
## Remove parentheses around Broad IDs
ge_melt$Broad_ID <- gsub("\\(|\\)", "", ge_melt$Broad_ID)

saveRDS(ge_melt, "./../crispr_lineages_giant_files/ge_melt_18Q3.rds", compress = "xz")
ge_melt <- readRDS("./../crispr_lineages_giant_files/ge_melt_18Q3.rds")

3.4 G2P

g2p <- read.delim("./data_munging/g2p_full_level_A_dataset_withGroupedLineages.csv", sep = "\t", header = TRUE, row.names = 1)
g2p <- merge(g2p, lineage_converter, by = "grouped_general_doid", all.x = TRUE)
g2p$Drug <- tolower(g2p$Drug)
g2p[g2p == -1] <- NA
g2p$Ref[g2p$Ref == "None"] <- NA
g2p$Alt[g2p$Alt == "None"] <- NA
g2p$Drug_Gene <- ifelse(is.na(g2p$Drug) | is.na(g2p$Gene), NA, paste0(g2p$Drug, "_", g2p$Gene))
g2p$position <- paste0("g.chr", g2p$Chromosome, ":", g2p$End, g2p$Ref, ">", g2p$Alt)
g2p$position <- ifelse(grepl("NA", g2p$position), NA, g2p$position)
g2p <- subset(g2p, grepl("^CID", g2p$DrugID))


g2p_drug_genes <- as.character(unique(g2p$Drug_Gene[!is.na(g2p$Drug_Gene)]))
g2p_genes <- unique(sapply(strsplit(g2p_drug_genes, "_", fixed = TRUE), function(x) x[2]))
g2p_drugs <- unique(sapply(strsplit(g2p_drug_genes, "_", fixed = TRUE), function(x) x[1]))

g2p_genes
##  [1] "IDH2"    "ABL1"    "NPM1"    "PML"     "FLT3"    "PDGFRA"  "DNMT3A" 
##  [8] "ALK"     "EGFR"    "ERBB2"   "KRAS"    "MET"     "ROS1"    "RET"    
## [15] "BRAF"    "ERBB3"   "ESR1"    "CYP19A1" "AKT1"    "KIT"     "TPMT"   
## [22] "DPYD"    "JAK2"    "MGMT"    "TSC1"    "G6PD"    "UGT1A1"  "PDGFRB" 
## [29] "TSC2"    "PDGFB"   "BRCA2"   "MYD88"   "BRCA1"   "PTCH1"
g2p_drugs
##  [1] "enasidenib"            "bosutinib monohydrate"
##  [3] "daunorubicin"          "ponatinib"            
##  [5] "arsenic"               "imatinib"             
##  [7] "dasatinib"             "nilotinib"            
##  [9] "midostaurin"           "tretinoin"            
## [11] "ceritinib"             "crizotinib"           
## [13] "gefitinib"             "afatinib"             
## [15] "erlotinib"             "icotinib"             
## [17] "alectinib"             "azd"                  
## [19] "cabozantinib"          "brigatinib"           
## [21] "osimertinib"           "trametinib"           
## [23] "vemurafenib"           "dabrafenib"           
## [25] "ap26113"               "selumetinib"          
## [27] "lapatinib"             "docetaxel"            
## [29] "cyclophosphamide"      "neratinib"            
## [31] "palbociclib"           "anastrozole"          
## [33] "fulvestrant"           "letrozole"            
## [35] "everolimus"            "sunitinib"            
## [37] "purine"                "capecitabine"         
## [39] "ruxolitinib"           "guanine"              
## [41] "temozolomide"          "tegafur"              
## [43] "pralidoxime mesylate"  "irinotecan"           
## [45] "belinostat"            "regorafenib"          
## [47] "2-fluoropyrimidine"    "fluorouracil"         
## [49] "pazopanib"             "cobimetinib"          
## [51] "olaparib"              "ibrutinib"            
## [53] "nafomine malate"       "vandetanib"           
## [55] "rucaparib"             "niraparib"            
## [57] "vismodegib"
# Order and genes taken from pink heatmapo from Daniel's analyses
g2p_genes <- c("EGFR", "KRAS", "ERBB2", "ERBB3", "MET", "ALK", "ROS1", "PDGFRA", "ABL1", "KIT", "PDGFRB", "PDGFB", "BRAF", "G6PD", "RET", "BRCA1", "BRCA2", "UGT1A1", "TSC1", "TSC2", "AKT1", "IDH2", "DPYD", "ESR1", "CYP19A1", "TPMT", "FLT3", "NPM1", "DNMT3A", "PML", "PTCH1", "JAK2", "MYD88", "MGMT")

3.5 CRISPR

3.5.1 DepMap dependency probabilities

dep <- read.delim("./data_munging/gene_dependency_18Q3.csv.gz", sep = ",", header  = TRUE, check.names = FALSE)
# Remove Entrez gene IDs from colnames
colnames(dep) <- gsub(" .*", "", colnames(dep))

3.5.2 Merge CRISPR data and annotations

The latest CRISPR CERES score data (18Q3, August 2018) was pulled from the DepMap Data Portal (Broad Institute Cancer Dependency Map 2018, Meyers et al. 2017).

crispr <- read.delim("./data_munging/gene_effect_18Q3.csv.gz", sep = ",", header  = TRUE, check.names = FALSE)
# Remove Entrez gene IDs from colnames
colnames(crispr) <- gsub(" .*", "", colnames(crispr))

Merge annotation data:

# Melt CRISPR dataset for merging
crispr_melt <- melt(crispr, id.vars = "Broad_ID", measure.vars = colnames(crispr)[2:ncol(crispr)], variable.name = "Hugo_Symbol", value.name = "Score")
# Melt dependency probabilities dataset for merging
dep_melt <- melt(dep, id.vars = "Broad_ID", measure.vars = colnames(dep)[2:ncol(dep)], variable.name = "Hugo_Symbol", value.name = "Dep_Prob")
# Merge dependency probabilities
crispr_melt <- merge(crispr_melt, dep_melt, by = c("Broad_ID", "Hugo_Symbol"), all.x = TRUE)
# Merge cell line metadata
crispr_melt <- merge(crispr_melt, ccl_info, by = "Broad_ID", all.x = TRUE)
crispr_melt <- merge(crispr_melt, crispr_meta, by = c("CCLE_Name", "Broad_ID"), all.x = TRUE)
# Merge mutation annotations
crispr_muts <- merge(crispr_melt, maf_df, by = c("Hugo_Symbol", "CCLE_Name", "Broad_ID"), all.x = TRUE)
crispr_muts$Hugo_Symbol <- factor(crispr_muts$Hugo_Symbol)
crispr_muts <- crispr_muts %>% mutate(Mutation_Status_Nonsilent = if_else(is.na(Mutation_Status_Nonsilent), "Other", Mutation_Status_Nonsilent))
# Summarize number of mutant and Other cell lines
crispr_muts_summ <- crispr_muts %>% group_by(Hugo_Symbol) %>%
  summarize(N_Nonsilent_Other = sum(Mutation_Status_Nonsilent == "Other"),
            N_Nonsilent_Mutant = sum(Mutation_Status_Nonsilent == "Mutant"))
# Merge test results back into full dataset, which restores information lost in the summarization
crispr_data <- merge(crispr_muts_summ, crispr_muts, by = "Hugo_Symbol")
# Add Color columns
crispr_data$Color_Nonsilent <- ifelse(crispr_data$Mutation_Status_Nonsilent == "Other", "thistle", "darkorchid")
crispr_data$Color_Nonsilent <- factor(crispr_data$Color_Nonsilent)
# Cell line lineages
crispr_data <- merge(crispr_data, ccl_converter, by = c("CCLE_Name", "Broad_ID"), all.x = TRUE)
levels(crispr_data$lineage_name) <- sort(levels(crispr_data$lineage_name), decreasing = TRUE)
# Copy number
crispr_data <- merge(crispr_data, cn_melt, by = c("Hugo_Symbol", "Broad_ID"), all.x = TRUE)
# Gene expression (RPKM)
ge_filt <- filter(ge_melt, Hugo_Symbol %in% unique(crispr_data$Hugo_Symbol) & Broad_ID %in% unique(crispr_data$Broad_ID))
crispr_data <- merge(crispr_data, ge_filt, by = c("Hugo_Symbol", "Broad_ID", "CCLE_Name"), all.x = TRUE)
crispr_data$RPKM_log2 <- log2(crispr_data$RPKM + 0.0001)
saveRDS(crispr_data, "./../crispr_lineages_giant_files/crispr_data_18Q3.rds", compress = "xz")
crispr_data <- readRDS("./../crispr_lineages_giant_files/crispr_data_18Q3.rds")

crispr_data_ptmuts <- filter(crispr_data, Reference_Allele_Length == 1 | Reference_Allele_Length == 0 | is.na(Reference_Allele_Length))
crispr_data_ptmuts$Keep_PtMut_Tests <- ifelse(crispr_data_ptmuts$Reference_Allele_Length == 1 | is.na(crispr_data_ptmuts$Reference_Allele_Length), TRUE, ifelse(crispr_data_ptmuts$Tumor_Seq_Allele1_Length == 1, TRUE, FALSE))
crispr_data_ptmuts <- filter(crispr_data_ptmuts, Keep_PtMut_Tests == TRUE)

# Filter CRISPR for G2P genes in G2P
crispr_data_g2p <- filter(crispr_data_ptmuts, Hugo_Symbol %in% g2p_genes)
crispr_data_g2p$Hugo_Symbol <- factor(crispr_data_g2p$Hugo_Symbol, levels = g2p_genes)

3.6 Drug screens

# Drug metadata
drug_meta <- read.delim("./data_munging/drug_id_drug_name_table_10_12_2018.tsv", sep = "\t", header = FALSE)
colnames(drug_meta) <- c("CID", "Drug")
drug_meta$Drug <- tolower(drug_meta$Drug)
maf_df_g2p <- filter(maf_df, Hugo_Symbol %in% g2p_genes)
ge_filt <- filter(ge_melt, Hugo_Symbol %in% g2p_genes)


# CCLE
ccle <- read.delim("./data_munging/data_drug_auc_ccle_10_12_2018.csv", sep = "\t", header  = TRUE, row.names = 1, check.names = FALSE)
ccle <- merge(drug_meta, ccle, by = "CID")
ccle_melt <- melt(ccle, id.vars = c("CID", "Drug"), measure.vars = colnames(ccle)[3:ncol(ccle)], variable.name = "accession_id", value.name = "AUC")
ccle_grid <- expand.grid("accession_id" = unique(ccle_melt$accession_id), "Hugo_Symbol" = g2p_genes)
ccle_data <- merge(ccle_grid, ccle_melt, by = "accession_id", all.x = TRUE)
ccle_data <- merge(ccle_data, ccl_converter, by = "accession_id", all.x = TRUE)
ccle_data <- merge(ccle_data, maf_df_g2p, by = c("Hugo_Symbol", "CCLE_Name", "Broad_ID"), all.x = TRUE)
ccle_data$Mutation_Status_Nonsilent <- ifelse(is.na(ccle_data$Mutation_Status_Nonsilent), "Other", ccle_data$Mutation_Status_Nonsilent)
ccle_data <- merge(ccle_data, ge_filt, by = c("Hugo_Symbol", "CCLE_Name", "Broad_ID"), all.x = TRUE)
ccle_data$Hugo_Symbol <- factor(ccle_data$Hugo_Symbol)
ccle_data$AUC <- as.numeric(ccle_data$AUC)
ccle_data$Color_Nonsilent <- ifelse(ccle_data$Mutation_Status_Nonsilent == "Other", "palegreen3", "springgreen4")
ccle_data$Color_Nonsilent <- factor(ccle_data$Color_Nonsilent)
ccle_data <- filter(ccle_data, !is.na(ccle_data$AUC))
ccle_data$Drug_Gene <- paste0(ccle_data$Drug, "_", ccle_data$Hugo_Symbol)
saveRDS(ccle_data, "./data_munging/rds/ccle_data_18Q3_g2pgenes.rds", compress = "xz")

# CTRP
ctrp <- read.delim("./data_munging/data_drug_auc_ctrp_10_12_2018.csv", sep = "\t", header  = TRUE, row.names = 1, check.names = FALSE)
ctrp <- merge(drug_meta, ctrp, by = "CID")
ctrp_melt <- melt(ctrp, id.vars = c("CID", "Drug"), measure.vars = colnames(ctrp)[3:ncol(ctrp)], variable.name = "accession_id", value.name = "AUC")
ctrp_grid <- expand.grid("accession_id" = unique(ctrp_melt$accession_id), "Hugo_Symbol" = g2p_genes)
ctrp_data <- merge(ctrp_grid, ctrp_melt, by = "accession_id", all.x = TRUE)
ctrp_data <- merge(ctrp_data, ccl_converter, by = "accession_id", all.x = TRUE)
ctrp_data <- merge(ctrp_data, maf_df_g2p, by = c("Hugo_Symbol", "CCLE_Name", "Broad_ID"), all.x = TRUE)
ctrp_data$Mutation_Status_Nonsilent <- ifelse(is.na(ctrp_data$Mutation_Status_Nonsilent), "Other", ctrp_data$Mutation_Status_Nonsilent)
ctrp_data <- merge(ctrp_data, ge_filt, by = c("Hugo_Symbol", "CCLE_Name", "Broad_ID"), all.x = TRUE)
ctrp_data$Hugo_Symbol <- factor(ctrp_data$Hugo_Symbol)
ctrp_data$AUC <- as.numeric(ctrp_data$AUC)
ctrp_data$Color_Nonsilent <- ifelse(ctrp_data$Mutation_Status_Nonsilent == "Other", "slategray3", "steelblue4")
ctrp_data$Color_Nonsilent <- factor(ctrp_data$Color_Nonsilent)
ctrp_data <- filter(ctrp_data, !is.na(ctrp_data$AUC))
ctrp_data$Drug_Gene <- paste0(ctrp_data$Drug, "_", ctrp_data$Hugo_Symbol)
saveRDS(ctrp_data, "./data_munging/rds/ctrp_data_18Q3_g2pgenes.rds", compress = "xz")

# GDSC
gdsc <- read.delim("./data_munging/data_drug_auc_gdsc_10_12_2018.csv", sep = "\t", header  = TRUE, row.names = 1, check.names = FALSE)
gdsc <- merge(drug_meta, gdsc, by = "CID")
gdsc_melt <- melt(gdsc, id.vars = c("CID", "Drug"), measure.vars = colnames(gdsc)[3:ncol(gdsc)], variable.name = "accession_id", value.name = "AUC")
gdsc_grid <- expand.grid("accession_id" = unique(gdsc_melt$accession_id), "Hugo_Symbol" = g2p_genes)
gdsc_data <- merge(gdsc_grid, gdsc_melt, by = "accession_id", all.x = TRUE)
gdsc_data <- merge(gdsc_data, ccl_converter, by = "accession_id", all.x = TRUE)
gdsc_data <- merge(gdsc_data, maf_df_g2p, by = c("Hugo_Symbol", "CCLE_Name", "Broad_ID"), all.x = TRUE)
gdsc_data$Mutation_Status_Nonsilent <- ifelse(is.na(gdsc_data$Mutation_Status_Nonsilent), "Other", gdsc_data$Mutation_Status_Nonsilent)
gdsc_data <- merge(gdsc_data, ge_filt, by = c("Hugo_Symbol", "CCLE_Name", "Broad_ID"), all.x = TRUE)
gdsc_data$Hugo_Symbol <- factor(gdsc_data$Hugo_Symbol)
gdsc_data$AUC <- as.numeric(gdsc_data$AUC)
gdsc_data$Color_Nonsilent <- ifelse(gdsc_data$Mutation_Status_Nonsilent == "Other", "paleturquoise3", "turquoise4")
gdsc_data$Color_Nonsilent <- factor(gdsc_data$Color_Nonsilent)
gdsc_data <- filter(gdsc_data, !is.na(gdsc_data$AUC))
gdsc_data$Drug_Gene <- paste0(gdsc_data$Drug, "_", gdsc_data$Hugo_Symbol)
saveRDS(gdsc_data, "./data_munging/rds/gdsc_data_18Q3_g2pgenes.rds", compress = "xz")
ccle_data <- readRDS("./data_munging/rds/ccle_data_18Q3_g2pgenes.rds")
ccle_data_ptmuts <- filter(ccle_data, Reference_Allele_Length == 1 | Reference_Allele_Length == 0 | is.na(Reference_Allele_Length))
ccle_data_ptmuts$Keep_PtMut_Tests <- ifelse(ccle_data_ptmuts$Reference_Allele_Length == 1 | is.na(ccle_data_ptmuts$Reference_Allele_Length), TRUE, ifelse(ccle_data_ptmuts$Tumor_Seq_Allele1_Length == 1, TRUE, FALSE))
ccle_data_ptmuts <- filter(ccle_data_ptmuts, Keep_PtMut_Tests == TRUE)

ctrp_data <- readRDS("./data_munging/rds/ctrp_data_18Q3_g2pgenes.rds")
ctrp_data_ptmuts <- filter(ctrp_data, Reference_Allele_Length == 1 | Reference_Allele_Length == 0 | is.na(Reference_Allele_Length))
ctrp_data_ptmuts$Keep_PtMut_Tests <- ifelse(ctrp_data_ptmuts$Reference_Allele_Length == 1 | is.na(ctrp_data_ptmuts$Reference_Allele_Length), TRUE, ifelse(ctrp_data_ptmuts$Tumor_Seq_Allele1_Length == 1, TRUE, FALSE))
ctrp_data_ptmuts <- filter(ctrp_data_ptmuts, Keep_PtMut_Tests == TRUE)

gdsc_data <- readRDS("./data_munging/rds/gdsc_data_18Q3_g2pgenes.rds")
gdsc_data_ptmuts <- filter(gdsc_data, Reference_Allele_Length == 1 | Reference_Allele_Length == 0 | is.na(Reference_Allele_Length))
gdsc_data_ptmuts$Keep_PtMut_Tests <- ifelse(gdsc_data_ptmuts$Reference_Allele_Length == 1 | is.na(gdsc_data_ptmuts$Reference_Allele_Length), TRUE, ifelse(gdsc_data_ptmuts$Tumor_Seq_Allele1_Length == 1, TRUE, FALSE))
gdsc_data_ptmuts <- filter(gdsc_data_ptmuts, Keep_PtMut_Tests == TRUE)

# Filter drug screen datasets for G2P drug-gene associations
ccle_data_g2p <- filter(ccle_data_ptmuts, Drug_Gene %in% g2p_drug_genes)
ctrp_data_g2p <- filter(ctrp_data_ptmuts, Drug_Gene %in% g2p_drug_genes)
gdsc_data_g2p <- filter(gdsc_data_ptmuts, Drug_Gene %in% g2p_drug_genes)

# Filter drug screen datasets for G2P genes in drug-gene associations
ccle_data_g2p_genesfilt <- filter(ccle_data_ptmuts, Hugo_Symbol %in% g2p_genes)
ccle_data_g2p_genesfilt$Hugo_Symbol <- ordered(ccle_data_g2p_genesfilt$Hugo_Symbol, levels = g2p_genes)
ctrp_data_g2p_genesfilt <- filter(ctrp_data_ptmuts, Hugo_Symbol %in% g2p_genes)
ctrp_data_g2p_genesfilt$Hugo_Symbol <- ordered(ctrp_data_g2p_genesfilt$Hugo_Symbol, levels = g2p_genes)
gdsc_data_g2p_genesfilt <- filter(gdsc_data_ptmuts, Hugo_Symbol %in% g2p_genes)
gdsc_data_g2p_genesfilt$Hugo_Symbol <- ordered(gdsc_data_g2p_genesfilt$Hugo_Symbol, levels = g2p_genes)

4 Mutation Status Wilcoxon tests

4.1 CRISPR

4.1.1 G2P genes

crispr_signif_g2p_gene <- compare_means(Score ~ Mutation_Status_Nonsilent, group.by = c("Hugo_Symbol"), data = crispr_data_g2p, method = "wilcox.test", p.adjust.method = "BH")
crispr_signif_g2p_gene <- adj_signif(crispr_signif_g2p_gene)
crispr_signif_g2p_gene <- crispr_signif_g2p_gene[order(crispr_signif_g2p_gene$p),]
saveRDS(crispr_signif_g2p_gene, "./data_munging/rds/crispr_signif_g2p_gene.rds")
crispr_signif_g2p_gene <- readRDS("./data_munging/rds/crispr_signif_g2p_gene.rds")

crispr_signif_g2p_20gene <- as.character(crispr_signif_g2p_gene$Hugo_Symbol[0:20])

knitr::kable(crispr_signif_g2p_gene[, c("Hugo_Symbol", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "Wilcoxon test results for Level A point mutations (* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
Wilcoxon test results for Level A point mutations (* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)
Hugo_Symbol p p.adj p.format p.signif p.signif.adj
KRAS 0.0000000 0.0000000 <2e-16 **** ****
BRAF 0.0000000 0.0000000 <2e-16 **** ****
TSC2 0.0123492 0.1145397 0.012
NA
JAK2 0.0164691 0.1145397 0.016
NA
UGT1A1 0.0173545 0.1145397 0.017
NA
CYP19A1 0.0266336 0.1464846 0.027
NA
DPYD 0.0395906 0.1866413 0.040
NA
ERBB2 0.2205184 0.7187459 0.221 NA NA
BRCA2 0.2325878 0.7187459 0.233 NA NA
RET 0.2906604 0.7187459 0.291 NA NA
ALK 0.2998088 0.7187459 0.300 NA NA
PDGFRA 0.3319033 0.7187459 0.332 NA NA
BRCA1 0.3510923 0.7187459 0.351 NA NA
EGFR 0.3543454 0.7187459 0.354 NA NA
NPM1 0.3647284 0.7187459 0.365 NA NA
MYD88 0.3819214 0.7187459 0.382 NA NA
ROS1 0.3825781 0.7187459 0.383 NA NA
PDGFRB 0.3945583 0.7187459 0.395 NA NA
PTCH1 0.4615402 0.7187459 0.462 NA NA
ESR1 0.4662732 0.7187459 0.466 NA NA
PDGFB 0.4681793 0.7187459 0.468 NA NA
MGMT 0.4791639 0.7187459 0.479 NA NA
MET 0.6731081 0.8828534 0.673 NA NA
DNMT3A 0.6819627 0.8828534 0.682 NA NA
TSC1 0.6872265 0.8828534 0.687 NA NA
FLT3 0.6955814 0.8828534 0.696 NA NA
IDH2 0.7750457 0.9120325 0.775 NA NA
PML 0.7843574 0.9120325 0.784 NA NA
ERBB3 0.8014831 0.9120325 0.801 NA NA
ABL1 0.8737848 0.9611633 0.874 NA NA
KIT 0.9113147 0.9690846 0.911 NA NA
AKT1 0.9397184 0.9690846 0.940 NA NA
TPMT 0.9768760 0.9768760 0.977 NA NA 
crispr_data_signif_g2p_gene_filt <- filter(crispr_data_ptmuts, Hugo_Symbol %in% crispr_signif_g2p_20gene)
crispr_data_signif_g2p_gene <- merge(crispr_data_signif_g2p_gene_filt, crispr_signif_g2p_gene, by = "Hugo_Symbol")
crispr_data_signif_g2p_gene$Hugo_Symbol <- ordered(crispr_data_signif_g2p_gene$Hugo_Symbol, levels = crispr_signif_g2p_20gene)
crispr_data_signif_g2p_gene_color <- as.character(crispr_data_signif_g2p_gene$Color_Nonsilent)
names(crispr_data_signif_g2p_gene_color) <- crispr_data_signif_g2p_gene$Mutation_Status_Nonsilent
crispr_data_signif_g2p_gene <- merge(crispr_data_signif_g2p_gene, crispr_data_signif_g2p_gene %>% group_by(Hugo_Symbol) %>% summarize(Text_y = max(Score)), by = "Hugo_Symbol")

crispr_data_signif_g2p_gene_text <- unique(data.frame(p.signif = crispr_data_signif_g2p_gene$p.signif, p.signif.adj = crispr_data_signif_g2p_gene$p.signif.adj,  Hugo_Symbol = crispr_data_signif_g2p_gene$Hugo_Symbol, Text_y = crispr_data_signif_g2p_gene$Text_y))

crispr_data_signif_g2p_gene_plot <- ggplot(data = crispr_data_signif_g2p_gene, aes(x = Mutation_Status_Nonsilent, y = Score)) +
  facet_wrap(~ Hugo_Symbol, drop = FALSE, nrow = 2, scales = "free_y") +
  geom_jitter(aes(color = Mutation_Status_Nonsilent), alpha = 0.5, width = 0.3) +
  geom_boxplot(color = "black", fill = NA, outlier.shape = NA) +
  geom_hline(yintercept = 0, lty = 2, color = "darkgray") +
  scale_color_manual(values = crispr_data_signif_g2p_gene_color) + 
  geom_text(data = crispr_data_signif_g2p_gene_text, mapping = aes(x = 1.5, y = Text_y, label = p.signif), nudge_y = 0.2) +
  theme(legend.position = "top", axis.text.x = element_blank(), axis.ticks.x = element_blank(), axis.title.x = element_blank()) +
  labs(y = "CERES Score",
       color = "Mutation Status",
       title = "CERES scores for select Level A G2P genes",
       subtitle = "Genes are sorted by increasing p-value.")
crispr_data_signif_g2p_gene_plot

# ggsave("./plots_18Q3/manuscript/crispr_data_signif_g2p_gene_plot.png", crispr_data_signif_g2p_gene_plot, width = 12, height = 7, units = "in")

4.1.2 G2P genes and lineage

crispr_signif_g2p_lineage <- compare_means(Score ~ Mutation_Status_Nonsilent, group.by = c("Hugo_Symbol", "group_general_lineage_name"), data = crispr_data_g2p, method = "wilcox.test", p.adjust.method = "BH")
crispr_signif_g2p_lineage <- adj_signif(crispr_signif_g2p_lineage)
crispr_signif_g2p_lineage <- crispr_signif_g2p_lineage[order(crispr_signif_g2p_lineage$p),]
saveRDS(crispr_signif_g2p_lineage, "./data_munging/rds/crispr_signif_g2p_lineage.rds")

# write.table(crispr_signif_g2p_lineage, file = "~/Desktop/crispr_signif_g2p_lineage.csv", quote = FALSE, sep = ",", row.names = FALSE)
crispr_signif_g2p_lineage <- readRDS("./data_munging/rds/crispr_signif_g2p_lineage.rds")

knitr::kable(filter(crispr_signif_g2p_lineage, p < 0.1)[, c("Hugo_Symbol", "group_general_lineage_name", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "Wilcoxon test results comparing non-silent mutant vs other cell lines by lineage, p < 0.1 (* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
Wilcoxon test results comparing non-silent mutant vs other cell lines by lineage, p < 0.1 (* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)
Hugo_Symbol group_general_lineage_name p p.adj p.format p.signif p.signif.adj
KRAS lung cancer 0.0000000 0.0000009 2.5e-09 **** ****
KRAS ovarian cancer 0.0001488 0.0266283 0.00015 ***
KRAS colorectal cancer 0.0010547 0.1258600 0.00105 ** NA
KRAS stomach cancer 0.0040001 0.3580128 0.00400 ** NA
BRAF skin cancer 0.0054870 0.3928703 0.00549 ** NA
BRAF ovarian cancer 0.0107679 0.6424844 0.01077
NA
BRAF breast cancer 0.0136283 0.6969908 0.01363
NA
PDGFRA uterine cancer 0.0224142 0.7800150 0.02241
NA
KRAS breast cancer 0.0237414 0.7800150 0.02374
NA
ROS1 esophageal cancer 0.0292725 0.7800150 0.02927
NA
BRAF cancer 0.0294387 0.7800150 0.02944
NA
BRCA1 breast cancer 0.0312722 0.7800150 0.03127
NA
ERBB3 lung cancer 0.0336500 0.7800150 0.03365
NA
KRAS leukemia 0.0360247 0.7800150 0.03602
NA
ROS1 head and neck cancer 0.0363586 0.7800150 0.03636
NA
MGMT colorectal cancer 0.0372425 0.7800150 0.03724
NA
PDGFRA colorectal cancer 0.0491408 0.7800150 0.04914
NA
DNMT3A uterine cancer 0.0572376 0.7800150 0.05724 NA NA
BRCA1 colorectal cancer 0.0587865 0.7800150 0.05879 NA NA
ALK peripheral nervous system neoplasm 0.0607704 0.7800150 0.06077 NA NA
FLT3 liver cancer 0.0678603 0.7800150 0.06786 NA NA
DPYD skin cancer 0.0714670 0.7800150 0.07147 NA NA
BRCA2 ovarian cancer 0.0816592 0.7800150 0.08166 NA NA
TSC1 uterine cancer 0.0966619 0.7800150 0.09666 NA NA
ROS1 kidney cancer 0.0977184 0.7800150 0.09772 NA NA
DPYD central nervous system cancer 0.0978273 0.7800150 0.09783 NA NA
EGFR uterine cancer 0.0984998 0.7800150 0.09850 NA NA 
crispr_data_signif_g2p_lineage <- merge(crispr_data_signif_g2p_gene_filt, crispr_signif_g2p_lineage, by = c("Hugo_Symbol", "group_general_lineage_name"))
crispr_data_signif_g2p_lineage$Hugo_Symbol <- ordered(crispr_data_signif_g2p_lineage$Hugo_Symbol, levels = crispr_signif_g2p_20gene)
crispr_data_signif_g2p_lineage_color <- as.character(crispr_data_signif_g2p_lineage$Color_Nonsilent)
names(crispr_data_signif_g2p_lineage_color) <- crispr_data_signif_g2p_lineage$Mutation_Status_Nonsilent
crispr_data_signif_g2p_lineage <- merge(crispr_data_signif_g2p_lineage, crispr_data_signif_g2p_lineage %>% group_by(Hugo_Symbol) %>% summarize(Text_y = max(Score)), by = "Hugo_Symbol")

crispr_data_signif_g2p_lineage_text <- unique(data.frame(p.signif = crispr_data_signif_g2p_lineage$p.signif, p.signif.adj = crispr_data_signif_g2p_lineage$p.signif.adj,  group_general_lineage_name = crispr_data_signif_g2p_lineage$group_general_lineage_name, Hugo_Symbol = crispr_data_signif_g2p_lineage$Hugo_Symbol, Text_y = crispr_data_signif_g2p_lineage$Text_y))

crispr_data_signif_g2p_lineage_plot <- ggplot(data = crispr_data_signif_g2p_lineage, aes(x = group_general_lineage_name, y = Score)) +
  facet_wrap(~ Hugo_Symbol, nrow = 4, scales = "free_y") +
  geom_point(aes(color = Mutation_Status_Nonsilent), alpha = 0.5) +
  geom_hline(yintercept = 0, lty = 2, color = "darkgray") +
  scale_color_manual(values = crispr_data_signif_g2p_lineage_color) +
  geom_text(data = crispr_data_signif_g2p_lineage_text, mapping = aes(x = group_general_lineage_name, y = Text_y, label = p.signif), angle = 90, vjust = 0.8, nudge_y = 0.1) +
  theme(legend.position = "top", axis.text.x = element_text(angle = 90, hjust = 1, vjust = 0.4, size = 10)) +
  labs(y = "CERES Score",
       x = "Lineage",
       color = "Mutation Status",
       title = "CERES score by cell line lineage for significant Level A G2P genes",
       subtitle = "* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001\nGenes are sorted by increasing lineage-agnostic p-value.")
crispr_data_signif_g2p_lineage_plot

# ggsave("./plots_18Q3/manuscript/crispr_crispr_data_signif_g2p_lineage_plot.png", crispr_data_signif_g2p_lineage_plot, width = 12, height = 15, units = "in")
crispr_data_signif_g2p_lineage_summ <- crispr_data_signif_g2p_lineage %>% group_by(Hugo_Symbol, group_general_lineage_name, Mutation_Status_Nonsilent) %>% tally()
# write.table(crispr_data_signif_g2p_lineage_summ, file = "~/Desktop/crispr_data_signif_g2p_lineage_summ_20181005.tsv", quote = FALSE, sep = "\t")

knitr::kable(crispr_data_signif_g2p_lineage_summ, caption = "Mutant/Other counts for gene-lineage combinations") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
Mutant/Other counts for gene-lineage combinations
Hugo_Symbol group_general_lineage_name Mutation_Status_Nonsilent n
KRAS bone cancer Mutant 1
KRAS bone cancer Other 15
KRAS breast cancer Mutant 2
KRAS breast cancer Other 24
KRAS colorectal cancer Mutant 14
KRAS colorectal cancer Other 13
KRAS esophageal cancer Mutant 1
KRAS esophageal cancer Other 13
KRAS leukemia Mutant 2
KRAS leukemia Other 19
KRAS lung cancer Mutant 22
KRAS lung cancer Other 48
KRAS multiple myeloma Mutant 4
KRAS multiple myeloma Other 12
KRAS ovarian cancer Mutant 9
KRAS ovarian cancer Other 26
KRAS pancreatic cancer Mutant 23
KRAS pancreatic cancer Other 1
KRAS stomach cancer Mutant 5
KRAS stomach cancer Other 10
KRAS urinary bladder cancer Mutant 2
KRAS urinary bladder cancer Other 19
KRAS uterine cancer Mutant 7
KRAS uterine cancer Other 11
BRAF bone cancer Mutant 1
BRAF bone cancer Other 14
BRAF breast cancer Mutant 3
BRAF breast cancer Other 22
BRAF cancer Mutant 2
BRAF cancer Other 16
BRAF central nervous system cancer Mutant 2
BRAF central nervous system cancer Other 43
BRAF colorectal cancer Mutant 13
BRAF colorectal cancer Other 15
BRAF esophageal cancer Mutant 2
BRAF esophageal cancer Other 12
BRAF liver cancer Mutant 1
BRAF liver cancer Other 15
BRAF lung cancer Mutant 3
BRAF lung cancer Other 66
BRAF multiple myeloma Mutant 2
BRAF multiple myeloma Other 14
BRAF ovarian cancer Mutant 3
BRAF ovarian cancer Other 31
BRAF pancreatic cancer Mutant 2
BRAF pancreatic cancer Other 21
BRAF peripheral nervous system neoplasm Mutant 1
BRAF peripheral nervous system neoplasm Other 12
BRAF skin cancer Mutant 23
BRAF skin cancer Other 8
BRAF stomach cancer Mutant 1
BRAF stomach cancer Other 14
BRAF thyroid cancer Mutant 1
BRAF thyroid cancer Other 2
BRAF urinary bladder cancer Mutant 1
BRAF urinary bladder cancer Other 20
BRAF uterine cancer Mutant 5
BRAF uterine cancer Other 14
TSC2 breast cancer Mutant 1
TSC2 breast cancer Other 25
TSC2 cancer Mutant 1
TSC2 cancer Other 17
TSC2 central nervous system cancer Mutant 1
TSC2 central nervous system cancer Other 43
TSC2 colorectal cancer Mutant 5
TSC2 colorectal cancer Other 22
TSC2 esophageal cancer Mutant 1
TSC2 esophageal cancer Other 13
TSC2 kidney cancer Mutant 1
TSC2 kidney cancer Other 21
TSC2 leukemia Mutant 2
TSC2 leukemia Other 19
TSC2 liver cancer Mutant 2
TSC2 liver cancer Other 14
TSC2 lymphoma Mutant 2
TSC2 lymphoma Other 9
TSC2 multiple myeloma Mutant 2
TSC2 multiple myeloma Other 14
TSC2 pancreatic cancer Mutant 2
TSC2 pancreatic cancer Other 21
TSC2 peripheral nervous system neoplasm Mutant 1
TSC2 peripheral nervous system neoplasm Other 12
TSC2 rhabdomyosarcoma Mutant 1
TSC2 rhabdomyosarcoma Other 6
TSC2 stomach cancer Mutant 2
TSC2 stomach cancer Other 13
TSC2 uterine cancer Mutant 9
TSC2 uterine cancer Other 10
JAK2 colorectal cancer Mutant 1
JAK2 colorectal cancer Other 27
JAK2 esophageal cancer Mutant 1
JAK2 esophageal cancer Other 13
JAK2 leukemia Mutant 1
JAK2 leukemia Other 20
JAK2 lung cancer Mutant 2
JAK2 lung cancer Other 67
JAK2 lymphoma Mutant 1
JAK2 lymphoma Other 10
JAK2 ovarian cancer Mutant 1
JAK2 ovarian cancer Other 34
JAK2 urinary bladder cancer Mutant 2
JAK2 urinary bladder cancer Other 19
JAK2 uterine cancer Mutant 5
JAK2 uterine cancer Other 13
UGT1A1 bone cancer Mutant 2
UGT1A1 bone cancer Other 14
UGT1A1 colorectal cancer Mutant 1
UGT1A1 colorectal cancer Other 25
UGT1A1 esophageal cancer Mutant 1
UGT1A1 esophageal cancer Other 13
UGT1A1 kidney cancer Mutant 1
UGT1A1 kidney cancer Other 21
UGT1A1 lung cancer Mutant 2
UGT1A1 lung cancer Other 67
UGT1A1 skin cancer Mutant 2
UGT1A1 skin cancer Other 28
UGT1A1 stomach cancer Mutant 1
UGT1A1 stomach cancer Other 14
UGT1A1 uterine cancer Mutant 3
UGT1A1 uterine cancer Other 16
CYP19A1 breast cancer Mutant 1
CYP19A1 breast cancer Other 25
CYP19A1 esophageal cancer Mutant 1
CYP19A1 esophageal cancer Other 13
CYP19A1 lymphoma Mutant 1
CYP19A1 lymphoma Other 10
CYP19A1 peripheral nervous system neoplasm Mutant 1
CYP19A1 peripheral nervous system neoplasm Other 12
CYP19A1 stomach cancer Mutant 1
CYP19A1 stomach cancer Other 14
CYP19A1 urinary bladder cancer Mutant 1
CYP19A1 urinary bladder cancer Other 20
CYP19A1 uterine cancer Mutant 2
CYP19A1 uterine cancer Other 16
DPYD bone cancer Mutant 1
DPYD bone cancer Other 15
DPYD breast cancer Mutant 2
DPYD breast cancer Other 24
DPYD central nervous system cancer Mutant 1
DPYD central nervous system cancer Other 44
DPYD colorectal cancer Mutant 4
DPYD colorectal cancer Other 24
DPYD head and neck cancer Mutant 1
DPYD head and neck cancer Other 14
DPYD kidney cancer Mutant 2
DPYD kidney cancer Other 20
DPYD leukemia Mutant 1
DPYD leukemia Other 21
DPYD liver cancer Mutant 1
DPYD liver cancer Other 15
DPYD lung cancer Mutant 4
DPYD lung cancer Other 65
DPYD lymphoma Mutant 1
DPYD lymphoma Other 10
DPYD multiple myeloma Mutant 1
DPYD multiple myeloma Other 15
DPYD ovarian cancer Mutant 2
DPYD ovarian cancer Other 33
DPYD rhabdomyosarcoma Mutant 1
DPYD rhabdomyosarcoma Other 6
DPYD skin cancer Mutant 4
DPYD skin cancer Other 25
DPYD urinary bladder cancer Mutant 1
DPYD urinary bladder cancer Other 20
DPYD uterine cancer Mutant 2
DPYD uterine cancer Other 16
ERBB2 breast cancer Mutant 1
ERBB2 breast cancer Other 25
ERBB2 colorectal cancer Mutant 3
ERBB2 colorectal cancer Other 25
ERBB2 head and neck cancer Mutant 1
ERBB2 head and neck cancer Other 14
ERBB2 kidney cancer Mutant 1
ERBB2 kidney cancer Other 21
ERBB2 leukemia Mutant 1
ERBB2 leukemia Other 20
ERBB2 lung cancer Mutant 3
ERBB2 lung cancer Other 66
ERBB2 ovarian cancer Mutant 2
ERBB2 ovarian cancer Other 33
ERBB2 stomach cancer Mutant 2
ERBB2 stomach cancer Other 13
ERBB2 urinary bladder cancer Mutant 2
ERBB2 urinary bladder cancer Other 20
ERBB2 uterine cancer Mutant 5
ERBB2 uterine cancer Other 14
BRCA2 bone cancer Mutant 1
BRCA2 bone cancer Other 15
BRCA2 breast cancer Mutant 5
BRCA2 breast cancer Other 21
BRCA2 cancer Mutant 3
BRCA2 cancer Other 15
BRCA2 central nervous system cancer Mutant 2
BRCA2 central nervous system cancer Other 43
BRCA2 colorectal cancer Mutant 7
BRCA2 colorectal cancer Other 22
BRCA2 esophageal cancer Mutant 2
BRCA2 esophageal cancer Other 12
BRCA2 kidney cancer Mutant 2
BRCA2 kidney cancer Other 20
BRCA2 leukemia Mutant 3
BRCA2 leukemia Other 18
BRCA2 liver cancer Mutant 1
BRCA2 liver cancer Other 15
BRCA2 lung cancer Mutant 6
BRCA2 lung cancer Other 63
BRCA2 multiple myeloma Mutant 1
BRCA2 multiple myeloma Other 15
BRCA2 ovarian cancer Mutant 2
BRCA2 ovarian cancer Other 33
BRCA2 pancreatic cancer Mutant 1
BRCA2 pancreatic cancer Other 22
BRCA2 skin cancer Mutant 6
BRCA2 skin cancer Other 23
BRCA2 stomach cancer Mutant 2
BRCA2 stomach cancer Other 13
BRCA2 uterine cancer Mutant 7
BRCA2 uterine cancer Other 15
RET bone cancer Mutant 1
RET bone cancer Other 15
RET cancer Mutant 2
RET cancer Other 16
RET central nervous system cancer Mutant 1
RET central nervous system cancer Other 44
RET colorectal cancer Mutant 2
RET colorectal cancer Other 25
RET esophageal cancer Mutant 1
RET esophageal cancer Other 13
RET kidney cancer Mutant 1
RET kidney cancer Other 21
RET leukemia Mutant 1
RET leukemia Other 20
RET lung cancer Mutant 5
RET lung cancer Other 64
RET ovarian cancer Mutant 2
RET ovarian cancer Other 33
RET skin cancer Mutant 2
RET skin cancer Other 27
RET uterine cancer Mutant 2
RET uterine cancer Other 16
ALK breast cancer Mutant 2
ALK breast cancer Other 24
ALK cancer Mutant 2
ALK cancer Other 16
ALK colorectal cancer Mutant 8
ALK colorectal cancer Other 20
ALK esophageal cancer Mutant 2
ALK esophageal cancer Other 12
ALK leukemia Mutant 3
ALK leukemia Other 18
ALK liver cancer Mutant 1
ALK liver cancer Other 15
ALK lung cancer Mutant 7
ALK lung cancer Other 63
ALK lymphoma Mutant 1
ALK lymphoma Other 10
ALK ovarian cancer Mutant 2
ALK ovarian cancer Other 33
ALK pancreatic cancer Mutant 1
ALK pancreatic cancer Other 22
ALK peripheral nervous system neoplasm Mutant 2
ALK peripheral nervous system neoplasm Other 11
ALK skin cancer Mutant 3
ALK skin cancer Other 26
ALK uterine cancer Mutant 3
ALK uterine cancer Other 16
PDGFRA breast cancer Mutant 1
PDGFRA breast cancer Other 25
PDGFRA cancer Mutant 1
PDGFRA cancer Other 17
PDGFRA central nervous system cancer Mutant 1
PDGFRA central nervous system cancer Other 44
PDGFRA colorectal cancer Mutant 3
PDGFRA colorectal cancer Other 24
PDGFRA esophageal cancer Mutant 1
PDGFRA esophageal cancer Other 13
PDGFRA kidney cancer Mutant 1
PDGFRA kidney cancer Other 21
PDGFRA leukemia Mutant 3
PDGFRA leukemia Other 18
PDGFRA lung cancer Mutant 8
PDGFRA lung cancer Other 63
PDGFRA ovarian cancer Mutant 1
PDGFRA ovarian cancer Other 34
PDGFRA pancreatic cancer Mutant 1
PDGFRA pancreatic cancer Other 22
PDGFRA skin cancer Mutant 3
PDGFRA skin cancer Other 26
PDGFRA urinary bladder cancer Mutant 2
PDGFRA urinary bladder cancer Other 19
PDGFRA uterine cancer Mutant 4
PDGFRA uterine cancer Other 14
BRCA1 breast cancer Mutant 2
BRCA1 breast cancer Other 23
BRCA1 colorectal cancer Mutant 5
BRCA1 colorectal cancer Other 23
BRCA1 head and neck cancer Mutant 1
BRCA1 head and neck cancer Other 14
BRCA1 liver cancer Mutant 2
BRCA1 liver cancer Other 14
BRCA1 lung cancer Mutant 4
BRCA1 lung cancer Other 65
BRCA1 lymphoma Mutant 1
BRCA1 lymphoma Other 10
BRCA1 ovarian cancer Mutant 3
BRCA1 ovarian cancer Other 32
BRCA1 pancreatic cancer Mutant 1
BRCA1 pancreatic cancer Other 22
BRCA1 peripheral nervous system neoplasm Mutant 1
BRCA1 peripheral nervous system neoplasm Other 12
BRCA1 skin cancer Mutant 2
BRCA1 skin cancer Other 27
BRCA1 stomach cancer Mutant 2
BRCA1 stomach cancer Other 13
BRCA1 urinary bladder cancer Mutant 2
BRCA1 urinary bladder cancer Other 19
BRCA1 uterine cancer Mutant 5
BRCA1 uterine cancer Other 13
EGFR bone cancer Mutant 1
EGFR bone cancer Other 15
EGFR breast cancer Mutant 1
EGFR breast cancer Other 25
EGFR central nervous system cancer Mutant 4
EGFR central nervous system cancer Other 41
EGFR colorectal cancer Mutant 3
EGFR colorectal cancer Other 26
EGFR esophageal cancer Mutant 4
EGFR esophageal cancer Other 11
EGFR leukemia Mutant 2
EGFR leukemia Other 19
EGFR liver cancer Mutant 1
EGFR liver cancer Other 15
EGFR lung cancer Mutant 7
EGFR lung cancer Other 60
EGFR lymphoma Mutant 1
EGFR lymphoma Other 10
EGFR multiple myeloma Mutant 2
EGFR multiple myeloma Other 14
EGFR ovarian cancer Mutant 2
EGFR ovarian cancer Other 33
EGFR skin cancer Mutant 1
EGFR skin cancer Other 28
EGFR stomach cancer Mutant 1
EGFR stomach cancer Other 14
EGFR uterine cancer Mutant 8
EGFR uterine cancer Other 11
NPM1 central nervous system cancer Mutant 2
NPM1 central nervous system cancer Other 43
NPM1 ovarian cancer Mutant 1
NPM1 ovarian cancer Other 34
NPM1 urinary bladder cancer Mutant 1
NPM1 urinary bladder cancer Other 20
NPM1 uterine cancer Mutant 1
NPM1 uterine cancer Other 17
MYD88 bone cancer Mutant 1
MYD88 bone cancer Other 15
MYD88 breast cancer Mutant 1
MYD88 breast cancer Other 25
MYD88 colorectal cancer Mutant 1
MYD88 colorectal cancer Other 26
MYD88 leukemia Mutant 1
MYD88 leukemia Other 20
MYD88 multiple myeloma Mutant 1
MYD88 multiple myeloma Other 15
MYD88 pancreatic cancer Mutant 1
MYD88 pancreatic cancer Other 22
MYD88 urinary bladder cancer Mutant 1
MYD88 urinary bladder cancer Other 20
MYD88 uterine cancer Mutant 3
MYD88 uterine cancer Other 15
ROS1 bone cancer Mutant 1
ROS1 bone cancer Other 15
ROS1 breast cancer Mutant 2
ROS1 breast cancer Other 24
ROS1 cancer Mutant 2
ROS1 cancer Other 16
ROS1 central nervous system cancer Mutant 3
ROS1 central nervous system cancer Other 42
ROS1 colorectal cancer Mutant 4
ROS1 colorectal cancer Other 22
ROS1 esophageal cancer Mutant 3
ROS1 esophageal cancer Other 11
ROS1 head and neck cancer Mutant 3
ROS1 head and neck cancer Other 12
ROS1 kidney cancer Mutant 2
ROS1 kidney cancer Other 20
ROS1 leukemia Mutant 1
ROS1 leukemia Other 20
ROS1 liver cancer Mutant 5
ROS1 liver cancer Other 11
ROS1 lung cancer Mutant 3
ROS1 lung cancer Other 66
ROS1 lymphoma Mutant 2
ROS1 lymphoma Other 9
ROS1 ovarian cancer Mutant 1
ROS1 ovarian cancer Other 34
ROS1 pancreatic cancer Mutant 1
ROS1 pancreatic cancer Other 22
ROS1 peripheral nervous system neoplasm Mutant 1
ROS1 peripheral nervous system neoplasm Other 12
ROS1 skin cancer Mutant 5
ROS1 skin cancer Other 25
ROS1 urinary bladder cancer Mutant 1
ROS1 urinary bladder cancer Other 20
ROS1 uterine cancer Mutant 7
ROS1 uterine cancer Other 12
PDGFRB breast cancer Mutant 4
PDGFRB breast cancer Other 22
PDGFRB cancer Mutant 2
PDGFRB cancer Other 16
PDGFRB central nervous system cancer Mutant 1
PDGFRB central nervous system cancer Other 44
PDGFRB colorectal cancer Mutant 3
PDGFRB colorectal cancer Other 24
PDGFRB kidney cancer Mutant 1
PDGFRB kidney cancer Other 21
PDGFRB leukemia Mutant 1
PDGFRB leukemia Other 20
PDGFRB lung cancer Mutant 5
PDGFRB lung cancer Other 64
PDGFRB ovarian cancer Mutant 2
PDGFRB ovarian cancer Other 33
PDGFRB rhabdomyosarcoma Mutant 1
PDGFRB rhabdomyosarcoma Other 6
PDGFRB skin cancer Mutant 2
PDGFRB skin cancer Other 27
PDGFRB urinary bladder cancer Mutant 1
PDGFRB urinary bladder cancer Other 20
PDGFRB uterine cancer Mutant 4
PDGFRB uterine cancer Other 16
PTCH1 breast cancer Mutant 4
PTCH1 breast cancer Other 22
PTCH1 colorectal cancer Mutant 4
PTCH1 colorectal cancer Other 24
PTCH1 esophageal cancer Mutant 1
PTCH1 esophageal cancer Other 13
PTCH1 kidney cancer Mutant 1
PTCH1 kidney cancer Other 21
PTCH1 leukemia Mutant 1
PTCH1 leukemia Other 21
PTCH1 liver cancer Mutant 1
PTCH1 liver cancer Other 15
PTCH1 lung cancer Mutant 2
PTCH1 lung cancer Other 67
PTCH1 lymphoma Mutant 1
PTCH1 lymphoma Other 11
PTCH1 ovarian cancer Mutant 3
PTCH1 ovarian cancer Other 32
PTCH1 skin cancer Mutant 1
PTCH1 skin cancer Other 28
PTCH1 stomach cancer Mutant 1
PTCH1 stomach cancer Other 14
PTCH1 urinary bladder cancer Mutant 2
PTCH1 urinary bladder cancer Other 19
PTCH1 uterine cancer Mutant 5
PTCH1 uterine cancer Other 14
ESR1 colorectal cancer Mutant 1
ESR1 colorectal cancer Other 26
ESR1 esophageal cancer Mutant 1
ESR1 esophageal cancer Other 13
ESR1 head and neck cancer Mutant 1
ESR1 head and neck cancer Other 14
ESR1 leukemia Mutant 3
ESR1 leukemia Other 18
ESR1 liver cancer Mutant 1
ESR1 liver cancer Other 15
ESR1 lung cancer Mutant 3
ESR1 lung cancer Other 66
ESR1 stomach cancer Mutant 2
ESR1 stomach cancer Other 13
ESR1 uterine cancer Mutant 2
ESR1 uterine cancer Other 16

4.2 CCLE

4.2.1 G2P gene and drug

ccle_signif_g2p <- compare_means(AUC ~ Mutation_Status_Nonsilent, group.by = "Drug_Gene", data = ccle_data_g2p, method = "wilcox.test", p.adjust.method = "BH")
ccle_signif_g2p <- adj_signif(ccle_signif_g2p)
ccle_signif_g2p <- ccle_signif_g2p[order(ccle_signif_g2p$p),]
saveRDS(ccle_signif_g2p, "./data_munging/rds/ccle_signif_g2p_gene.rds")

ccle_signif_g2p_ByDrug <- lapply(unique(ccle_data_g2p_genesfilt$Drug), WilcoxonByDrug, dataset = ccle_data_g2p_genesfilt, data_name = "ccle", grouping_var = "gene")
names(ccle_signif_g2p_ByDrug) <- unique(ccle_data_g2p_genesfilt$Drug)
saveRDS(ccle_signif_g2p_ByDrug, "./data_munging/rds/ccle_signif_g2p_ByDrug.rds")
ccle_signif_g2p <- readRDS("./data_munging/rds/ccle_signif_g2p_gene.rds")

knitr::kable(ccle_signif_g2p[, c("Drug_Gene", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "CCLE: Wilcoxon test results for level A G2P drug-gene associations (* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
CCLE: Wilcoxon test results for level A G2P drug-gene associations (* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)
Drug_Gene p p.adj p.format p.signif p.signif.adj
selumetinib_KRAS 0.0004853 0.0043681 0.00049 *** **
lapatinib_ERBB2 0.0500292 0.1724797 0.05003 NA NA
nilotinib_UGT1A1 0.0574932 0.1724797 0.05749 NA NA
erlotinib_MET 0.1724618 0.3880391 0.17246 NA NA
erlotinib_KRAS 0.3430622 0.4860797 0.34306 NA NA
lapatinib_KRAS 0.3717079 0.4860797 0.37171 NA NA
erlotinib_EGFR 0.3780620 0.4860797 0.37806 NA NA
irinotecan_UGT1A1 0.8309879 0.9348613 0.83099 NA NA
nilotinib_ABL1 0.9989982 0.9989982 0.99900 NA NA 
ccle_signif_g2p_ByDrug <- readRDS("./data_munging/rds/ccle_signif_g2p_ByDrug.rds")
ccle_signif_g2p_ByDrug_all <- rbindlist(ccle_signif_g2p_ByDrug, use.names = TRUE)
ccle_signif_g2p_ByDrug_all <- ccle_signif_g2p_ByDrug_all[order(ccle_signif_g2p_ByDrug_all$p),]

knitr::kable(ccle_signif_g2p_ByDrug_all[, c("Hugo_Symbol", "Drug", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "CCLE: By-drug Wilcoxon test results for point mutations in level A G2P genes (* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
CCLE: By-drug Wilcoxon test results for point mutations in level A G2P genes (* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)
Hugo_Symbol Drug p p.adj p.format p.signif p.signif.adj
BRAF selumetinib 0.0000000 0.0000016 4.8e-08 **** ****
KRAS selumetinib 0.0004853 0.0082509 0.00049 *** **
KRAS irinotecan 0.0107870 0.2265486 0.011
NA
ERBB3 lapatinib 0.0129696 0.4409649 0.013
NA
FLT3 irinotecan 0.0133264 0.2265486 0.013
NA
ERBB3 nilotinib 0.0219026 0.7446883 0.022
NA
BRAF erlotinib 0.0224018 0.4604309 0.022
NA
KIT lapatinib 0.0299886 0.4872398 0.030
NA
ERBB2 erlotinib 0.0361008 0.4604309 0.036
NA
PDGFB erlotinib 0.0406263 0.4604309 0.041
NA
TSC2 irinotecan 0.0425134 0.4818182 0.043
NA
ERBB2 lapatinib 0.0500292 0.4872398 0.050 NA NA
UGT1A1 nilotinib 0.0574932 0.8315963 0.057 NA NA
ROS1 lapatinib 0.0638294 0.4872398 0.064 NA NA
JAK2 irinotecan 0.0704563 0.5988785 0.070 NA NA
MGMT lapatinib 0.0716529 0.4872398 0.072 NA NA
BRCA2 selumetinib 0.0801455 0.6177935 0.08015 NA NA
BRAF nilotinib 0.0823341 0.8315963 0.082 NA NA
G6PD selumetinib 0.0848649 0.6177935 0.08486 NA NA
DNMT3A lapatinib 0.0910216 0.4905489 0.091 NA NA
IDH2 selumetinib 0.0923191 0.6177935 0.09232 NA NA
ROS1 erlotinib 0.0964090 0.7043128 0.096 NA NA
G6PD nilotinib 0.0978349 0.8315963 0.098 NA NA
AKT1 irinotecan 0.0995560 0.6555760 0.100 NA NA
PTCH1 selumetinib 0.1105610 0.6177935 0.11056 NA NA
BRAF irinotecan 0.1223433 0.6555760 0.122 NA NA
PDGFRA selumetinib 0.1271928 0.6177935 0.12719 NA NA
AKT1 nilotinib 0.1319214 0.8961394 0.132 NA NA
TSC2 lapatinib 0.1353477 0.4905489 0.135 NA NA
BRCA2 lapatinib 0.1454060 0.4905489 0.145 NA NA
DNMT3A selumetinib 0.1475871 0.6272450 0.14759 NA NA
PDGFRA erlotinib 0.1494369 0.7043128 0.149 NA NA
ERBB3 erlotinib 0.1517945 0.7043128 0.152 NA NA
PDGFRA lapatinib 0.1524894 0.4905489 0.152 NA NA
BRAF lapatinib 0.1535431 0.4905489 0.154 NA NA
MGMT erlotinib 0.1554862 0.7043128 0.155 NA NA
RET lapatinib 0.1587070 0.4905489 0.159 NA NA
ESR1 irinotecan 0.1628356 0.6555760 0.163 NA NA
DPYD nilotinib 0.1716871 0.8961394 0.172 NA NA
MET erlotinib 0.1724618 0.7043128 0.172 NA NA
JAK2 selumetinib 0.1725059 0.6516888 0.17251 NA NA
TPMT irinotecan 0.1771488 0.6555760 0.177 NA NA
IDH2 nilotinib 0.1844993 0.8961394 0.184 NA NA
PDGFB lapatinib 0.1902003 0.5389009 0.190 NA NA
JAK2 erlotinib 0.2076226 0.7043128 0.208 NA NA
IDH2 erlotinib 0.2087321 0.7043128 0.209 NA NA
PDGFRB irinotecan 0.2131484 0.6555760 0.213 NA NA
EGFR irinotecan 0.2306603 0.6555760 0.231 NA NA
MGMT irinotecan 0.2444998 0.6555760 0.244 NA NA
ERBB2 nilotinib 0.2469369 0.9412676 0.247 NA NA
JAK2 lapatinib 0.2481605 0.6059107 0.248 NA NA
BRCA2 irinotecan 0.2519045 0.6555760 0.252 NA NA
DPYD irinotecan 0.2565617 0.6555760 0.257 NA NA
PDGFB nilotinib 0.2614178 0.9412676 0.261 NA NA
NPM1 lapatinib 0.2652151 0.6059107 0.265 NA NA
PML lapatinib 0.2673135 0.6059107 0.267 NA NA
DNMT3A irinotecan 0.2699431 0.6555760 0.270 NA NA
BRCA2 erlotinib 0.2904280 0.7043128 0.290 NA NA
KRAS nilotinib 0.2905710 0.9412676 0.291 NA NA
TSC1 selumetinib 0.3026265 0.9776385 0.30263 NA NA
PML erlotinib 0.3071538 0.7043128 0.307 NA NA
RET selumetinib 0.3162948 0.9776385 0.31629 NA NA
JAK2 nilotinib 0.3242397 0.9412676 0.324 NA NA
CYP19A1 irinotecan 0.3281397 0.7321035 0.328 NA NA
KRAS erlotinib 0.3430622 0.7043128 0.343 NA NA
MET irinotecan 0.3595819 0.7321035 0.360 NA NA
CYP19A1 nilotinib 0.3614358 0.9412676 0.361 NA NA
BRCA1 erlotinib 0.3656704 0.7043128 0.366 NA NA
CYP19A1 selumetinib 0.3657355 0.9863877 0.36574 NA NA
MYD88 irinotecan 0.3660517 0.7321035 0.366 NA NA
KRAS lapatinib 0.3717079 0.7898793 0.372 NA NA
MET nilotinib 0.3749787 0.9412676 0.375 NA NA
RET erlotinib 0.3769409 0.7043128 0.377 NA NA
EGFR erlotinib 0.3780620 0.7043128 0.378 NA NA
KIT erlotinib 0.3945572 0.7043128 0.395 NA NA
NPM1 erlotinib 0.4081068 0.7043128 0.408 NA NA
AKT1 erlotinib 0.4089836 0.7043128 0.409 NA NA
TSC2 erlotinib 0.4143017 0.7043128 0.414 NA NA
ALK irinotecan 0.4159284 0.7856426 0.416 NA NA
KIT selumetinib 0.4291048 0.9863877 0.42910 NA NA
BRCA2 nilotinib 0.4329522 0.9412676 0.433 NA NA
DNMT3A nilotinib 0.4393202 0.9412676 0.439 NA NA
ABL1 lapatinib 0.4453225 0.8186706 0.445 NA NA
FLT3 erlotinib 0.4536996 0.7345612 0.454 NA NA
ESR1 selumetinib 0.4556101 0.9863877 0.45561 NA NA
MYD88 lapatinib 0.4587151 0.8186706 0.459 NA NA
ALK lapatinib 0.4609038 0.8186706 0.461 NA NA
PDGFRB nilotinib 0.4795241 0.9412676 0.480 NA NA
ROS1 irinotecan 0.4834670 0.8355783 0.483 NA NA
TPMT erlotinib 0.4842070 0.7483199 0.484 NA NA
DPYD lapatinib 0.4951753 0.8186706 0.495 NA NA
PDGFB irinotecan 0.5117862 0.8355783 0.512 NA NA
ESR1 nilotinib 0.5209092 0.9412676 0.521 NA NA
NPM1 nilotinib 0.5225901 0.9412676 0.523 NA NA
BRCA1 lapatinib 0.5346294 0.8186706 0.535 NA NA
IDH2 irinotecan 0.5383687 0.8355783 0.538 NA NA
ESR1 erlotinib 0.5463206 0.8076043 0.546 NA NA
MET lapatinib 0.5678884 0.8186706 0.568 NA NA
CYP19A1 erlotinib 0.5725012 0.8110433 0.573 NA NA
EGFR selumetinib 0.5763443 0.9863877 0.57634 NA NA
PDGFRB lapatinib 0.5810825 0.8186706 0.581 NA NA
UGT1A1 lapatinib 0.5880643 0.8186706 0.588 NA NA
FLT3 nilotinib 0.5913464 0.9412676 0.591 NA NA
PDGFRA irinotecan 0.5925752 0.8355783 0.593 NA NA
RET nilotinib 0.5975829 0.9412676 0.598 NA NA
TSC1 irinotecan 0.6014923 0.8355783 0.601 NA NA
AKT1 lapatinib 0.6019637 0.8186706 0.602 NA NA
TSC2 selumetinib 0.6111574 0.9863877 0.61116 NA NA
ERBB2 irinotecan 0.6286426 0.8355783 0.629 NA NA
PML irinotecan 0.6294330 0.8355783 0.629 NA NA
G6PD lapatinib 0.6332410 0.8280844 0.633 NA NA
RET irinotecan 0.6389716 0.8355783 0.639 NA NA
TSC1 erlotinib 0.6505989 0.8848145 0.651 NA NA
MET selumetinib 0.6524774 0.9863877 0.65248 NA NA
KIT nilotinib 0.6606331 0.9412676 0.661 NA NA
ABL1 selumetinib 0.6628862 0.9863877 0.66289 NA NA
PDGFRB selumetinib 0.6645199 0.9863877 0.66452 NA NA
ABL1 irinotecan 0.6660281 0.8387021 0.666 NA NA
TPMT nilotinib 0.6679929 0.9412676 0.668 NA NA
ROS1 nilotinib 0.6819122 0.9412676 0.682 NA NA
DPYD erlotinib 0.6840148 0.8944809 0.684 NA NA
DPYD selumetinib 0.6868738 0.9863877 0.68687 NA NA
MYD88 nilotinib 0.6912056 0.9412676 0.691 NA NA
TSC2 nilotinib 0.6921085 0.9412676 0.692 NA NA
CYP19A1 lapatinib 0.6950890 0.8752973 0.695 NA NA
PTCH1 irinotecan 0.7162618 0.8697465 0.716 NA NA
MYD88 selumetinib 0.7246756 0.9863877 0.72468 NA NA
PTCH1 erlotinib 0.7302464 0.9195695 0.730 NA NA
TSC1 lapatinib 0.7401698 0.8933363 0.740 NA NA
PDGFB selumetinib 0.7634636 0.9863877 0.76346 NA NA
G6PD erlotinib 0.7787902 0.9278477 0.779 NA NA
PTCH1 lapatinib 0.7871784 0.8933363 0.787 NA NA
EGFR lapatinib 0.7947247 0.8933363 0.795 NA NA
ALK nilotinib 0.7983903 0.9829706 0.798 NA NA
TSC1 nilotinib 0.7988924 0.9829706 0.799 NA NA
IDH2 lapatinib 0.8145125 0.8933363 0.815 NA NA
BRCA1 irinotecan 0.8210965 0.9114060 0.821 NA NA
ERBB2 selumetinib 0.8218228 0.9863877 0.82182 NA NA
UGT1A1 erlotinib 0.8238031 0.9278477 0.824 NA NA
G6PD irinotecan 0.8254252 0.9114060 0.825 NA NA
ROS1 selumetinib 0.8271911 0.9863877 0.82719 NA NA
ALK selumetinib 0.8278795 0.9863877 0.82788 NA NA
PDGFRB erlotinib 0.8279937 0.9278477 0.828 NA NA
MGMT nilotinib 0.8301945 0.9829706 0.830 NA NA
UGT1A1 irinotecan 0.8309879 0.9114060 0.831 NA NA
ABL1 erlotinib 0.8522490 0.9278477 0.852 NA NA
FLT3 selumetinib 0.8527746 0.9863877 0.85277 NA NA
FLT3 lapatinib 0.8614733 0.9153153 0.861 NA NA
PDGFRA nilotinib 0.8621321 0.9829706 0.862 NA NA
ERBB3 selumetinib 0.8669447 0.9863877 0.86694 NA NA
NPM1 selumetinib 0.8832243 0.9863877 0.88322 NA NA
KIT irinotecan 0.8862231 0.9200633 0.886 NA NA
MYD88 erlotinib 0.8885739 0.9278477 0.889 NA NA
UGT1A1 selumetinib 0.8917738 0.9863877 0.89177 NA NA
NPM1 irinotecan 0.8930026 0.9200633 0.893 NA NA
DNMT3A erlotinib 0.9005581 0.9278477 0.901 NA NA
TPMT lapatinib 0.9089736 0.9365183 0.909 NA NA
PML nilotinib 0.9170484 0.9829706 0.917 NA NA
AKT1 selumetinib 0.9187209 0.9863877 0.91872 NA NA
MGMT selumetinib 0.9254057 0.9863877 0.92541 NA NA
ALK erlotinib 0.9492432 0.9492432 0.949 NA NA
PML selumetinib 0.9504098 0.9863877 0.95041 NA NA
BRCA1 nilotinib 0.9506540 0.9829706 0.951 NA NA
PTCH1 nilotinib 0.9525059 0.9829706 0.953 NA NA
EGFR nilotinib 0.9540597 0.9829706 0.954 NA NA
BRCA1 selumetinib 0.9592240 0.9863877 0.95922 NA NA
ESR1 lapatinib 0.9641363 0.9641363 0.964 NA NA
ERBB3 irinotecan 0.9705439 0.9705439 0.971 NA NA
TPMT selumetinib 0.9863877 0.9863877 0.98639 NA NA
ABL1 nilotinib 0.9989982 0.9989982 0.999 NA NA

4.2.2 G2P gene, drug, and lineage

ccle_signif_g2p_lineage <- lapply(unique(ccle_data_g2p_genesfilt$Drug), WilcoxonByDrug, dataset = ccle_data_g2p_genesfilt, data_name = "ccle", grouping_var = "lineage")
names(ccle_signif_g2p_lineage) <- unique(ccle_signif_g2p_lineage$Drug)
saveRDS(ccle_signif_g2p_lineage, "./data_munging/rds/ccle_signif_g2p_lineage.rds")
ccle_signif_g2p_lineage <- readRDS("./data_munging/rds/ccle_signif_g2p_lineage.rds")
ccle_signif_g2p_lineage <- rbindlist(ccle_signif_g2p_lineage, use.names = TRUE)
ccle_signif_g2p_lineage <- ccle_signif_g2p_lineage[order(ccle_signif_g2p_lineage$p),]

knitr::kable(ccle_signif_g2p_lineage[1:500, c("Hugo_Symbol", "Drug", "group_general_lineage_name", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "CCLE: Wilcoxon test results for level A G2P drug-gene associations across lineages (* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
CCLE: Wilcoxon test results for level A G2P drug-gene associations across lineages (* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)
Hugo_Symbol Drug group_general_lineage_name p p.adj p.format p.signif p.signif.adj
PTCH1 erlotinib breast cancer 0.0072436 0.7568546 0.0072 ** NA
KRAS selumetinib lung cancer 0.0113753 0.8331539 0.011
NA
PDGFRB nilotinib breast cancer 0.0121613 0.9762516 0.012
NA
BRCA2 erlotinib lung cancer 0.0160367 0.7568546 0.0160
NA
ROS1 erlotinib liver cancer 0.0162268 0.7568546 0.0162
NA
FLT3 irinotecan lung cancer 0.0206398 0.8210738 0.021
NA
JAK2 nilotinib uterine cancer 0.0221907 0.9762516 0.022
NA
BRAF selumetinib lung cancer 0.0230794 0.8331539 0.023
NA
ALK erlotinib colorectal cancer 0.0239007 0.7568546 0.0239
NA
DPYD erlotinib lung cancer 0.0245224 0.7568546 0.0245
NA
PDGFRA erlotinib colorectal cancer 0.0246982 0.7568546 0.0247
NA
PTCH1 erlotinib colorectal cancer 0.0246982 0.7568546 0.0247
NA
PDGFRA lapatinib colorectal cancer 0.0247295 0.8482309 0.025
NA
PTCH1 lapatinib colorectal cancer 0.0247295 0.8482309 0.025
NA
BRCA2 lapatinib lung cancer 0.0257350 0.8482309 0.026
NA
BRAF selumetinib ovarian cancer 0.0289512 0.8331539 0.029
NA
ALK lapatinib colorectal cancer 0.0296565 0.8482309 0.030
NA
TSC1 irinotecan uterine cancer 0.0355608 0.8210738 0.036
NA
MET nilotinib colorectal cancer 0.0360247 0.9762516 0.036
NA
EGFR erlotinib colorectal cancer 0.0384617 0.7568546 0.0385
NA
EGFR lapatinib colorectal cancer 0.0384949 0.8482309 0.038
NA
UGT1A1 nilotinib lung cancer 0.0399097 0.9762516 0.040
NA
ABL1 lapatinib skin cancer 0.0404770 0.8482309 0.040
NA
PTCH1 lapatinib breast cancer 0.0412580 0.8482309 0.041
NA
PDGFB erlotinib colorectal cancer 0.0416349 0.7568546 0.0416
NA
PDGFB lapatinib colorectal cancer 0.0416793 0.8482309 0.042
NA
BRCA2 selumetinib lung cancer 0.0424366 0.8331539 0.042
NA
ABL1 irinotecan uterine cancer 0.0443755 0.8210738 0.044
NA
KRAS nilotinib uterine cancer 0.0447916 0.9762516 0.045
NA
TSC1 erlotinib uterine cancer 0.0450371 0.7568546 0.0450
NA
DPYD selumetinib lung cancer 0.0491283 0.8331539 0.049
NA
ERBB2 lapatinib ovarian cancer 0.0506973 0.8482309 0.051 NA NA
BRCA2 lapatinib skin cancer 0.0540402 0.8482309 0.054 NA NA
BRCA1 lapatinib liver cancer 0.0540779 0.8482309 0.054 NA NA
ESR1 lapatinib lung cancer 0.0545880 0.8482309 0.055 NA NA
KIT selumetinib lung cancer 0.0552756 0.8331539 0.055 NA NA
MET selumetinib stomach cancer 0.0578826 0.8331539 0.058 NA NA
MET nilotinib pancreatic cancer 0.0600471 0.9762516 0.060 NA NA
MET irinotecan uterine cancer 0.0607704 0.8210738 0.061 NA NA
TSC1 nilotinib urinary bladder cancer 0.0607704 0.9762516 0.061 NA NA
TSC2 selumetinib pancreatic cancer 0.0613902 0.8331539 0.061 NA NA
TSC1 nilotinib uterine cancer 0.0622469 0.9762516 0.062 NA NA
DNMT3A selumetinib lung cancer 0.0642266 0.8331539 0.064 NA NA
ALK selumetinib lung cancer 0.0645049 0.8331539 0.065 NA NA
ABL1 selumetinib lung cancer 0.0656886 0.8331539 0.066 NA NA
ERBB3 nilotinib lung cancer 0.0666587 0.9762516 0.067 NA NA
DPYD lapatinib colorectal cancer 0.0667981 0.8482309 0.067 NA NA
BRAF irinotecan uterine cancer 0.0675869 0.8210738 0.068 NA NA
FLT3 erlotinib esophageal cancer 0.0678603 0.7568546 0.0679 NA NA
ESR1 nilotinib uterine cancer 0.0678603 0.9762516 0.068 NA NA
DPYD lapatinib lung cancer 0.0685101 0.8482309 0.069 NA NA
KIT erlotinib lung cancer 0.0724051 0.7568546 0.0724 NA NA
PML selumetinib uterine cancer 0.0737528 0.8331539 0.074 NA NA
PDGFRB nilotinib lung cancer 0.0749574 0.9762516 0.075 NA NA
MET lapatinib pancreatic cancer 0.0768665 0.8482309 0.077 NA NA
KRAS lapatinib pancreatic cancer 0.0772704 0.8482309 0.077 NA NA
KRAS selumetinib pancreatic cancer 0.0772704 0.8331539 0.077 NA NA
PDGFRA lapatinib uterine cancer 0.0782207 0.8482309 0.078 NA NA
ERBB3 nilotinib uterine cancer 0.0786823 0.9762516 0.079 NA NA
ROS1 selumetinib liver cancer 0.0831041 0.8331539 0.083 NA NA
RET erlotinib colorectal cancer 0.0847541 0.7568546 0.0848 NA NA
BRAF irinotecan ovarian cancer 0.0848219 0.8210738 0.085 NA NA
KIT lapatinib lung cancer 0.0852267 0.8482309 0.085 NA NA
BRCA2 lapatinib colorectal cancer 0.0893678 0.8482309 0.089 NA NA
AKT1 lapatinib lung cancer 0.0931283 0.8482309 0.093 NA NA
RET lapatinib lung cancer 0.0931290 0.8482309 0.093 NA NA
ABL1 irinotecan urinary bladder cancer 0.0933907 0.8210738 0.093 NA NA
PML irinotecan colorectal cancer 0.0933907 0.8210738 0.093 NA NA
PTCH1 irinotecan urinary bladder cancer 0.0933907 0.8210738 0.093 NA NA
ABL1 nilotinib urinary bladder cancer 0.0933907 0.9762516 0.093 NA NA
PTCH1 nilotinib urinary bladder cancer 0.0933907 0.9762516 0.093 NA NA
PDGFRB irinotecan lung cancer 0.0965728 0.8210738 0.097 NA NA
ESR1 irinotecan lung cancer 0.0965728 0.8210738 0.097 NA NA
EGFR irinotecan lung cancer 0.0968657 0.8210738 0.097 NA NA
DNMT3A selumetinib skin cancer 0.0997555 0.8331539 0.100 NA NA
AKT1 erlotinib lung cancer 0.1002136 0.7568546 0.1002 NA NA
KRAS irinotecan colorectal cancer 0.1004125 0.8210738 0.100 NA NA
ALK lapatinib ovarian cancer 0.1049251 0.8482309 0.105 NA NA
ERBB3 erlotinib colorectal cancer 0.1053883 0.7568546 0.1054 NA NA
NPM1 lapatinib ovarian cancer 0.1057360 0.8482309 0.106 NA NA
TSC1 lapatinib pancreatic cancer 0.1057748 0.8482309 0.106 NA NA
FLT3 selumetinib pancreatic cancer 0.1057748 0.8331539 0.106 NA NA
KRAS selumetinib breast cancer 0.1064506 0.8331539 0.106 NA NA
TSC2 selumetinib breast cancer 0.1064506 0.8331539 0.106 NA NA
MYD88 selumetinib breast cancer 0.1064506 0.8331539 0.106 NA NA
EGFR lapatinib breast cancer 0.1066232 0.8482309 0.107 NA NA
NPM1 nilotinib ovarian cancer 0.1066232 0.9762516 0.107 NA NA
ALK selumetinib leukemia 0.1066232 0.8331539 0.107 NA NA
ESR1 selumetinib leukemia 0.1066232 0.8331539 0.107 NA NA
MYD88 selumetinib leukemia 0.1066232 0.8331539 0.107 NA NA
BRCA1 nilotinib ovarian cancer 0.1113338 0.9762516 0.111 NA NA
TSC1 erlotinib colorectal cancer 0.1119614 0.7568546 0.1120 NA NA
MGMT erlotinib colorectal cancer 0.1119614 0.7568546 0.1120 NA NA
TSC1 selumetinib lung cancer 0.1119900 0.8331539 0.112 NA NA
TSC1 lapatinib colorectal cancer 0.1120393 0.8482309 0.112 NA NA
MGMT lapatinib colorectal cancer 0.1120393 0.8482309 0.112 NA NA
TSC1 selumetinib colorectal cancer 0.1120393 0.8331539 0.112 NA NA
MGMT selumetinib colorectal cancer 0.1120393 0.8331539 0.112 NA NA
G6PD erlotinib uterine cancer 0.1162024 0.7568546 0.1162 NA NA
G6PD lapatinib uterine cancer 0.1162024 0.8482309 0.116 NA NA
MYD88 irinotecan pancreatic cancer 0.1166774 0.8210738 0.117 NA NA
PDGFB nilotinib colorectal cancer 0.1166774 0.9762516 0.117 NA NA
G6PD selumetinib uterine cancer 0.1166774 0.8331539 0.117 NA NA
DPYD selumetinib uterine cancer 0.1166774 0.8331539 0.117 NA NA
BRCA2 irinotecan skin cancer 0.1168894 0.8210738 0.117 NA NA
ERBB2 nilotinib stomach cancer 0.1175249 0.9762516 0.118 NA NA
BRCA1 lapatinib breast cancer 0.1185025 0.8482309 0.119 NA NA
PDGFB irinotecan central nervous system cancer 0.1185714 0.8210738 0.119 NA NA
AKT1 selumetinib lung cancer 0.1202806 0.8331539 0.120 NA NA
KRAS erlotinib urinary bladder cancer 0.1206908 0.7568546 0.1207 NA NA
TSC1 selumetinib uterine cancer 0.1230143 0.8331539 0.123 NA NA
EGFR lapatinib stomach cancer 0.1230779 0.8482309 0.123 NA NA
ERBB3 selumetinib breast cancer 0.1234614 0.8331539 0.123 NA NA
KIT selumetinib breast cancer 0.1234614 0.8331539 0.123 NA NA
RET nilotinib lung cancer 0.1239790 0.9762516 0.124 NA NA
BRCA2 lapatinib ovarian cancer 0.1239798 0.8482309 0.124 NA NA
ROS1 lapatinib cancer 0.1255065 0.8482309 0.126 NA NA
ERBB3 irinotecan breast cancer 0.1257864 0.8210738 0.126 NA NA
KIT irinotecan breast cancer 0.1257864 0.8210738 0.126 NA NA
ERBB3 selumetinib lung cancer 0.1269262 0.8331539 0.127 NA NA
DNMT3A nilotinib skin cancer 0.1278076 0.9762516 0.128 NA NA
DPYD nilotinib lung cancer 0.1288548 0.9762516 0.129 NA NA
BRCA2 lapatinib esophageal cancer 0.1288851 0.8482309 0.129 NA NA
PDGFB nilotinib uterine cancer 0.1288851 0.9762516 0.129 NA NA
DPYD nilotinib uterine cancer 0.1288851 0.9762516 0.129 NA NA
AKT1 selumetinib esophageal cancer 0.1288851 0.8331539 0.129 NA NA
G6PD erlotinib skin cancer 0.1293349 0.7568546 0.1293 NA NA
EGFR lapatinib skin cancer 0.1293349 0.8482309 0.129 NA NA
ALK erlotinib skin cancer 0.1296396 0.7568546 0.1296 NA NA
PDGFRA erlotinib leukemia 0.1318356 0.7568546 0.1318 NA NA
PDGFRA selumetinib leukemia 0.1320261 0.8331539 0.132 NA NA
ABL1 erlotinib ovarian cancer 0.1331112 0.7568546 0.1331 NA NA
RET erlotinib central nervous system cancer 0.1331112 0.7568546 0.1331 NA NA
BRCA2 erlotinib colorectal cancer 0.1348672 0.7568546 0.1349 NA NA
MET erlotinib breast cancer 0.1351663 0.7568546 0.1352 NA NA
ALK erlotinib breast cancer 0.1351663 0.7568546 0.1352 NA NA
FLT3 selumetinib leukemia 0.1351663 0.8331539 0.135 NA NA
MET erlotinib esophageal cancer 0.1357972 0.7568546 0.1358 NA NA
ERBB3 erlotinib urinary bladder cancer 0.1366410 0.7568546 0.1366 NA NA
TSC2 erlotinib multiple myeloma 0.1366410 0.7568546 0.1366 NA NA
DPYD irinotecan skin cancer 0.1368680 0.8210738 0.137 NA NA
BRAF erlotinib breast cancer 0.1373948 0.7568546 0.1374 NA NA
PML lapatinib colorectal cancer 0.1378403 0.8482309 0.138 NA NA
MET irinotecan urinary bladder cancer 0.1415789 0.8210738 0.142 NA NA
ROS1 irinotecan urinary bladder cancer 0.1415789 0.8210738 0.142 NA NA
PDGFRA irinotecan colorectal cancer 0.1415789 0.8210738 0.142 NA NA
PDGFRB irinotecan urinary bladder cancer 0.1415789 0.8210738 0.142 NA NA
TSC1 irinotecan colorectal cancer 0.1415789 0.8210738 0.142 NA NA
TSC2 irinotecan multiple myeloma 0.1415789 0.8210738 0.142 NA NA
AKT1 irinotecan uterine cancer 0.1415789 0.8210738 0.142 NA NA
DPYD irinotecan uterine cancer 0.1415789 0.8210738 0.142 NA NA
TPMT irinotecan urinary bladder cancer 0.1415789 0.8210738 0.142 NA NA
NPM1 irinotecan urinary bladder cancer 0.1415789 0.8210738 0.142 NA NA
PTCH1 irinotecan colorectal cancer 0.1415789 0.8210738 0.142 NA NA
MGMT irinotecan colorectal cancer 0.1415789 0.8210738 0.142 NA NA
BRAF nilotinib urinary bladder cancer 0.1415789 0.9762516 0.142 NA NA
BRCA1 nilotinib liver cancer 0.1415789 0.9762516 0.142 NA NA
TSC1 nilotinib liver cancer 0.1415789 0.9762516 0.142 NA NA
TSC2 nilotinib liver cancer 0.1415789 0.9762516 0.142 NA NA
BRAF lapatinib ovarian cancer 0.1420455 0.8482309 0.142 NA NA
ERBB3 lapatinib breast cancer 0.1420946 0.8482309 0.142 NA NA
KIT lapatinib breast cancer 0.1420946 0.8482309 0.142 NA NA
DNMT3A irinotecan uterine cancer 0.1436861 0.8210738 0.144 NA NA
KRAS lapatinib urinary bladder cancer 0.1436861 0.8482309 0.144 NA NA
PDGFRA erlotinib uterine cancer 0.1445098 0.7568546 0.1445 NA NA
FLT3 selumetinib skin cancer 0.1447271 0.8331539 0.145 NA NA
PDGFRA irinotecan leukemia 0.1453683 0.8210738 0.145 NA NA
DNMT3A erlotinib colorectal cancer 0.1484735 0.7568546 0.1485 NA NA
DNMT3A lapatinib colorectal cancer 0.1485618 0.8482309 0.149 NA NA
KRAS selumetinib uterine cancer 0.1498043 0.8331539 0.150 NA NA
BRCA2 irinotecan colorectal cancer 0.1507856 0.8210738 0.151 NA NA
PDGFRA nilotinib pancreatic cancer 0.1520926 0.9762516 0.152 NA NA
PDGFRB selumetinib breast cancer 0.1545257 0.8331539 0.155 NA NA
ERBB3 erlotinib cancer 0.1547289 0.7568546 0.1547 NA NA
ERBB3 lapatinib cancer 0.1547289 0.8482309 0.155 NA NA
PML selumetinib cancer 0.1547289 0.8331539 0.155 NA NA
DPYD lapatinib uterine cancer 0.1598562 0.8482309 0.160 NA NA
TPMT lapatinib uterine cancer 0.1598562 0.8482309 0.160 NA NA
BRCA1 irinotecan pancreatic cancer 0.1603996 0.8210738 0.160 NA NA
TSC2 irinotecan uterine cancer 0.1610524 0.8210738 0.161 NA NA
KRAS nilotinib pancreatic cancer 0.1628980 0.9762516 0.163 NA NA
KRAS irinotecan ovarian cancer 0.1637103 0.8210738 0.164 NA NA
TSC2 erlotinib kidney cancer 0.1637344 0.7568546 0.1637 NA NA
DPYD erlotinib kidney cancer 0.1637344 0.7568546 0.1637 NA NA
TSC2 lapatinib kidney cancer 0.1637344 0.8482309 0.164 NA NA
DPYD lapatinib kidney cancer 0.1637344 0.8482309 0.164 NA NA
ERBB3 lapatinib central nervous system cancer 0.1646318 0.8482309 0.165 NA NA
BRAF nilotinib colorectal cancer 0.1650718 0.9762516 0.165 NA NA
TSC2 erlotinib central nervous system cancer 0.1656214 0.7568546 0.1656 NA NA
FLT3 lapatinib pancreatic cancer 0.1656214 0.8482309 0.166 NA NA
BRCA1 selumetinib skin cancer 0.1657045 0.8331539 0.166 NA NA
PTCH1 selumetinib lung cancer 0.1664869 0.8331539 0.166 NA NA
TSC2 irinotecan pancreatic cancer 0.1682659 0.8210738 0.168 NA NA
ROS1 lapatinib central nervous system cancer 0.1691178 0.8482309 0.169 NA NA
ERBB2 erlotinib breast cancer 0.1692825 0.7568546 0.1693 NA NA
PDGFRB erlotinib ovarian cancer 0.1701169 0.7568546 0.1701 NA NA
TSC1 selumetinib ovarian cancer 0.1701169 0.8331539 0.170 NA NA
BRAF lapatinib liver cancer 0.1709035 0.8482309 0.171 NA NA
TSC1 lapatinib liver cancer 0.1709035 0.8482309 0.171 NA NA
TSC2 lapatinib liver cancer 0.1709035 0.8482309 0.171 NA NA
EGFR irinotecan colorectal cancer 0.1719754 0.8210738 0.172 NA NA
PDGFRB irinotecan uterine cancer 0.1719754 0.8210738 0.172 NA NA
ERBB3 lapatinib urinary bladder cancer 0.1719754 0.8482309 0.172 NA NA
FLT3 lapatinib peripheral nervous system neoplasm 0.1752442 0.8482309 0.175 NA NA
DPYD nilotinib kidney cancer 0.1752442 0.9762516 0.175 NA NA
ROS1 erlotinib esophageal cancer 0.1771433 0.7568546 0.1771 NA NA
FLT3 lapatinib esophageal cancer 0.1771433 0.8482309 0.177 NA NA
PTCH1 erlotinib stomach cancer 0.1772617 0.7568546 0.1773 NA NA
PTCH1 selumetinib stomach cancer 0.1772617 0.8331539 0.177 NA NA
BRCA2 nilotinib lung cancer 0.1787793 0.9762516 0.179 NA NA
JAK2 lapatinib lung cancer 0.1788700 0.8482309 0.179 NA NA
AKT1 irinotecan pancreatic cancer 0.1801913 0.8210738 0.180 NA NA
KRAS erlotinib stomach cancer 0.1819959 0.7568546 0.1820 NA NA
ERBB2 lapatinib stomach cancer 0.1819959 0.8482309 0.182 NA NA
BRCA2 erlotinib breast cancer 0.1821948 0.7568546 0.1822 NA NA
DPYD irinotecan breast cancer 0.1845726 0.8210738 0.185 NA NA
BRAF erlotinib ovarian cancer 0.1852333 0.7568546 0.1852 NA NA
ABL1 nilotinib skin cancer 0.1892630 0.9762516 0.189 NA NA
KRAS irinotecan stomach cancer 0.1904303 0.8210738 0.190 NA NA
PTCH1 irinotecan stomach cancer 0.1904303 0.8210738 0.190 NA NA
ALK nilotinib cancer 0.1904303 0.9762516 0.190 NA NA
DNMT3A nilotinib cancer 0.1904303 0.9762516 0.190 NA NA
ERBB3 selumetinib colorectal cancer 0.1916946 0.8331539 0.192 NA NA
ESR1 nilotinib lung cancer 0.1919810 0.9762516 0.192 NA NA
BRCA2 erlotinib esophageal cancer 0.1930591 0.7568546 0.1931 NA NA
AKT1 nilotinib uterine cancer 0.1930591 0.9762516 0.193 NA NA
KIT erlotinib colorectal cancer 0.1934468 0.7568546 0.1934 NA NA
IDH2 erlotinib colorectal cancer 0.1934468 0.7568546 0.1934 NA NA
G6PD lapatinib skin cancer 0.1935824 0.8745269 0.194 NA NA
MET erlotinib lung cancer 0.1938456 0.7568546 0.1938 NA NA
BRCA2 selumetinib cancer 0.1948506 0.8331539 0.195 NA NA
BRAF selumetinib skin cancer 0.1950864 0.8331539 0.195 NA NA
ERBB2 selumetinib ovarian cancer 0.1975069 0.8331539 0.198 NA NA
ROS1 erlotinib skin cancer 0.1990220 0.7568546 0.1990 NA NA
TSC1 irinotecan urinary bladder cancer 0.1994900 0.8210738 0.199 NA NA
BRCA2 nilotinib pancreatic cancer 0.2000451 0.9762516 0.200 NA NA
ERBB3 nilotinib breast cancer 0.2030171 0.9762516 0.203 NA NA
KIT nilotinib breast cancer 0.2030171 0.9762516 0.203 NA NA
PDGFRB selumetinib central nervous system cancer 0.2036719 0.8331539 0.204 NA NA
BRCA2 lapatinib pancreatic cancer 0.2037725 0.8745269 0.204 NA NA
NPM1 selumetinib ovarian cancer 0.2037725 0.8331539 0.204 NA NA
DPYD erlotinib colorectal cancer 0.2055349 0.7568546 0.2055 NA NA
FLT3 erlotinib leukemia 0.2092579 0.7568546 0.2093 NA NA
ABL1 lapatinib breast cancer 0.2094824 0.8745269 0.209 NA NA
ALK irinotecan cancer 0.2112995 0.8210738 0.211 NA NA
BRCA2 irinotecan cancer 0.2112995 0.8210738 0.211 NA NA
DNMT3A irinotecan cancer 0.2112995 0.8210738 0.211 NA NA
PTCH1 nilotinib ovarian cancer 0.2120452 0.9762516 0.212 NA NA
DPYD nilotinib skin cancer 0.2131635 0.9762516 0.213 NA NA
ESR1 erlotinib lung cancer 0.2135828 0.7568546 0.2136 NA NA
KRAS erlotinib multiple myeloma 0.2148469 0.7568546 0.2148 NA NA
ERBB2 erlotinib urinary bladder cancer 0.2148469 0.7568546 0.2148 NA NA
MET erlotinib multiple myeloma 0.2148469 0.7568546 0.2148 NA NA
ABL1 erlotinib multiple myeloma 0.2148469 0.7568546 0.2148 NA NA
BRAF erlotinib multiple myeloma 0.2148469 0.7568546 0.2148 NA NA
IDH2 erlotinib multiple myeloma 0.2148469 0.7568546 0.2148 NA NA
PML erlotinib urinary bladder cancer 0.2148469 0.7568546 0.2148 NA NA
G6PD nilotinib multiple myeloma 0.2148469 0.9762516 0.215 NA NA
ERBB3 selumetinib urinary bladder cancer 0.2148469 0.8331539 0.215 NA NA
ABL1 selumetinib multiple myeloma 0.2148469 0.8331539 0.215 NA NA
BRAF selumetinib multiple myeloma 0.2148469 0.8331539 0.215 NA NA
TPMT erlotinib uterine cancer 0.2149029 0.7568546 0.2149 NA NA
FLT3 irinotecan pancreatic cancer 0.2154995 0.8210738 0.215 NA NA
TSC2 lapatinib colorectal cancer 0.2217000 0.8745269 0.222 NA NA
BRAF erlotinib skin cancer 0.2222197 0.7568546 0.2222 NA NA
EGFR selumetinib lymphoma 0.2225128 0.8331539 0.223 NA NA
MET selumetinib lymphoma 0.2225128 0.8331539 0.223 NA NA
BRCA1 selumetinib lymphoma 0.2225128 0.8331539 0.223 NA NA
TSC2 selumetinib lymphoma 0.2225128 0.8331539 0.223 NA NA
CYP19A1 selumetinib lymphoma 0.2225128 0.8331539 0.223 NA NA
DNMT3A selumetinib lymphoma 0.2225128 0.8331539 0.223 NA NA
PML selumetinib lymphoma 0.2225128 0.8331539 0.223 NA NA
JAK2 selumetinib lymphoma 0.2225128 0.8331539 0.223 NA NA
MET nilotinib breast cancer 0.2225834 0.9762516 0.223 NA NA
ALK nilotinib breast cancer 0.2225834 0.9762516 0.223 NA NA
EGFR erlotinib lung cancer 0.2227201 0.7568546 0.2227 NA NA
JAK2 erlotinib lung cancer 0.2229781 0.7568546 0.2230 NA NA
PDGFRB erlotinib skin cancer 0.2249831 0.7568546 0.2250 NA NA
BRCA1 erlotinib skin cancer 0.2249831 0.7568546 0.2250 NA NA
PTCH1 nilotinib skin cancer 0.2271467 0.9762516 0.227 NA NA
PTCH1 erlotinib ovarian cancer 0.2279926 0.7568546 0.2280 NA NA
ERBB3 irinotecan colorectal cancer 0.2291019 0.8210738 0.229 NA NA
PDGFB irinotecan uterine cancer 0.2291019 0.8210738 0.229 NA NA
ESR1 irinotecan uterine cancer 0.2291019 0.8210738 0.229 NA NA
CYP19A1 irinotecan urinary bladder cancer 0.2291019 0.8210738 0.229 NA NA
JAK2 irinotecan urinary bladder cancer 0.2291019 0.8210738 0.229 NA NA
DNMT3A erlotinib multiple myeloma 0.2291019 0.7568546 0.2291 NA NA
MYD88 nilotinib urinary bladder cancer 0.2291019 0.9762516 0.229 NA NA
ERBB3 lapatinib colorectal cancer 0.2296985 0.8745269 0.230 NA NA
BRAF nilotinib breast cancer 0.2301393 0.9762516 0.230 NA NA
ERBB3 selumetinib uterine cancer 0.2311904 0.8331539 0.231 NA NA
ALK nilotinib colorectal cancer 0.2315990 0.9762516 0.232 NA NA
ABL1 selumetinib uterine cancer 0.2315990 0.8331539 0.232 NA NA
KRAS lapatinib stomach cancer 0.2324205 0.8745269 0.232 NA NA
DNMT3A nilotinib uterine cancer 0.2327515 0.9762516 0.233 NA NA
FLT3 selumetinib esophageal cancer 0.2337218 0.8331539 0.234 NA NA
DNMT3A lapatinib urinary bladder cancer 0.2348183 0.8745269 0.235 NA NA
PDGFRA erlotinib urinary bladder cancer 0.2353333 0.7568546 0.2353 NA NA
BRCA2 erlotinib liver cancer 0.2353333 0.7568546 0.2353 NA NA
ESR1 erlotinib liver cancer 0.2353333 0.7568546 0.2353 NA NA
DNMT3A lapatinib liver cancer 0.2353333 0.8745269 0.235 NA NA
PTCH1 lapatinib liver cancer 0.2353333 0.8745269 0.235 NA NA
ERBB3 nilotinib multiple myeloma 0.2353333 0.9762516 0.235 NA NA
KRAS selumetinib urinary bladder cancer 0.2353333 0.8331539 0.235 NA NA
ALK selumetinib liver cancer 0.2353333 0.8331539 0.235 NA NA
UGT1A1 selumetinib lung cancer 0.2378069 0.8331539 0.238 NA NA
TSC2 nilotinib central nervous system cancer 0.2381412 0.9762516 0.238 NA NA
PTCH1 selumetinib lymphoma 0.2394381 0.8331539 0.239 NA NA
EGFR selumetinib central nervous system cancer 0.2398054 0.8331539 0.240 NA NA
ROS1 irinotecan esophageal cancer 0.2415666 0.8210738 0.242 NA NA
CYP19A1 irinotecan esophageal cancer 0.2415666 0.8210738 0.242 NA NA
PDGFRB erlotinib rhabdomyosarcoma 0.2415666 0.7568546 0.2416 NA NA
FLT3 erlotinib rhabdomyosarcoma 0.2415666 0.7568546 0.2416 NA NA
ROS1 lapatinib head and neck cancer 0.2415666 0.8745269 0.242 NA NA
ABL1 lapatinib head and neck cancer 0.2415666 0.8745269 0.242 NA NA
PDGFB lapatinib head and neck cancer 0.2415666 0.8745269 0.242 NA NA
ESR1 lapatinib head and neck cancer 0.2415666 0.8745269 0.242 NA NA
ROS1 nilotinib esophageal cancer 0.2415666 0.9762516 0.242 NA NA
CYP19A1 nilotinib esophageal cancer 0.2415666 0.9762516 0.242 NA NA
ROS1 selumetinib head and neck cancer 0.2415666 0.8331539 0.242 NA NA
ABL1 selumetinib head and neck cancer 0.2415666 0.8331539 0.242 NA NA
ESR1 selumetinib head and neck cancer 0.2415666 0.8331539 0.242 NA NA
ALK irinotecan skin cancer 0.2422957 0.8210738 0.242 NA NA
BRAF erlotinib lung cancer 0.2426480 0.7568546 0.2426 NA NA
MET irinotecan stomach cancer 0.2433450 0.8210738 0.243 NA NA
BRCA2 nilotinib cancer 0.2433450 0.9762516 0.243 NA NA
DPYD lapatinib breast cancer 0.2452781 0.8745269 0.245 NA NA
ALK nilotinib ovarian cancer 0.2452781 0.9762516 0.245 NA NA
BRCA2 nilotinib ovarian cancer 0.2452781 0.9762516 0.245 NA NA
FLT3 selumetinib lung cancer 0.2466947 0.8331539 0.247 NA NA
PDGFRB lapatinib central nervous system cancer 0.2468433 0.8745269 0.247 NA NA
FLT3 irinotecan uterine cancer 0.2471600 0.8210738 0.247 NA NA
EGFR erlotinib stomach cancer 0.2474822 0.7568546 0.2475 NA NA
ERBB3 erlotinib stomach cancer 0.2474822 0.7568546 0.2475 NA NA
ERBB3 lapatinib stomach cancer 0.2474822 0.8745269 0.247 NA NA
PTCH1 lapatinib stomach cancer 0.2474822 0.8745269 0.247 NA NA
PDGFRA selumetinib uterine cancer 0.2477656 0.8331539 0.248 NA NA
NPM1 erlotinib ovarian cancer 0.2479502 0.7568546 0.2480 NA NA
PDGFRA lapatinib pancreatic cancer 0.2479502 0.8745269 0.248 NA NA
MYD88 selumetinib pancreatic cancer 0.2479502 0.8331539 0.248 NA NA
BRCA2 selumetinib colorectal cancer 0.2480312 0.8331539 0.248 NA NA
PDGFRA selumetinib lung cancer 0.2507813 0.8331539 0.251 NA NA
ERBB2 selumetinib uterine cancer 0.2558147 0.8331539 0.256 NA NA
ALK erlotinib leukemia 0.2559453 0.7568546 0.2559 NA NA
ESR1 erlotinib leukemia 0.2559453 0.7568546 0.2559 NA NA
MYD88 erlotinib leukemia 0.2559453 0.7568546 0.2559 NA NA
UGT1A1 nilotinib uterine cancer 0.2565476 0.9762516 0.257 NA NA
AKT1 nilotinib lung cancer 0.2569508 0.9762516 0.257 NA NA
ROS1 selumetinib skin cancer 0.2585839 0.8331539 0.259 NA NA
PTCH1 erlotinib skin cancer 0.2598636 0.7568546 0.2599 NA NA
PDGFRB irinotecan breast cancer 0.2615722 0.8288447 0.262 NA NA
EGFR nilotinib stomach cancer 0.2615722 0.9762516 0.262 NA NA
ROS1 erlotinib central nervous system cancer 0.2616903 0.7568546 0.2617 NA NA
AKT1 erlotinib pancreatic cancer 0.2635043 0.7568546 0.2635 NA NA
BRCA1 nilotinib stomach cancer 0.2635525 0.9762516 0.264 NA NA
KRAS erlotinib lung cancer 0.2638047 0.7568546 0.2638 NA NA
ERBB3 erlotinib uterine cancer 0.2643467 0.7568546 0.2643 NA NA
EGFR lapatinib uterine cancer 0.2681301 0.9093286 0.268 NA NA
ERBB3 selumetinib cancer 0.2683816 0.8331539 0.268 NA NA
PDGFB selumetinib cancer 0.2683816 0.8331539 0.268 NA NA
BRCA2 erlotinib skin cancer 0.2693612 0.7568546 0.2694 NA NA
BRCA1 irinotecan uterine cancer 0.2718987 0.8288447 0.272 NA NA
MYD88 irinotecan uterine cancer 0.2718987 0.8288447 0.272 NA NA
EGFR nilotinib breast cancer 0.2751412 0.9762516 0.275 NA NA
TSC1 lapatinib uterine cancer 0.2772528 0.9093286 0.277 NA NA
RET irinotecan lung cancer 0.2773127 0.8288447 0.277 NA NA
KRAS irinotecan urinary bladder cancer 0.2776470 0.8288447 0.278 NA NA
KRAS erlotinib esophageal cancer 0.2780757 0.7568546 0.2781 NA NA
ABL1 erlotinib esophageal cancer 0.2780757 0.7568546 0.2781 NA NA
AKT1 lapatinib esophageal cancer 0.2780757 0.9093286 0.278 NA NA
BRCA2 selumetinib esophageal cancer 0.2780757 0.8331539 0.278 NA NA
MET nilotinib lung cancer 0.2798702 0.9762516 0.280 NA NA
DPYD erlotinib uterine cancer 0.2824479 0.7568546 0.2824 NA NA
KIT selumetinib uterine cancer 0.2830739 0.8331539 0.283 NA NA
CYP19A1 selumetinib uterine cancer 0.2830739 0.8331539 0.283 NA NA
ROS1 lapatinib liver cancer 0.2881756 0.9093286 0.288 NA NA
ROS1 erlotinib cancer 0.2888444 0.7568546 0.2888 NA NA
BRCA2 lapatinib cancer 0.2888444 0.9093286 0.289 NA NA
BRAF irinotecan thyroid cancer 0.2888444 0.8288447 0.289 NA NA
ROS1 erlotinib head and neck cancer 0.2888444 0.7568546 0.2888 NA NA
ABL1 erlotinib head and neck cancer 0.2888444 0.7568546 0.2888 NA NA
ESR1 erlotinib head and neck cancer 0.2888444 0.7568546 0.2888 NA NA
BRAF lapatinib thyroid cancer 0.2888444 0.9093286 0.289 NA NA
ERBB2 erlotinib uterine cancer 0.2895232 0.7568546 0.2895 NA NA
KRAS selumetinib ovarian cancer 0.2903634 0.8331539 0.290 NA NA
ERBB2 erlotinib stomach cancer 0.2920390 0.7568546 0.2920 NA NA
BRCA2 erlotinib stomach cancer 0.2920390 0.7568546 0.2920 NA NA
BRCA2 lapatinib stomach cancer 0.2920390 0.9093286 0.292 NA NA
BRCA2 irinotecan ovarian cancer 0.2929123 0.8288447 0.293 NA NA
KRAS erlotinib colorectal cancer 0.2945672 0.7568546 0.2946 NA NA
PML erlotinib colorectal cancer 0.2947890 0.7568546 0.2948 NA NA
ROS1 lapatinib kidney cancer 0.2962699 0.9093286 0.296 NA NA
PDGFRA lapatinib kidney cancer 0.2962699 0.9093286 0.296 NA NA
TSC2 lapatinib central nervous system cancer 0.2972977 0.9093286 0.297 NA NA
ERBB3 irinotecan central nervous system cancer 0.2980928 0.8288447 0.298 NA NA
ERBB3 erlotinib ovarian cancer 0.2984290 0.7568546 0.2984 NA NA
PDGFRA erlotinib pancreatic cancer 0.2984290 0.7568546 0.2984 NA NA
PDGFB erlotinib central nervous system cancer 0.2984290 0.7568546 0.2984 NA NA
DPYD erlotinib ovarian cancer 0.2984290 0.7568546 0.2984 NA NA
PML erlotinib ovarian cancer 0.2984290 0.7568546 0.2984 NA NA
TSC1 selumetinib pancreatic cancer 0.2984290 0.8331539 0.298 NA NA
RET selumetinib skin cancer 0.2985238 0.8331539 0.299 NA NA
ABL1 selumetinib central nervous system cancer 0.2985746 0.8331539 0.299 NA NA
ALK erlotinib ovarian cancer 0.2986821 0.7568546 0.2987 NA NA
ALK selumetinib ovarian cancer 0.2986821 0.8331539 0.299 NA NA
PTCH1 selumetinib breast cancer 0.2988613 0.8331539 0.299 NA NA
BRCA2 selumetinib uterine cancer 0.3023721 0.8331539 0.302 NA NA
TSC1 irinotecan lung cancer 0.3052194 0.8288447 0.305 NA NA
DPYD selumetinib skin cancer 0.3058394 0.8331539 0.306 NA NA
BRAF lapatinib lung cancer 0.3088662 0.9093286 0.309 NA NA
ALK nilotinib leukemia 0.3096559 0.9762516 0.310 NA NA
ESR1 nilotinib leukemia 0.3096559 0.9762516 0.310 NA NA
MYD88 nilotinib leukemia 0.3096559 0.9762516 0.310 NA NA
MET selumetinib skin cancer 0.3104523 0.8331539 0.310 NA NA
ROS1 erlotinib colorectal cancer 0.3117958 0.7824875 0.3118 NA NA
ROS1 selumetinib colorectal cancer 0.3119010 0.8331539 0.312 NA NA
BRCA2 nilotinib uterine cancer 0.3125279 0.9762516 0.313 NA NA
MET irinotecan esophageal cancer 0.3129507 0.8288447 0.313 NA NA
MET nilotinib esophageal cancer 0.3129507 0.9762516 0.313 NA NA
JAK2 nilotinib lung cancer 0.3147561 0.9762516 0.315 NA NA
ABL1 lapatinib urinary bladder cancer 0.3147701 0.9093286 0.315 NA NA
PTCH1 lapatinib urinary bladder cancer 0.3147701 0.9093286 0.315 NA NA
DNMT3A selumetinib liver cancer 0.3153025 0.8331539 0.315 NA NA
PTCH1 selumetinib liver cancer 0.3153025 0.8331539 0.315 NA NA
ALK lapatinib skin cancer 0.3164462 0.9093286 0.316 NA NA
ABL1 lapatinib central nervous system cancer 0.3172951 0.9093286 0.317 NA NA
PDGFRB nilotinib skin cancer 0.3184251 0.9762516 0.318 NA NA
DNMT3A lapatinib lung cancer 0.3190115 0.9093286 0.319 NA NA
ABL1 erlotinib skin cancer 0.3205245 0.7831512 0.3205 NA NA
ERBB2 lapatinib urinary bladder cancer 0.3205296 0.9093286 0.321 NA NA
PML lapatinib urinary bladder cancer 0.3205296 0.9093286 0.321 NA NA
BRAF erlotinib urinary bladder cancer 0.3210620 0.7831512 0.3211 NA NA
G6PD erlotinib multiple myeloma 0.3210620 0.7831512 0.3211 NA NA
TSC2 nilotinib multiple myeloma 0.3210620 0.9762516 0.321 NA NA
ERBB2 selumetinib urinary bladder cancer 0.3210620 0.8331539 0.321 NA NA
PML selumetinib urinary bladder cancer 0.3210620 0.8331539 0.321 NA NA
MET selumetinib colorectal cancer 0.3210792 0.8331539 0.321 NA NA
BRAF nilotinib lung cancer 0.3225205 0.9762516 0.323 NA NA
BRCA1 nilotinib lung cancer 0.3231507 0.9762516 0.323 NA NA
BRAF nilotinib pancreatic cancer 0.3271296 0.9762516 0.327 NA NA
BRAF erlotinib bone cancer 0.3329216 0.7962686 0.3329 NA NA
FLT3 erlotinib peripheral nervous system neoplasm 0.3329216 0.7962686 0.3329 NA NA
ALK lapatinib peripheral nervous system neoplasm 0.3329216 0.9239859 0.333 NA NA
BRAF lapatinib bone cancer 0.3329216 0.9239859 0.333 NA NA
TSC2 nilotinib kidney cancer 0.3329216 0.9762516 0.333 NA NA
ALK selumetinib peripheral nervous system neoplasm 0.3329216 0.8331539 0.333 NA NA
BRAF selumetinib bone cancer 0.3329216 0.8331539 0.333 NA NA
FLT3 selumetinib bone cancer 0.3329216 0.8331539 0.333 NA NA
FLT3 selumetinib peripheral nervous system neoplasm 0.3329216 0.8331539 0.333 NA NA
BRAF selumetinib stomach cancer 0.3351769 0.8331539 0.335 NA NA
IDH2 selumetinib stomach cancer 0.3351769 0.8331539 0.335 NA NA
PML selumetinib stomach cancer 0.3351769 0.8331539 0.335 NA NA
ALK erlotinib lymphoma 0.3355921 0.7962686 0.3356 NA NA
BRCA1 lapatinib ovarian cancer 0.3389565 0.9239859 0.339 NA NA
TSC2 erlotinib pancreatic cancer 0.3390103 0.7971323 0.3390 NA NA
DPYD irinotecan lung cancer 0.3397830 0.8288447 0.340 NA NA
TSC1 lapatinib lung cancer 0.3398569 0.9239859 0.340 NA NA
EGFR selumetinib skin cancer 0.3406050 0.8344827 0.341 NA NA
ABL1 irinotecan skin cancer 0.3419452 0.8288447 0.342 NA NA
BRCA2 selumetinib skin cancer 0.3421059 0.8344827 0.342 NA NA
PDGFRA nilotinib uterine cancer 0.3463248 0.9762516 0.346 NA NA
ABL1 irinotecan multiple myeloma 0.3495748 0.8288447 0.350 NA NA
KIT irinotecan uterine cancer 0.3495748 0.8288447 0.350 NA NA
BRAF irinotecan multiple myeloma 0.3495748 0.8288447 0.350 NA NA
BRAF irinotecan urinary bladder cancer 0.3495748 0.8288447 0.350 NA NA
CYP19A1 irinotecan uterine cancer 0.3495748 0.8288447 0.350 NA NA
ERBB3 nilotinib urinary bladder cancer 0.3495748 0.9762516 0.350 NA NA
MET nilotinib urinary bladder cancer 0.3495748 0.9762516 0.350 NA NA
ROS1 nilotinib urinary bladder cancer 0.3495748 0.9762516 0.350 NA NA
PDGFRB nilotinib urinary bladder cancer 0.3495748 0.9762516 0.350 NA NA
TPMT nilotinib urinary bladder cancer 0.3495748 0.9762516 0.350 NA NA
NPM1 nilotinib urinary bladder cancer 0.3495748 0.9762516 0.350 NA NA
UGT1A1 irinotecan lung cancer 0.3498972 0.8288447 0.350 NA NA
KRAS irinotecan breast cancer 0.3583265 0.8288447 0.358 NA NA
ERBB2 irinotecan breast cancer 0.3583265 0.8288447 0.358 NA NA
BRCA2 irinotecan breast cancer 0.3583265 0.8288447 0.358 NA NA
TSC2 irinotecan breast cancer 0.3583265 0.8288447 0.358 NA NA
MYD88 irinotecan breast cancer 0.3583265 0.8288447 0.358 NA NA
PDGFRB erlotinib breast cancer 0.3591109 0.8368567 0.3591 NA NA
PDGFB lapatinib uterine cancer 0.3630984 0.9303768 0.363 NA NA
NPM1 lapatinib uterine cancer 0.3630984 0.9303768 0.363 NA NA
ERBB2 nilotinib uterine cancer 0.3647362 0.9863473 0.365 NA NA
PDGFRB nilotinib ovarian cancer 0.3661566 0.9863473 0.366 NA NA
ALK nilotinib lymphoma 0.3664589 0.9863473 0.366 NA NA
FLT3 irinotecan leukemia 0.3673822 0.8288447 0.367 NA NA
DPYD erlotinib skin cancer 0.3679866 0.8499513 0.3680 NA NA
FLT3 lapatinib leukemia 0.3697918 0.9303768 0.370 NA NA
AKT1 selumetinib pancreatic cancer 0.3710451 0.8918146 0.371 NA NA
KRAS erlotinib pancreatic cancer 0.3714467 0.8504174 0.3714 NA NA
ERBB3 irinotecan multiple myeloma 0.3744145 0.8288447 0.374 NA NA
ERBB3 irinotecan lung cancer 0.3767591 0.8288447 0.377 NA NA
MET irinotecan lung cancer 0.3767591 0.8288447 0.377 NA NA
KIT irinotecan lung cancer 0.3767591 0.8288447 0.377 NA NA
ALK nilotinib uterine cancer 0.3775292 0.9863473 0.378 NA NA
ALK nilotinib lung cancer 0.3778327 0.9863473 0.378 NA NA
ALK lapatinib esophageal cancer 0.3825145 0.9303768 0.383 NA NA
NPM1 selumetinib central nervous system cancer 0.3825673 0.8918146 0.383 NA NA
ERBB3 irinotecan stomach cancer 0.3827331 0.8288447 0.383 NA NA
ESR1 irinotecan stomach cancer 0.3827331 0.8288447 0.383 NA NA
ALK irinotecan lymphoma 0.3848208 0.8288447 0.385 NA NA

4.3 CTRP

4.3.1 G2P gene and drug

ctrp_signif_g2p <- compare_means(AUC ~ Mutation_Status_Nonsilent, group.by = "Drug_Gene", data = ctrp_data_g2p, method = "wilcox.test", p.adjust.method = "BH")
ctrp_signif_g2p <- adj_signif(ctrp_signif_g2p)
ctrp_signif_g2p <- ctrp_signif_g2p[order(ctrp_signif_g2p$p),]
saveRDS(ctrp_signif_g2p, "./data_munging/rds/ctrp_signif_g2p_gene.rds")

ctrp_signif_g2p_ByDrug <- lapply(unique(ctrp_data_g2p_genesfilt$Drug), WilcoxonByDrug, dataset = ctrp_data_g2p_genesfilt, data_name = "CTRP", grouping_var = "gene")
names(ctrp_signif_g2p_ByDrug) <- unique(ctrp_data_g2p_genesfilt$Drug)
saveRDS(ctrp_signif_g2p_ByDrug, "./data_munging/rds/ctrp_signif_g2p_ByDrug.rds")
ctrp_signif_g2p <- readRDS("./data_munging/rds/ctrp_signif_g2p_gene.rds")

knitr::kable(ctrp_signif_g2p[, c("Drug_Gene", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "CTRP: Wilcoxon test results for level A G2P drug-gene associations (* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
CTRP: Wilcoxon test results for level A G2P drug-gene associations (* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)
Drug_Gene p p.adj p.format p.signif p.signif.adj
vemurafenib_BRAF 0.0000005 0.0000236 4.9e-07 **** ****
lapatinib_KRAS 0.0000056 0.0001343 5.6e-06 **** ***
selumetinib_KRAS 0.0002012 0.0032190 0.00020 *** **
dabrafenib_BRAF 0.0002722 0.0032664 0.00027 *** **
gefitinib_KRAS 0.0040210 0.0386011 0.00402 **
imatinib_PDGFRB 0.0054451 0.0435604 0.00545 **
trametinib_BRAF 0.0064941 0.0445309 0.00649 **
cyclophosphamide_ERBB2 0.0089622 0.0537731 0.00896 ** NA
afatinib_KRAS 0.0107829 0.0575089 0.01078
NA
azd_KRAS 0.0127676 0.0612847 0.01277
NA
pazopanib_UGT1A1 0.0341719 0.1491138 0.03417
NA
crizotinib_MET 0.0436200 0.1744801 0.04362
NA
crizotinib_ALK 0.0595488 0.2048823 0.05955 NA NA
fulvestrant_ERBB2 0.0667862 0.2048823 0.06679 NA NA
crizotinib_ROS1 0.0682314 0.2048823 0.06823 NA NA
gefitinib_MET 0.0682941 0.2048823 0.06829 NA NA
dabrafenib_G6PD 0.0952173 0.2688489 0.09522 NA NA
sunitinib_PDGFRA 0.1625269 0.4059909 0.16253 NA NA
temozolomide_MGMT 0.1678755 0.4059909 0.16788 NA NA
vandetanib_RET 0.1691629 0.4059909 0.16916 NA NA
afatinib_ERBB2 0.1962848 0.4486509 0.19628 NA NA
neratinib_ERBB2 0.2066706 0.4509176 0.20667 NA NA
azd_EGFR 0.2197291 0.4585650 0.21973 NA NA
afatinib_EGFR 0.2518397 0.5036794 0.25184 NA NA
ibrutinib_MYD88 0.3177454 0.5850208 0.31775 NA NA
regorafenib_PDGFRA 0.3247031 0.5850208 0.32470 NA NA
imatinib_PDGFB 0.3290742 0.5850208 0.32907 NA NA
regorafenib_KIT 0.4759780 0.8159623 0.47598 NA NA
olaparib_BRCA2 0.5281161 0.8473422 0.52812 NA NA
sunitinib_KIT 0.5322976 0.8473422 0.53230 NA NA
erlotinib_EGFR 0.5472418 0.8473422 0.54724 NA NA
imatinib_ABL1 0.5818558 0.8613135 0.58186 NA NA
cabozantinib_RET 0.6089852 0.8613135 0.60899 NA NA
nilotinib_ABL1 0.6182260 0.8613135 0.61823 NA NA
imatinib_KIT 0.6429646 0.8613135 0.64296 NA NA
erlotinib_MET 0.6459851 0.8613135 0.64599 NA NA
fulvestrant_ESR1 0.6748204 0.8754427 0.67482 NA NA
afatinib_ERBB3 0.6959010 0.8790329 0.69590 NA NA
nilotinib_UGT1A1 0.7429748 0.8953061 0.74297 NA NA
fluorouracil_DPYD 0.7693491 0.8953061 0.76935 NA NA
dasatinib_ABL1 0.7801253 0.8953061 0.78013 NA NA
olaparib_BRCA1 0.8126710 0.8953061 0.81267 NA NA
erlotinib_KRAS 0.8197849 0.8953061 0.81978 NA NA
ruxolitinib_JAK2 0.8206972 0.8953061 0.82070 NA NA
imatinib_PDGFRA 0.8550665 0.9120709 0.85507 NA NA
gefitinib_EGFR 0.8875800 0.9156890 0.88758 NA NA
lapatinib_ERBB2 0.8966122 0.9156890 0.89661 NA NA
belinostat_UGT1A1 0.9223455 0.9223455 0.92235 NA NA 
ctrp_signif_g2p_ByDrug <- readRDS("./data_munging/rds/ctrp_signif_g2p_ByDrug.rds")
ctrp_signif_g2p_ByDrug_all <- rbindlist(ctrp_signif_g2p_ByDrug, use.names = TRUE)
ctrp_signif_g2p_ByDrug_all <- ctrp_signif_g2p_ByDrug_all[order(ctrp_signif_g2p_ByDrug_all$p),]

knitr::kable(ctrp_signif_g2p_ByDrug_all[, c("Hugo_Symbol", "Drug", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "CTRP: By-drug Wilcoxon test results for point mutations in level A G2P genes (* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
CTRP: By-drug Wilcoxon test results for point mutations in level A G2P genes (* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)
Hugo_Symbol Drug p p.adj p.format p.signif p.signif.adj
BRAF vemurafenib 0.0000005 0.0000167 4.9e-07 **** ****
KRAS lapatinib 0.0000056 0.0001902 5.6e-06 **** ***
KRAS trametinib 0.0000123 0.0004073 1.2e-05 **** ***
KRAS pazopanib 0.0000172 0.0005849 1.7e-05 **** ***
KRAS ibrutinib 0.0000293 0.0009955 2.9e-05 **** ***
MYD88 vemurafenib 0.0000321 0.0005454 3.2e-05 **** ***
KRAS selumetinib 0.0002012 0.0035372 0.00020 *** **
BRAF selumetinib 0.0002081 0.0035372 0.00021 *** **
BRAF olaparib 0.0002505 0.0085179 0.00025 *** **
BRAF dabrafenib 0.0002722 0.0089827 0.00027 *** **
KRAS sunitinib 0.0004277 0.0145425 0.00043 ***
KRAS neratinib 0.0004366 0.0148460 0.00044 ***
EGFR vemurafenib 0.0006405 0.0072593 0.00064 *** **
BRAF afatinib 0.0008985 0.0305482 0.0009 ***
KRAS vandetanib 0.0012628 0.0296819 0.0013 **
DNMT3A vandetanib 0.0017460 0.0296819 0.0017 **
KRAS cabozantinib 0.0020791 0.0706877 0.0021 ** NA
DNMT3A lapatinib 0.0028992 0.0492861 0.0029 **
CYP19A1 vemurafenib 0.0034645 0.0294485 0.00346 **
KRAS olaparib 0.0035982 0.0611698 0.00360 ** NA
KRAS gefitinib 0.0040210 0.1367124 0.004 ** NA
BRAF neratinib 0.0041088 0.0698503 0.00411 ** NA
BRAF pazopanib 0.0041184 0.0700128 0.0041 ** NA
BRAF ibrutinib 0.0051142 0.0869422 0.0051 ** NA
DNMT3A selumetinib 0.0054340 0.0615849 0.00543 ** NA
PDGFRB imatinib 0.0054451 0.1851319 0.0054 ** NA
PML fulvestrant 0.0061906 0.2104795 0.0062 ** NA
BRAF ruxolitinib 0.0062716 0.2132360 0.0063 ** NA
PDGFRB cabozantinib 0.0062762 0.1066960 0.0063 ** NA
BRAF trametinib 0.0064941 0.1071526 0.0065 ** NA
DNMT3A gefitinib 0.0080435 0.1367399 0.008 ** NA
ERBB2 cyclophosphamide 0.0089622 0.3047143 0.009 ** NA
KRAS regorafenib 0.0098050 0.1882113 0.0098 ** NA
ERBB2 cabozantinib 0.0100336 0.1091138 0.0100
NA
KRAS afatinib 0.0107829 0.1699989 0.0108
NA
PML crizotinib 0.0111785 0.3800698 0.011
NA
KRAS vemurafenib 0.0119766 0.0814412 0.01198
NA
MYD88 vandetanib 0.0123446 0.1399058 0.0123
NA
KRAS azd 0.0127676 0.2040480 0.013
NA
ERBB3 cabozantinib 0.0128369 0.1091138 0.0128
NA
BRAF temozolomide 0.0137195 0.4000874 0.014
NA
KIT ibrutinib 0.0142737 0.1617685 0.0143
NA
TPMT sunitinib 0.0149004 0.2533066 0.01490
NA
DNMT3A afatinib 0.0149999 0.1699989 0.0150
NA
PML fluorouracil 0.0155734 0.5294946 0.016
NA
RET azd 0.0156276 0.2040480 0.016
NA
PTCH1 trametinib 0.0159153 0.1750680 0.0159
NA
ROS1 pazopanib 0.0165094 0.1871070 0.0165
NA
PDGFB regorafenib 0.0165670 0.1882113 0.0166
NA
CYP19A1 regorafenib 0.0166069 0.1882113 0.0166
NA
UGT1A1 azd 0.0180042 0.2040480 0.018
NA
BRAF cyclophosphamide 0.0222337 0.3779730 0.022
NA
ALK neratinib 0.0230681 0.2614389 0.02307
NA
DNMT3A trametinib 0.0232930 0.1921671 0.0233
NA
ESR1 imatinib 0.0245120 0.4167035 0.0245
NA
BRCA1 fulvestrant 0.0266668 0.4533360 0.0267
NA
JAK2 temozolomide 0.0271063 0.4000874 0.027
NA
DNMT3A crizotinib 0.0276455 0.3866447 0.028
NA
BRAF dasatinib 0.0300319 0.7302743 0.030
NA
BRAF lapatinib 0.0305016 0.3456843 0.0305
NA
PML selumetinib 0.0317252 0.2169061 0.03173
NA
PDGFRA ibrutinib 0.0333483 0.2315548 0.0333
NA
DNMT3A ibrutinib 0.0340522 0.2315548 0.0341
NA
UGT1A1 pazopanib 0.0341719 0.2904612 0.0342
NA
TSC2 vemurafenib 0.0345796 0.1751927 0.03458
NA
DPYD selumetinib 0.0356352 0.2169061 0.03564
NA
DNMT3A neratinib 0.0356380 0.3029234 0.03564
NA
MET vemurafenib 0.0360691 0.1751927 0.03607
NA
KIT cabozantinib 0.0362427 0.1752370 0.0362
NA
PDGFRB afatinib 0.0366997 0.2708095 0.0367
NA
ROS1 gefitinib 0.0380067 0.3938390 0.038
NA
TPMT selumetinib 0.0382776 0.2169061 0.03828
NA
TSC2 cabozantinib 0.0383320 0.1752370 0.0383
NA
ROS1 cabozantinib 0.0390533 0.1752370 0.0391
NA
BRAF fluorouracil 0.0393299 0.5857145 0.039
NA
KIT afatinib 0.0398249 0.2708095 0.0398
NA
FLT3 cabozantinib 0.0412322 0.1752370 0.0412
NA
MET sunitinib 0.0414057 0.3813132 0.04141
NA
BRAF azd 0.0415725 0.3045006 0.042
NA
DNMT3A erlotinib 0.0426319 0.4945308 0.043
NA
CYP19A1 imatinib 0.0430959 0.4184794 0.0431
NA
FLT3 olaparib 0.0434999 0.3890797 0.04350
NA
MET crizotinib 0.0436200 0.3866447 0.044
NA
ROS1 azd 0.0447795 0.3045006 0.045
NA
ROS1 olaparib 0.0457741 0.3890797 0.04577
NA
TSC1 nilotinib 0.0489600 0.4507292 0.049
NA
BRCA1 belinostat 0.0497327 0.9332615 0.05
NA
PDGFRB regorafenib 0.0500392 0.3550591 0.0500 NA NA
ALK dasatinib 0.0501428 0.7302743 0.050 NA NA
MET selumetinib 0.0507587 0.2252140 0.05076 NA NA
KRAS crizotinib 0.0508005 0.3866447 0.051 NA NA
PTCH1 regorafenib 0.0522146 0.3550591 0.0522 NA NA
PTCH1 vemurafenib 0.0527029 0.2006954 0.05270 NA NA
RET selumetinib 0.0529915 0.2252140 0.05299 NA NA
BRCA1 vemurafenib 0.0531252 0.2006954 0.05313 NA NA
ALK vandetanib 0.0531880 0.4520980 0.0532 NA NA
PDGFRA gefitinib 0.0538638 0.3938390 0.054 NA NA
MET nilotinib 0.0553000 0.4507292 0.055 NA NA
JAK2 nilotinib 0.0558396 0.4507292 0.056 NA NA
TPMT imatinib 0.0564058 0.4184794 0.0564 NA NA
BRCA2 temozolomide 0.0567584 0.4000874 0.057 NA NA
MYD88 temozolomide 0.0574402 0.4000874 0.057 NA NA
NPM1 lapatinib 0.0576027 0.4247950 0.0576 NA NA
MGMT dabrafenib 0.0578528 0.6995857 0.05785 NA NA
IDH2 olaparib 0.0581368 0.3953299 0.05814 NA NA
PTCH1 temozolomide 0.0588364 0.4000874 0.059 NA NA
ALK crizotinib 0.0595488 0.3866447 0.060 NA NA
JAK2 cabozantinib 0.0601835 0.1902348 0.0602 NA NA
ABL1 cyclophosphamide 0.0608027 0.6890967 0.061 NA NA
PDGFRB sunitinib 0.0609026 0.3813132 0.06090 NA NA
PTCH1 imatinib 0.0615411 0.4184794 0.0615 NA NA
DPYD neratinib 0.0622681 0.4234232 0.06227 NA NA
PDGFRA lapatinib 0.0624698 0.4247950 0.0625 NA NA
PTCH1 erlotinib 0.0624883 0.4945308 0.062 NA NA
MET cabozantinib 0.0628214 0.1902348 0.0628 NA NA
CYP19A1 dasatinib 0.0644360 0.7302743 0.064 NA NA
PTCH1 sunitinib 0.0653514 0.3813132 0.06535 NA NA
UGT1A1 cabozantinib 0.0659861 0.1902348 0.0660 NA NA
ERBB2 fulvestrant 0.0667862 0.7405746 0.0668 NA NA
AKT1 cabozantinib 0.0671417 0.1902348 0.0671 NA NA
DNMT3A sunitinib 0.0672906 0.3813132 0.06729 NA NA
EGFR regorafenib 0.0674563 0.3598309 0.0675 NA NA
ROS1 crizotinib 0.0682314 0.3866447 0.068 NA NA
MET gefitinib 0.0682941 0.3938390 0.068 NA NA
ROS1 erlotinib 0.0687863 0.4945308 0.069 NA NA
JAK2 erlotinib 0.0694206 0.4945308 0.069 NA NA
JAK2 gefitinib 0.0695010 0.3938390 0.070 NA NA
KRAS ruxolitinib 0.0698118 0.9314078 0.0698 NA NA
KRAS nilotinib 0.0700538 0.4507292 0.070 NA NA
TPMT afatinib 0.0710783 0.3521922 0.0711 NA NA
DPYD azd 0.0712184 0.4035707 0.071 NA NA
ALK afatinib 0.0725102 0.3521922 0.0725 NA NA
PDGFRA vemurafenib 0.0735826 0.2190817 0.07358 NA NA
G6PD regorafenib 0.0740828 0.3598309 0.0741 NA NA
KIT selumetinib 0.0746874 0.2821523 0.07469 NA NA
NPM1 pazopanib 0.0750765 0.5105199 0.0751 NA NA
TPMT cabozantinib 0.0751475 0.1965396 0.0751 NA NA
TSC1 vemurafenib 0.0759962 0.2190817 0.07600 NA NA
PML vemurafenib 0.0789218 0.2190817 0.07892 NA NA
TSC1 fluorouracil 0.0794633 0.5857145 0.079 NA NA
UGT1A1 sunitinib 0.0800633 0.3888788 0.08006 NA NA
DNMT3A fluorouracil 0.0810167 0.5857145 0.081 NA NA
G6PD nilotinib 0.0817599 0.4507292 0.082 NA NA
PDGFRA erlotinib 0.0818940 0.4945308 0.082 NA NA
ERBB2 dabrafenib 0.0822127 0.6995857 0.08221 NA NA
RET afatinib 0.0832455 0.3537932 0.0832 NA NA
PDGFRB trametinib 0.0837396 0.4658024 0.0837 NA NA
BRCA2 vemurafenib 0.0837665 0.2190817 0.08377 NA NA
MYD88 nilotinib 0.0840035 0.4507292 0.084 NA NA
BRCA1 azd 0.0871239 0.4231730 0.087 NA NA
TPMT crizotinib 0.0889926 0.4322498 0.089 NA NA
KIT trametinib 0.0892804 0.4658024 0.0893 NA NA
RET fluorouracil 0.0904485 0.5857145 0.090 NA NA
BRCA2 pazopanib 0.0923309 0.5232086 0.0923 NA NA
TPMT dasatinib 0.0925509 0.7866823 0.093 NA NA
ROS1 nilotinib 0.0927972 0.4507292 0.093 NA NA
PDGFRA temozolomide 0.0937160 0.5310575 0.094 NA NA
G6PD dabrafenib 0.0952173 0.6995857 0.09522 NA NA
RET cyclophosphamide 0.0968718 0.8234099 0.097 NA NA
DNMT3A olaparib 0.0996068 0.5644383 0.09961 NA NA
DPYD afatinib 0.1034804 0.3909259 0.1035 NA NA
ABL1 trametinib 0.1038508 0.4658024 0.1039 NA NA
MGMT imatinib 0.1047274 0.5934553 0.1047 NA NA
DPYD vandetanib 0.1050806 0.6681475 0.1051 NA NA
PDGFB ibrutinib 0.1088089 0.5415524 0.1088 NA NA
MGMT erlotinib 0.1093037 0.4945308 0.109 NA NA
AKT1 crizotinib 0.1095589 0.4656252 0.110 NA NA
AKT1 azd 0.1125486 0.4576031 0.113 NA NA
RET trametinib 0.1129218 0.4658024 0.1129 NA NA
UGT1A1 dabrafenib 0.1142522 0.6995857 0.11425 NA NA
ESR1 fluorouracil 0.1147435 0.5857145 0.115 NA NA
DNMT3A pazopanib 0.1153640 0.5603392 0.1154 NA NA
PDGFB vemurafenib 0.1163543 0.2825748 0.11635 NA NA
PTCH1 lapatinib 0.1167103 0.6029902 0.1167 NA NA
AKT1 sunitinib 0.1198936 0.4988051 0.11989 NA NA
PDGFRA azd 0.1211302 0.4576031 0.121 NA NA
BRCA1 nilotinib 0.1242641 0.4564231 0.124 NA NA
TPMT neratinib 0.1244008 0.6384596 0.12440 NA NA
TSC1 cabozantinib 0.1252422 0.3041597 0.1252 NA NA
PML gefitinib 0.1255530 0.6098289 0.126 NA NA
ERBB2 fluorouracil 0.1257464 0.5857145 0.126 NA NA
CYP19A1 ibrutinib 0.1269984 0.5415524 0.1270 NA NA
CYP19A1 dabrafenib 0.1271974 0.6995857 0.12720 NA NA
ALK ibrutinib 0.1274241 0.5415524 0.1274 NA NA
PTCH1 nilotinib 0.1277181 0.4564231 0.128 NA NA
NPM1 erlotinib 0.1307567 0.4945308 0.131 NA NA
EGFR trametinib 0.1316155 0.4825901 0.1316 NA NA
NPM1 sunitinib 0.1320366 0.4988051 0.13204 NA NA
ROS1 regorafenib 0.1323222 0.5623696 0.1323 NA NA
JAK2 vemurafenib 0.1329072 0.3012562 0.13291 NA NA
BRAF imatinib 0.1350841 0.6561226 0.1351 NA NA
BRCA2 neratinib 0.1369451 0.6384596 0.13695 NA NA
PTCH1 olaparib 0.1376429 0.6685514 0.13764 NA NA
TPMT ruxolitinib 0.1408874 0.9314078 0.1409 NA NA
UGT1A1 selumetinib 0.1423368 0.4163122 0.14234 NA NA
MGMT fluorouracil 0.1432551 0.5857145 0.143 NA NA
BRCA2 erlotinib 0.1458082 0.4945308 0.146 NA NA
ALK erlotinib 0.1462901 0.4945308 0.146 NA NA
FLT3 nilotinib 0.1476259 0.4564231 0.148 NA NA
DPYD nilotinib 0.1476663 0.4564231 0.148 NA NA
G6PD trametinib 0.1496537 0.4938571 0.1497 NA NA
TSC1 sunitinib 0.1518085 0.5023558 0.15181 NA NA
AKT1 neratinib 0.1528627 0.6384596 0.15286 NA NA
DPYD fulvestrant 0.1532097 0.7405746 0.1532 NA NA
ERBB2 erlotinib 0.1533325 0.4945308 0.153 NA NA
G6PD selumetinib 0.1551003 0.4163122 0.15510 NA NA
PDGFRB selumetinib 0.1562725 0.4163122 0.15627 NA NA
ALK azd 0.1572449 0.5346326 0.157 NA NA
FLT3 vemurafenib 0.1577275 0.3259020 0.15773 NA NA
NPM1 crizotinib 0.1583886 0.5983568 0.158 NA NA
CYP19A1 fluorouracil 0.1588485 0.5857145 0.159 NA NA
DNMT3A dasatinib 0.1589015 0.8981810 0.159 NA NA
ALK selumetinib 0.1591782 0.4163122 0.15918 NA NA
KIT erlotinib 0.1599953 0.4945308 0.160 NA NA
CYP19A1 belinostat 0.1605668 0.9332615 0.16 NA NA
UGT1A1 olaparib 0.1608514 0.6836186 0.16085 NA NA
ABL1 ruxolitinib 0.1623760 0.9314078 0.1624 NA NA
PDGFRA sunitinib 0.1625269 0.5023558 0.16253 NA NA
AKT1 vemurafenib 0.1629510 0.3259020 0.16295 NA NA
CYP19A1 nilotinib 0.1633178 0.4627337 0.163 NA NA
RET lapatinib 0.1635140 0.6029902 0.1635 NA NA
ROS1 ruxolitinib 0.1652562 0.9314078 0.1653 NA NA
TPMT gefitinib 0.1653865 0.6634491 0.165 NA NA
CYP19A1 cyclophosphamide 0.1664216 0.8874508 0.166 NA NA
MET cyclophosphamide 0.1671638 0.8874508 0.167 NA NA
MGMT temozolomide 0.1678755 0.7065822 0.168 NA NA
ERBB2 dasatinib 0.1679727 0.8981810 0.168 NA NA
TSC1 neratinib 0.1690040 0.6384596 0.16900 NA NA
RET vandetanib 0.1691629 0.6681475 0.1692 NA NA
ROS1 afatinib 0.1715284 0.5539450 0.1715 NA NA
ALK fluorouracil 0.1722690 0.5857145 0.172 NA NA
IDH2 fulvestrant 0.1760724 0.7405746 0.1761 NA NA
BRCA2 selumetinib 0.1762300 0.4279871 0.17623 NA NA
IDH2 imatinib 0.1770530 0.6851658 0.1771 NA NA
TSC1 dabrafenib 0.1796741 0.8398900 0.17967 NA NA
ABL1 belinostat 0.1800207 0.9332615 0.18 NA NA
G6PD gefitinib 0.1809687 0.6634491 0.181 NA NA
PDGFRB pazopanib 0.1809713 0.6888301 0.1810 NA NA
ALK lapatinib 0.1820481 0.6029902 0.1820 NA NA
KIT pazopanib 0.1823374 0.6888301 0.1823 NA NA
UGT1A1 cyclophosphamide 0.1827105 0.8874508 0.183 NA NA
ESR1 trametinib 0.1839575 0.5233822 0.1840 NA NA
CYP19A1 sunitinib 0.1840148 0.5213753 0.18401 NA NA
RET ruxolitinib 0.1851983 0.9314078 0.1852 NA NA
MET fulvestrant 0.1858576 0.7405746 0.1859 NA NA
ALK temozolomide 0.1882566 0.7065822 0.188 NA NA
PDGFRA trametinib 0.1903208 0.5233822 0.1903 NA NA
MGMT vandetanib 0.1909706 0.6681475 0.1910 NA NA
JAK2 azd 0.1912155 0.5910299 0.191 NA NA
ERBB2 afatinib 0.1962848 0.5539450 0.1963 NA NA
DPYD vemurafenib 0.1972116 0.3725107 0.19721 NA NA
BRCA1 cabozantinib 0.1984399 0.4341695 0.1984 NA NA
IDH2 afatinib 0.2002219 0.5539450 0.2002 NA NA
BRCA1 sunitinib 0.2029629 0.5308261 0.20296 NA NA
PTCH1 cabozantinib 0.2043150 0.4341695 0.2043 NA NA
KRAS temozolomide 0.2044885 0.7065822 0.204 NA NA
RET gefitinib 0.2049189 0.6634491 0.205 NA NA
JAK2 vandetanib 0.2056568 0.6681475 0.2057 NA NA
TPMT lapatinib 0.2063631 0.6029902 0.2064 NA NA
ERBB2 neratinib 0.2066706 0.7012154 0.20667 NA NA
ABL1 temozolomide 0.2078183 0.7065822 0.208 NA NA
G6PD vandetanib 0.2082743 0.6681475 0.2083 NA NA
PDGFB ruxolitinib 0.2112854 0.9314078 0.2113 NA NA
JAK2 regorafenib 0.2116803 0.7996810 0.2117 NA NA
MGMT afatinib 0.2118025 0.5539450 0.2118 NA NA
TSC1 ibrutinib 0.2141178 0.7299037 0.2141 NA NA
RET erlotinib 0.2156089 0.5141116 0.216 NA NA
MET trametinib 0.2171377 0.5469503 0.2171 NA NA
TPMT olaparib 0.2193329 0.6914387 0.21933 NA NA
MET vandetanib 0.2195544 0.6681475 0.2196 NA NA
EGFR azd 0.2197291 0.5979347 0.220 NA NA
UGT1A1 crizotinib 0.2205241 0.6987047 0.221 NA NA
PDGFRA cabozantinib 0.2210144 0.4420288 0.2210 NA NA
AKT1 erlotinib 0.2216745 0.5141116 0.222 NA NA
ROS1 lapatinib 0.2232310 0.6029902 0.2232 NA NA
AKT1 vandetanib 0.2252466 0.6681475 0.2252 NA NA
DPYD erlotinib 0.2260758 0.5141116 0.226 NA NA
IDH2 erlotinib 0.2268140 0.5141116 0.227 NA NA
KIT neratinib 0.2272109 0.7012154 0.22721 NA NA
TSC1 azd 0.2297525 0.5979347 0.230 NA NA
NPM1 fulvestrant 0.2309231 0.7405746 0.2309 NA NA
MGMT dasatinib 0.2320758 0.8981810 0.232 NA NA
FLT3 ibrutinib 0.2324658 0.7299037 0.2325 NA NA
ROS1 fulvestrant 0.2343543 0.7405746 0.2344 NA NA
TPMT vandetanib 0.2358167 0.6681475 0.2358 NA NA
DPYD gefitinib 0.2382705 0.6634491 0.238 NA NA
RET crizotinib 0.2389903 0.6987047 0.239 NA NA
MGMT lapatinib 0.2397677 0.6029902 0.2398 NA NA
ROS1 trametinib 0.2403793 0.5469503 0.2404 NA NA
MYD88 dabrafenib 0.2408578 0.8398900 0.24086 NA NA
AKT1 lapatinib 0.2447114 0.6029902 0.2447 NA NA
PML nilotinib 0.2462058 0.6439228 0.246 NA NA
KIT crizotinib 0.2466017 0.6987047 0.247 NA NA
PDGFB pazopanib 0.2466642 0.7489184 0.2467 NA NA
RET neratinib 0.2474878 0.7012154 0.24749 NA NA
PDGFB azd 0.2475165 0.5979347 0.248 NA NA
MGMT vemurafenib 0.2488404 0.4452933 0.24884 NA NA
MGMT gefitinib 0.2498351 0.6634491 0.250 NA NA
MET olaparib 0.2511607 0.6914387 0.25116 NA NA
G6PD sunitinib 0.2518013 0.5738528 0.25180 NA NA
EGFR afatinib 0.2518397 0.6116107 0.2518 NA NA
TPMT trametinib 0.2520717 0.5469503 0.2521 NA NA
JAK2 cyclophosphamide 0.2532387 0.9645613 0.253 NA NA
TSC2 cyclophosphamide 0.2553250 0.9645613 0.255 NA NA
UGT1A1 regorafenib 0.2573217 0.8332306 0.2573 NA NA
MGMT ruxolitinib 0.2579077 0.9314078 0.2579 NA NA
NPM1 ibrutinib 0.2580132 0.7299037 0.2580 NA NA
PDGFRB ibrutinib 0.2584041 0.7299037 0.2584 NA NA
TPMT pazopanib 0.2589317 0.7489184 0.2589 NA NA
AKT1 olaparib 0.2619009 0.6914387 0.26190 NA NA
IDH2 lapatinib 0.2631941 0.6029902 0.2632 NA NA
PML olaparib 0.2632816 0.6914387 0.26328 NA NA
MET pazopanib 0.2643242 0.7489184 0.2643 NA NA
TSC2 azd 0.2666255 0.5979347 0.267 NA NA
TSC1 dasatinib 0.2684477 0.8981810 0.268 NA NA
MYD88 cabozantinib 0.2705198 0.5109818 0.2705 NA NA
AKT1 gefitinib 0.2710276 0.6634491 0.271 NA NA
MYD88 lapatinib 0.2727428 0.6029902 0.2727 NA NA
JAK2 fulvestrant 0.2731170 0.7405746 0.2731 NA NA
CYP19A1 lapatinib 0.2738891 0.6029902 0.2739 NA NA
ERBB2 gefitinib 0.2741193 0.6634491 0.274 NA NA
PDGFRA selumetinib 0.2749493 0.6232184 0.27495 NA NA
KRAS fulvestrant 0.2766131 0.7405746 0.2766 NA NA
TSC1 imatinib 0.2772743 0.6851658 0.2773 NA NA
MGMT trametinib 0.2783193 0.5469503 0.2783 NA NA
ALK imatinib 0.2787671 0.6851658 0.2788 NA NA
MGMT fulvestrant 0.2788073 0.7405746 0.2788 NA NA
AKT1 ibrutinib 0.2790808 0.7299037 0.2791 NA NA
ROS1 sunitinib 0.2791187 0.5738528 0.27912 NA NA
FLT3 dabrafenib 0.2794287 0.8398900 0.27943 NA NA
ABL1 fulvestrant 0.2803031 0.7405746 0.2803 NA NA
TSC2 sunitinib 0.2822305 0.5738528 0.28223 NA NA
ERBB2 trametinib 0.2825628 0.5469503 0.2826 NA NA
CYP19A1 fulvestrant 0.2831609 0.7405746 0.2832 NA NA
BRCA1 lapatinib 0.2837601 0.6029902 0.2838 NA NA
EGFR vandetanib 0.2853916 0.6968774 0.2854 NA NA
PTCH1 dasatinib 0.2856356 0.8981810 0.286 NA NA
ERBB3 sunitinib 0.2869264 0.5738528 0.28693 NA NA
ESR1 olaparib 0.2881802 0.6914387 0.28818 NA NA
TPMT fluorouracil 0.2892300 0.8392181 0.289 NA NA
MET regorafenib 0.2896133 0.8332306 0.2896 NA NA
PDGFRB neratinib 0.2911880 0.7411173 0.29119 NA NA
IDH2 vandetanib 0.2935755 0.6968774 0.2936 NA NA
ERBB2 imatinib 0.2961755 0.6851658 0.2962 NA NA
NPM1 azd 0.2976666 0.5979347 0.298 NA NA
DPYD belinostat 0.2978744 0.9332615 0.30 NA NA
UGT1A1 ruxolitinib 0.2979995 0.9314078 0.2980 NA NA
TSC2 dasatinib 0.2997123 0.8981810 0.300 NA NA
MGMT nilotinib 0.3000538 0.6835150 0.300 NA NA
NPM1 cabozantinib 0.3013980 0.5150108 0.3014 NA NA
ABL1 crizotinib 0.3022158 0.7904106 0.302 NA NA
PTCH1 azd 0.3023110 0.5979347 0.302 NA NA
ABL1 cabozantinib 0.3029475 0.5150108 0.3029 NA NA
CYP19A1 olaparib 0.3043830 0.6914387 0.30438 NA NA
ESR1 gefitinib 0.3045810 0.6634491 0.305 NA NA
PDGFB neratinib 0.3051659 0.7411173 0.30517 NA NA
ALK vemurafenib 0.3064787 0.5210137 0.30648 NA NA
PDGFRA vandetanib 0.3074459 0.6968774 0.3074 NA NA
AKT1 afatinib 0.3079994 0.6638151 0.3080 NA NA
BRAF belinostat 0.3085030 0.9332615 0.31 NA NA
TSC1 selumetinib 0.3094377 0.6575550 0.30944 NA NA
DNMT3A imatinib 0.3100619 0.6851658 0.3101 NA NA
TPMT erlotinib 0.3109754 0.6608228 0.311 NA NA
PML trametinib 0.3122459 0.5469503 0.3122 NA NA
ALK trametinib 0.3149108 0.5469503 0.3149 NA NA
RET dasatinib 0.3153187 0.8981810 0.315 NA NA
UGT1A1 imatinib 0.3163786 0.6851658 0.3164 NA NA
MYD88 gefitinib 0.3170349 0.6634491 0.317 NA NA
EGFR olaparib 0.3170528 0.6914387 0.31705 NA NA
MYD88 ibrutinib 0.3177454 0.7476014 0.3177 NA NA
FLT3 pazopanib 0.3190784 0.8345127 0.3191 NA NA
ROS1 temozolomide 0.3206533 0.7644487 0.321 NA NA
TSC2 nilotinib 0.3227612 0.6835150 0.323 NA NA
BRCA1 temozolomide 0.3234468 0.7644487 0.323 NA NA
PDGFRA regorafenib 0.3247031 0.8332306 0.3247 NA NA
G6PD cabozantinib 0.3251186 0.5263825 0.3251 NA NA
ALK olaparib 0.3253829 0.6914387 0.32538 NA NA
IDH2 dabrafenib 0.3256308 0.8398900 0.32563 NA NA
PDGFRB ruxolitinib 0.3271325 0.9314078 0.3271 NA NA
PDGFB imatinib 0.3290742 0.6851658 0.3291 NA NA
BRCA1 regorafenib 0.3293828 0.8332306 0.3294 NA NA
ABL1 fluorouracil 0.3296373 0.8392181 0.330 NA NA
UGT1A1 ibrutinib 0.3298241 0.7476014 0.3298 NA NA
ERBB3 imatinib 0.3301067 0.6851658 0.3301 NA NA
ESR1 lapatinib 0.3306838 0.6259186 0.3307 NA NA
TPMT azd 0.3307900 0.5979347 0.331 NA NA
MET lapatinib 0.3313687 0.6259186 0.3314 NA NA
KIT gefitinib 0.3317245 0.6634491 0.332 NA NA
MYD88 afatinib 0.3320613 0.6638151 0.3321 NA NA
PDGFRA fluorouracil 0.3334048 0.8392181 0.333 NA NA
IDH2 neratinib 0.3337619 0.7446930 0.33376 NA NA
MYD88 azd 0.3389331 0.5979347 0.339 NA NA
PML imatinib 0.3392370 0.6851658 0.3392 NA NA
ERBB2 selumetinib 0.3397053 0.6794106 0.33971 NA NA
ABL1 afatinib 0.3423060 0.6638151 0.3423 NA NA
KRAS imatinib 0.3425829 0.6851658 0.3426 NA NA
TSC1 regorafenib 0.3430949 0.8332306 0.3431 NA NA
ESR1 nilotinib 0.3452748 0.6835150 0.345 NA NA
NPM1 fluorouracil 0.3455604 0.8392181 0.346 NA NA
BRAF nilotinib 0.3473234 0.6835150 0.347 NA NA
ERBB3 belinostat 0.3479934 0.9332615 0.35 NA NA
IDH2 cabozantinib 0.3499020 0.5407576 0.3499 NA NA
NPM1 neratinib 0.3504438 0.7446930 0.35044 NA NA
TSC2 afatinib 0.3514315 0.6638151 0.3514 NA NA
KRAS dasatinib 0.3522956 0.8981810 0.352 NA NA
ERBB3 cyclophosphamide 0.3561490 0.9793614 0.356 NA NA
IDH2 azd 0.3568667 0.5979347 0.357 NA NA
PDGFB dasatinib 0.3571989 0.8981810 0.357 NA NA
NPM1 dabrafenib 0.3577714 0.8398900 0.35777 NA NA
BRAF fulvestrant 0.3578334 0.8690240 0.3578 NA NA
ALK gefitinib 0.3595266 0.6791058 0.360 NA NA
NPM1 temozolomide 0.3616494 0.7644487 0.362 NA NA
PDGFB nilotinib 0.3618609 0.6835150 0.362 NA NA
UGT1A1 temozolomide 0.3627228 0.7644487 0.363 NA NA
MET dabrafenib 0.3629609 0.8398900 0.36296 NA NA
PDGFRB belinostat 0.3636843 0.9332615 0.36 NA NA
ERBB3 lapatinib 0.3667711 0.6475307 0.3668 NA NA
IDH2 vemurafenib 0.3678300 0.5955342 0.36783 NA NA
TPMT regorafenib 0.3679816 0.8340916 0.3680 NA NA
ERBB3 azd 0.3693126 0.5979347 0.369 NA NA
JAK2 afatinib 0.3737944 0.6674950 0.3738 NA NA
FLT3 temozolomide 0.3743174 0.7644487 0.374 NA NA
ROS1 cyclophosphamide 0.3774686 0.9793614 0.377 NA NA
ABL1 ibrutinib 0.3777841 0.8027912 0.3778 NA NA
PDGFRA pazopanib 0.3783240 0.9187869 0.3783 NA NA
EGFR lapatinib 0.3809004 0.6475307 0.3809 NA NA
PML sunitinib 0.3810854 0.7198280 0.38109 NA NA
BRCA2 trametinib 0.3821071 0.6252529 0.3821 NA NA
EGFR ruxolitinib 0.3825743 0.9314078 0.3826 NA NA
PML dasatinib 0.3857611 0.8981810 0.386 NA NA
MGMT neratinib 0.3926360 0.7852720 0.39264 NA NA
PML afatinib 0.3926441 0.6674950 0.3926 NA NA
BRAF cabozantinib 0.3934771 0.5686724 0.3935 NA NA
ROS1 vemurafenib 0.3937304 0.6084924 0.39373 NA NA
ERBB3 dabrafenib 0.3967421 0.8398900 0.39674 NA NA
TPMT cyclophosphamide 0.3978413 0.9793614 0.398 NA NA
RET belinostat 0.3979105 0.9332615 0.40 NA NA
ALK dabrafenib 0.3998459 0.8398900 0.39985 NA NA
PDGFRA dasatinib 0.4012694 0.8981810 0.401 NA NA
NPM1 vandetanib 0.4033915 0.8222586 0.4034 NA NA
PML ruxolitinib 0.4077983 0.9314078 0.4078 NA NA
AKT1 trametinib 0.4079935 0.6252529 0.4080 NA NA
KIT dabrafenib 0.4097454 0.8398900 0.40975 NA NA
RET regorafenib 0.4107421 0.8471493 0.4107 NA NA
ERBB3 vandetanib 0.4111293 0.8222586 0.4111 NA NA
KRAS dabrafenib 0.4111914 0.8398900 0.41119 NA NA
DPYD temozolomide 0.4129554 0.7644487 0.413 NA NA
FLT3 lapatinib 0.4146955 0.6714118 0.4147 NA NA
ESR1 temozolomide 0.4151428 0.7644487 0.415 NA NA
BRCA2 cabozantinib 0.4162945 0.5686724 0.4163 NA NA
TSC2 trametinib 0.4168352 0.6252529 0.4168 NA NA
PML erlotinib 0.4170584 0.8218115 0.417 NA NA
CYP19A1 cabozantinib 0.4181415 0.5686724 0.4181 NA NA
JAK2 crizotinib 0.4182454 0.9896386 0.418 NA NA
ALK fulvestrant 0.4191815 0.9110805 0.4192 NA NA
PTCH1 selumetinib 0.4194027 0.7472482 0.41940 NA NA
EGFR dasatinib 0.4226734 0.8981810 0.423 NA NA
BRCA2 azd 0.4237037 0.6548149 0.424 NA NA
KIT cyclophosphamide 0.4256579 0.9793614 0.426 NA NA
ESR1 ibrutinib 0.4291778 0.8107592 0.4292 NA NA
EGFR ibrutinib 0.4292255 0.8107592 0.4292 NA NA
NPM1 selumetinib 0.4302455 0.7472482 0.43025 NA NA
PML pazopanib 0.4313542 0.9261994 0.4314 NA NA
TPMT dabrafenib 0.4326706 0.8398900 0.43267 NA NA
PDGFRB fluorouracil 0.4341969 0.8677771 0.434 NA NA
PML temozolomide 0.4354604 0.7644487 0.435 NA NA
ESR1 cabozantinib 0.4356954 0.5697555 0.4357 NA NA
ERBB3 ruxolitinib 0.4364470 0.9314078 0.4364 NA NA
MYD88 fulvestrant 0.4383092 0.9110805 0.4383 NA NA
CYP19A1 temozolomide 0.4385706 0.7644487 0.439 NA NA
IDH2 trametinib 0.4390903 0.6262131 0.4391 NA NA
ESR1 sunitinib 0.4399411 0.7545287 0.43994 NA NA
BRCA2 vandetanib 0.4404474 0.8272351 0.4404 NA NA
IDH2 selumetinib 0.4434340 0.7472482 0.44343 NA NA
ALK nilotinib 0.4451309 0.7927775 0.445 NA NA
TSC2 neratinib 0.4493579 0.8334472 0.44936 NA NA
MET temozolomide 0.4496757 0.7644487 0.450 NA NA
ERBB3 pazopanib 0.4547800 0.9261994 0.4548 NA NA
IDH2 dasatinib 0.4572773 0.9092193 0.457 NA NA
ESR1 erlotinib 0.4580536 0.8218115 0.458 NA NA
BRAF erlotinib 0.4592476 0.8218115 0.459 NA NA
G6PD vemurafenib 0.4602214 0.6539778 0.46022 NA NA
ESR1 vemurafenib 0.4616314 0.6539778 0.46163 NA NA
BRAF vandetanib 0.4622785 0.8272351 0.4623 NA NA
PDGFB fluorouracil 0.4641195 0.8677771 0.464 NA NA
MGMT sunitinib 0.4645056 0.7545287 0.46451 NA NA
JAK2 sunitinib 0.4660324 0.7545287 0.46603 NA NA
FLT3 regorafenib 0.4660591 0.8471493 0.4661 NA NA
G6PD fluorouracil 0.4661924 0.8677771 0.466 NA NA
ABL1 gefitinib 0.4664039 0.8346175 0.466 NA NA
AKT1 ruxolitinib 0.4679864 0.9314078 0.4680 NA NA
TPMT ibrutinib 0.4703605 0.8416977 0.4704 NA NA
DNMT3A cabozantinib 0.4741169 0.5970360 0.4741 NA NA
ERBB2 azd 0.4751190 0.6739725 0.475 NA NA
CYP19A1 azd 0.4757453 0.6739725 0.476 NA NA
KIT regorafenib 0.4759780 0.8471493 0.4760 NA NA
CYP19A1 selumetinib 0.4763756 0.7472482 0.47638 NA NA
UGT1A1 fluorouracil 0.4767219 0.8677771 0.477 NA NA
BRCA2 afatinib 0.4780707 0.7569737 0.4781 NA NA
MYD88 trametinib 0.4783281 0.6262131 0.4783 NA NA
BRCA2 crizotinib 0.4789637 0.9896386 0.479 NA NA
BRCA1 neratinib 0.4793342 0.8334472 0.47933 NA NA
BRCA1 imatinib 0.4803511 0.9073299 0.4804 NA NA
G6PD dasatinib 0.4813514 0.9092193 0.481 NA NA
EGFR dabrafenib 0.4817681 0.8681874 0.48177 NA NA
JAK2 trametinib 0.4825043 0.6262131 0.4825 NA NA
G6PD lapatinib 0.4825811 0.7270249 0.4826 NA NA
IDH2 pazopanib 0.4829493 0.9261994 0.4829 NA NA
ABL1 selumetinib 0.4835135 0.7472482 0.48351 NA NA
MGMT belinostat 0.4836415 0.9332615 0.48 NA NA
BRCA2 belinostat 0.4837494 0.9332615 0.48 NA NA
FLT3 belinostat 0.4844586 0.9332615 0.48 NA NA
BRCA1 fluorouracil 0.4849343 0.8677771 0.485 NA NA
DNMT3A temozolomide 0.4872219 0.7776868 0.487 NA NA
ALK regorafenib 0.4873433 0.8471493 0.4873 NA NA
DPYD ruxolitinib 0.4879108 0.9314078 0.4879 NA NA
MET afatinib 0.4898065 0.7569737 0.4898 NA NA
PDGFRA neratinib 0.4902631 0.8334472 0.49026 NA NA
MGMT crizotinib 0.4938707 0.9896386 0.494 NA NA
TSC1 vandetanib 0.4950385 0.8415654 0.4950 NA NA
DPYD lapatinib 0.4952434 0.7270249 0.4952 NA NA
PTCH1 pazopanib 0.4968297 0.9261994 0.4968 NA NA
TSC1 temozolomide 0.5032091 0.7776868 0.503 NA NA
DPYD cyclophosphamide 0.5045811 0.9793614 0.505 NA NA
RET sunitinib 0.5118218 0.7868747 0.51182 NA NA
DPYD trametinib 0.5123073 0.6262131 0.5123 NA NA
UGT1A1 trametinib 0.5123562 0.6262131 0.5124 NA NA
PML lapatinib 0.5131940 0.7270249 0.5132 NA NA
MET neratinib 0.5169277 0.8369306 0.51693 NA NA
RET pazopanib 0.5175936 0.9261994 0.5176 NA NA
TSC2 ruxolitinib 0.5176922 0.9314078 0.5177 NA NA
DPYD dabrafenib 0.5177549 0.8681874 0.51775 NA NA
BRCA1 gefitinib 0.5187110 0.8466777 0.519 NA NA
PDGFRA nilotinib 0.5194411 0.7927775 0.519 NA NA
ABL1 regorafenib 0.5196255 0.8471493 0.5196 NA NA
NPM1 gefitinib 0.5229480 0.8466777 0.523 NA NA
DPYD regorafenib 0.5244529 0.8471493 0.5245 NA NA
BRCA2 olaparib 0.5281161 0.9728161 0.52812 NA NA
DNMT3A nilotinib 0.5289852 0.7927775 0.529 NA NA
AKT1 cyclophosphamide 0.5303222 0.9793614 0.530 NA NA
PDGFRA ruxolitinib 0.5303811 0.9314078 0.5304 NA NA
KIT sunitinib 0.5322976 0.7868747 0.53230 NA NA
FLT3 dasatinib 0.5331194 0.9367075 0.533 NA NA
G6PD cyclophosphamide 0.5360224 0.9793614 0.536 NA NA
ERBB3 crizotinib 0.5361343 0.9896386 0.536 NA NA
MYD88 imatinib 0.5393201 0.9425360 0.5393 NA NA
TSC1 lapatinib 0.5398720 0.7342259 0.5399 NA NA
RET vemurafenib 0.5409337 0.7294806 0.54093 NA NA
BRCA2 dabrafenib 0.5419188 0.8681874 0.54192 NA NA
TSC2 crizotinib 0.5427013 0.9896386 0.543 NA NA
PTCH1 fulvestrant 0.5427377 0.9110805 0.5427 NA NA
BRCA2 cyclophosphamide 0.5442614 0.9793614 0.544 NA NA
NPM1 nilotinib 0.5448245 0.7927775 0.545 NA NA
EGFR erlotinib 0.5472418 0.8891239 0.547 NA NA
EGFR nilotinib 0.5479716 0.7927775 0.548 NA NA
ESR1 regorafenib 0.5481555 0.8471493 0.5482 NA NA
TSC2 erlotinib 0.5491647 0.8891239 0.549 NA NA
ERBB3 selumetinib 0.5514235 0.8151478 0.55142 NA NA
MGMT azd 0.5517454 0.7386733 0.552 NA NA
TSC2 temozolomide 0.5520727 0.8087434 0.552 NA NA
MYD88 neratinib 0.5522299 0.8534462 0.55223 NA NA
JAK2 dabrafenib 0.5524829 0.8681874 0.55248 NA NA
IDH2 ruxolitinib 0.5558028 0.9314078 0.5558 NA NA
PDGFRB fulvestrant 0.5559160 0.9110805 0.5559 NA NA
PDGFB gefitinib 0.5559298 0.8546038 0.556 NA NA
ERBB2 vemurafenib 0.5578381 0.7294806 0.55784 NA NA
TSC2 vandetanib 0.5599331 0.8665251 0.5599 NA NA
ERBB2 vandetanib 0.5606927 0.8665251 0.5607 NA NA
PDGFRB nilotinib 0.5622570 0.7927775 0.562 NA NA
JAK2 ibrutinib 0.5688103 0.9669776 0.5688 NA NA
RET fulvestrant 0.5689282 0.9110805 0.5689 NA NA
MGMT olaparib 0.5699313 0.9728161 0.56993 NA NA
PDGFB olaparib 0.5706892 0.9728161 0.57069 NA NA
FLT3 fulvestrant 0.5722357 0.9110805 0.5722 NA NA
KRAS cyclophosphamide 0.5770737 0.9793614 0.577 NA NA
PML belinostat 0.5778444 0.9332615 0.58 NA NA
PDGFRB gefitinib 0.5781143 0.8546038 0.578 NA NA
DPYD sunitinib 0.5784482 0.8194683 0.57845 NA NA
MYD88 pazopanib 0.5788620 0.9261994 0.5789 NA NA
UGT1A1 afatinib 0.5812670 0.8592643 0.5813 NA NA
ABL1 imatinib 0.5818558 0.9425360 0.5819 NA NA
FLT3 imatinib 0.5821546 0.9425360 0.5822 NA NA
ERBB3 nilotinib 0.5829246 0.7927775 0.583 NA NA
DNMT3A cyclophosphamide 0.5843537 0.9793614 0.584 NA NA
PML cabozantinib 0.5847529 0.6901833 0.5848 NA NA
ROS1 belinostat 0.5877641 0.9332615 0.59 NA NA
AKT1 temozolomide 0.5884213 0.8087434 0.588 NA NA
KIT lapatinib 0.5885275 0.7696129 0.5885 NA NA
ERBB3 fulvestrant 0.5897197 0.9110805 0.5897 NA NA
KIT azd 0.5928965 0.7386733 0.593 NA NA
PDGFRB temozolomide 0.5946643 0.8087434 0.595 NA NA
DPYD cabozantinib 0.5989674 0.6901833 0.5990 NA NA
G6PD ibrutinib 0.6023586 0.9736731 0.6024 NA NA
DNMT3A vemurafenib 0.6061305 0.7525336 0.60613 NA NA
MET azd 0.6072926 0.7386733 0.607 NA NA
G6PD azd 0.6083192 0.7386733 0.608 NA NA
MGMT cyclophosphamide 0.6089169 0.9793614 0.609 NA NA
RET cabozantinib 0.6089852 0.6901833 0.6090 NA NA
PDGFB erlotinib 0.6129494 0.9151456 0.613 NA NA
MYD88 ruxolitinib 0.6181728 0.9314078 0.6182 NA NA
ABL1 nilotinib 0.6182260 0.8084494 0.618 NA NA
CYP19A1 vandetanib 0.6183456 0.8720434 0.6183 NA NA
TSC1 trametinib 0.6186725 0.7291497 0.6187 NA NA
ERBB2 temozolomide 0.6194974 0.8101120 0.619 NA NA
PDGFRB vemurafenib 0.6197336 0.7525336 0.61973 NA NA
TSC1 olaparib 0.6197994 0.9728161 0.61980 NA NA
BRCA1 pazopanib 0.6211989 0.9261994 0.6212 NA NA
PDGFRA dabrafenib 0.6212605 0.9318907 0.62126 NA NA
BRCA1 dasatinib 0.6214626 0.9367075 0.621 NA NA
NPM1 ruxolitinib 0.6223011 0.9314078 0.6223 NA NA
TSC2 lapatinib 0.6258155 0.7879401 0.6258 NA NA
CYP19A1 ruxolitinib 0.6276320 0.9314078 0.6276 NA NA
ERBB2 ruxolitinib 0.6293981 0.9314078 0.6294 NA NA
DNMT3A ruxolitinib 0.6300700 0.9314078 0.6301 NA NA
KIT vandetanib 0.6306055 0.8720434 0.6306 NA NA
AKT1 regorafenib 0.6309258 0.9326729 0.6309 NA NA
AKT1 fluorouracil 0.6312805 0.9561079 0.631 NA NA
RET imatinib 0.6313687 0.9504694 0.6314 NA NA
ESR1 azd 0.6359850 0.7424789 0.636 NA NA
IDH2 crizotinib 0.6363824 0.9896386 0.636 NA NA
TSC1 erlotinib 0.6364596 0.9151456 0.636 NA NA
ERBB3 gefitinib 0.6397928 0.8848141 0.640 NA NA
TSC1 crizotinib 0.6420105 0.9896386 0.642 NA NA
KIT imatinib 0.6429646 0.9504694 0.6430 NA NA
AKT1 pazopanib 0.6440994 0.9261994 0.6441 NA NA
PDGFB selumetinib 0.6445370 0.8818646 0.64454 NA NA
MET erlotinib 0.6459851 0.9151456 0.646 NA NA
BRCA1 selumetinib 0.6484298 0.8818646 0.64843 NA NA
PDGFRA afatinib 0.6518163 0.8631215 0.6518 NA NA
DNMT3A azd 0.6551284 0.7424789 0.655 NA NA
MYD88 fluorouracil 0.6552215 0.9561079 0.655 NA NA
IDH2 cyclophosphamide 0.6554963 0.9793614 0.655 NA NA
UGT1A1 neratinib 0.6590084 0.9509752 0.65901 NA NA
BRCA2 ibrutinib 0.6602730 0.9736731 0.6603 NA NA
PTCH1 belinostat 0.6603291 0.9332615 0.66 NA NA
UGT1A1 lapatinib 0.6619661 0.7879401 0.6620 NA NA
TSC1 pazopanib 0.6622597 0.9261994 0.6623 NA NA
BRAF regorafenib 0.6631522 0.9394657 0.6632 NA NA
AKT1 dasatinib 0.6650170 0.9367075 0.665 NA NA
ALK belinostat 0.6654501 0.9332615 0.67 NA NA
G6PD afatinib 0.6656317 0.8631215 0.6656 NA NA
PDGFRA fulvestrant 0.6659409 0.9110805 0.6659 NA NA
PML dabrafenib 0.6659420 0.9324432 0.66594 NA NA
RET nilotinib 0.6667141 0.8395660 0.667 NA NA
BRCA2 lapatinib 0.6720665 0.7879401 0.6721 NA NA
NPM1 cyclophosphamide 0.6729128 0.9793614 0.673 NA NA
G6PD fulvestrant 0.6741823 0.9110805 0.6742 NA NA
PDGFRB crizotinib 0.6743149 0.9896386 0.674 NA NA
ESR1 fulvestrant 0.6748204 0.9110805 0.6748 NA NA
KIT olaparib 0.6772410 0.9728161 0.67724 NA NA
ESR1 neratinib 0.6776713 0.9509752 0.67767 NA NA
PTCH1 dabrafenib 0.6781405 0.9324432 0.67814 NA NA
ABL1 azd 0.6783940 0.7440450 0.678 NA NA
ABL1 olaparib 0.6795493 0.9728161 0.67955 NA NA
EGFR cabozantinib 0.6800714 0.7458848 0.6801 NA NA
ALK ruxolitinib 0.6822022 0.9664531 0.6822 NA NA
UGT1A1 gefitinib 0.6824391 0.8848141 0.682 NA NA
ABL1 vandetanib 0.6832739 0.8720434 0.6833 NA NA
TSC1 fulvestrant 0.6874271 0.9110805 0.6874 NA NA
PTCH1 fluorouracil 0.6889362 0.9561079 0.689 NA NA
PTCH1 crizotinib 0.6896847 0.9896386 0.690 NA NA
ERBB2 belinostat 0.6914232 0.9332615 0.69 NA NA
CYP19A1 afatinib 0.6916918 0.8631215 0.6917 NA NA
JAK2 olaparib 0.6925765 0.9728161 0.69258 NA NA
PML regorafenib 0.6943881 0.9410069 0.6944 NA NA
ERBB3 afatinib 0.6959010 0.8631215 0.6959 NA NA
EGFR fulvestrant 0.6967086 0.9110805 0.6967 NA NA
BRCA2 dasatinib 0.6990595 0.9367075 0.699 NA NA
TSC2 fluorouracil 0.7001121 0.9561079 0.700 NA NA
G6PD pazopanib 0.7046983 0.9261994 0.7047 NA NA
KRAS belinostat 0.7060390 0.9332615 0.71 NA NA
PDGFRB azd 0.7069233 0.7511060 0.707 NA NA
BRCA2 imatinib 0.7069599 0.9654406 0.7070 NA NA
BRCA1 vandetanib 0.7073522 0.8720434 0.7074 NA NA
UGT1A1 erlotinib 0.7111266 0.9491271 0.711 NA NA
FLT3 gefitinib 0.7182420 0.8848141 0.718 NA NA
TSC1 belinostat 0.7219457 0.9332615 0.72 NA NA
ROS1 vandetanib 0.7251785 0.8720434 0.7252 NA NA
FLT3 erlotinib 0.7258031 0.9491271 0.726 NA NA
PDGFB vandetanib 0.7261157 0.8720434 0.7261 NA NA
MET fluorouracil 0.7280738 0.9561079 0.728 NA NA
FLT3 trametinib 0.7282232 0.8286678 0.7282 NA NA
ROS1 ibrutinib 0.7285250 0.9736731 0.7285 NA NA
PML cyclophosphamide 0.7303617 0.9793614 0.730 NA NA
TSC1 ruxolitinib 0.7316331 0.9851643 0.7316 NA NA
AKT1 imatinib 0.7320299 0.9654406 0.7320 NA NA
TSC2 gefitinib 0.7322403 0.8848141 0.732 NA NA
PTCH1 afatinib 0.7324281 0.8631215 0.7324 NA NA
ERBB3 neratinib 0.7332982 0.9509752 0.73330 NA NA
FLT3 selumetinib 0.7342484 0.8927666 0.73425 NA NA
ERBB3 fluorouracil 0.7345804 0.9561079 0.735 NA NA
ERBB2 nilotinib 0.7346282 0.8710739 0.735 NA NA
TSC1 afatinib 0.7361919 0.8631215 0.7362 NA NA
PDGFB sunitinib 0.7395816 0.9565998 0.73958 NA NA
PDGFRA crizotinib 0.7420103 0.9896386 0.742 NA NA
UGT1A1 nilotinib 0.7429748 0.8710739 0.743 NA NA
MGMT selumetinib 0.7434177 0.8927666 0.74342 NA NA
PML vandetanib 0.7438018 0.8720434 0.7438 NA NA
G6PD olaparib 0.7455081 0.9728161 0.74551 NA NA
BRCA2 gefitinib 0.7477970 0.8848141 0.748 NA NA
TSC2 imatinib 0.7480994 0.9654406 0.7481 NA NA
JAK2 selumetinib 0.7485902 0.8927666 0.74859 NA NA
DPYD crizotinib 0.7496551 0.9896386 0.750 NA NA
MYD88 crizotinib 0.7508273 0.9896386 0.751 NA NA
PDGFRB dasatinib 0.7535038 0.9367075 0.754 NA NA
PTCH1 gefitinib 0.7546944 0.8848141 0.755 NA NA
PDGFRB dabrafenib 0.7547325 0.9480461 0.75473 NA NA
NPM1 olaparib 0.7587867 0.9728161 0.75879 NA NA
G6PD temozolomide 0.7612249 0.9585795 0.761 NA NA
PDGFRB lapatinib 0.7618885 0.8634737 0.7619 NA NA
BRCA2 regorafenib 0.7635037 0.9410069 0.7635 NA NA
DPYD imatinib 0.7666734 0.9654406 0.7667 NA NA
TSC2 olaparib 0.7680842 0.9728161 0.76808 NA NA
EGFR sunitinib 0.7681397 0.9565998 0.76814 NA NA
DPYD fluorouracil 0.7693491 0.9561079 0.769 NA NA
FLT3 sunitinib 0.7714998 0.9565998 0.77150 NA NA
MYD88 dasatinib 0.7715129 0.9367075 0.772 NA NA
EGFR fluorouracil 0.7720863 0.9561079 0.772 NA NA
ERBB2 ibrutinib 0.7726805 0.9736731 0.7727 NA NA
PDGFRB vandetanib 0.7728525 0.8735853 0.7729 NA NA
TSC2 belinostat 0.7739206 0.9332615 0.77 NA NA
UGT1A1 vemurafenib 0.7774617 0.9065616 0.77746 NA NA
ESR1 dasatinib 0.7776986 0.9367075 0.778 NA NA
KIT dasatinib 0.7790279 0.9367075 0.779 NA NA
MYD88 regorafenib 0.7798439 0.9410069 0.7798 NA NA
ABL1 dasatinib 0.7801253 0.9367075 0.780 NA NA
ROS1 dasatinib 0.7804679 0.9367075 0.780 NA NA
BRCA1 erlotinib 0.7809136 0.9494085 0.781 NA NA
MYD88 selumetinib 0.7817427 0.8927666 0.78174 NA NA
RET ibrutinib 0.7824502 0.9736731 0.7825 NA NA
EGFR belinostat 0.7834615 0.9332615 0.78 NA NA
CYP19A1 neratinib 0.7845031 0.9509752 0.78450 NA NA
MET belinostat 0.7848683 0.9332615 0.78 NA NA
PDGFRB cyclophosphamide 0.7850095 0.9793614 0.785 NA NA
MGMT cabozantinib 0.7880782 0.8373331 0.7881 NA NA
BRCA1 trametinib 0.7902084 0.8422588 0.7902 NA NA
ALK pazopanib 0.7907566 0.9261994 0.7908 NA NA
NPM1 trametinib 0.7912128 0.8422588 0.7912 NA NA
MYD88 sunitinib 0.7948466 0.9565998 0.79485 NA NA
FLT3 fluorouracil 0.7949588 0.9561079 0.795 NA NA
BRCA2 fulvestrant 0.7961724 0.9582702 0.7962 NA NA
ESR1 vandetanib 0.7965042 0.8735853 0.7965 NA NA
IDH2 belinostat 0.7972643 0.9332615 0.80 NA NA
NPM1 regorafenib 0.8002281 0.9410069 0.8002 NA NA
ROS1 dabrafenib 0.8003190 0.9480461 0.80032 NA NA
CYP19A1 erlotinib 0.8021724 0.9494085 0.802 NA NA
TSC2 dabrafenib 0.8039511 0.9480461 0.80395 NA NA
ERBB2 pazopanib 0.8041509 0.9261994 0.8042 NA NA
EGFR imatinib 0.8043300 0.9690754 0.8043 NA NA
ERBB3 vemurafenib 0.8058873 0.9065616 0.80589 NA NA
IDH2 gefitinib 0.8069304 0.9145211 0.807 NA NA
AKT1 fulvestrant 0.8069482 0.9582702 0.8069 NA NA
TPMT temozolomide 0.8089661 0.9600068 0.809 NA NA
NPM1 dasatinib 0.8123866 0.9367075 0.812 NA NA
BRCA1 olaparib 0.8126710 0.9728161 0.81267 NA NA
FLT3 afatinib 0.8136811 0.9017076 0.8137 NA NA
TSC2 pazopanib 0.8156658 0.9261994 0.8157 NA NA
EGFR selumetinib 0.8175946 0.8927666 0.81759 NA NA
KRAS fluorouracil 0.8178870 0.9561079 0.818 NA NA
DNMT3A dabrafenib 0.8196290 0.9480461 0.81963 NA NA
KRAS erlotinib 0.8197849 0.9494085 0.820 NA NA
JAK2 ruxolitinib 0.8206972 0.9851643 0.8207 NA NA
ABL1 neratinib 0.8209775 0.9509752 0.82098 NA NA
JAK2 pazopanib 0.8212255 0.9261994 0.8212 NA NA
ESR1 afatinib 0.8221452 0.9017076 0.8221 NA NA
AKT1 selumetinib 0.8255265 0.8927666 0.82553 NA NA
ERBB3 dasatinib 0.8265066 0.9367075 0.827 NA NA
ERBB3 regorafenib 0.8265906 0.9410069 0.8266 NA NA
G6PD belinostat 0.8270727 0.9332615 0.83 NA NA
BRCA2 sunitinib 0.8280670 0.9565998 0.82807 NA NA
TSC2 regorafenib 0.8307456 0.9410069 0.8307 NA NA
ABL1 dabrafenib 0.8331314 0.9480461 0.83313 NA NA
JAK2 imatinib 0.8347277 0.9690754 0.8347 NA NA
ABL1 pazopanib 0.8358559 0.9261994 0.8359 NA NA
TPMT nilotinib 0.8378567 0.9337740 0.838 NA NA
BRCA2 ruxolitinib 0.8386749 0.9851643 0.8387 NA NA
TPMT fulvestrant 0.8400737 0.9582702 0.8401 NA NA
KIT belinostat 0.8435673 0.9332615 0.84 NA NA
ABL1 sunitinib 0.8440587 0.9565998 0.84406 NA NA
EGFR cyclophosphamide 0.8442118 0.9793614 0.844 NA NA
TPMT belinostat 0.8445547 0.9332615 0.84 NA NA
PDGFRB erlotinib 0.8448409 0.9494085 0.845 NA NA
PML azd 0.8448624 0.8704643 0.845 NA NA
PDGFB fulvestrant 0.8455325 0.9582702 0.8455 NA NA
DNMT3A belinostat 0.8463546 0.9332615 0.85 NA NA
ALK cabozantinib 0.8474970 0.8731787 0.8475 NA NA
JAK2 belinostat 0.8481782 0.9332615 0.85 NA NA
ESR1 ruxolitinib 0.8489985 0.9851643 0.8490 NA NA
MGMT pazopanib 0.8490601 0.9261994 0.8491 NA NA
PDGFB afatinib 0.8499921 0.9031166 0.8500 NA NA
BRCA1 ibrutinib 0.8510774 0.9736731 0.8511 NA NA
IDH2 nilotinib 0.8513822 0.9337740 0.851 NA NA
CYP19A1 pazopanib 0.8533966 0.9261994 0.8534 NA NA
PDGFRA imatinib 0.8550665 0.9690754 0.8551 NA NA
PDGFB crizotinib 0.8558808 0.9896386 0.856 NA NA
PTCH1 neratinib 0.8565156 0.9509752 0.85652 NA NA
G6PD neratinib 0.8580742 0.9509752 0.85807 NA NA
ERBB3 temozolomide 0.8609254 0.9600068 0.861 NA NA
FLT3 neratinib 0.8622113 0.9509752 0.86221 NA NA
ERBB3 trametinib 0.8637892 0.8907826 0.8638 NA NA
ROS1 selumetinib 0.8640047 0.8927666 0.86400 NA NA
MET ruxolitinib 0.8650705 0.9851643 0.8651 NA NA
TSC2 selumetinib 0.8665087 0.8927666 0.86651 NA NA
BRCA1 cyclophosphamide 0.8713387 0.9793614 0.871 NA NA
ALK cyclophosphamide 0.8716671 0.9793614 0.872 NA NA
ERBB2 regorafenib 0.8725903 0.9410069 0.8726 NA NA
EGFR temozolomide 0.8736252 0.9600068 0.874 NA NA
PML ibrutinib 0.8740839 0.9736731 0.8741 NA NA
MET ibrutinib 0.8773082 0.9736731 0.8773 NA NA
G6PD erlotinib 0.8787499 0.9494085 0.879 NA NA
PDGFB cabozantinib 0.8796954 0.8796954 0.8797 NA NA
BRCA1 ruxolitinib 0.8813093 0.9851643 0.8813 NA NA
ERBB3 olaparib 0.8819557 0.9728161 0.88196 NA NA
NPM1 vemurafenib 0.8824014 0.9065616 0.88240 NA NA
ESR1 pazopanib 0.8825243 0.9261994 0.8825 NA NA
ABL1 vemurafenib 0.8828642 0.9065616 0.88286 NA NA
KIT vemurafenib 0.8838594 0.9065616 0.88386 NA NA
BRAF crizotinib 0.8847422 0.9896386 0.885 NA NA
MGMT regorafenib 0.8856536 0.9410069 0.8857 NA NA
FLT3 azd 0.8863568 0.8863568 0.886 NA NA
TSC2 fulvestrant 0.8866945 0.9688694 0.8867 NA NA
RET temozolomide 0.8870447 0.9600068 0.887 NA NA
EGFR gefitinib 0.8875800 0.9734748 0.888 NA NA
MET dasatinib 0.8890135 0.9662257 0.889 NA NA
PML neratinib 0.8916365 0.9509752 0.89164 NA NA
ABL1 erlotinib 0.8935609 0.9494085 0.894 NA NA
KIT nilotinib 0.8943017 0.9501956 0.894 NA NA
MGMT ibrutinib 0.8947146 0.9736731 0.8947 NA NA
JAK2 lapatinib 0.8953005 0.9427410 0.8953 NA NA
MET imatinib 0.8955374 0.9790505 0.8955 NA NA
ERBB2 lapatinib 0.8966122 0.9427410 0.8966 NA NA
BRCA2 fluorouracil 0.8966696 0.9561079 0.897 NA NA
MYD88 belinostat 0.8969609 0.9332615 0.90 NA NA
CYP19A1 crizotinib 0.8996262 0.9896386 0.900 NA NA
IDH2 sunitinib 0.9001651 0.9857115 0.90017 NA NA
FLT3 cyclophosphamide 0.9009165 0.9793614 0.901 NA NA
NPM1 belinostat 0.9011013 0.9332615 0.90 NA NA
IDH2 temozolomide 0.9035358 0.9600068 0.904 NA NA
TPMT vemurafenib 0.9065616 0.9065616 0.90656 NA NA
ESR1 crizotinib 0.9085657 0.9896386 0.909 NA NA
JAK2 dasatinib 0.9093889 0.9662257 0.909 NA NA
ESR1 cyclophosphamide 0.9094059 0.9793614 0.909 NA NA
RET olaparib 0.9112727 0.9728161 0.91127 NA NA
DNMT3A fulvestrant 0.9118771 0.9688694 0.9119 NA NA
PTCH1 vandetanib 0.9121958 0.9305740 0.9122 NA NA
JAK2 fluorouracil 0.9122887 0.9561079 0.912 NA NA
PTCH1 ruxolitinib 0.9145576 0.9851643 0.9146 NA NA
PDGFB lapatinib 0.9150133 0.9427410 0.9150 NA NA
AKT1 dabrafenib 0.9165171 0.9896121 0.91652 NA NA
DPYD pazopanib 0.9171346 0.9261994 0.9171 NA NA
ROS1 fluorouracil 0.9179969 0.9561079 0.918 NA NA
PDGFRA olaparib 0.9187781 0.9728161 0.91878 NA NA
EGFR neratinib 0.9192244 0.9509752 0.91922 NA NA
PTCH1 cyclophosphamide 0.9194906 0.9793614 0.919 NA NA
TSC2 ibrutinib 0.9206937 0.9736731 0.9207 NA NA
PDGFB cyclophosphamide 0.9213531 0.9793614 0.921 NA NA
ESR1 selumetinib 0.9216779 0.9216779 0.92168 NA NA
MYD88 cyclophosphamide 0.9220687 0.9793614 0.922 NA NA
CYP19A1 trametinib 0.9221480 0.9221480 0.9221 NA NA
UGT1A1 belinostat 0.9223455 0.9332615 0.92 NA NA
JAK2 neratinib 0.9230054 0.9509752 0.92301 NA NA
ESR1 belinostat 0.9247735 0.9332615 0.92 NA NA
PDGFRA belinostat 0.9258624 0.9332615 0.93 NA NA
EGFR pazopanib 0.9261994 0.9261994 0.9262 NA NA
BRCA2 nilotinib 0.9267694 0.9548533 0.927 NA NA
UGT1A1 vandetanib 0.9276534 0.9305740 0.9277 NA NA
FLT3 vandetanib 0.9305740 0.9305740 0.9306 NA NA
AKT1 belinostat 0.9332615 0.9332615 0.93 NA NA
BRCA1 afatinib 0.9350732 0.9634087 0.9351 NA NA
ERBB3 ibrutinib 0.9351931 0.9736731 0.9352 NA NA
IDH2 ibrutinib 0.9361769 0.9736731 0.9362 NA NA
EGFR crizotinib 0.9363173 0.9896386 0.936 NA NA
IDH2 fluorouracil 0.9380996 0.9561079 0.938 NA NA
MYD88 olaparib 0.9407553 0.9728161 0.94076 NA NA
ERBB2 sunitinib 0.9415781 0.9857115 0.94158 NA NA
FLT3 ruxolitinib 0.9427873 0.9851643 0.9428 NA NA
IDH2 regorafenib 0.9449361 0.9661684 0.9449 NA NA
CYP19A1 gefitinib 0.9492185 0.9871832 0.949 NA NA
ROS1 neratinib 0.9510033 0.9510033 0.95100 NA NA
NPM1 imatinib 0.9542718 0.9790505 0.9543 NA NA
KIT fluorouracil 0.9561079 0.9561079 0.956 NA NA
G6PD ruxolitinib 0.9561889 0.9851643 0.9562 NA NA
PDGFRB olaparib 0.9563573 0.9728161 0.95636 NA NA
ABL1 lapatinib 0.9564785 0.9564785 0.9565 NA NA
ALK sunitinib 0.9567200 0.9857115 0.95672 NA NA
PDGFB temozolomide 0.9628530 0.9895199 0.963 NA NA
MYD88 erlotinib 0.9646182 0.9832344 0.965 NA NA
PTCH1 ibrutinib 0.9649617 0.9736731 0.9650 NA NA
TSC1 cyclophosphamide 0.9655074 0.9793614 0.966 NA NA
ESR1 dabrafenib 0.9659108 0.9896121 0.96591 NA NA
DNMT3A regorafenib 0.9661684 0.9661684 0.9662 NA NA
BRCA1 dabrafenib 0.9666621 0.9896121 0.96666 NA NA
KIT fulvestrant 0.9667212 0.9765345 0.9667 NA NA
ERBB2 olaparib 0.9669476 0.9728161 0.96695 NA NA
AKT1 nilotinib 0.9672155 0.9672155 0.967 NA NA
ROS1 imatinib 0.9684583 0.9790505 0.9685 NA NA
ERBB2 crizotinib 0.9689644 0.9896386 0.969 NA NA
TSC1 gefitinib 0.9708568 0.9871832 0.971 NA NA
DPYD olaparib 0.9728161 0.9728161 0.97282 NA NA
DPYD ibrutinib 0.9736731 0.9736731 0.9737 NA NA
G6PD crizotinib 0.9756109 0.9896386 0.976 NA NA
UGT1A1 fulvestrant 0.9765345 0.9765345 0.9765 NA NA
DPYD dasatinib 0.9779403 0.9980158 0.978 NA NA
G6PD imatinib 0.9790505 0.9790505 0.9791 NA NA
PDGFRA cyclophosphamide 0.9793614 0.9793614 0.979 NA NA
ERBB3 erlotinib 0.9832344 0.9832344 0.983 NA NA
BRAF gefitinib 0.9871832 0.9871832 0.987 NA NA
BRCA1 crizotinib 0.9886434 0.9896386 0.989 NA NA
KIT temozolomide 0.9895199 0.9895199 0.990 NA NA
RET dabrafenib 0.9896121 0.9896121 0.98961 NA NA
FLT3 crizotinib 0.9896386 0.9896386 0.990 NA NA
BRAF sunitinib 0.9897961 0.9897961 0.98980 NA NA
NPM1 afatinib 0.9954026 0.9954026 0.9954 NA NA
KIT ruxolitinib 0.9977843 0.9977843 0.9978 NA NA
UGT1A1 dasatinib 0.9980158 0.9980158 0.998 NA NA

4.3.2 G2P gene, drug, and lineage

ctrp_signif_g2p_lineage <- lapply(unique(ctrp_data_g2p_genesfilt$Drug), WilcoxonByDrug, dataset = ctrp_data_g2p_genesfilt, data_name = "ctrp", grouping_var = "lineage")
names(ctrp_signif_g2p_lineage) <- unique(ctrp_signif_g2p_lineage$Drug)
saveRDS(ctrp_signif_g2p_lineage, "./data_munging/rds/ctrp_signif_g2p_lineage.rds")
ctrp_signif_g2p_lineage <- readRDS("./data_munging/rds/ctrp_signif_g2p_lineage.rds")
ctrp_signif_g2p_lineage <- rbindlist(ctrp_signif_g2p_lineage, use.names = TRUE)
ctrp_signif_g2p_lineage <- ctrp_signif_g2p_lineage[order(ctrp_signif_g2p_lineage$p),]

knitr::kable(ctrp_signif_g2p_lineage[1:500, c("Hugo_Symbol", "Drug", "group_general_lineage_name", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "CTRP: Wilcoxon test results for level A G2P drug-gene associations across lineages (* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
CTRP: Wilcoxon test results for level A G2P drug-gene associations across lineages (* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)
Hugo_Symbol Drug group_general_lineage_name p p.adj p.format p.signif p.signif.adj
KRAS afatinib lung cancer 0.0025065 0.6912862 0.0025 ** NA
DNMT3A neratinib colorectal cancer 0.0041658 0.8529308 0.0042 ** NA
DNMT3A erlotinib colorectal cancer 0.0050761 0.7676457 0.0051 ** NA
DNMT3A lapatinib colorectal cancer 0.0050761 0.6833597 0.0051 ** NA
DPYD lapatinib lung cancer 0.0056839 0.6833597 0.0057 ** NA
KRAS neratinib lung cancer 0.0057872 0.8529308 0.0058 ** NA
MET gefitinib lung cancer 0.0063673 0.7599673 0.0064 ** NA
PDGFRA lapatinib colorectal cancer 0.0065289 0.6833597 0.0065 ** NA
BRAF vemurafenib lung cancer 0.0068499 0.7314712 0.0068 ** NA
PDGFRA gefitinib colorectal cancer 0.0072904 0.7599673 0.0073 ** NA
PDGFRA erlotinib colorectal cancer 0.0074408 0.7676457 0.0074 ** NA
TSC1 crizotinib colorectal cancer 0.0076703 0.7938410 0.0077 ** NA
PTCH1 crizotinib colorectal cancer 0.0076839 0.7938410 0.0077 ** NA
KRAS ibrutinib lung cancer 0.0078408 0.8391700 0.0078 ** NA
DNMT3A vandetanib colorectal cancer 0.0090136 0.7394946 0.009 ** NA
DPYD afatinib lung cancer 0.0091936 0.6912862 0.0092 ** NA
ROS1 afatinib liver cancer 0.0098014 0.6912862 0.0098 ** NA
PDGFRA neratinib colorectal cancer 0.0112178 0.8529308 0.0112
NA
BRAF vemurafenib skin cancer 0.0118984 0.7314712 0.0119
NA
MET afatinib lung cancer 0.0132162 0.6912862 0.0132
NA
BRCA2 azd leukemia 0.0134187 0.7271108 0.013
NA
KRAS azd stomach cancer 0.0134789 0.7271108 0.013
NA
MET neratinib lung cancer 0.0135414 0.8529308 0.0135
NA
ALK crizotinib colorectal cancer 0.0143589 0.7938410 0.0144
NA
BRCA2 sunitinib leukemia 0.0145304 0.8066353 0.015
NA
DPYD erlotinib lung cancer 0.0152755 0.7676457 0.0153
NA
PTCH1 sunitinib colorectal cancer 0.0156421 0.8066353 0.016
NA
PML pazopanib leukemia 0.0157226 0.8418010 0.016
NA
KRAS pazopanib lung cancer 0.0158506 0.8418010 0.016
NA
BRAF regorafenib colorectal cancer 0.0162093 0.8854684 0.016
NA
ROS1 gefitinib liver cancer 0.0162268 0.7599673 0.0162
NA
KRAS lapatinib lung cancer 0.0163255 0.7642264 0.0163
NA
ALK cabozantinib uterine cancer 0.0167538 0.7847230 0.017
NA
KRAS dasatinib pancreatic cancer 0.0169480 0.8497291 0.017
NA
MYD88 regorafenib uterine cancer 0.0171587 0.8854684 0.017
NA
PTCH1 cabozantinib colorectal cancer 0.0173031 0.7847230 0.017
NA
KRAS ruxolitinib stomach cancer 0.0173309 0.8822148 0.017
NA
ERBB3 vandetanib colorectal cancer 0.0177013 0.7394946 0.018
NA
PDGFRA vandetanib colorectal cancer 0.0177013 0.7394946 0.018
NA
DPYD gefitinib lung cancer 0.0182476 0.7599673 0.0182
NA
DPYD neratinib lung cancer 0.0183318 0.8529308 0.0183
NA
DPYD vandetanib lung cancer 0.0187611 0.7394946 0.019
NA
ESR1 vandetanib lung cancer 0.0190259 0.7394946 0.019
NA
PDGFRB afatinib lung cancer 0.0198446 0.6912862 0.0198
NA
TSC1 erlotinib colorectal cancer 0.0198606 0.7676457 0.0199
NA
KRAS crizotinib lung cancer 0.0201104 0.7938410 0.0201
NA
ESR1 lapatinib leukemia 0.0201323 0.7642264 0.0201
NA
DNMT3A lapatinib lung cancer 0.0204725 0.7642264 0.0205
NA
ESR1 afatinib lung cancer 0.0212259 0.6912862 0.0212
NA
PDGFRA crizotinib colorectal cancer 0.0214507 0.7938410 0.0215
NA
EGFR crizotinib colorectal cancer 0.0221532 0.7938410 0.0222
NA
MGMT sunitinib colorectal cancer 0.0222701 0.8066353 0.022
NA
PTCH1 vemurafenib colorectal cancer 0.0224118 0.7314712 0.0224
NA
ERBB3 pazopanib uterine cancer 0.0227096 0.8418010 0.023
NA
PDGFRA afatinib colorectal cancer 0.0229718 0.6912862 0.0230
NA
KRAS sunitinib lung cancer 0.0234082 0.8066353 0.023
NA
PML crizotinib colorectal cancer 0.0235755 0.7938410 0.0236
NA
ROS1 crizotinib liver cancer 0.0237385 0.7938410 0.0237
NA
BRCA2 crizotinib colorectal cancer 0.0241905 0.7938410 0.0242
NA
MYD88 cabozantinib uterine cancer 0.0246271 0.7847230 0.025
NA
ABL1 erlotinib multiple myeloma 0.0246982 0.7676457 0.0247
NA
KRAS neratinib urinary bladder cancer 0.0253038 0.8529308 0.0253
NA
KRAS sunitinib urinary bladder cancer 0.0253038 0.8066353 0.025
NA
ERBB3 temozolomide colorectal cancer 0.0258624 0.9030339 0.026
NA
ABL1 regorafenib central nervous system cancer 0.0263962 0.8854684 0.026
NA
DNMT3A gefitinib colorectal cancer 0.0264534 0.7599673 0.0265
NA
KRAS crizotinib pancreatic cancer 0.0266140 0.7938410 0.0266
NA
ROS1 pazopanib esophageal cancer 0.0266603 0.8418010 0.027
NA
ROS1 vandetanib esophageal cancer 0.0266603 0.7394946 0.027
NA
ROS1 lapatinib liver cancer 0.0274686 0.7642264 0.0275
NA
PML gefitinib leukemia 0.0277314 0.7599673 0.0277
NA
ROS1 gefitinib lung cancer 0.0279208 0.7599673 0.0279
NA
ERBB2 fluorouracil urinary bladder cancer 0.0282115 0.8769250 0.028
NA
ROS1 vandetanib liver cancer 0.0283870 0.7394946 0.028
NA
UGT1A1 imatinib uterine cancer 0.0284153 0.9011066 0.028
NA
PDGFRB regorafenib ovarian cancer 0.0284921 0.8854684 0.028
NA
PML sunitinib leukemia 0.0287699 0.8066353 0.029
NA
ERBB3 neratinib multiple myeloma 0.0290963 0.8529308 0.0291
NA
ERBB3 nilotinib colorectal cancer 0.0291265 0.9164407 0.029
NA
PDGFRB temozolomide cancer 0.0294801 0.9030339 0.029
NA
ESR1 imatinib uterine cancer 0.0295794 0.9011066 0.030
NA
MET vemurafenib esophageal cancer 0.0299640 0.7314712 0.0300
NA
KRAS azd lung cancer 0.0304746 0.7271108 0.030
NA
ALK trametinib lung cancer 0.0305841 0.7221611 0.031
NA
KRAS ibrutinib stomach cancer 0.0306542 0.8391700 0.0307
NA
KRAS selumetinib colorectal cancer 0.0313618 0.7681714 0.031
NA
BRAF temozolomide lung cancer 0.0313700 0.9030339 0.031
NA
KRAS cyclophosphamide multiple myeloma 0.0319476 0.8197782 0.032
NA
ABL1 afatinib multiple myeloma 0.0320740 0.6912862 0.0321
NA
MGMT crizotinib colorectal cancer 0.0322621 0.7938410 0.0323
NA
PDGFB regorafenib colorectal cancer 0.0322633 0.8854684 0.032
NA
BRCA1 sunitinib skin cancer 0.0327988 0.8066353 0.033
NA
MET vandetanib pancreatic cancer 0.0329940 0.7394946 0.033
NA
ALK cabozantinib colorectal cancer 0.0331557 0.7847230 0.033
NA
PDGFRA pazopanib urinary bladder cancer 0.0333682 0.8418010 0.033
NA
PDGFRA sunitinib urinary bladder cancer 0.0333682 0.8066353 0.033
NA
RET selumetinib ovarian cancer 0.0336207 0.7681714 0.034
NA
KRAS crizotinib stomach cancer 0.0341136 0.7938410 0.0341
NA
KRAS vandetanib leukemia 0.0341311 0.7394946 0.034
NA
ABL1 imatinib head and neck cancer 0.0346137 0.9011066 0.035
NA
ABL1 vandetanib skin cancer 0.0352921 0.7394946 0.035
NA
ROS1 neratinib head and neck cancer 0.0353082 0.8529308 0.0353
NA
PML olaparib leukemia 0.0353914 0.8663279 0.035
NA
DPYD ibrutinib lung cancer 0.0359037 0.8391700 0.0359
NA
ROS1 neratinib esophageal cancer 0.0360247 0.8529308 0.0360
NA
ERBB3 erlotinib breast cancer 0.0360402 0.7676457 0.0360
NA
KIT erlotinib breast cancer 0.0360402 0.7676457 0.0360
NA
PDGFRA fluorouracil leukemia 0.0365708 0.8769250 0.037
NA
KIT erlotinib lung cancer 0.0369711 0.7676457 0.0370
NA
ALK fluorouracil cancer 0.0372425 0.8769250 0.037
NA
ERBB3 cabozantinib uterine cancer 0.0373498 0.7847230 0.037
NA
EGFR ibrutinib esophageal cancer 0.0380522 0.8391700 0.0381
NA
KRAS ibrutinib pancreatic cancer 0.0380990 0.8391700 0.0381
NA
MET imatinib pancreatic cancer 0.0382678 0.9011066 0.038
NA
PML temozolomide ovarian cancer 0.0385590 0.9030339 0.039
NA
MET imatinib colorectal cancer 0.0387179 0.9011066 0.039
NA
EGFR temozolomide central nervous system cancer 0.0391646 0.9030339 0.039
NA
KRAS trametinib colorectal cancer 0.0393672 0.7221611 0.039
NA
TSC1 sunitinib ovarian cancer 0.0394732 0.8066353 0.039
NA
ABL1 ruxolitinib central nervous system cancer 0.0397303 0.8822148 0.040
NA
KRAS vandetanib stomach cancer 0.0398326 0.7394946 0.040
NA
DPYD dasatinib skin cancer 0.0399773 0.8497291 0.040
NA
PTCH1 erlotinib colorectal cancer 0.0402003 0.7676457 0.0402
NA
EGFR olaparib ovarian cancer 0.0405047 0.8663279 0.041
NA
BRCA1 vandetanib skin cancer 0.0406267 0.7394946 0.041
NA
ROS1 lapatinib lung cancer 0.0410603 0.7642264 0.0411
NA
KRAS afatinib stomach cancer 0.0415064 0.6912862 0.0415
NA
ABL1 neratinib multiple myeloma 0.0416793 0.8529308 0.0417
NA
KRAS vandetanib urinary bladder cancer 0.0416793 0.7394946 0.042
NA
FLT3 vemurafenib lung cancer 0.0416919 0.7314712 0.0417
NA
DNMT3A crizotinib colorectal cancer 0.0420547 0.7938410 0.0421
NA
ESR1 imatinib leukemia 0.0423676 0.9011066 0.042
NA
ERBB3 imatinib breast cancer 0.0428111 0.9011066 0.043
NA
KIT imatinib breast cancer 0.0428111 0.9011066 0.043
NA
ERBB3 afatinib breast cancer 0.0428256 0.6912862 0.0428
NA
KIT afatinib breast cancer 0.0428256 0.6912862 0.0428
NA
EGFR sunitinib colorectal cancer 0.0429878 0.8066353 0.043
NA
KRAS lapatinib ovarian cancer 0.0430706 0.7642264 0.0431
NA
TSC1 sunitinib urinary bladder cancer 0.0435376 0.8066353 0.044
NA
EGFR belinostat esophageal cancer 0.0443755 1.0000000 0.044
NA
MYD88 vemurafenib uterine cancer 0.0447737 0.7314712 0.0448
NA
RET ruxolitinib lung cancer 0.0447889 0.8822148 0.045
NA
TSC2 cyclophosphamide colorectal cancer 0.0448547 0.8197782 0.045
NA
EGFR afatinib central nervous system cancer 0.0452348 0.6912862 0.0452
NA
KIT gefitinib lung cancer 0.0453934 0.7599673 0.0454
NA
KRAS lapatinib urinary bladder cancer 0.0456472 0.7642264 0.0456
NA
ERBB2 olaparib uterine cancer 0.0457486 0.8663279 0.046
NA
MET ibrutinib lung cancer 0.0457695 0.8391700 0.0458
NA
ALK azd colorectal cancer 0.0459607 0.7271108 0.046
NA
KRAS lapatinib pancreatic cancer 0.0460969 0.7642264 0.0461
NA
TSC1 lapatinib ovarian cancer 0.0461687 0.7642264 0.0462
NA
ERBB3 imatinib lung cancer 0.0462808 0.9011066 0.046
NA
DPYD azd uterine cancer 0.0465344 0.7271108 0.047
NA
MET crizotinib pancreatic cancer 0.0465588 0.7938410 0.0466
NA
KRAS vemurafenib colorectal cancer 0.0467426 0.7314712 0.0467
NA
ESR1 pazopanib leukemia 0.0469732 0.8418010 0.047
NA
ESR1 olaparib leukemia 0.0470163 0.8663279 0.047
NA
BRAF belinostat skin cancer 0.0470840 1.0000000 0.047
NA
PTCH1 lapatinib breast cancer 0.0471253 0.7642264 0.0471
NA
ALK cyclophosphamide colorectal cancer 0.0471288 0.8197782 0.047
NA
BRCA1 belinostat ovarian cancer 0.0471767 1.0000000 0.047
NA
KRAS sunitinib stomach cancer 0.0473417 0.8066353 0.047
NA
KRAS neratinib stomach cancer 0.0473910 0.8529308 0.0474
NA
BRAF selumetinib breast cancer 0.0475334 0.7681714 0.048
NA
KRAS neratinib breast cancer 0.0475466 0.8529308 0.0475
NA
ESR1 neratinib lung cancer 0.0479042 0.8529308 0.0479
NA
ROS1 lapatinib esophageal cancer 0.0480598 0.7642264 0.0481
NA
TSC2 crizotinib liver cancer 0.0480598 0.7938410 0.0481
NA
TSC2 olaparib liver cancer 0.0480598 0.8663279 0.048
NA
DNMT3A sunitinib skin cancer 0.0481068 0.8066353 0.048
NA
TSC2 cyclophosphamide leukemia 0.0481068 0.8197782 0.048
NA
PTCH1 afatinib breast cancer 0.0483810 0.6912862 0.0484
NA
ALK imatinib uterine cancer 0.0489944 0.9011066 0.049
NA
PTCH1 temozolomide lung cancer 0.0491138 0.9030339 0.049
NA
KRAS gefitinib pancreatic cancer 0.0497301 0.7599673 0.0497
NA
ALK vemurafenib colorectal cancer 0.0500323 0.7314712 0.0500 NA NA
KRAS afatinib ovarian cancer 0.0501805 0.6912862 0.0502 NA NA
KIT ibrutinib esophageal cancer 0.0504933 0.8391700 0.0505 NA NA
MGMT cabozantinib colorectal cancer 0.0505597 0.7847230 0.051 NA NA
MGMT ruxolitinib colorectal cancer 0.0505597 0.8822148 0.051 NA NA
DNMT3A afatinib colorectal cancer 0.0507550 0.6912862 0.0508 NA NA
ROS1 sunitinib esophageal cancer 0.0508413 0.8066353 0.051 NA NA
ROS1 afatinib esophageal cancer 0.0508413 0.6912862 0.0508 NA NA
KRAS selumetinib ovarian cancer 0.0510079 0.7681714 0.051 NA NA
BRCA1 crizotinib colorectal cancer 0.0513246 0.7938410 0.0513 NA NA
DNMT3A dasatinib uterine cancer 0.0518329 0.8497291 0.052 NA NA
PDGFRB azd breast cancer 0.0520203 0.7271108 0.052 NA NA
BRAF dabrafenib skin cancer 0.0520617 0.9150307 0.052 NA NA
EGFR cabozantinib colorectal cancer 0.0524804 0.7847230 0.052 NA NA
ALK sunitinib colorectal cancer 0.0527831 0.8066353 0.053 NA NA
BRCA2 afatinib leukemia 0.0530118 0.6912862 0.0530 NA NA
PML afatinib leukemia 0.0530118 0.6912862 0.0530 NA NA
RET gefitinib colorectal cancer 0.0530182 0.7599673 0.0530 NA NA
MET regorafenib colorectal cancer 0.0533112 0.8854684 0.053 NA NA
PDGFRA azd urinary bladder cancer 0.0533272 0.7271108 0.053 NA NA
PML cabozantinib uterine cancer 0.0537201 0.7847230 0.054 NA NA
BRAF cabozantinib breast cancer 0.0537829 0.7847230 0.054 NA NA
ALK ruxolitinib skin cancer 0.0543689 0.8822148 0.054 NA NA
ABL1 sunitinib skin cancer 0.0543898 0.8066353 0.054 NA NA
KIT pazopanib lung cancer 0.0545007 0.8418010 0.055 NA NA
ABL1 temozolomide urinary bladder cancer 0.0545731 0.9030339 0.055 NA NA
KRAS lapatinib stomach cancer 0.0546335 0.7642264 0.0546 NA NA
BRCA2 neratinib lung cancer 0.0554424 0.8529308 0.0554 NA NA
KRAS selumetinib breast cancer 0.0555760 0.7681714 0.056 NA NA
ERBB3 neratinib breast cancer 0.0555905 0.8529308 0.0556 NA NA
KIT neratinib breast cancer 0.0555905 0.8529308 0.0556 NA NA
ROS1 regorafenib lung cancer 0.0556831 0.8854684 0.056 NA NA
ESR1 lapatinib lung cancer 0.0556834 0.7642264 0.0557 NA NA
FLT3 olaparib skin cancer 0.0557479 0.8663279 0.056 NA NA
RET olaparib skin cancer 0.0558531 0.8663279 0.056 NA NA
UGT1A1 imatinib lung cancer 0.0559703 0.9011066 0.056 NA NA
ABL1 regorafenib multiple myeloma 0.0562097 0.8854684 0.056 NA NA
ERBB3 cyclophosphamide leukemia 0.0562585 0.8197782 0.056 NA NA
KIT sunitinib lung cancer 0.0567449 0.8066353 0.057 NA NA
DNMT3A selumetinib lung cancer 0.0572020 0.7681714 0.057 NA NA
KRAS pazopanib uterine cancer 0.0580343 0.8418010 0.058 NA NA
PTCH1 sunitinib ovarian cancer 0.0581372 0.8066353 0.058 NA NA
DNMT3A pazopanib colorectal cancer 0.0586608 0.8418010 0.059 NA NA
ERBB2 neratinib urinary bladder cancer 0.0600471 0.8529308 0.0600 NA NA
ERBB2 cyclophosphamide colorectal cancer 0.0600533 0.8197782 0.060 NA NA
BRCA2 nilotinib uterine cancer 0.0603642 0.9164407 0.060 NA NA
BRAF vandetanib uterine cancer 0.0605263 0.7394946 0.061 NA NA
ERBB3 olaparib lung cancer 0.0608868 0.8663279 0.061 NA NA
ROS1 erlotinib central nervous system cancer 0.0608881 0.7676457 0.0609 NA NA
ALK ruxolitinib leukemia 0.0611778 0.8822148 0.061 NA NA
PML lapatinib leukemia 0.0612053 0.7642264 0.0612 NA NA
ERBB3 vandetanib multiple myeloma 0.0612277 0.7394946 0.061 NA NA
MET afatinib pancreatic cancer 0.0616828 0.6912862 0.0617 NA NA
PML fluorouracil leukemia 0.0619660 0.8769250 0.062 NA NA
ALK selumetinib lung cancer 0.0620029 0.7681714 0.062 NA NA
TSC1 erlotinib ovarian cancer 0.0624477 0.7676457 0.0624 NA NA
ALK ruxolitinib ovarian cancer 0.0624477 0.8822148 0.062 NA NA
KRAS pazopanib stomach cancer 0.0627473 0.8418010 0.063 NA NA
KRAS gefitinib stomach cancer 0.0627765 0.7599673 0.0628 NA NA
BRCA2 dasatinib skin cancer 0.0628910 0.8497291 0.063 NA NA
KRAS dasatinib leukemia 0.0629912 0.8497291 0.063 NA NA
ROS1 gefitinib esophageal cancer 0.0633067 0.7599673 0.0633 NA NA
ROS1 erlotinib esophageal cancer 0.0633067 0.7676457 0.0633 NA NA
ROS1 fluorouracil esophageal cancer 0.0633067 0.8769250 0.063 NA NA
ESR1 cabozantinib leukemia 0.0637788 0.7847230 0.064 NA NA
PML olaparib uterine cancer 0.0640369 0.8663279 0.064 NA NA
BRCA2 trametinib skin cancer 0.0640460 0.7221611 0.064 NA NA
KIT afatinib lymphoma 0.0647375 0.6912862 0.0647 NA NA
ERBB2 crizotinib ovarian cancer 0.0647375 0.7938410 0.0647 NA NA
TSC2 crizotinib colorectal cancer 0.0648245 0.7938410 0.0648 NA NA
RET selumetinib colorectal cancer 0.0650308 0.7681714 0.065 NA NA
PDGFRB fluorouracil lung cancer 0.0651691 0.8769250 0.065 NA NA
ALK lapatinib leukemia 0.0658074 0.7642264 0.0658 NA NA
DNMT3A ibrutinib colorectal cancer 0.0661478 0.8391700 0.0661 NA NA
RET trametinib lung cancer 0.0662020 0.7221611 0.066 NA NA
PDGFRB crizotinib colorectal cancer 0.0670340 0.7938410 0.0670 NA NA
BRCA2 olaparib lung cancer 0.0670595 0.8663279 0.067 NA NA
DNMT3A trametinib skin cancer 0.0673289 0.7221611 0.067 NA NA
ALK imatinib lung cancer 0.0674395 0.9011066 0.067 NA NA
PDGFRB nilotinib cancer 0.0674437 0.9164407 0.067 NA NA
PTCH1 lapatinib colorectal cancer 0.0675698 0.7642264 0.0676 NA NA
MET ruxolitinib esophageal cancer 0.0675728 0.8822148 0.068 NA NA
PDGFRA dasatinib urinary bladder cancer 0.0675773 0.8497291 0.068 NA NA
ABL1 dasatinib multiple myeloma 0.0675773 0.8497291 0.068 NA NA
KIT belinostat esophageal cancer 0.0675869 1.0000000 0.068 NA NA
BRAF fulvestrant colorectal cancer 0.0677460 1.0000000 0.068 NA NA
KRAS trametinib pancreatic cancer 0.0677987 0.7221611 0.068 NA NA
ROS1 trametinib liver cancer 0.0678363 0.7221611 0.068 NA NA
EGFR regorafenib uterine cancer 0.0678421 0.8854684 0.068 NA NA
ERBB3 afatinib multiple myeloma 0.0678603 0.6912862 0.0679 NA NA
PML cabozantinib leukemia 0.0678976 0.7847230 0.068 NA NA
ALK dasatinib lung cancer 0.0681080 0.8497291 0.068 NA NA
PDGFRA vemurafenib colorectal cancer 0.0684208 0.7314712 0.0684 NA NA
JAK2 nilotinib lung cancer 0.0691445 0.9164407 0.069 NA NA
BRCA2 erlotinib colorectal cancer 0.0695507 0.7676457 0.0696 NA NA
TSC1 sunitinib colorectal cancer 0.0695632 0.8066353 0.070 NA NA
MET pazopanib pancreatic cancer 0.0697242 0.8418010 0.070 NA NA
DPYD neratinib skin cancer 0.0698690 0.8529308 0.0699 NA NA
BRAF nilotinib pancreatic cancer 0.0699348 0.9164407 0.070 NA NA
DPYD imatinib breast cancer 0.0699348 0.9011066 0.070 NA NA
KRAS erlotinib breast cancer 0.0699544 0.7676457 0.0700 NA NA
DPYD belinostat skin cancer 0.0704215 1.0000000 0.070 NA NA
ALK gefitinib lung cancer 0.0709278 0.7599673 0.0709 NA NA
ERBB2 dasatinib urinary bladder cancer 0.0713326 0.8497291 0.071 NA NA
BRCA2 olaparib colorectal cancer 0.0716540 0.8663279 0.072 NA NA
EGFR vandetanib multiple myeloma 0.0717435 0.7394946 0.072 NA NA
KRAS erlotinib urinary bladder cancer 0.0718137 0.7676457 0.0718 NA NA
DNMT3A sunitinib urinary bladder cancer 0.0718137 0.8066353 0.072 NA NA
TSC1 olaparib urinary bladder cancer 0.0718137 0.8663279 0.072 NA NA
DNMT3A fluorouracil lung cancer 0.0720685 0.8769250 0.072 NA NA
BRCA2 cyclophosphamide lung cancer 0.0727183 0.8197782 0.073 NA NA
BRAF crizotinib pancreatic cancer 0.0728945 0.7938410 0.0729 NA NA
DPYD ruxolitinib breast cancer 0.0729164 0.8822148 0.073 NA NA
PTCH1 ruxolitinib colorectal cancer 0.0729215 0.8822148 0.073 NA NA
BRCA2 fluorouracil leukemia 0.0731526 0.8769250 0.073 NA NA
ESR1 crizotinib lung cancer 0.0733782 0.7938410 0.0734 NA NA
NPM1 azd central nervous system cancer 0.0734587 0.7271108 0.073 NA NA
KRAS regorafenib lung cancer 0.0737326 0.8854684 0.074 NA NA
ROS1 cabozantinib cancer 0.0750492 0.7847230 0.075 NA NA
TSC1 vandetanib ovarian cancer 0.0750923 0.7394946 0.075 NA NA
TSC1 crizotinib ovarian cancer 0.0750923 0.7938410 0.0751 NA NA
RET azd ovarian cancer 0.0750923 0.7271108 0.075 NA NA
ERBB2 gefitinib urinary bladder cancer 0.0757365 0.7599673 0.0757 NA NA
KIT afatinib lung cancer 0.0757717 0.6912862 0.0758 NA NA
NPM1 nilotinib central nervous system cancer 0.0758856 0.9164407 0.076 NA NA
TSC2 ruxolitinib colorectal cancer 0.0759307 0.8822148 0.076 NA NA
ALK fluorouracil colorectal cancer 0.0764159 0.8769250 0.076 NA NA
KRAS nilotinib colorectal cancer 0.0765288 0.9164407 0.077 NA NA
EGFR gefitinib esophageal cancer 0.0766522 0.7599673 0.0767 NA NA
EGFR lapatinib esophageal cancer 0.0766522 0.7642264 0.0767 NA NA
DPYD afatinib skin cancer 0.0769419 0.6912862 0.0769 NA NA
MET vandetanib lung cancer 0.0776530 0.7394946 0.078 NA NA
BRAF pazopanib pancreatic cancer 0.0782082 0.8418010 0.078 NA NA
ROS1 cabozantinib central nervous system cancer 0.0785835 0.7847230 0.079 NA NA
BRCA1 vemurafenib uterine cancer 0.0789314 0.7314712 0.0789 NA NA
BRAF trametinib cancer 0.0790716 0.7221611 0.079 NA NA
KRAS cyclophosphamide ovarian cancer 0.0797705 0.8197782 0.080 NA NA
BRCA2 ruxolitinib breast cancer 0.0800000 0.8822148 0.080 NA NA
KRAS vandetanib lung cancer 0.0800176 0.7394946 0.080 NA NA
BRAF olaparib skin cancer 0.0801319 0.8663279 0.080 NA NA
KRAS dabrafenib ovarian cancer 0.0802998 0.9150307 0.080 NA NA
EGFR olaparib lung cancer 0.0805733 0.8663279 0.081 NA NA
UGT1A1 pazopanib uterine cancer 0.0808500 0.8418010 0.081 NA NA
JAK2 nilotinib uterine cancer 0.0809717 0.9164407 0.081 NA NA
PDGFB afatinib colorectal cancer 0.0814486 0.6912862 0.0814 NA NA
BRAF dasatinib pancreatic cancer 0.0816592 0.8497291 0.082 NA NA
RET temozolomide ovarian cancer 0.0817762 0.9030339 0.082 NA NA
ROS1 vandetanib skin cancer 0.0818469 0.7394946 0.082 NA NA
BRCA2 crizotinib leukemia 0.0818833 0.7938410 0.0819 NA NA
ERBB3 gefitinib breast cancer 0.0821572 0.7599673 0.0822 NA NA
KIT gefitinib breast cancer 0.0821572 0.7599673 0.0822 NA NA
ROS1 dasatinib esophageal cancer 0.0823479 0.8497291 0.082 NA NA
RET fluorouracil skin cancer 0.0827595 0.8769250 0.083 NA NA
RET azd colorectal cancer 0.0827595 0.7271108 0.083 NA NA
ROS1 sunitinib liver cancer 0.0831041 0.8066353 0.083 NA NA
TSC1 neratinib ovarian cancer 0.0832096 0.8529308 0.0832 NA NA
PML erlotinib ovarian cancer 0.0832096 0.7676457 0.0832 NA NA
KRAS nilotinib leukemia 0.0840017 0.9164407 0.084 NA NA
MET neratinib pancreatic cancer 0.0842313 0.8529308 0.0842 NA NA
ESR1 dasatinib lung cancer 0.0849730 0.8497291 0.085 NA NA
TSC1 fluorouracil colorectal cancer 0.0852058 0.8769250 0.085 NA NA
PTCH1 crizotinib lung cancer 0.0855764 0.7938410 0.0856 NA NA
EGFR ruxolitinib colorectal cancer 0.0855932 0.8822148 0.086 NA NA
ROS1 azd lung cancer 0.0856060 0.7271108 0.086 NA NA
ABL1 neratinib central nervous system cancer 0.0856980 0.8529308 0.0857 NA NA
PTCH1 imatinib colorectal cancer 0.0861703 0.9011066 0.086 NA NA
ERBB2 afatinib urinary bladder cancer 0.0866014 0.6912862 0.0866 NA NA
AKT1 afatinib uterine cancer 0.0867554 0.6912862 0.0868 NA NA
DPYD crizotinib uterine cancer 0.0867554 0.7938410 0.0868 NA NA
BRAF ruxolitinib cancer 0.0867554 0.8822148 0.087 NA NA
RET pazopanib ovarian cancer 0.0867614 0.8418010 0.087 NA NA
ALK vemurafenib lung cancer 0.0877391 0.7314712 0.0877 NA NA
ABL1 ruxolitinib lung cancer 0.0877608 0.8822148 0.088 NA NA
BRCA1 dasatinib stomach cancer 0.0883078 0.8497291 0.088 NA NA
PDGFRB fluorouracil colorectal cancer 0.0884426 0.8769250 0.088 NA NA
BRAF ruxolitinib skin cancer 0.0885042 0.8822148 0.089 NA NA
PML azd leukemia 0.0889977 0.7271108 0.089 NA NA
PDGFRB ruxolitinib breast cancer 0.0890887 0.8822148 0.089 NA NA
ROS1 vandetanib lung cancer 0.0891452 0.7394946 0.089 NA NA
ABL1 nilotinib lung cancer 0.0895034 0.9164407 0.090 NA NA
PTCH1 ibrutinib lung cancer 0.0897361 0.8391700 0.0897 NA NA
DNMT3A selumetinib skin cancer 0.0897491 0.7681714 0.090 NA NA
DNMT3A cabozantinib skin cancer 0.0897491 0.7847230 0.090 NA NA
PDGFRB neratinib lung cancer 0.0898202 0.8529308 0.0898 NA NA
DNMT3A nilotinib colorectal cancer 0.0898829 0.9164407 0.090 NA NA
DPYD selumetinib skin cancer 0.0899225 0.7681714 0.090 NA NA
ERBB2 nilotinib lung cancer 0.0901602 0.9164407 0.090 NA NA
PML regorafenib leukemia 0.0901836 0.8854684 0.090 NA NA
ALK afatinib lung cancer 0.0902394 0.6912862 0.0902 NA NA
PDGFRA fluorouracil urinary bladder cancer 0.0907210 0.8769250 0.091 NA NA
KRAS imatinib urinary bladder cancer 0.0908008 0.9011066 0.091 NA NA
EGFR regorafenib multiple myeloma 0.0908008 0.8854684 0.091 NA NA
KRAS cabozantinib urinary bladder cancer 0.0908008 0.7847230 0.091 NA NA
PTCH1 ibrutinib breast cancer 0.0912556 0.8391700 0.0913 NA NA
EGFR fluorouracil leukemia 0.0914352 0.8769250 0.091 NA NA
BRAF gefitinib uterine cancer 0.0919110 0.7599673 0.0919 NA NA
AKT1 selumetinib uterine cancer 0.0921936 0.7681714 0.092 NA NA
MYD88 sunitinib leukemia 0.0922896 0.8066353 0.092 NA NA
KRAS azd leukemia 0.0922896 0.7271108 0.092 NA NA
ROS1 azd leukemia 0.0922896 0.7271108 0.092 NA NA
FLT3 nilotinib leukemia 0.0923237 0.9164407 0.092 NA NA
TSC1 fluorouracil lung cancer 0.0923827 0.8769250 0.092 NA NA
PDGFRB imatinib leukemia 0.0924178 0.9011066 0.092 NA NA
PDGFRB neratinib leukemia 0.0924235 0.8529308 0.0924 NA NA
KRAS erlotinib leukemia 0.0924263 0.7676457 0.0924 NA NA
ROS1 erlotinib leukemia 0.0924263 0.7676457 0.0924 NA NA
PDGFB vemurafenib colorectal cancer 0.0926050 0.7314712 0.0926 NA NA
FLT3 vemurafenib leukemia 0.0928402 0.7314712 0.0928 NA NA
MET gefitinib leukemia 0.0930011 0.7599673 0.0930 NA NA
RET gefitinib leukemia 0.0930011 0.7599673 0.0930 NA NA
ERBB3 vemurafenib lung cancer 0.0930419 0.7314712 0.0930 NA NA
KRAS olaparib stomach cancer 0.0933970 0.8663279 0.093 NA NA
BRAF temozolomide ovarian cancer 0.0934021 0.9030339 0.093 NA NA
FLT3 lapatinib leukemia 0.0934766 0.7642264 0.0935 NA NA
DNMT3A vemurafenib colorectal cancer 0.0935262 0.7314712 0.0935 NA NA
EGFR neratinib esophageal cancer 0.0939833 0.8529308 0.0940 NA NA
KIT gefitinib esophageal cancer 0.0939833 0.7599673 0.0940 NA NA
KIT lapatinib esophageal cancer 0.0939833 0.7642264 0.0940 NA NA
EGFR dasatinib esophageal cancer 0.0939833 0.8497291 0.094 NA NA
TSC1 lapatinib colorectal cancer 0.0942468 0.7642264 0.0942 NA NA
ERBB2 regorafenib lung cancer 0.0942951 0.8854684 0.094 NA NA
TSC2 imatinib pancreatic cancer 0.0949051 0.9011066 0.095 NA NA
ERBB2 crizotinib colorectal cancer 0.0952844 0.7938410 0.0953 NA NA
ERBB3 ibrutinib uterine cancer 0.0954832 0.8391700 0.0955 NA NA
EGFR dasatinib ovarian cancer 0.0955170 0.8497291 0.096 NA NA
TSC1 vemurafenib colorectal cancer 0.0962528 0.7314712 0.0963 NA NA
PDGFRA trametinib lung cancer 0.0963051 0.7221611 0.096 NA NA
RET vemurafenib skin cancer 0.0964854 0.7314712 0.0965 NA NA
KRAS temozolomide stomach cancer 0.0965802 0.9030339 0.097 NA NA
FLT3 nilotinib skin cancer 0.0967521 0.9164407 0.097 NA NA
MYD88 afatinib leukemia 0.0968566 0.6912862 0.0969 NA NA
RET erlotinib colorectal cancer 0.0968751 0.7676457 0.0969 NA NA
ESR1 erlotinib colorectal cancer 0.0971718 0.7676457 0.0972 NA NA
ESR1 vandetanib colorectal cancer 0.0971718 0.7394946 0.097 NA NA
MYD88 vandetanib colorectal cancer 0.0971718 0.7394946 0.097 NA NA
EGFR cyclophosphamide leukemia 0.0971718 0.8197782 0.097 NA NA
ERBB2 cyclophosphamide leukemia 0.0971718 0.8197782 0.097 NA NA
ROS1 fluorouracil liver cancer 0.0972544 0.8769250 0.097 NA NA
ESR1 neratinib colorectal cancer 0.0974920 0.8529308 0.0975 NA NA
PML cabozantinib skin cancer 0.0974920 0.7847230 0.097 NA NA
ERBB3 ruxolitinib lymphoma 0.0974920 0.8822148 0.097 NA NA
ABL1 ruxolitinib lymphoma 0.0974920 0.8822148 0.097 NA NA
FLT3 ruxolitinib lymphoma 0.0974920 0.8822148 0.097 NA NA
ALK temozolomide lung cancer 0.0977465 0.9030339 0.098 NA NA
MYD88 sunitinib colorectal cancer 0.0978162 0.8066353 0.098 NA NA
PDGFRA selumetinib colorectal cancer 0.0978273 0.7681714 0.098 NA NA
ROS1 fluorouracil lymphoma 0.0978273 0.8769250 0.098 NA NA
PML crizotinib skin cancer 0.0978273 0.7938410 0.0978 NA NA
KIT azd central nervous system cancer 0.0978273 0.7271108 0.098 NA NA
MGMT azd central nervous system cancer 0.0978273 0.7271108 0.098 NA NA
KRAS erlotinib uterine cancer 0.0979938 0.7676457 0.0980 NA NA
TSC2 temozolomide central nervous system cancer 0.0980483 0.9030339 0.098 NA NA
BRCA1 crizotinib uterine cancer 0.0981077 0.7938410 0.0981 NA NA
BRAF neratinib central nervous system cancer 0.0981668 0.8529308 0.0982 NA NA
TSC2 olaparib central nervous system cancer 0.0981786 0.8663279 0.098 NA NA
ALK temozolomide pancreatic cancer 0.0983402 0.9030339 0.098 NA NA
KIT regorafenib central nervous system cancer 0.0985474 0.8854684 0.099 NA NA
PDGFRB selumetinib cancer 0.0988825 0.7681714 0.099 NA NA
BRAF afatinib central nervous system cancer 0.0989211 0.6912862 0.0989 NA NA
BRAF gefitinib central nervous system cancer 0.0989348 0.7599673 0.0989 NA NA
ERBB2 fluorouracil uterine cancer 0.0989811 0.8769250 0.099 NA NA
TSC2 erlotinib stomach cancer 0.0992761 0.7676457 0.0993 NA NA
BRCA2 selumetinib central nervous system cancer 0.0993275 0.7681714 0.099 NA NA
BRAF cabozantinib pancreatic cancer 0.0995927 0.7847230 0.100 NA NA
ERBB3 erlotinib lymphoma 0.0997714 0.7676457 0.0998 NA NA
ABL1 erlotinib lymphoma 0.0997714 0.7676457 0.0998 NA NA
FLT3 erlotinib lymphoma 0.0997714 0.7676457 0.0998 NA NA
EGFR trametinib esophageal cancer 0.0999747 0.7221611 0.100 NA NA
BRCA2 ruxolitinib leukemia 0.1002709 0.8822148 0.100 NA NA
PML temozolomide breast cancer 0.1003110 0.9030339 0.100 NA NA
PDGFRB vemurafenib breast cancer 0.1004251 0.7314712 0.1004 NA NA
ESR1 gefitinib lung cancer 0.1005758 0.7599673 0.1006 NA NA
PTCH1 azd lung cancer 0.1006545 0.7271108 0.101 NA NA
PTCH1 fluorouracil uterine cancer 0.1006822 0.8769250 0.101 NA NA
ROS1 cabozantinib breast cancer 0.1006836 0.7847230 0.101 NA NA
ERBB3 erlotinib ovarian cancer 0.1007022 0.7676457 0.1007 NA NA
DPYD erlotinib ovarian cancer 0.1007022 0.7676457 0.1007 NA NA
ERBB3 lapatinib ovarian cancer 0.1007022 0.7642264 0.1007 NA NA
DPYD lapatinib ovarian cancer 0.1007022 0.7642264 0.1007 NA NA
ERBB3 fluorouracil ovarian cancer 0.1007022 0.8769250 0.101 NA NA
DPYD fluorouracil ovarian cancer 0.1007022 0.8769250 0.101 NA NA
ROS1 ibrutinib lymphoma 0.1007022 0.8391700 0.1007 NA NA
TSC1 temozolomide urinary bladder cancer 0.1007767 0.9030339 0.101 NA NA
BRCA1 belinostat lung cancer 0.1010301 1.0000000 0.101 NA NA
TSC2 neratinib breast cancer 0.1012080 0.8529308 0.1012 NA NA
MYD88 neratinib breast cancer 0.1012080 0.8529308 0.1012 NA NA
ALK crizotinib breast cancer 0.1012080 0.7938410 0.1012 NA NA
CYP19A1 crizotinib breast cancer 0.1012080 0.7938410 0.1012 NA NA
PDGFRA cabozantinib ovarian cancer 0.1012080 0.7847230 0.101 NA NA
BRCA2 erlotinib lung cancer 0.1014012 0.7676457 0.1014 NA NA
KIT pazopanib pancreatic cancer 0.1017219 0.8418010 0.102 NA NA
MYD88 fluorouracil pancreatic cancer 0.1017219 0.8769250 0.102 NA NA
ERBB3 vemurafenib pancreatic cancer 0.1017219 0.7314712 0.1017 NA NA
JAK2 erlotinib lung cancer 0.1018451 0.7676457 0.1018 NA NA
MET azd pancreatic cancer 0.1021217 0.7271108 0.102 NA NA
BRCA2 temozolomide lung cancer 0.1022487 0.9030339 0.102 NA NA
PDGFRB nilotinib leukemia 0.1023097 0.9164407 0.102 NA NA
PDGFRA neratinib pancreatic cancer 0.1023127 0.8529308 0.1023 NA NA
MYD88 sunitinib pancreatic cancer 0.1023127 0.8066353 0.102 NA NA
ROS1 selumetinib pancreatic cancer 0.1023127 0.7681714 0.102 NA NA
ERBB3 imatinib pancreatic cancer 0.1023127 0.9011066 0.102 NA NA
PDGFRA imatinib pancreatic cancer 0.1023127 0.9011066 0.102 NA NA
FLT3 erlotinib leukemia 0.1024179 0.7676457 0.1024 NA NA
MET crizotinib leukemia 0.1024179 0.7938410 0.1024 NA NA
RET crizotinib leukemia 0.1024179 0.7938410 0.1024 NA NA
MET erlotinib lung cancer 0.1028116 0.7676457 0.1028 NA NA
PDGFRA crizotinib pancreatic cancer 0.1028649 0.7938410 0.1029 NA NA
TSC2 erlotinib pancreatic cancer 0.1028912 0.7676457 0.1029 NA NA
ROS1 regorafenib pancreatic cancer 0.1028912 0.8854684 0.103 NA NA
PDGFRA vandetanib pancreatic cancer 0.1029175 0.7394946 0.103 NA NA
TSC2 vandetanib breast cancer 0.1029175 0.7394946 0.103 NA NA
MYD88 vandetanib breast cancer 0.1029175 0.7394946 0.103 NA NA
FLT3 cabozantinib pancreatic cancer 0.1029175 0.7847230 0.103 NA NA
EGFR temozolomide stomach cancer 0.1029929 0.9030339 0.103 NA NA
MET lapatinib lung cancer 0.1033170 0.7642264 0.1033 NA NA
PDGFRB vemurafenib leukemia 0.1033360 0.7314712 0.1033 NA NA
ROS1 vandetanib head and neck cancer 0.1038560 0.7394946 0.104 NA NA
RET cyclophosphamide colorectal cancer 0.1039322 0.8197782 0.104 NA NA
MYD88 selumetinib leukemia 0.1040192 0.7681714 0.104 NA NA
RET crizotinib colorectal cancer 0.1041180 0.7938410 0.1041 NA NA
ROS1 pazopanib lung cancer 0.1043091 0.8418010 0.104 NA NA
PDGFRA ibrutinib leukemia 0.1043154 0.8391700 0.1043 NA NA
ESR1 ibrutinib leukemia 0.1043154 0.8391700 0.1043 NA NA
PDGFRA lapatinib skin cancer 0.1043295 0.7642264 0.1043 NA NA
FLT3 erlotinib colorectal cancer 0.1043344 0.7676457 0.1043 NA NA

4.4 GDSC

4.4.1 G2P gene and drug

gdsc_signif_g2p <- compare_means(AUC ~ Mutation_Status_Nonsilent, group.by = "Drug_Gene", data = gdsc_data_g2p, method = "wilcox.test", p.adjust.method = "BH")
gdsc_signif_g2p <- adj_signif(gdsc_signif_g2p)
gdsc_signif_g2p <- gdsc_signif_g2p[order(gdsc_signif_g2p$p),]
saveRDS(gdsc_signif_g2p, "./data_munging/rds/gdsc_signif_g2p_gene.rds")

gdsc_signif_g2p_ByDrug <- lapply(unique(gdsc_data_g2p_genesfilt$Drug), WilcoxonByDrug, dataset = gdsc_data_g2p_genesfilt, data_name = "gdsc", grouping_var = "gene")
names(gdsc_signif_g2p_ByDrug) <- unique(gdsc_data_g2p_genesfilt$Drug)
saveRDS(gdsc_signif_g2p_ByDrug, "./data_munging/rds/gdsc_signif_g2p_ByDrug.rds")
gdsc_signif_g2p <- readRDS("./data_munging/rds/gdsc_signif_g2p_gene.rds")

knitr::kable(gdsc_signif_g2p[, c("Drug_Gene", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "GDSC: Wilcoxon test results for level A G2P drug-gene associations (* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
GDSC: Wilcoxon test results for level A G2P drug-gene associations (* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)
Drug_Gene p p.adj p.format p.signif p.signif.adj
dabrafenib_BRAF 0.0001234 0.0034674 0.00012 *** **
trametinib_BRAF 0.0001576 0.0034674 0.00016 *** **
afatinib_ERBB2 0.0171962 0.2522113 0.01720
NA
ponatinib_ABL1 0.0614896 0.6763861 0.06149 NA NA
lapatinib_ERBB2 0.1230985 0.8133548 0.12310 NA NA
erlotinib_MET 0.1281272 0.8133548 0.12813 NA NA
crizotinib_MET 0.1305419 0.8133548 0.13054 NA NA
gefitinib_EGFR 0.1651667 0.8133548 0.16517 NA NA
afatinib_KRAS 0.1838668 0.8133548 0.18387 NA NA
alectinib_ROS1 0.2335276 0.8133548 0.23353 NA NA
dabrafenib_G6PD 0.2443393 0.8133548 0.24434 NA NA
imatinib_PDGFB 0.2502352 0.8133548 0.25024 NA NA
rucaparib_BRCA2 0.3140675 0.8133548 0.31407 NA NA
imatinib_PDGFRA 0.3143676 0.8133548 0.31437 NA NA
crizotinib_ALK 0.3700920 0.8133548 0.37009 NA NA
gefitinib_MET 0.3977576 0.8133548 0.39776 NA NA
pazopanib_UGT1A1 0.3984406 0.8133548 0.39844 NA NA
belinostat_UGT1A1 0.4041103 0.8133548 0.40411 NA NA
tretinoin_PML 0.4081601 0.8133548 0.40816 NA NA
dasatinib_ABL1 0.4250747 0.8133548 0.42507 NA NA
afatinib_EGFR 0.4594260 0.8133548 0.45943 NA NA
imatinib_ABL1 0.4679914 0.8133548 0.46799 NA NA
imatinib_PDGFRB 0.4699331 0.8133548 0.46993 NA NA
erlotinib_KRAS 0.4886809 0.8133548 0.48868 NA NA
nilotinib_UGT1A1 0.4918297 0.8133548 0.49183 NA NA
sunitinib_PDGFRA 0.4989956 0.8133548 0.49900 NA NA
cabozantinib_RET 0.4991041 0.8133548 0.49910 NA NA
afatinib_ERBB3 0.5614904 0.8250718 0.56149 NA NA
rucaparib_BRCA1 0.5768966 0.8250718 0.57690 NA NA
gefitinib_KRAS 0.6235545 0.8250718 0.62355 NA NA
lapatinib_KRAS 0.6456344 0.8250718 0.64563 NA NA
midostaurin_FLT3 0.6526579 0.8250718 0.65266 NA NA
sunitinib_KIT 0.6583214 0.8250718 0.65832 NA NA
temozolomide_MGMT 0.6634570 0.8250718 0.66346 NA NA
alectinib_ALK 0.6916060 0.8250718 0.69161 NA NA
docetaxel_ERBB2 0.7052502 0.8250718 0.70525 NA NA
palbociclib_ERBB2 0.7083268 0.8250718 0.70833 NA NA
vismodegib_PTCH1 0.7198241 0.8250718 0.71982 NA NA
nilotinib_ABL1 0.7313136 0.8250718 0.73131 NA NA
imatinib_KIT 0.7505218 0.8255740 0.75052 NA NA
bosutinib monohydrate_ABL1 0.7708229 0.8272245 0.77082 NA NA
ruxolitinib_JAK2 0.8523436 0.8929314 0.85234 NA NA
crizotinib_ROS1 0.9055984 0.9218958 0.90560 NA NA
erlotinib_EGFR 0.9218958 0.9218958 0.92190 NA NA 
gdsc_signif_g2p_ByDrug <- readRDS("./data_munging/rds/gdsc_signif_g2p_ByDrug.rds")
gdsc_signif_g2p_ByDrug_all <- rbindlist(gdsc_signif_g2p_ByDrug, use.names = TRUE)
gdsc_signif_g2p_ByDrug_all <- gdsc_signif_g2p_ByDrug_all[order(gdsc_signif_g2p_ByDrug_all$p),]

knitr::kable(gdsc_signif_g2p_ByDrug_all[, c("Hugo_Symbol", "Drug", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "GDSC: by-drug Wilcoxon test results for point mutations in level A G2P genes (* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
GDSC: by-drug Wilcoxon test results for point mutations in level A G2P genes (* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)
Hugo_Symbol Drug p p.adj p.format p.signif p.signif.adj
KRAS trametinib 0.0000000 0.0000003 8.5e-09 **** ****
BRAF dabrafenib 0.0001234 0.0041947 0.00012 *** **
BRAF trametinib 0.0001576 0.0026794 0.00016 *** **
PDGFRB cabozantinib 0.0005036 0.0171218 0.0005 ***
KRAS palbociclib 0.0017081 0.0580770 0.0017 ** NA
PDGFRB tretinoin 0.0032063 0.1090147 0.0032 ** NA
ROS1 cabozantinib 0.0037056 0.0629948 0.0037 ** NA
KRAS pazopanib 0.0043870 0.1308570 0.0044 ** NA
BRCA2 midostaurin 0.0058907 0.2002841 0.0059 ** NA
TSC1 temozolomide 0.0073262 0.2490920 0.0073 ** NA
ABL1 pazopanib 0.0076975 0.1308570 0.0077 ** NA
ALK palbociclib 0.0089754 0.1525816 0.0090 ** NA
ROS1 trametinib 0.0160528 0.1819317 0.01605
NA
DNMT3A temozolomide 0.0163008 0.2771142 0.0163
NA
BRCA1 tretinoin 0.0170421 0.2897149 0.0170
NA
ERBB2 afatinib 0.0171962 0.5609625 0.017
NA
BRAF bosutinib monohydrate 0.0181741 0.3173957 0.018
NA
KIT bosutinib monohydrate 0.0186703 0.3173957 0.019
NA
ABL1 gefitinib 0.0196537 0.6682274 0.020
NA
BRCA2 erlotinib 0.0208851 0.6683217 0.021
NA
DPYD lapatinib 0.0212882 0.6812223 0.021
NA
TPMT cabozantinib 0.0218657 0.2413818 0.0219
NA
MGMT docetaxel 0.0241785 0.6845085 0.024
NA
UGT1A1 trametinib 0.0274916 0.2336787 0.02749
NA
KRAS dabrafenib 0.0278924 0.3904427 0.02789
NA
FLT3 cabozantinib 0.0283979 0.2413818 0.0284
NA
TSC1 sunitinib 0.0300384 0.5453213 0.030
NA
ERBB3 ponatinib 0.0344904 0.9972326 0.034
NA
NPM1 tretinoin 0.0355459 0.3525943 0.0355
NA
JAK2 dabrafenib 0.0362699 0.3904427 0.03627
NA
FLT3 crizotinib 0.0371049 0.3575404 0.037
NA
UGT1A1 afatinib 0.0384529 0.5609625 0.038
NA
UGT1A1 midostaurin 0.0385592 0.6011299 0.0386
NA
ERBB3 temozolomide 0.0387034 0.4275924 0.0387
NA
ESR1 imatinib 0.0394429 0.7846892 0.039
NA
TSC1 crizotinib 0.0396633 0.3575404 0.040
NA
BRCA2 crizotinib 0.0408902 0.3575404 0.041
NA
TSC1 tretinoin 0.0414817 0.3525943 0.0415
NA
ABL1 cabozantinib 0.0433477 0.2947646 0.0433
NA
DNMT3A sunitinib 0.0480660 0.5453213 0.048
NA
TPMT temozolomide 0.0503050 0.4275924 0.0503 NA NA
TSC1 rucaparib 0.0503265 0.8376438 0.050 NA NA
NPM1 dabrafenib 0.0506987 0.3904427 0.05070 NA NA
ABL1 afatinib 0.0507264 0.5609625 0.051 NA NA
KIT nilotinib 0.0509383 0.7074000 0.051 NA NA
RET sunitinib 0.0511239 0.5453213 0.051 NA NA
ERBB3 dabrafenib 0.0574180 0.3904427 0.05742 NA NA
TSC1 bosutinib monohydrate 0.0576889 0.6538081 0.058 NA NA
DNMT3A crizotinib 0.0577322 0.3575404 0.058 NA NA
PML crizotinib 0.0605225 0.3575404 0.061 NA NA
RET alectinib 0.0609957 0.6998836 0.061 NA NA
ABL1 ponatinib 0.0614896 0.9972326 0.061 NA NA
PDGFRA alectinib 0.0638924 0.6998836 0.064 NA NA
PTCH1 cabozantinib 0.0650780 0.3687756 0.0651 NA NA
PDGFB ruxolitinib 0.0653257 0.7847293 0.065 NA NA
TPMT belinostat 0.0656977 0.6734824 0.066 NA NA
ABL1 ruxolitinib 0.0661262 0.7847293 0.066 NA NA
PDGFRB belinostat 0.0666829 0.6734824 0.067 NA NA
CYP19A1 ruxolitinib 0.0692408 0.7847293 0.069 NA NA
DNMT3A docetaxel 0.0692678 0.6845085 0.069 NA NA
BRCA2 lapatinib 0.0716745 0.7620951 0.072 NA NA
KIT trametinib 0.0733706 0.4303556 0.07337 NA NA
TPMT dabrafenib 0.0737570 0.4179561 0.07376 NA NA
BRAF belinostat 0.0744959 0.6734824 0.074 NA NA
PDGFRB dasatinib 0.0763115 0.9447103 0.076 NA NA
DPYD crizotinib 0.0771266 0.3575404 0.077 NA NA
TSC1 nilotinib 0.0779898 0.7074000 0.078 NA NA
ERBB2 crizotinib 0.0782120 0.3575404 0.078 NA NA
ALK gefitinib 0.0794375 0.7564295 0.079 NA NA
FLT3 erlotinib 0.0848216 0.6714960 0.085 NA NA
AKT1 nilotinib 0.0856959 0.7074000 0.086 NA NA
PDGFRB midostaurin 0.0887296 0.6011299 0.0887 NA NA
JAK2 trametinib 0.0900127 0.4303556 0.09001 NA NA
UGT1A1 tretinoin 0.0911112 0.3862972 0.0911 NA NA
BRCA2 tretinoin 0.0916313 0.3862972 0.0916 NA NA
ABL1 docetaxel 0.0918631 0.6845085 0.092 NA NA
BRCA2 dasatinib 0.0931223 0.9447103 0.093 NA NA
IDH2 cabozantinib 0.0934140 0.4267811 0.0934 NA NA
TPMT alectinib 0.0935866 0.6998836 0.094 NA NA
ROS1 erlotinib 0.0943399 0.6714960 0.094 NA NA
MYD88 ruxolitinib 0.0954788 0.8115699 0.095 NA NA
NPM1 dasatinib 0.0957018 0.9447103 0.096 NA NA
TPMT tretinoin 0.0957413 0.3862972 0.0957 NA NA
MET lapatinib 0.0972319 0.7620951 0.097 NA NA
DNMT3A rucaparib 0.0975186 0.8376438 0.098 NA NA
RET palbociclib 0.0983382 0.7307299 0.0983 NA NA
ERBB2 gefitinib 0.0989296 0.7564295 0.099 NA NA
FLT3 imatinib 0.0990080 0.7846892 0.099 NA NA
JAK2 cabozantinib 0.1004191 0.4267811 0.1004 NA NA
BRCA2 palbociclib 0.1027690 0.7307299 0.1028 NA NA
MYD88 trametinib 0.1042757 0.4303556 0.10428 NA NA
PML midostaurin 0.1046555 0.6011299 0.1047 NA NA
TSC2 tretinoin 0.1061419 0.3862972 0.1061 NA NA
ABL1 trametinib 0.1069974 0.4303556 0.10700 NA NA
PDGFRA gefitinib 0.1077698 0.7564295 0.108 NA NA
CYP19A1 imatinib 0.1086620 0.7846892 0.109 NA NA
ERBB3 midostaurin 0.1104412 0.6011299 0.1104 NA NA
TSC2 dabrafenib 0.1118016 0.4630570 0.11180 NA NA
BRAF palbociclib 0.1131136 0.7307299 0.1131 NA NA
ROS1 tretinoin 0.1136424 0.3862972 0.1136 NA NA
ROS1 ponatinib 0.1143242 0.9972326 0.114 NA NA
ESR1 temozolomide 0.1154649 0.6370529 0.1155 NA NA
G6PD bosutinib monohydrate 0.1162560 0.8517410 0.116 NA NA
BRCA2 imatinib 0.1174800 0.7846892 0.117 NA NA
PDGFRA tretinoin 0.1216752 0.3862972 0.1217 NA NA
MGMT afatinib 0.1228036 0.5609625 0.123 NA NA
ERBB2 lapatinib 0.1230985 0.7620951 0.123 NA NA
TPMT ruxolitinib 0.1231531 0.8374409 0.123 NA NA
ERBB2 midostaurin 0.1231748 0.6011299 0.1232 NA NA
IDH2 belinostat 0.1232427 0.6734824 0.123 NA NA
KIT tretinoin 0.1249785 0.3862972 0.1250 NA NA
UGT1A1 bosutinib monohydrate 0.1252560 0.8517410 0.125 NA NA
ALK dabrafenib 0.1254923 0.4630570 0.12549 NA NA
MYD88 docetaxel 0.1258052 0.6845085 0.126 NA NA
MGMT gefitinib 0.1263998 0.7564295 0.126 NA NA
PTCH1 midostaurin 0.1266216 0.6011299 0.1266 NA NA
MET erlotinib 0.1281272 0.6714960 0.128 NA NA
MGMT erlotinib 0.1288089 0.6714960 0.129 NA NA
MET crizotinib 0.1305419 0.5221677 0.131 NA NA
ERBB2 temozolomide 0.1311049 0.6370529 0.1311 NA NA
IDH2 temozolomide 0.1311580 0.6370529 0.1312 NA NA
TSC2 nilotinib 0.1328358 0.7074000 0.133 NA NA
PDGFRA afatinib 0.1332170 0.5609625 0.133 NA NA
PTCH1 gefitinib 0.1346354 0.7564295 0.135 NA NA
PDGFRA nilotinib 0.1346957 0.7074000 0.135 NA NA
MET belinostat 0.1348014 0.6734824 0.135 NA NA
EGFR dabrafenib 0.1350723 0.4630570 0.13507 NA NA
PDGFRA trametinib 0.1350935 0.4303556 0.13509 NA NA
MET dabrafenib 0.1361932 0.4630570 0.13619 NA NA
JAK2 vismodegib 0.1385135 0.8104430 0.14 NA NA
ALK trametinib 0.1385711 0.4303556 0.13857 NA NA
TSC2 trametinib 0.1392327 0.4303556 0.13923 NA NA
PDGFRA cabozantinib 0.1407290 0.4442478 0.1407 NA NA
UGT1A1 lapatinib 0.1409522 0.7620951 0.141 NA NA
BRAF rucaparib 0.1413053 0.8376438 0.141 NA NA
AKT1 midostaurin 0.1419954 0.6011299 0.1420 NA NA
ALK lapatinib 0.1428928 0.7620951 0.143 NA NA
KIT cabozantinib 0.1434514 0.4442478 0.1435 NA NA
KRAS cabozantinib 0.1437272 0.4442478 0.1437 NA NA
PDGFB erlotinib 0.1449924 0.6714960 0.145 NA NA
ERBB3 imatinib 0.1453832 0.7846892 0.145 NA NA
UGT1A1 erlotinib 0.1468898 0.6714960 0.147 NA NA
RET docetaxel 0.1477981 0.6845085 0.148 NA NA
G6PD alectinib 0.1491983 0.6998836 0.149 NA NA
NPM1 belinostat 0.1498150 0.6734824 0.150 NA NA
IDH2 rucaparib 0.1502920 0.8376438 0.150 NA NA
MET imatinib 0.1511805 0.7846892 0.151 NA NA
AKT1 bosutinib monohydrate 0.1516806 0.8595235 0.152 NA NA
BRAF alectinib 0.1526449 0.6998836 0.153 NA NA
FLT3 nilotinib 0.1535908 0.7074000 0.154 NA NA
TSC2 afatinib 0.1594651 0.5609625 0.159 NA NA
BRAF vismodegib 0.1624273 0.8104430 0.16 NA NA
IDH2 afatinib 0.1625545 0.5609625 0.163 NA NA
TSC2 temozolomide 0.1628876 0.6854745 0.1629 NA NA
EGFR gefitinib 0.1651667 0.7564295 0.165 NA NA
BRCA1 midostaurin 0.1683042 0.6011299 0.1683 NA NA
ROS1 docetaxel 0.1704250 0.6845085 0.170 NA NA
TSC1 trametinib 0.1714196 0.4856889 0.17142 NA NA
PDGFB tretinoin 0.1722109 0.4533977 0.1722 NA NA
PTCH1 tretinoin 0.1733580 0.4533977 0.1734 NA NA
TSC2 crizotinib 0.1757036 0.6247240 0.176 NA NA
ESR1 nilotinib 0.1779167 0.7074000 0.178 NA NA
NPM1 cabozantinib 0.1781069 0.5046363 0.1781 NA NA
JAK2 docetaxel 0.1783666 0.6845085 0.178 NA NA
ERBB2 belinostat 0.1805478 0.6734824 0.181 NA NA
G6PD docetaxel 0.1822668 0.6845085 0.182 NA NA
MYD88 afatinib 0.1823685 0.5609625 0.182 NA NA
KRAS afatinib 0.1838668 0.5609625 0.184 NA NA
MET afatinib 0.1841947 0.5609625 0.184 NA NA
ABL1 belinostat 0.1850848 0.6734824 0.185 NA NA
DNMT3A nilotinib 0.1870610 0.7074000 0.187 NA NA
PTCH1 bosutinib monohydrate 0.1879013 0.8678254 0.188 NA NA
BRCA2 alectinib 0.1881297 0.6998836 0.188 NA NA
ALK sunitinib 0.1882759 0.8777619 0.188 NA NA
ALK afatinib 0.1885392 0.5609625 0.189 NA NA
TSC2 sunitinib 0.1886391 0.8777619 0.189 NA NA
PDGFRB dabrafenib 0.1895855 0.5719432 0.18959 NA NA
TSC1 midostaurin 0.1925940 0.6011299 0.1926 NA NA
NPM1 imatinib 0.1935911 0.7846892 0.194 NA NA
NPM1 midostaurin 0.1944832 0.6011299 0.1945 NA NA
MGMT cabozantinib 0.1946541 0.5090952 0.1947 NA NA
PML alectinib 0.1950849 0.6998836 0.195 NA NA
FLT3 rucaparib 0.1971116 0.8376438 0.197 NA NA
BRAF ruxolitinib 0.1976786 0.9414093 0.198 NA NA
TSC2 docetaxel 0.1988212 0.6845085 0.199 NA NA
JAK2 gefitinib 0.1997501 0.7564295 0.200 NA NA
ESR1 gefitinib 0.2002313 0.7564295 0.200 NA NA
UGT1A1 palbociclib 0.2007621 0.7307299 0.2008 NA NA
PML palbociclib 0.2018104 0.7307299 0.2018 NA NA
KIT dabrafenib 0.2027554 0.5719432 0.20276 NA NA
PDGFRB erlotinib 0.2028937 0.7675082 0.203 NA NA
IDH2 vismodegib 0.2041835 0.8104430 0.20 NA NA
TSC2 ponatinib 0.2051961 0.9972326 0.205 NA NA
FLT3 dasatinib 0.2059686 0.9447103 0.206 NA NA
JAK2 temozolomide 0.2108300 0.6854745 0.2108 NA NA
G6PD afatinib 0.2109900 0.5609625 0.211 NA NA
EGFR crizotinib 0.2113667 0.6763734 0.211 NA NA
ABL1 palbociclib 0.2122468 0.7307299 0.2122 NA NA
ESR1 palbociclib 0.2146985 0.7307299 0.2147 NA NA
NPM1 erlotinib 0.2158617 0.7675082 0.216 NA NA
PTCH1 temozolomide 0.2167760 0.6854745 0.2168 NA NA
ESR1 belinostat 0.2186179 0.6734824 0.219 NA NA
MYD88 belinostat 0.2195610 0.6734824 0.220 NA NA
BRCA1 vismodegib 0.2203270 0.8104430 0.22 NA NA
PML temozolomide 0.2217712 0.6854745 0.2218 NA NA
PDGFB vismodegib 0.2233811 0.8104430 0.22 NA NA
ROS1 belinostat 0.2235080 0.6734824 0.224 NA NA
KRAS tretinoin 0.2237016 0.5432753 0.2237 NA NA
NPM1 alectinib 0.2246258 0.6998836 0.225 NA NA
DNMT3A dasatinib 0.2260896 0.9447103 0.226 NA NA
ALK ruxolitinib 0.2294413 0.9414093 0.229 NA NA
PDGFB afatinib 0.2297013 0.5609625 0.230 NA NA
DPYD ponatinib 0.2315390 0.9972326 0.232 NA NA
G6PD ruxolitinib 0.2325984 0.9414093 0.233 NA NA
KIT vismodegib 0.2326739 0.8104430 0.23 NA NA
ROS1 alectinib 0.2335276 0.6998836 0.234 NA NA
ABL1 lapatinib 0.2342922 0.8759947 0.234 NA NA
PTCH1 belinostat 0.2376997 0.6734824 0.238 NA NA
JAK2 alectinib 0.2385373 0.6998836 0.239 NA NA
MGMT palbociclib 0.2389195 0.7307299 0.2389 NA NA
TSC2 alectinib 0.2393143 0.6998836 0.239 NA NA
CYP19A1 trametinib 0.2426959 0.5652949 0.24270 NA NA
G6PD dabrafenib 0.2443393 0.5719432 0.24434 NA NA
DPYD trametinib 0.2458254 0.5652949 0.24583 NA NA
G6PD vismodegib 0.2460143 0.8104430 0.25 NA NA
ABL1 alectinib 0.2470177 0.6998836 0.247 NA NA
TSC1 vismodegib 0.2476631 0.8104430 0.25 NA NA
IDH2 bosutinib monohydrate 0.2477175 0.8678254 0.248 NA NA
ERBB3 tretinoin 0.2487626 0.5613501 0.2488 NA NA
NPM1 docetaxel 0.2488101 0.6845085 0.249 NA NA
RET trametinib 0.2493948 0.5652949 0.24939 NA NA
KRAS ponatinib 0.2496849 0.9972326 0.250 NA NA
PDGFB imatinib 0.2502352 0.7846892 0.250 NA NA
MGMT lapatinib 0.2514271 0.8759947 0.251 NA NA
ERBB2 dabrafenib 0.2521562 0.5719432 0.25216 NA NA
PML dabrafenib 0.2532744 0.5719432 0.25327 NA NA
EGFR dasatinib 0.2539632 0.9447103 0.254 NA NA
BRCA1 bosutinib monohydrate 0.2550079 0.8678254 0.255 NA NA
BRCA2 afatinib 0.2553180 0.5609625 0.255 NA NA
PML sunitinib 0.2560406 0.8777619 0.256 NA NA
TSC2 palbociclib 0.2593090 0.7307299 0.2593 NA NA
IDH2 ponatinib 0.2610616 0.9972326 0.261 NA NA
PTCH1 ponatinib 0.2619913 0.9972326 0.262 NA NA
UGT1A1 crizotinib 0.2625570 0.7638022 0.263 NA NA
TPMT docetaxel 0.2626723 0.6845085 0.263 NA NA
PTCH1 afatinib 0.2628105 0.5609625 0.263 NA NA
PDGFB lapatinib 0.2633229 0.8759947 0.263 NA NA
DNMT3A afatinib 0.2639824 0.5609625 0.264 NA NA
TPMT vismodegib 0.2650075 0.8104430 0.27 NA NA
BRAF docetaxel 0.2666895 0.6845085 0.267 NA NA
MGMT midostaurin 0.2670503 0.7109289 0.2671 NA NA
DNMT3A cabozantinib 0.2687536 0.6476573 0.2688 NA NA
DPYD dabrafenib 0.2691497 0.5719432 0.26915 NA NA
JAK2 tretinoin 0.2702044 0.5613501 0.2702 NA NA
EGFR alectinib 0.2707820 0.7081991 0.271 NA NA
ALK belinostat 0.2712457 0.7094119 0.271 NA NA
AKT1 vismodegib 0.2724738 0.8104430 0.27 NA NA
KRAS docetaxel 0.2725554 0.6845085 0.273 NA NA
NPM1 lapatinib 0.2737483 0.8759947 0.274 NA NA
TPMT nilotinib 0.2737875 0.7074000 0.274 NA NA
PDGFRB nilotinib 0.2738696 0.7074000 0.274 NA NA
ERBB2 trametinib 0.2740267 0.5823067 0.27403 NA NA
NPM1 temozolomide 0.2747200 0.7783735 0.2747 NA NA
PDGFB nilotinib 0.2752114 0.7074000 0.275 NA NA
JAK2 rucaparib 0.2799799 0.8376438 0.280 NA NA
KIT ruxolitinib 0.2812051 0.9414093 0.281 NA NA
PDGFRB docetaxel 0.2818564 0.6845085 0.282 NA NA
PDGFRA midostaurin 0.2883532 0.7109289 0.2884 NA NA
ERBB3 cabozantinib 0.2887403 0.6476573 0.2887 NA NA
MET palbociclib 0.2900431 0.7307299 0.2900 NA NA
MET vismodegib 0.2900560 0.8104430 0.29 NA NA
BRCA2 bosutinib monohydrate 0.2907814 0.8678254 0.291 NA NA
KRAS midostaurin 0.2927354 0.7109289 0.2927 NA NA
PTCH1 pazopanib 0.2950783 0.9239682 0.2951 NA NA
AKT1 alectinib 0.2956410 0.7179852 0.296 NA NA
UGT1A1 imatinib 0.2957214 0.7846892 0.296 NA NA
ROS1 bosutinib monohydrate 0.2963370 0.8678254 0.296 NA NA
FLT3 trametinib 0.2977892 0.5955784 0.29779 NA NA
ERBB2 tretinoin 0.3012993 0.5613501 0.3013 NA NA
AKT1 ruxolitinib 0.3044779 0.9414093 0.304 NA NA
TSC1 ruxolitinib 0.3045736 0.9414093 0.305 NA NA
DPYD cabozantinib 0.3047799 0.6476573 0.3048 NA NA
IDH2 pazopanib 0.3050404 0.9239682 0.3050 NA NA
PTCH1 nilotinib 0.3093982 0.7074000 0.309 NA NA
BRAF tretinoin 0.3097622 0.5613501 0.3098 NA NA
DPYD afatinib 0.3107947 0.6215893 0.311 NA NA
TSC1 imatinib 0.3108496 0.7846892 0.311 NA NA
MGMT rucaparib 0.3112521 0.8376438 0.311 NA NA
TPMT gefitinib 0.3116629 0.8402334 0.312 NA NA
ERBB2 dasatinib 0.3121664 0.9447103 0.312 NA NA
MET tretinoin 0.3136957 0.5613501 0.3137 NA NA
BRCA2 rucaparib 0.3140675 0.8376438 0.314 NA NA
PDGFRA imatinib 0.3143676 0.7846892 0.314 NA NA
ESR1 rucaparib 0.3155348 0.8376438 0.316 NA NA
KRAS belinostat 0.3158051 0.7166062 0.316 NA NA
ERBB2 imatinib 0.3160344 0.7846892 0.316 NA NA
CYP19A1 belinostat 0.3161498 0.7166062 0.316 NA NA
KIT rucaparib 0.3176892 0.8376438 0.318 NA NA
PTCH1 palbociclib 0.3180803 0.7307299 0.3181 NA NA
NPM1 nilotinib 0.3197255 0.7074000 0.320 NA NA
ROS1 rucaparib 0.3210092 0.8376438 0.321 NA NA
DPYD vismodegib 0.3255816 0.8104430 0.33 NA NA
IDH2 gefitinib 0.3258316 0.8402334 0.326 NA NA
FLT3 gefitinib 0.3274937 0.8402334 0.327 NA NA
MGMT dabrafenib 0.3282216 0.6564431 0.32822 NA NA
IDH2 docetaxel 0.3288933 0.7454914 0.329 NA NA
TSC2 lapatinib 0.3311360 0.8842093 0.331 NA NA
EGFR midostaurin 0.3312793 0.7508998 0.3313 NA NA
ERBB2 nilotinib 0.3322155 0.7074000 0.332 NA NA
PDGFB palbociclib 0.3327587 0.7307299 0.3328 NA NA
ROS1 nilotinib 0.3339538 0.7074000 0.334 NA NA
ERBB3 gefitinib 0.3353927 0.8402334 0.335 NA NA
BRAF imatinib 0.3365852 0.7846892 0.337 NA NA
MET pazopanib 0.3375577 0.9239682 0.3376 NA NA
ERBB3 bosutinib monohydrate 0.3381914 0.8678254 0.338 NA NA
RET vismodegib 0.3393340 0.8104430 0.34 NA NA
ERBB2 pazopanib 0.3398016 0.9239682 0.3398 NA NA
PDGFRB rucaparib 0.3399009 0.8376438 0.340 NA NA
MYD88 rucaparib 0.3422485 0.8376438 0.342 NA NA
PDGFRB vismodegib 0.3432087 0.8104430 0.34 NA NA
DPYD rucaparib 0.3449122 0.8376438 0.345 NA NA
DPYD dasatinib 0.3450704 0.9447103 0.345 NA NA
BRCA1 alectinib 0.3475727 0.7403839 0.348 NA NA
MET bosutinib monohydrate 0.3480988 0.8678254 0.348 NA NA
IDH2 tretinoin 0.3482943 0.5921004 0.3483 NA NA
BRCA2 belinostat 0.3501637 0.7440979 0.350 NA NA
G6PD ponatinib 0.3562978 0.9972326 0.356 NA NA
CYP19A1 alectinib 0.3564980 0.7403839 0.356 NA NA
DNMT3A vismodegib 0.3575484 0.8104430 0.36 NA NA
PTCH1 docetaxel 0.3578141 0.7603550 0.358 NA NA
BRAF nilotinib 0.3579029 0.7074000 0.358 NA NA
KIT afatinib 0.3580267 0.6762727 0.358 NA NA
MET sunitinib 0.3589333 0.8777619 0.359 NA NA
BRAF pazopanib 0.3592410 0.9239682 0.3592 NA NA
PDGFB gefitinib 0.3627861 0.8402334 0.363 NA NA
BRCA2 pazopanib 0.3630866 0.9239682 0.3631 NA NA
PDGFRB lapatinib 0.3673411 0.8842093 0.367 NA NA
TSC1 lapatinib 0.3673411 0.8842093 0.367 NA NA
TSC1 pazopanib 0.3683895 0.9239682 0.3684 NA NA
ALK crizotinib 0.3700920 0.8464147 0.370 NA NA
TSC1 palbociclib 0.3704875 0.7307299 0.3705 NA NA
NPM1 crizotinib 0.3719543 0.8464147 0.372 NA NA
G6PD palbociclib 0.3728013 0.7307299 0.3728 NA NA
ERBB2 ruxolitinib 0.3785733 0.9526741 0.379 NA NA
PDGFB dasatinib 0.3792939 0.9447103 0.379 NA NA
KRAS dasatinib 0.3806744 0.9447103 0.381 NA NA
NPM1 bosutinib monohydrate 0.3813570 0.8678254 0.381 NA NA
G6PD nilotinib 0.3817505 0.7074000 0.382 NA NA
DPYD temozolomide 0.3822258 0.8360585 0.3822 NA NA
ERBB2 bosutinib monohydrate 0.3828642 0.8678254 0.383 NA NA
PTCH1 alectinib 0.3832319 0.7403839 0.383 NA NA
BRCA2 gefitinib 0.3852457 0.8402334 0.385 NA NA
RET imatinib 0.3884249 0.7846892 0.388 NA NA
ERBB3 belinostat 0.3891061 0.7587223 0.389 NA NA
BRCA1 dasatinib 0.3928660 0.9447103 0.393 NA NA
ESR1 vismodegib 0.3942862 0.8378583 0.39 NA NA
AKT1 tretinoin 0.3944562 0.6307930 0.3945 NA NA
ALK dasatinib 0.3952274 0.9447103 0.395 NA NA
TSC1 alectinib 0.3956481 0.7403839 0.396 NA NA
AKT1 palbociclib 0.3961746 0.7307299 0.3962 NA NA
CYP19A1 nilotinib 0.3966596 0.7074000 0.397 NA NA
MET gefitinib 0.3977576 0.8402334 0.398 NA NA
UGT1A1 pazopanib 0.3984406 0.9239682 0.3984 NA NA
UGT1A1 sunitinib 0.3992388 0.8777619 0.399 NA NA
NPM1 palbociclib 0.3996308 0.7307299 0.3996 NA NA
ALK temozolomide 0.4005886 0.8360585 0.4006 NA NA
KIT erlotinib 0.4010455 0.8537089 0.401 NA NA
IDH2 crizotinib 0.4011464 0.8464147 0.401 NA NA
PDGFRA rucaparib 0.4016231 0.8467310 0.402 NA NA
UGT1A1 belinostat 0.4041103 0.7587223 0.404 NA NA
BRCA1 erlotinib 0.4046403 0.8537089 0.405 NA NA
PDGFB docetaxel 0.4060325 0.8036630 0.406 NA NA
PML tretinoin 0.4081601 0.6307930 0.4082 NA NA
DNMT3A ruxolitinib 0.4082055 0.9526741 0.408 NA NA
PDGFRA palbociclib 0.4083491 0.7307299 0.4083 NA NA
IDH2 trametinib 0.4108540 0.7083580 0.41085 NA NA
RET lapatinib 0.4130391 0.8842093 0.413 NA NA
BRCA1 trametinib 0.4159320 0.7083580 0.41593 NA NA
DNMT3A trametinib 0.4166812 0.7083580 0.41668 NA NA
PDGFRA bosutinib monohydrate 0.4175132 0.8678810 0.418 NA NA
MYD88 alectinib 0.4215902 0.7403839 0.422 NA NA
BRCA1 nilotinib 0.4230452 0.7074000 0.423 NA NA
JAK2 belinostat 0.4239919 0.7587223 0.424 NA NA
ABL1 dasatinib 0.4250747 0.9447103 0.425 NA NA
ESR1 docetaxel 0.4254686 0.8036630 0.425 NA NA
ERBB2 erlotinib 0.4285389 0.8537089 0.429 NA NA
KIT gefitinib 0.4300536 0.8402334 0.430 NA NA
BRCA1 ponatinib 0.4319743 0.9972326 0.432 NA NA
UGT1A1 dasatinib 0.4335809 0.9447103 0.434 NA NA
PDGFB temozolomide 0.4372281 0.8360585 0.4372 NA NA
DNMT3A imatinib 0.4384088 0.7846892 0.438 NA NA
FLT3 temozolomide 0.4398840 0.8360585 0.4399 NA NA
IDH2 lapatinib 0.4399819 0.8842093 0.440 NA NA
CYP19A1 midostaurin 0.4400719 0.7825538 0.4401 NA NA
ABL1 rucaparib 0.4411690 0.8467310 0.441 NA NA
ABL1 dabrafenib 0.4415642 0.7445082 0.44156 NA NA
KIT lapatinib 0.4421047 0.8842093 0.442 NA NA
FLT3 pazopanib 0.4421181 0.9239682 0.4421 NA NA
TSC2 pazopanib 0.4425985 0.9239682 0.4426 NA NA
MYD88 nilotinib 0.4453090 0.7074000 0.445 NA NA
ERBB2 alectinib 0.4455420 0.7403839 0.446 NA NA
ESR1 crizotinib 0.4487601 0.8464147 0.449 NA NA
AKT1 dabrafenib 0.4490980 0.7445082 0.44910 NA NA
PDGFRA dabrafenib 0.4498286 0.7445082 0.44983 NA NA
RET afatinib 0.4515995 0.7810241 0.452 NA NA
G6PD tretinoin 0.4531080 0.6698118 0.4531 NA NA
CYP19A1 dasatinib 0.4547296 0.9447103 0.455 NA NA
PML bosutinib monohydrate 0.4556704 0.8678810 0.456 NA NA
KRAS vismodegib 0.4564329 0.8556940 0.46 NA NA
PDGFB alectinib 0.4572960 0.7403839 0.457 NA NA
CYP19A1 erlotinib 0.4583847 0.8537089 0.458 NA NA
MYD88 temozolomide 0.4590388 0.8360585 0.4590 NA NA
EGFR afatinib 0.4594260 0.7810241 0.459 NA NA
DPYD bosutinib monohydrate 0.4594664 0.8678810 0.459 NA NA
KIT temozolomide 0.4596217 0.8360585 0.4596 NA NA
PML imatinib 0.4608455 0.7846892 0.461 NA NA
JAK2 nilotinib 0.4609294 0.7074000 0.461 NA NA
DNMT3A erlotinib 0.4620527 0.8537089 0.462 NA NA
MET nilotinib 0.4620552 0.7074000 0.462 NA NA
BRCA1 belinostat 0.4653768 0.7769514 0.465 NA NA
BRAF erlotinib 0.4662981 0.8537089 0.466 NA NA
PTCH1 sunitinib 0.4664159 0.8777619 0.466 NA NA
ABL1 imatinib 0.4679914 0.7846892 0.468 NA NA
BRCA2 ponatinib 0.4687534 0.9972326 0.469 NA NA
PDGFRB imatinib 0.4699331 0.7846892 0.470 NA NA
PTCH1 dasatinib 0.4723552 0.9447103 0.472 NA NA
ERBB3 palbociclib 0.4724268 0.8031255 0.4724 NA NA
MGMT trametinib 0.4735520 0.7350776 0.47355 NA NA
TSC2 vismodegib 0.4749053 0.8556940 0.47 NA NA
PTCH1 trametinib 0.4756384 0.7350776 0.47564 NA NA
PDGFRB ruxolitinib 0.4765472 0.9526741 0.477 NA NA
MYD88 tretinoin 0.4774785 0.6757916 0.4775 NA NA
PDGFRA vismodegib 0.4781819 0.8556940 0.48 NA NA
BRCA1 ruxolitinib 0.4788739 0.9526741 0.479 NA NA
G6PD belinostat 0.4798818 0.7769514 0.480 NA NA
NPM1 ruxolitinib 0.4817234 0.9526741 0.482 NA NA
PDGFB ponatinib 0.4821695 0.9972326 0.482 NA NA
G6PD pazopanib 0.4835225 0.9239682 0.4835 NA NA
ERBB2 sunitinib 0.4842706 0.8777619 0.484 NA NA
CYP19A1 docetaxel 0.4847190 0.8413401 0.485 NA NA
PDGFRB afatinib 0.4872986 0.7852762 0.487 NA NA
KRAS erlotinib 0.4886809 0.8537089 0.489 NA NA
TSC2 erlotinib 0.4915604 0.8537089 0.492 NA NA
UGT1A1 nilotinib 0.4918297 0.7074000 0.492 NA NA
CYP19A1 lapatinib 0.4937490 0.8940161 0.494 NA NA
PDGFB dabrafenib 0.4964153 0.7445082 0.49642 NA NA
RET tretinoin 0.4969056 0.6757916 0.4969 NA NA
ALK midostaurin 0.4971993 0.7825538 0.4972 NA NA
MYD88 cabozantinib 0.4985291 0.9262331 0.4985 NA NA
PDGFRA sunitinib 0.4989956 0.8777619 0.499 NA NA
RET cabozantinib 0.4991041 0.9262331 0.4991 NA NA
EGFR nilotinib 0.4993412 0.7074000 0.499 NA NA
ERBB3 lapatinib 0.5028840 0.8940161 0.503 NA NA
RET crizotinib 0.5041789 0.8464147 0.504 NA NA
G6PD imatinib 0.5046668 0.7846892 0.505 NA NA
CYP19A1 afatinib 0.5081199 0.7852762 0.508 NA NA
DPYD midostaurin 0.5086465 0.7825538 0.5086 NA NA
ERBB3 pazopanib 0.5092517 0.9239682 0.5093 NA NA
PDGFRB sunitinib 0.5106193 0.8777619 0.511 NA NA
BRAF gefitinib 0.5109860 0.8402334 0.511 NA NA
PML vismodegib 0.5118312 0.8701130 0.51 NA NA
KIT palbociclib 0.5134101 0.8071578 0.5134 NA NA
ESR1 dabrafenib 0.5138002 0.7445082 0.51380 NA NA
PDGFRB temozolomide 0.5143244 0.8360585 0.5143 NA NA
FLT3 dabrafenib 0.5153597 0.7445082 0.51536 NA NA
MYD88 dasatinib 0.5156798 0.9470657 0.516 NA NA
DPYD ruxolitinib 0.5165164 0.9526741 0.517 NA NA
CYP19A1 sunitinib 0.5166344 0.8777619 0.517 NA NA
DPYD docetaxel 0.5183010 0.8413401 0.518 NA NA
MET docetaxel 0.5196512 0.8413401 0.520 NA NA
DPYD imatinib 0.5204070 0.7846892 0.520 NA NA
EGFR imatinib 0.5206143 0.7846892 0.521 NA NA
DPYD gefitinib 0.5210093 0.8402334 0.521 NA NA
DNMT3A palbociclib 0.5222786 0.8071578 0.5223 NA NA
DPYD alectinib 0.5225472 0.8075729 0.523 NA NA
NPM1 gefitinib 0.5227495 0.8402334 0.523 NA NA
PDGFB trametinib 0.5280206 0.7805521 0.52802 NA NA
BRAF sunitinib 0.5308225 0.8777619 0.531 NA NA
MYD88 midostaurin 0.5310291 0.7825538 0.5310 NA NA
ABL1 crizotinib 0.5320626 0.8464147 0.532 NA NA
DNMT3A midostaurin 0.5328652 0.7825538 0.5329 NA NA
G6PD erlotinib 0.5348254 0.8537089 0.535 NA NA
ERBB3 nilotinib 0.5371710 0.7305525 0.537 NA NA
TSC2 imatinib 0.5394738 0.7846892 0.539 NA NA
ABL1 midostaurin 0.5402282 0.7825538 0.5402 NA NA
PTCH1 dabrafenib 0.5410696 0.7445082 0.54107 NA NA
BRCA2 temozolomide 0.5416844 0.8360585 0.5417 NA NA
TSC2 midostaurin 0.5433441 0.7825538 0.5433 NA NA
AKT1 cabozantinib 0.5467795 0.9262331 0.5468 NA NA
UGT1A1 dabrafenib 0.5474325 0.7445082 0.54743 NA NA
PDGFB midostaurin 0.5477164 0.7825538 0.5477 NA NA
UGT1A1 temozolomide 0.5500430 0.8360585 0.5500 NA NA
MGMT crizotinib 0.5501355 0.8464147 0.550 NA NA
RET bosutinib monohydrate 0.5509591 0.9571596 0.551 NA NA
ROS1 gefitinib 0.5511895 0.8402334 0.551 NA NA
KIT midostaurin 0.5523909 0.7825538 0.5524 NA NA
CYP19A1 pazopanib 0.5523979 0.9239682 0.5524 NA NA
ERBB3 alectinib 0.5530430 0.8175419 0.553 NA NA
MGMT ponatinib 0.5540759 0.9972326 0.554 NA NA
AKT1 belinostat 0.5547454 0.8458949 0.555 NA NA
CYP19A1 tretinoin 0.5549899 0.7257560 0.5550 NA NA
TSC2 dasatinib 0.5568736 0.9470657 0.557 NA NA
MYD88 erlotinib 0.5580136 0.8537089 0.558 NA NA
ALK pazopanib 0.5581192 0.9239682 0.5581 NA NA
RET ruxolitinib 0.5597886 0.9526741 0.560 NA NA
ERBB3 afatinib 0.5614904 0.7959129 0.561 NA NA
JAK2 crizotinib 0.5623793 0.8464147 0.562 NA NA
PML pazopanib 0.5629739 0.9239682 0.5630 NA NA
TSC1 erlotinib 0.5633547 0.8537089 0.563 NA NA
ESR1 sunitinib 0.5643768 0.8777619 0.564 NA NA
G6PD rucaparib 0.5646292 0.8467310 0.565 NA NA
RET gefitinib 0.5658382 0.8402334 0.566 NA NA
PDGFB sunitinib 0.5660424 0.8777619 0.566 NA NA
FLT3 sunitinib 0.5660424 0.8777619 0.566 NA NA
EGFR temozolomide 0.5669345 0.8360585 0.5669 NA NA
JAK2 palbociclib 0.5675682 0.8390139 0.5676 NA NA
FLT3 lapatinib 0.5679419 0.9537394 0.568 NA NA
CYP19A1 gefitinib 0.5683932 0.8402334 0.568 NA NA
JAK2 erlotinib 0.5702807 0.8537089 0.570 NA NA
TSC2 cabozantinib 0.5710996 0.9262331 0.5711 NA NA
TSC1 docetaxel 0.5725527 0.8563752 0.573 NA NA
BRCA1 rucaparib 0.5768966 0.8467310 0.577 NA NA
MGMT belinostat 0.5789471 0.8458949 0.579 NA NA
ALK cabozantinib 0.5795396 0.9262331 0.5795 NA NA
ABL1 sunitinib 0.5802023 0.8777619 0.580 NA NA
ROS1 midostaurin 0.5814725 0.7908026 0.5815 NA NA
ALK rucaparib 0.5819295 0.8467310 0.582 NA NA
TSC2 ruxolitinib 0.5824296 0.9526741 0.582 NA NA
PDGFRA docetaxel 0.5828922 0.8563752 0.583 NA NA
PTCH1 ruxolitinib 0.5835921 0.9526741 0.584 NA NA
RET ponatinib 0.5838741 0.9972326 0.584 NA NA
RET nilotinib 0.5840052 0.7528214 0.584 NA NA
TSC2 rucaparib 0.5851976 0.8467310 0.585 NA NA
NPM1 ponatinib 0.5854791 0.9972326 0.585 NA NA
BRCA1 afatinib 0.5859699 0.7959129 0.586 NA NA
EGFR ponatinib 0.5861711 0.9972326 0.586 NA NA
PDGFRA temozolomide 0.5883211 0.8360585 0.5883 NA NA
EGFR tretinoin 0.5940328 0.7480413 0.5940 NA NA
KIT pazopanib 0.5948891 0.9239682 0.5949 NA NA
PML rucaparib 0.5950165 0.8467310 0.595 NA NA
EGFR lapatinib 0.5960871 0.9537394 0.596 NA NA
ESR1 ruxolitinib 0.5973766 0.9526741 0.597 NA NA
MGMT nilotinib 0.5978288 0.7528214 0.598 NA NA
MYD88 vismodegib 0.5979041 0.9680352 0.60 NA NA
ABL1 erlotinib 0.5985108 0.8537089 0.599 NA NA
IDH2 sunitinib 0.6010327 0.8777619 0.601 NA NA
CYP19A1 cabozantinib 0.6024929 0.9262331 0.6025 NA NA
BRAF crizotinib 0.6026642 0.8464147 0.603 NA NA
TPMT trametinib 0.6050220 0.8571145 0.60502 NA NA
ROS1 sunitinib 0.6060667 0.8777619 0.606 NA NA
BRCA2 docetaxel 0.6116514 0.8563752 0.612 NA NA
TSC1 ponatinib 0.6125905 0.9972326 0.613 NA NA
MET ponatinib 0.6159349 0.9972326 0.616 NA NA
PML ponatinib 0.6178115 0.9972326 0.618 NA NA
AKT1 pazopanib 0.6189835 0.9239682 0.6190 NA NA
CYP19A1 crizotinib 0.6190452 0.8464147 0.619 NA NA
JAK2 afatinib 0.6195384 0.7959129 0.620 NA NA
G6PD sunitinib 0.6213525 0.8777619 0.621 NA NA
MGMT bosutinib monohydrate 0.6222029 0.9571596 0.622 NA NA
KRAS gefitinib 0.6235545 0.8503583 0.624 NA NA
DNMT3A tretinoin 0.6240726 0.7578025 0.6241 NA NA
PDGFB belinostat 0.6267736 0.8458949 0.627 NA NA
MYD88 pazopanib 0.6271722 0.9239682 0.6272 NA NA
ROS1 afatinib 0.6282804 0.7959129 0.628 NA NA
TPMT afatinib 0.6320485 0.7959129 0.632 NA NA
AKT1 trametinib 0.6346674 0.8631476 0.63467 NA NA
EGFR sunitinib 0.6347395 0.8777619 0.635 NA NA
PML erlotinib 0.6360548 0.8537089 0.636 NA NA
PDGFRB alectinib 0.6381495 0.8897754 0.638 NA NA
KRAS imatinib 0.6424818 0.8938878 0.642 NA NA
MGMT sunitinib 0.6441449 0.8777619 0.644 NA NA
EGFR ruxolitinib 0.6447588 0.9526741 0.645 NA NA
NPM1 rucaparib 0.6448258 0.8467310 0.645 NA NA
DNMT3A ponatinib 0.6448404 0.9972326 0.645 NA NA
KRAS lapatinib 0.6456344 0.9838238 0.646 NA NA
UGT1A1 gefitinib 0.6466857 0.8503583 0.647 NA NA
PDGFB rucaparib 0.6469333 0.8467310 0.647 NA NA
ALK docetaxel 0.6482988 0.8563752 0.648 NA NA
FLT3 midostaurin 0.6526579 0.8534757 0.6527 NA NA
ERBB3 ruxolitinib 0.6532068 0.9526741 0.653 NA NA
TSC2 gefitinib 0.6534622 0.8503583 0.653 NA NA
UGT1A1 alectinib 0.6542466 0.8897754 0.654 NA NA
TSC2 bosutinib monohydrate 0.6543872 0.9571596 0.654 NA NA
KIT sunitinib 0.6583214 0.8777619 0.658 NA NA
PTCH1 crizotinib 0.6605698 0.8464147 0.661 NA NA
PDGFRB pazopanib 0.6626651 0.9239682 0.6627 NA NA
IDH2 erlotinib 0.6634451 0.8537089 0.663 NA NA
MGMT temozolomide 0.6634570 0.8360585 0.6635 NA NA
ALK vismodegib 0.6657344 0.9773105 0.67 NA NA
MYD88 palbociclib 0.6675616 0.8695381 0.6676 NA NA
FLT3 belinostat 0.6686147 0.8458949 0.669 NA NA
FLT3 ponatinib 0.6691061 0.9972326 0.669 NA NA
PDGFB crizotinib 0.6714054 0.8464147 0.671 NA NA
DNMT3A dabrafenib 0.6722330 0.8621835 0.67223 NA NA
FLT3 docetaxel 0.6723654 0.8563752 0.672 NA NA
MET ruxolitinib 0.6724758 0.9526741 0.672 NA NA
ROS1 pazopanib 0.6730661 0.9239682 0.6731 NA NA
BRCA2 nilotinib 0.6739857 0.8184112 0.674 NA NA
ROS1 temozolomide 0.6751390 0.8360585 0.6751 NA NA
PML gefitinib 0.6752846 0.8503583 0.675 NA NA
AKT1 rucaparib 0.6766724 0.8467310 0.677 NA NA
EGFR belinostat 0.6783585 0.8458949 0.678 NA NA
ESR1 dasatinib 0.6806688 0.9470657 0.681 NA NA
ERBB2 rucaparib 0.6813788 0.8467310 0.681 NA NA
ESR1 lapatinib 0.6823352 0.9878187 0.682 NA NA
PDGFRA erlotinib 0.6824019 0.8537089 0.682 NA NA
PDGFRA ponatinib 0.6831311 0.9972326 0.683 NA NA
ESR1 midostaurin 0.6835330 0.8607452 0.6835 NA NA
ESR1 tretinoin 0.6845216 0.8025426 0.6845 NA NA
BRCA1 dabrafenib 0.6846752 0.8621835 0.68468 NA NA
KRAS rucaparib 0.6847697 0.8467310 0.685 NA NA
BRCA1 palbociclib 0.6850052 0.8695381 0.6850 NA NA
RET belinostat 0.6890334 0.8458949 0.689 NA NA
MYD88 crizotinib 0.6896981 0.8464147 0.690 NA NA
CYP19A1 bosutinib monohydrate 0.6902719 0.9571596 0.690 NA NA
MGMT pazopanib 0.6911734 0.9239682 0.6912 NA NA
ALK alectinib 0.6916060 0.9044078 0.692 NA NA
MET temozolomide 0.6917583 0.8360585 0.6918 NA NA
ESR1 pazopanib 0.6922709 0.9239682 0.6923 NA NA
PML cabozantinib 0.6926459 0.9262331 0.6926 NA NA
PDGFB cabozantinib 0.6931930 0.9262331 0.6932 NA NA
ESR1 trametinib 0.6962680 0.9060078 0.69627 NA NA
ABL1 temozolomide 0.6987934 0.8360585 0.6988 NA NA
BRCA1 docetaxel 0.7001716 0.8563752 0.700 NA NA
BRCA1 crizotinib 0.7017863 0.8464147 0.702 NA NA
PML dasatinib 0.7028188 0.9470657 0.703 NA NA
TSC1 dasatinib 0.7033301 0.9470657 0.703 NA NA
G6PD crizotinib 0.7040235 0.8464147 0.704 NA NA
ERBB2 docetaxel 0.7052502 0.8563752 0.705 NA NA
UGT1A1 ponatinib 0.7062488 0.9972326 0.706 NA NA
ROS1 vismodegib 0.7075936 0.9773105 0.71 NA NA
ERBB2 palbociclib 0.7083268 0.8695381 0.7083 NA NA
TSC2 belinostat 0.7089749 0.8458949 0.709 NA NA
IDH2 dasatinib 0.7090830 0.9470657 0.709 NA NA
ALK erlotinib 0.7099827 0.8537089 0.710 NA NA
JAK2 dasatinib 0.7103203 0.9470657 0.710 NA NA
RET dabrafenib 0.7105653 0.8628293 0.71057 NA NA
KRAS ruxolitinib 0.7137147 0.9613264 0.714 NA NA
RET dasatinib 0.7148163 0.9470657 0.715 NA NA
KRAS temozolomide 0.7150718 0.8360585 0.7151 NA NA
ESR1 cabozantinib 0.7161231 0.9262331 0.7161 NA NA
EGFR trametinib 0.7194767 0.9060078 0.71948 NA NA
PTCH1 vismodegib 0.7198241 0.9773105 0.72 NA NA
ERBB3 erlotinib 0.7203169 0.8537089 0.720 NA NA
PDGFRB ponatinib 0.7240517 0.9972326 0.724 NA NA
ERBB3 rucaparib 0.7263040 0.8467310 0.726 NA NA
DPYD pazopanib 0.7284979 0.9239682 0.7285 NA NA
PDGFRB palbociclib 0.7303977 0.8695381 0.7304 NA NA
ABL1 nilotinib 0.7313136 0.8564973 0.731 NA NA
BRAF temozolomide 0.7335771 0.8360585 0.7336 NA NA
EGFR docetaxel 0.7346881 0.8613585 0.735 NA NA
PML ruxolitinib 0.7351319 0.9613264 0.735 NA NA
CYP19A1 temozolomide 0.7376987 0.8360585 0.7377 NA NA
PDGFRA crizotinib 0.7390621 0.8464147 0.739 NA NA
KIT dasatinib 0.7398951 0.9470657 0.740 NA NA
ERBB3 crizotinib 0.7406129 0.8464147 0.741 NA NA
AKT1 afatinib 0.7407741 0.8995114 0.741 NA NA
DPYD sunitinib 0.7414533 0.8823886 0.741 NA NA
KRAS bosutinib monohydrate 0.7414809 0.9571596 0.741 NA NA
TSC1 cabozantinib 0.7417760 0.9262331 0.7418 NA NA
CYP19A1 ponatinib 0.7421820 0.9972326 0.742 NA NA
PDGFRB bosutinib monohydrate 0.7429860 0.9571596 0.743 NA NA
IDH2 imatinib 0.7435570 0.9237192 0.744 NA NA
PDGFRA belinostat 0.7450686 0.8458949 0.745 NA NA
TPMT midostaurin 0.7460273 0.9058903 0.7460 NA NA
PML belinostat 0.7463779 0.8458949 0.746 NA NA
BRCA1 imatinib 0.7500850 0.9237192 0.750 NA NA
KIT imatinib 0.7505218 0.9237192 0.751 NA NA
EGFR palbociclib 0.7514260 0.8695381 0.7514 NA NA
DNMT3A bosutinib monohydrate 0.7551741 0.9571596 0.755 NA NA
PDGFRA pazopanib 0.7583124 0.9239682 0.7583 NA NA
DNMT3A alectinib 0.7613631 0.9273034 0.761 NA NA
TPMT rucaparib 0.7619662 0.8467310 0.762 NA NA
AKT1 gefitinib 0.7625117 0.8968173 0.763 NA NA
G6PD trametinib 0.7631155 0.9266403 0.76312 NA NA
EGFR pazopanib 0.7631271 0.9239682 0.7631 NA NA
MGMT alectinib 0.7636616 0.9273034 0.764 NA NA
PDGFB bosutinib monohydrate 0.7637526 0.9571596 0.764 NA NA
KRAS sunitinib 0.7642647 0.8823886 0.764 NA NA
PDGFRB gefitinib 0.7649324 0.8968173 0.765 NA NA
TPMT palbociclib 0.7668585 0.8695381 0.7669 NA NA
CYP19A1 palbociclib 0.7672395 0.8695381 0.7672 NA NA
ABL1 bosutinib monohydrate 0.7708229 0.9571596 0.771 NA NA
ALK tretinoin 0.7717427 0.8561605 0.7717 NA NA
PDGFRA lapatinib 0.7718304 0.9878187 0.772 NA NA
PDGFB pazopanib 0.7722360 0.9239682 0.7722 NA NA
ERBB2 vismodegib 0.7739594 0.9773105 0.77 NA NA
KIT docetaxel 0.7747007 0.8752363 0.775 NA NA
PML nilotinib 0.7777017 0.8564973 0.778 NA NA
DPYD tretinoin 0.7806169 0.8561605 0.7806 NA NA
EGFR rucaparib 0.7812134 0.8467310 0.781 NA NA
MET rucaparib 0.7852325 0.8467310 0.785 NA NA
MYD88 sunitinib 0.7863908 0.8823886 0.786 NA NA
NPM1 pazopanib 0.7880905 0.9239682 0.7881 NA NA
MYD88 imatinib 0.7889569 0.9350600 0.789 NA NA
BRAF ponatinib 0.7903167 0.9972326 0.790 NA NA
BRCA1 gefitinib 0.7929047 0.8986254 0.793 NA NA
FLT3 alectinib 0.7941809 0.9311087 0.794 NA NA
BRAF midostaurin 0.7943467 0.9164533 0.7943 NA NA
PTCH1 rucaparib 0.7952280 0.8467310 0.795 NA NA
PML docetaxel 0.7980096 0.8752363 0.798 NA NA
NPM1 vismodegib 0.8004491 0.9773105 0.80 NA NA
PDGFRB crizotinib 0.8019048 0.8848604 0.802 NA NA
ERBB3 trametinib 0.8021031 0.9403967 0.80210 NA NA
FLT3 afatinib 0.8043606 0.9430434 0.804 NA NA
JAK2 sunitinib 0.8046870 0.8823886 0.805 NA NA
KRAS nilotinib 0.8058237 0.8564973 0.806 NA NA
IDH2 nilotinib 0.8061151 0.8564973 0.806 NA NA
IDH2 ruxolitinib 0.8073056 0.9802461 0.807 NA NA
FLT3 tretinoin 0.8076478 0.8581257 0.8076 NA NA
DPYD belinostat 0.8079628 0.8861528 0.808 NA NA
ESR1 bosutinib monohydrate 0.8080005 0.9571596 0.808 NA NA
DPYD palbociclib 0.8111267 0.8753990 0.8111 NA NA
RET temozolomide 0.8158960 0.8948536 0.8159 NA NA
BRCA1 sunitinib 0.8165800 0.8823886 0.817 NA NA
ERBB3 dasatinib 0.8180600 0.9608776 0.818 NA NA
G6PD gefitinib 0.8202116 0.8995869 0.820 NA NA
FLT3 palbociclib 0.8239049 0.8753990 0.8239 NA NA
EGFR bosutinib monohydrate 0.8249647 0.9571596 0.825 NA NA
BRCA1 pazopanib 0.8251732 0.9335674 0.8252 NA NA
MET alectinib 0.8262519 0.9364188 0.826 NA NA
G6PD cabozantinib 0.8264953 0.9262331 0.8265 NA NA
ERBB3 sunitinib 0.8272393 0.8823886 0.827 NA NA
TSC1 dabrafenib 0.8273766 0.9700277 0.82738 NA NA
G6PD midostaurin 0.8281741 0.9164533 0.8282 NA NA
FLT3 ruxolitinib 0.8312495 0.9802461 0.831 NA NA
MET trametinib 0.8326323 0.9436500 0.83263 NA NA
BRCA1 cabozantinib 0.8333837 0.9262331 0.8334 NA NA
MGMT tretinoin 0.8349168 0.8602173 0.8349 NA NA
CYP19A1 rucaparib 0.8350834 0.8467310 0.835 NA NA
MET midostaurin 0.8355898 0.9164533 0.8356 NA NA
RET rucaparib 0.8423514 0.8467310 0.842 NA NA
BRAF cabozantinib 0.8425783 0.9262331 0.8426 NA NA
UGT1A1 rucaparib 0.8467310 0.8467310 0.847 NA NA
ERBB2 cabozantinib 0.8477762 0.9262331 0.8478 NA NA
DNMT3A gefitinib 0.8493836 0.9024701 0.849 NA NA
TPMT pazopanib 0.8511938 0.9335674 0.8512 NA NA
KRAS crizotinib 0.8512775 0.8966708 0.851 NA NA
MET cabozantinib 0.8512783 0.9262331 0.8513 NA NA
JAK2 imatinib 0.8521878 0.9739289 0.852 NA NA
JAK2 ruxolitinib 0.8523436 0.9802461 0.852 NA NA
UGT1A1 docetaxel 0.8542969 0.9076904 0.854 NA NA
MET dasatinib 0.8543593 0.9608776 0.854 NA NA
MYD88 ponatinib 0.8552763 0.9972326 0.855 NA NA
DPYD erlotinib 0.8604995 0.9307227 0.860 NA NA
ROS1 palbociclib 0.8627523 0.8888963 0.8628 NA NA
NPM1 afatinib 0.8655570 0.9518372 0.866 NA NA
UGT1A1 vismodegib 0.8657073 0.9773105 0.87 NA NA
NPM1 trametinib 0.8672776 0.9512077 0.86728 NA NA
G6PD dasatinib 0.8682306 0.9608776 0.868 NA NA
KIT crizotinib 0.8686498 0.8966708 0.869 NA NA
ESR1 ponatinib 0.8695576 0.9972326 0.870 NA NA
FLT3 bosutinib monohydrate 0.8695733 0.9571596 0.870 NA NA
DNMT3A lapatinib 0.8744953 0.9878187 0.874 NA NA
ERBB3 vismodegib 0.8804120 0.9773105 0.88 NA NA
TPMT ponatinib 0.8811769 0.9972326 0.881 NA NA
JAK2 midostaurin 0.8847197 0.9400146 0.8847 NA NA
BRCA2 ruxolitinib 0.8869414 0.9802461 0.887 NA NA
MYD88 bosutinib monohydrate 0.8892270 0.9571596 0.889 NA NA
JAK2 pazopanib 0.8907594 0.9464319 0.8908 NA NA
BRCA2 cabozantinib 0.8957636 0.9262331 0.8958 NA NA
ROS1 ruxolitinib 0.8966205 0.9802461 0.897 NA NA
PML trametinib 0.8969530 0.9530125 0.89695 NA NA
MGMT dasatinib 0.8989855 0.9608776 0.899 NA NA
ALK bosutinib monohydrate 0.9008561 0.9571596 0.901 NA NA
BRAF afatinib 0.9011510 0.9518372 0.901 NA NA
ROS1 crizotinib 0.9055984 0.9055984 0.906 NA NA
TSC1 belinostat 0.9061702 0.9585223 0.906 NA NA
ERBB3 docetaxel 0.9076995 0.9352056 0.908 NA NA
AKT1 temozolomide 0.9094399 0.9462406 0.9094 NA NA
CYP19A1 dabrafenib 0.9107211 0.9949724 0.91072 NA NA
ESR1 erlotinib 0.9133687 0.9307227 0.913 NA NA
BRCA1 lapatinib 0.9142372 0.9878187 0.914 NA NA
EGFR cabozantinib 0.9149328 0.9262331 0.9149 NA NA
BRCA2 sunitinib 0.9151190 0.9216497 0.915 NA NA
TSC1 gefitinib 0.9156569 0.9283678 0.916 NA NA
ROS1 imatinib 0.9157097 1.0000000 0.916 NA NA
ERBB2 ponatinib 0.9158815 0.9972326 0.916 NA NA
BRAF dasatinib 0.9161548 0.9608776 0.916 NA NA
BRCA2 dabrafenib 0.9168207 0.9949724 0.91682 NA NA
G6PD temozolomide 0.9184100 0.9462406 0.9184 NA NA
JAK2 lapatinib 0.9210478 0.9878187 0.921 NA NA
NPM1 sunitinib 0.9216497 0.9216497 0.922 NA NA
EGFR erlotinib 0.9218958 0.9307227 0.922 NA NA
ROS1 lapatinib 0.9246091 0.9878187 0.925 NA NA
PDGFRA ruxolitinib 0.9248089 0.9802461 0.925 NA NA
KIT ponatinib 0.9257639 0.9972326 0.926 NA NA
UGT1A1 cabozantinib 0.9262331 0.9262331 0.9262 NA NA
PTCH1 erlotinib 0.9275623 0.9307227 0.928 NA NA
MYD88 gefitinib 0.9283678 0.9283678 0.928 NA NA
TSC1 afatinib 0.9300086 0.9518372 0.930 NA NA
KIT belinostat 0.9303304 0.9585223 0.930 NA NA
RET erlotinib 0.9307227 0.9307227 0.931 NA NA
MYD88 lapatinib 0.9323054 0.9878187 0.932 NA NA
MGMT vismodegib 0.9400649 0.9773105 0.94 NA NA
BRCA2 trametinib 0.9421624 0.9707128 0.94216 NA NA
IDH2 alectinib 0.9437117 0.9851623 0.944 NA NA
IDH2 palbociclib 0.9443484 0.9443484 0.9443 NA NA
EGFR vismodegib 0.9448114 0.9773105 0.94 NA NA
IDH2 midostaurin 0.9477169 0.9563247 0.9477 NA NA
ABL1 vismodegib 0.9494533 0.9773105 0.95 NA NA
ESR1 afatinib 0.9503087 0.9518372 0.950 NA NA
ROS1 dasatinib 0.9512458 0.9608776 0.951 NA NA
UGT1A1 ruxolitinib 0.9514154 0.9802461 0.951 NA NA
PML afatinib 0.9518372 0.9518372 0.952 NA NA
BRCA1 temozolomide 0.9526259 0.9526259 0.9526 NA NA
ALK ponatinib 0.9561548 0.9972326 0.956 NA NA
RET midostaurin 0.9563247 0.9563247 0.9563 NA NA
BRAF lapatinib 0.9579143 0.9878187 0.958 NA NA
RET pazopanib 0.9581510 0.9871859 0.9582 NA NA
PDGFRA dasatinib 0.9608776 0.9608776 0.961 NA NA
ALK imatinib 0.9639389 1.0000000 0.964 NA NA
DPYD nilotinib 0.9678380 0.9911966 0.968 NA NA
G6PD lapatinib 0.9681165 0.9878187 0.968 NA NA
IDH2 dabrafenib 0.9684328 0.9949724 0.96843 NA NA
KIT alectinib 0.9692528 0.9851623 0.969 NA NA
AKT1 docetaxel 0.9695144 0.9695144 0.970 NA NA
DNMT3A belinostat 0.9723117 0.9723117 0.972 NA NA
CYP19A1 vismodegib 0.9723531 0.9773105 0.97 NA NA
BRCA2 vismodegib 0.9733078 0.9773105 0.97 NA NA
PML lapatinib 0.9738117 0.9878187 0.974 NA NA
FLT3 vismodegib 0.9773105 0.9773105 0.98 NA NA
MYD88 dabrafenib 0.9773916 0.9949724 0.97739 NA NA
PDGFRB trametinib 0.9784811 0.9784811 0.97848 NA NA
KRAS alectinib 0.9838427 0.9851623 0.984 NA NA
TPMT bosutinib monohydrate 0.9847665 0.9984574 0.985 NA NA
ESR1 alectinib 0.9851623 0.9851623 0.985 NA NA
PTCH1 lapatinib 0.9878187 0.9878187 0.988 NA NA
PTCH1 imatinib 0.9882665 1.0000000 0.988 NA NA
JAK2 ponatinib 0.9882767 0.9972326 0.988 NA NA
ALK nilotinib 0.9911966 0.9911966 0.991 NA NA
MGMT ruxolitinib 0.9946721 0.9946721 0.995 NA NA
ROS1 dabrafenib 0.9949724 0.9949724 0.99497 NA NA
ABL1 tretinoin 0.9968006 0.9968006 0.9968 NA NA
AKT1 ponatinib 0.9972326 0.9972326 0.997 NA NA
JAK2 bosutinib monohydrate 0.9984574 0.9984574 0.998 NA NA
DNMT3A pazopanib 0.9995159 0.9995159 0.9995 NA NA
MGMT imatinib 1.0000000 1.0000000 1.000 NA NA

4.4.2 G2P gene, drug, and lineage

gdsc_signif_g2p_lineage <- lapply(unique(gdsc_data_g2p_genesfilt$Drug), WilcoxonByDrug, dataset = gdsc_data_g2p_genesfilt, data_name = "gdsc", grouping_var = "lineage")
names(gdsc_signif_g2p_lineage) <- unique(gdsc_signif_g2p_lineage$Drug)
saveRDS(gdsc_signif_g2p_lineage, "./data_munging/rds/gdsc_signif_g2p_lineage.rds")
gdsc_signif_g2p_lineage <- readRDS("./data_munging/rds/gdsc_signif_g2p_lineage.rds")
gdsc_signif_g2p_lineage <- rbindlist(gdsc_signif_g2p_lineage, use.names = TRUE)
gdsc_signif_g2p_lineage <- gdsc_signif_g2p_lineage[order(gdsc_signif_g2p_lineage$p),]

knitr::kable(gdsc_signif_g2p_lineage[1:500, c("Hugo_Symbol", "Drug", "group_general_lineage_name", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "GDSC: Wilcoxon test results for level A G2P drug-gene associations across lineages (* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
GDSC: Wilcoxon test results for level A G2P drug-gene associations across lineages (* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)
Hugo_Symbol Drug group_general_lineage_name p p.adj p.format p.signif p.signif.adj
KRAS trametinib lung cancer 0.0002426 0.0681782 0.00024 *** NA
BRAF vismodegib colorectal cancer 0.0036265 0.7479461 0.0036 ** NA
DNMT3A cabozantinib colorectal cancer 0.0043493 0.8621814 0.0043 ** NA
DNMT3A afatinib lung cancer 0.0058092 0.9450922 0.0058 ** NA
PDGFRA temozolomide leukemia 0.0064479 0.8317711 0.0064 ** NA
TSC1 midostaurin colorectal cancer 0.0065173 0.9940428 0.0065 ** NA
BRAF temozolomide colorectal cancer 0.0066540 0.8317711 0.0067 ** NA
BRCA2 tretinoin lung cancer 0.0082065 0.8025128 0.0082 ** NA
KRAS docetaxel ovarian cancer 0.0088368 0.8289952 0.0088 ** NA
BRAF palbociclib colorectal cancer 0.0109043 0.7711320 0.011
NA
EGFR dabrafenib esophageal cancer 0.0114019 0.8365365 0.011
NA
PTCH1 afatinib breast cancer 0.0114661 0.9450922 0.0115
NA
DNMT3A temozolomide colorectal cancer 0.0115587 0.8317711 0.0116
NA
BRCA2 midostaurin breast cancer 0.0119252 0.9940428 0.0119
NA
DNMT3A tretinoin lung cancer 0.0133900 0.8025128 0.0134
NA
ALK dabrafenib lung cancer 0.0138360 0.8365365 0.014
NA
BRCA1 temozolomide colorectal cancer 0.0141747 0.8317711 0.0142
NA
PDGFRA temozolomide colorectal cancer 0.0149192 0.8317711 0.0149
NA
KRAS docetaxel lung cancer 0.0171315 0.8289952 0.0171
NA
PTCH1 bosutinib monohydrate lung cancer 0.0185929 0.8544492 0.019
NA
KRAS dabrafenib lung cancer 0.0187422 0.8365365 0.019
NA
KRAS palbociclib lung cancer 0.0187986 0.7711320 0.019
NA
BRAF temozolomide skin cancer 0.0188139 0.8317711 0.0188
NA
PDGFRA nilotinib colorectal cancer 0.0190089 0.8327971 0.019
NA
DPYD afatinib lung cancer 0.0196234 0.9450922 0.0196
NA
PDGFRA afatinib colorectal cancer 0.0199168 0.9450922 0.0199
NA
RET afatinib lung cancer 0.0200205 0.9450922 0.0200
NA
MGMT midostaurin colorectal cancer 0.0203026 0.9940428 0.0203
NA
DPYD gefitinib lung cancer 0.0206037 0.8632872 0.021
NA
BRAF afatinib breast cancer 0.0208476 0.9450922 0.0208
NA
BRCA2 vismodegib lung cancer 0.0210231 0.7479461 0.0210
NA
RET bosutinib monohydrate lung cancer 0.0217977 0.8544492 0.022
NA
TSC2 palbociclib colorectal cancer 0.0218681 0.7711320 0.022
NA
BRCA2 temozolomide colorectal cancer 0.0226392 0.8317711 0.0226
NA
PDGFRA vismodegib colorectal cancer 0.0227356 0.7479461 0.0227
NA
PML temozolomide colorectal cancer 0.0237503 0.8317711 0.0238
NA
ABL1 gefitinib lung cancer 0.0239750 0.8632872 0.024
NA
TSC2 rucaparib stomach cancer 0.0259435 0.7668585 0.026
NA
BRAF rucaparib skin cancer 0.0260817 0.7668585 0.026
NA
DNMT3A ruxolitinib colorectal cancer 0.0268621 1.0000000 0.027
NA
ABL1 imatinib central nervous system cancer 0.0274686 0.6724569 0.027
NA
PTCH1 gefitinib colorectal cancer 0.0280226 0.8632872 0.028
NA
ERBB2 palbociclib colorectal cancer 0.0290755 0.7711320 0.029
NA
DNMT3A bosutinib monohydrate lung cancer 0.0294906 0.8544492 0.029
NA
DNMT3A vismodegib colorectal cancer 0.0296372 0.7479461 0.0296
NA
ALK belinostat breast cancer 0.0300653 0.9302048 0.030
NA
EGFR trametinib lung cancer 0.0304895 0.8606196 0.03049
NA
TSC1 rucaparib urinary bladder cancer 0.0306542 0.7668585 0.031
NA
ABL1 pazopanib urinary bladder cancer 0.0306542 0.8564831 0.031
NA
TSC2 lapatinib leukemia 0.0308181 0.9609381 0.031
NA
DPYD tretinoin lung cancer 0.0308356 0.8025128 0.0308
NA
BRAF trametinib breast cancer 0.0316424 0.8606196 0.03164
NA
ERBB3 lapatinib leukemia 0.0322511 0.9609381 0.032
NA
TSC2 alectinib colorectal cancer 0.0328632 0.7717115 0.033
NA
PML cabozantinib ovarian cancer 0.0331037 0.8621814 0.0331
NA
RET trametinib lung cancer 0.0332811 0.8606196 0.03328
NA
ERBB3 vismodegib colorectal cancer 0.0333652 0.7479461 0.0334
NA
BRAF trametinib lung cancer 0.0334526 0.8606196 0.03345
NA
PDGFB midostaurin colorectal cancer 0.0336207 0.9940428 0.0336
NA
DPYD temozolomide kidney cancer 0.0337522 0.8317711 0.0338
NA
ROS1 nilotinib liver cancer 0.0337522 0.8327971 0.034
NA
BRAF dabrafenib cancer 0.0337522 0.8365365 0.034
NA
RET palbociclib lung cancer 0.0338327 0.7711320 0.034
NA
MET alectinib colorectal cancer 0.0339701 0.7717115 0.034
NA
PDGFRB bosutinib monohydrate ovarian cancer 0.0339978 0.8544492 0.034
NA
ALK afatinib ovarian cancer 0.0339978 0.9638639 0.0340
NA
PML vismodegib ovarian cancer 0.0339978 0.7479461 0.0340
NA
BRCA1 vismodegib colorectal cancer 0.0342748 0.7479461 0.0343
NA
ERBB2 alectinib colorectal cancer 0.0345781 0.7717115 0.035
NA
BRCA2 midostaurin leukemia 0.0347819 0.9940428 0.0348
NA
PML midostaurin leukemia 0.0347819 0.9940428 0.0348
NA
ALK gefitinib ovarian cancer 0.0349770 0.8632872 0.035
NA
PTCH1 temozolomide colorectal cancer 0.0352735 0.8317711 0.0353
NA
KRAS docetaxel colorectal cancer 0.0353914 0.8289952 0.0354
NA
TSC1 ponatinib uterine cancer 0.0355608 0.9908528 0.036
NA
EGFR palbociclib multiple myeloma 0.0357638 0.7711320 0.036
NA
KRAS palbociclib multiple myeloma 0.0357638 0.7711320 0.036
NA
BRAF dabrafenib lung cancer 0.0363494 0.8365365 0.036
NA
BRCA2 afatinib lung cancer 0.0365014 0.9638639 0.0365
NA
TSC2 dabrafenib leukemia 0.0365528 0.8365365 0.037
NA
ALK bosutinib monohydrate breast cancer 0.0367947 0.8544492 0.037
NA
BRCA2 vismodegib colorectal cancer 0.0370120 0.7479461 0.0370
NA
MET tretinoin colorectal cancer 0.0376252 0.8025128 0.0376
NA
ERBB3 dabrafenib leukemia 0.0379739 0.8365365 0.038
NA
ALK lapatinib leukemia 0.0391733 0.9609381 0.039
NA
PDGFRB ponatinib breast cancer 0.0392407 0.9908528 0.039
NA
MET ponatinib colorectal cancer 0.0394732 0.9908528 0.039
NA
ABL1 trametinib head and neck cancer 0.0394890 0.8606196 0.03949
NA
PDGFRA gefitinib colorectal cancer 0.0399772 0.8632872 0.040
NA
KIT nilotinib esophageal cancer 0.0410595 0.8327971 0.041
NA
TSC1 temozolomide colorectal cancer 0.0412966 0.8317711 0.0413
NA
PTCH1 cabozantinib ovarian cancer 0.0415632 0.8621814 0.0416
NA
BRCA2 trametinib stomach cancer 0.0416426 0.8606196 0.04164
NA
BRAF cabozantinib ovarian cancer 0.0416544 0.8621814 0.0417
NA
BRCA2 cabozantinib esophageal cancer 0.0416544 0.8621814 0.0417
NA
DNMT3A gefitinib lung cancer 0.0424297 0.8632872 0.042
NA
PDGFRB gefitinib breast cancer 0.0426101 0.8632872 0.043
NA
BRCA2 pazopanib colorectal cancer 0.0426985 0.8564831 0.043
NA
RET alectinib skin cancer 0.0428256 0.7717115 0.043
NA
ERBB2 temozolomide colorectal cancer 0.0429409 0.8317711 0.0429
NA
RET palbociclib skin cancer 0.0431187 0.7711320 0.043
NA
PDGFRA alectinib leukemia 0.0432158 0.7717115 0.043
NA
PDGFRA tretinoin lung cancer 0.0436045 0.8025128 0.0436
NA
ABL1 rucaparib urinary bladder cancer 0.0441713 0.7668585 0.044
NA
FLT3 bosutinib monohydrate lung cancer 0.0463289 0.8544492 0.046
NA
PML alectinib colorectal cancer 0.0467842 0.7717115 0.047
NA
FLT3 belinostat skin cancer 0.0471253 0.9302048 0.047
NA
BRCA2 dasatinib lung cancer 0.0472859 0.9492569 0.047
NA
PDGFRB nilotinib ovarian cancer 0.0480598 0.8327971 0.048
NA
ABL1 palbociclib colorectal cancer 0.0481068 0.7711320 0.048
NA
DNMT3A alectinib colorectal cancer 0.0483570 0.7717115 0.048
NA
EGFR nilotinib esophageal cancer 0.0489944 0.8327971 0.049
NA
DNMT3A trametinib lung cancer 0.0490065 0.8606196 0.04901
NA
BRCA2 gefitinib lung cancer 0.0493911 0.8632872 0.049
NA
TSC1 palbociclib uterine cancer 0.0494912 0.7711320 0.049
NA
KRAS belinostat pancreatic cancer 0.0502247 0.9302048 0.050 NA NA
BRCA1 tretinoin breast cancer 0.0506066 0.8025128 0.0506 NA NA
PDGFRA ponatinib skin cancer 0.0506610 0.9908528 0.051 NA NA
DPYD bosutinib monohydrate lung cancer 0.0511617 0.8544492 0.051 NA NA
BRCA2 sunitinib colorectal cancer 0.0513483 0.7483136 0.051 NA NA
ABL1 afatinib lung cancer 0.0516338 0.9638639 0.0516 NA NA
DNMT3A vismodegib lung cancer 0.0519932 0.7479461 0.0520 NA NA
PDGFB palbociclib colorectal cancer 0.0521396 0.7711320 0.052 NA NA
PTCH1 belinostat breast cancer 0.0524795 0.9302048 0.052 NA NA
TSC2 trametinib leukemia 0.0527387 0.8606196 0.05274 NA NA
BRCA2 palbociclib colorectal cancer 0.0527869 0.7711320 0.053 NA NA
PTCH1 vismodegib ovarian cancer 0.0529114 0.7479461 0.0529 NA NA
ROS1 ruxolitinib esophageal cancer 0.0529114 1.0000000 0.053 NA NA
ALK temozolomide colorectal cancer 0.0539276 0.8317711 0.0539 NA NA
ERBB3 trametinib leukemia 0.0543851 0.8606196 0.05439 NA NA
KRAS gefitinib pancreatic cancer 0.0544291 0.8632872 0.054 NA NA
ROS1 pazopanib skin cancer 0.0557586 0.8564831 0.056 NA NA
ALK afatinib breast cancer 0.0565897 0.9638639 0.0566 NA NA
MET vismodegib colorectal cancer 0.0565897 0.7479461 0.0566 NA NA
KRAS gefitinib stomach cancer 0.0578826 0.8632872 0.058 NA NA
TSC2 palbociclib stomach cancer 0.0578826 0.7711320 0.058 NA NA
ERBB2 afatinib stomach cancer 0.0578826 0.9638639 0.0579 NA NA
BRCA2 dabrafenib skin cancer 0.0584328 0.8365365 0.058 NA NA
KRAS belinostat lung cancer 0.0595435 0.9302048 0.060 NA NA
ROS1 trametinib liver cancer 0.0601556 0.8606196 0.06016 NA NA
TSC2 docetaxel leukemia 0.0601719 0.8289952 0.0602 NA NA
MET ponatinib uterine cancer 0.0607704 0.9908528 0.061 NA NA
ROS1 ponatinib uterine cancer 0.0607704 0.9908528 0.061 NA NA
AKT1 ponatinib uterine cancer 0.0607704 0.9908528 0.061 NA NA
JAK2 ponatinib uterine cancer 0.0607704 0.9908528 0.061 NA NA
ESR1 temozolomide leukemia 0.0612544 0.8317711 0.0613 NA NA
ROS1 alectinib lung cancer 0.0614632 0.7717115 0.061 NA NA
PTCH1 docetaxel ovarian cancer 0.0619696 0.8289952 0.0620 NA NA
ABL1 ruxolitinib urinary bladder cancer 0.0624074 1.0000000 0.062 NA NA
ABL1 trametinib central nervous system cancer 0.0628195 0.8606196 0.06282 NA NA
PTCH1 nilotinib ovarian cancer 0.0629818 0.8327971 0.063 NA NA
TSC2 cabozantinib colorectal cancer 0.0636580 0.8621814 0.0637 NA NA
PTCH1 pazopanib colorectal cancer 0.0640640 0.8564831 0.064 NA NA
BRAF belinostat ovarian cancer 0.0642523 0.9302048 0.064 NA NA
KRAS dabrafenib pancreatic cancer 0.0643551 0.8365365 0.064 NA NA
UGT1A1 dabrafenib skin cancer 0.0643740 0.8365365 0.064 NA NA
ERBB3 ponatinib lung cancer 0.0645994 0.9908528 0.065 NA NA
PDGFRB afatinib breast cancer 0.0649003 0.9638639 0.0649 NA NA
PDGFB afatinib colorectal cancer 0.0649003 0.9638639 0.0649 NA NA
PDGFRA bosutinib monohydrate lung cancer 0.0649888 0.8544492 0.065 NA NA
MET pazopanib breast cancer 0.0650308 0.8564831 0.065 NA NA
DPYD nilotinib skin cancer 0.0673289 0.8327971 0.067 NA NA
FLT3 nilotinib skin cancer 0.0673289 0.8327971 0.067 NA NA
PML ponatinib uterine cancer 0.0675869 0.9908528 0.068 NA NA
PDGFRB dabrafenib uterine cancer 0.0675869 0.8365365 0.068 NA NA
PTCH1 bosutinib monohydrate breast cancer 0.0676568 0.8544492 0.068 NA NA
ABL1 pazopanib head and neck cancer 0.0677256 0.8564831 0.068 NA NA
KRAS tretinoin urinary bladder cancer 0.0678363 0.8025128 0.0678 NA NA
TSC1 temozolomide urinary bladder cancer 0.0678603 0.8317711 0.0679 NA NA
KRAS pazopanib stomach cancer 0.0678603 0.8564831 0.068 NA NA
TSC2 pazopanib stomach cancer 0.0678603 0.8564831 0.068 NA NA
BRAF afatinib skin cancer 0.0685389 0.9638639 0.0685 NA NA
ERBB3 docetaxel leukemia 0.0686980 0.8289952 0.0687 NA NA
BRCA1 palbociclib colorectal cancer 0.0687662 0.7711320 0.069 NA NA
EGFR vismodegib leukemia 0.0688000 0.7479461 0.0688 NA NA
ROS1 cabozantinib colorectal cancer 0.0693828 0.8621814 0.0694 NA NA
ABL1 bosutinib monohydrate lung cancer 0.0694272 0.8544492 0.069 NA NA
TSC1 pazopanib colorectal cancer 0.0697238 0.8564831 0.070 NA NA
PDGFRB tretinoin lung cancer 0.0701997 0.8025128 0.0702 NA NA
BRAF dabrafenib breast cancer 0.0707577 0.8365365 0.071 NA NA
ESR1 pazopanib leukemia 0.0707593 0.8564831 0.071 NA NA
MGMT pazopanib colorectal cancer 0.0722196 0.8564831 0.072 NA NA
ABL1 temozolomide colorectal cancer 0.0722861 0.8317711 0.0723 NA NA
ABL1 ponatinib skin cancer 0.0722992 0.9908528 0.072 NA NA
UGT1A1 midostaurin skin cancer 0.0725404 0.9940428 0.0725 NA NA
PDGFRB rucaparib colorectal cancer 0.0734587 0.7668585 0.073 NA NA
ALK cabozantinib breast cancer 0.0734587 0.8621814 0.0735 NA NA
KRAS vismodegib ovarian cancer 0.0736564 0.7479461 0.0737 NA NA
BRCA1 afatinib ovarian cancer 0.0738513 0.9638639 0.0739 NA NA
FLT3 alectinib esophageal cancer 0.0738513 0.7717115 0.074 NA NA
PDGFRB midostaurin lung cancer 0.0743656 0.9940428 0.0744 NA NA
EGFR tretinoin multiple myeloma 0.0745316 0.8025128 0.0745 NA NA
KRAS tretinoin multiple myeloma 0.0745316 0.8025128 0.0745 NA NA
ROS1 dabrafenib esophageal cancer 0.0746392 0.8365365 0.075 NA NA
ROS1 ruxolitinib lung cancer 0.0746925 1.0000000 0.075 NA NA
BRCA2 pazopanib breast cancer 0.0759307 0.8564831 0.076 NA NA
BRCA2 alectinib skin cancer 0.0762889 0.7717115 0.076 NA NA
KRAS cabozantinib lung cancer 0.0775758 0.8621814 0.0776 NA NA
ROS1 dabrafenib liver cancer 0.0779787 0.8365365 0.078 NA NA
BRCA2 midostaurin colorectal cancer 0.0781575 0.9940428 0.0782 NA NA
DPYD pazopanib lung cancer 0.0782292 0.8564831 0.078 NA NA
PML vismodegib colorectal cancer 0.0789424 0.7479461 0.0789 NA NA
KRAS bosutinib monohydrate stomach cancer 0.0790716 0.8544492 0.079 NA NA
ALK palbociclib lung cancer 0.0792663 0.7711320 0.079 NA NA
BRAF bosutinib monohydrate skin cancer 0.0803620 0.8544492 0.080 NA NA
PDGFRB docetaxel lung cancer 0.0804210 0.8289952 0.0804 NA NA
BRAF gefitinib skin cancer 0.0805410 0.8632872 0.081 NA NA
BRCA2 dabrafenib lung cancer 0.0808542 0.8365365 0.081 NA NA
PDGFRA lapatinib lung cancer 0.0817639 0.9609381 0.082 NA NA
EGFR vismodegib colorectal cancer 0.0818238 0.7479461 0.0818 NA NA
ERBB3 nilotinib lung cancer 0.0821836 0.8327971 0.082 NA NA
PML nilotinib ovarian cancer 0.0823479 0.8327971 0.082 NA NA
TSC2 pazopanib colorectal cancer 0.0825412 0.8564831 0.083 NA NA
PDGFB ruxolitinib colorectal cancer 0.0827595 1.0000000 0.083 NA NA
MGMT ponatinib colorectal cancer 0.0832096 0.9908528 0.083 NA NA
BRCA2 rucaparib lung cancer 0.0832157 0.7668585 0.083 NA NA
ALK palbociclib ovarian cancer 0.0838482 0.7711320 0.084 NA NA
BRAF trametinib ovarian cancer 0.0838482 0.8606196 0.08385 NA NA
EGFR nilotinib colorectal cancer 0.0841119 0.8327971 0.084 NA NA
ERBB3 bosutinib monohydrate colorectal cancer 0.0841389 0.8544492 0.084 NA NA
ESR1 nilotinib leukemia 0.0842003 0.8327971 0.084 NA NA
PDGFB docetaxel colorectal cancer 0.0845458 0.8289952 0.0845 NA NA
MGMT docetaxel colorectal cancer 0.0845458 0.8289952 0.0845 NA NA
MET bosutinib monohydrate breast cancer 0.0845458 0.8544492 0.085 NA NA
PDGFRB bosutinib monohydrate colorectal cancer 0.0845458 0.8544492 0.085 NA NA
RET alectinib lung cancer 0.0854642 0.7717115 0.085 NA NA
KIT dabrafenib esophageal cancer 0.0856349 0.8365365 0.086 NA NA
RET gefitinib lung cancer 0.0856700 0.8632872 0.086 NA NA
FLT3 belinostat liver cancer 0.0864702 0.9302048 0.086 NA NA
ABL1 cabozantinib urinary bladder cancer 0.0864702 0.8621814 0.0865 NA NA
ABL1 alectinib urinary bladder cancer 0.0864702 0.7717115 0.086 NA NA
PTCH1 palbociclib breast cancer 0.0867309 0.7711320 0.087 NA NA
ROS1 afatinib esophageal cancer 0.0867554 0.9638639 0.0868 NA NA
ALK bosutinib monohydrate ovarian cancer 0.0883078 0.8544492 0.088 NA NA
PML belinostat ovarian cancer 0.0883078 0.9302048 0.088 NA NA
MET midostaurin esophageal cancer 0.0886674 0.9940428 0.0887 NA NA
BRCA1 belinostat breast cancer 0.0888878 0.9302048 0.089 NA NA
ABL1 alectinib central nervous system cancer 0.0888878 0.7717115 0.089 NA NA
ABL1 erlotinib central nervous system cancer 0.0889730 0.9136623 0.089 NA NA
MET docetaxel lung cancer 0.0890648 0.8289952 0.0891 NA NA
ABL1 docetaxel lung cancer 0.0890648 0.8289952 0.0891 NA NA
DNMT3A afatinib colorectal cancer 0.0907236 0.9638639 0.0907 NA NA
BRAF ruxolitinib skin cancer 0.0908020 1.0000000 0.091 NA NA
ALK gefitinib colorectal cancer 0.0914813 0.8632872 0.091 NA NA
ERBB2 pazopanib urinary bladder cancer 0.0916562 0.8564831 0.092 NA NA
EGFR afatinib lung cancer 0.0920035 0.9638639 0.0920 NA NA
MGMT cabozantinib colorectal cancer 0.0929927 0.8621814 0.0930 NA NA
JAK2 gefitinib lung cancer 0.0933519 0.8632872 0.093 NA NA
PTCH1 gefitinib breast cancer 0.0935234 0.8632872 0.094 NA NA
ROS1 rucaparib colorectal cancer 0.0936926 0.7668585 0.094 NA NA
ESR1 crizotinib leukemia 0.0941006 1.0000000 0.094 NA NA
AKT1 palbociclib lung cancer 0.0944480 0.7711320 0.094 NA NA
EGFR dabrafenib lung cancer 0.0945807 0.8365365 0.095 NA NA
MET gefitinib esophageal cancer 0.0946256 0.8632872 0.095 NA NA
ROS1 pazopanib lung cancer 0.0946406 0.8564831 0.095 NA NA
PDGFRA midostaurin skin cancer 0.0949051 0.9940428 0.0949 NA NA
PDGFRA alectinib skin cancer 0.0949051 0.7717115 0.095 NA NA
PML palbociclib colorectal cancer 0.0952826 0.7711320 0.095 NA NA
KRAS temozolomide urinary bladder cancer 0.0954832 0.8317711 0.0955 NA NA
FLT3 trametinib leukemia 0.0955170 0.8606196 0.09552 NA NA
FLT3 gefitinib leukemia 0.0957649 0.8632872 0.096 NA NA
IDH2 lapatinib leukemia 0.0960231 0.9609381 0.096 NA NA
JAK2 lapatinib leukemia 0.0960231 0.9609381 0.096 NA NA
ERBB3 docetaxel breast cancer 0.0960374 0.8289952 0.0960 NA NA
KIT docetaxel breast cancer 0.0960374 0.8289952 0.0960 NA NA
PDGFB vismodegib colorectal cancer 0.0960374 0.7479461 0.0960 NA NA
DNMT3A trametinib colorectal cancer 0.0967521 0.8606196 0.09675 NA NA
BRCA2 erlotinib lung cancer 0.0968751 0.9136623 0.097 NA NA
ESR1 temozolomide colorectal cancer 0.0978273 0.8317711 0.0978 NA NA
ESR1 rucaparib colorectal cancer 0.0978273 0.7668585 0.098 NA NA
CYP19A1 cabozantinib breast cancer 0.0978273 0.8621814 0.0978 NA NA
PML cabozantinib breast cancer 0.0978273 0.8621814 0.0978 NA NA
ESR1 alectinib colorectal cancer 0.0978273 0.7717115 0.098 NA NA
PDGFRA vismodegib lung cancer 0.0978819 0.7479461 0.0979 NA NA
CYP19A1 midostaurin breast cancer 0.0981786 0.9940428 0.0982 NA NA
KIT cabozantinib central nervous system cancer 0.0981786 0.8621814 0.0982 NA NA
BRCA2 ruxolitinib central nervous system cancer 0.0981786 1.0000000 0.098 NA NA
KRAS alectinib breast cancer 0.0981786 0.7717115 0.098 NA NA
PDGFRA alectinib breast cancer 0.0981786 0.7717115 0.098 NA NA
KIT ponatinib central nervous system cancer 0.0985474 0.9908528 0.099 NA NA
PDGFB ponatinib central nervous system cancer 0.0985474 0.9908528 0.099 NA NA
JAK2 docetaxel lung cancer 0.0987567 0.8289952 0.0988 NA NA
BRCA2 temozolomide central nervous system cancer 0.0989348 0.8317711 0.0989 NA NA
BRCA2 rucaparib central nervous system cancer 0.0989348 0.7668585 0.099 NA NA
BRAF pazopanib central nervous system cancer 0.0989348 0.8564831 0.099 NA NA
KIT trametinib central nervous system cancer 0.0989348 0.8606196 0.09893 NA NA
PDGFRB palbociclib ovarian cancer 0.0992761 0.7711320 0.099 NA NA
PDGFRB ruxolitinib ovarian cancer 0.0992761 1.0000000 0.099 NA NA
ESR1 bosutinib monohydrate colorectal cancer 0.0993422 0.8544492 0.099 NA NA
CYP19A1 bosutinib monohydrate breast cancer 0.0993422 0.8544492 0.099 NA NA
BRAF belinostat central nervous system cancer 0.0993422 0.9302048 0.099 NA NA
ALK rucaparib breast cancer 0.0993422 0.7668585 0.099 NA NA
CYP19A1 rucaparib breast cancer 0.0993422 0.7668585 0.099 NA NA
ESR1 vismodegib colorectal cancer 0.0993422 0.7479461 0.0993 NA NA
UGT1A1 nilotinib lung cancer 0.0995738 0.8327971 0.100 NA NA
ROS1 gefitinib central nervous system cancer 0.0997714 0.8632872 0.100 NA NA
BRCA2 gefitinib central nervous system cancer 0.0997714 0.8632872 0.100 NA NA
ESR1 tretinoin colorectal cancer 0.0997714 0.8025128 0.0998 NA NA
ERBB3 afatinib central nervous system cancer 0.0997714 0.9638639 0.0998 NA NA
ROS1 afatinib central nervous system cancer 0.0997714 0.9638639 0.0998 NA NA
BRCA2 afatinib central nervous system cancer 0.0997714 0.9638639 0.0998 NA NA
ROS1 vismodegib central nervous system cancer 0.0997714 0.7479461 0.0998 NA NA
BRCA2 vismodegib central nervous system cancer 0.0997714 0.7479461 0.0998 NA NA
ROS1 dabrafenib lymphoma 0.0997714 0.8365365 0.100 NA NA
BRCA2 dabrafenib central nervous system cancer 0.0997714 0.8365365 0.100 NA NA
BRAF ponatinib uterine cancer 0.0999747 0.9908528 0.100 NA NA
TSC2 ponatinib uterine cancer 0.0999747 0.9908528 0.100 NA NA
ABL1 bosutinib monohydrate central nervous system cancer 0.1000699 0.8544492 0.100 NA NA
ROS1 tretinoin central nervous system cancer 0.1002241 0.8025128 0.1002 NA NA
KIT tretinoin central nervous system cancer 0.1002241 0.8025128 0.1002 NA NA
BRCA2 tretinoin central nervous system cancer 0.1002241 0.8025128 0.1002 NA NA
ROS1 nilotinib central nervous system cancer 0.1002241 0.8327971 0.100 NA NA
BRCA2 nilotinib central nervous system cancer 0.1002241 0.8327971 0.100 NA NA
ESR1 nilotinib colorectal cancer 0.1002241 0.8327971 0.100 NA NA
ROS1 ruxolitinib lymphoma 0.1002241 1.0000000 0.100 NA NA
PDGFB dabrafenib colorectal cancer 0.1002541 0.8365365 0.100 NA NA
MYD88 midostaurin colorectal cancer 0.1007022 0.9940428 0.1007 NA NA
ESR1 ponatinib colorectal cancer 0.1007022 0.9908528 0.101 NA NA
MYD88 ponatinib colorectal cancer 0.1007022 0.9908528 0.101 NA NA
DNMT3A pazopanib colorectal cancer 0.1007979 0.8564831 0.101 NA NA
DNMT3A ponatinib colorectal cancer 0.1007979 0.9908528 0.101 NA NA
ALK trametinib lung cancer 0.1020435 0.8606196 0.10204 NA NA
PTCH1 lapatinib leukemia 0.1025823 0.9609381 0.103 NA NA
EGFR temozolomide colorectal cancer 0.1026642 0.8317711 0.1027 NA NA
ALK docetaxel colorectal cancer 0.1034076 0.8289952 0.1034 NA NA
ROS1 palbociclib liver cancer 0.1038762 0.7711320 0.104 NA NA
RET ruxolitinib colorectal cancer 0.1042175 1.0000000 0.104 NA NA
MET rucaparib esophageal cancer 0.1042183 0.7668585 0.104 NA NA
ROS1 rucaparib central nervous system cancer 0.1043295 0.7668585 0.104 NA NA
BRCA1 nilotinib lung cancer 0.1045816 0.8327971 0.105 NA NA
ERBB2 belinostat ovarian cancer 0.1049637 0.9302048 0.105 NA NA
PDGFRB vismodegib ovarian cancer 0.1049637 0.7479461 0.1050 NA NA
FLT3 cabozantinib esophageal cancer 0.1049637 0.8621814 0.1050 NA NA
ROS1 bosutinib monohydrate esophageal cancer 0.1051925 0.8544492 0.105 NA NA
FLT3 temozolomide colorectal cancer 0.1053346 0.8317711 0.1053 NA NA
JAK2 temozolomide colorectal cancer 0.1053346 0.8317711 0.1053 NA NA
FLT3 rucaparib colorectal cancer 0.1053346 0.7668585 0.105 NA NA
JAK2 rucaparib colorectal cancer 0.1053346 0.7668585 0.105 NA NA
FLT3 alectinib colorectal cancer 0.1053346 0.7717115 0.105 NA NA
JAK2 alectinib colorectal cancer 0.1053346 0.7717115 0.105 NA NA
DPYD dabrafenib skin cancer 0.1057748 0.8365365 0.106 NA NA
DNMT3A dabrafenib skin cancer 0.1057748 0.8365365 0.106 NA NA
PML dabrafenib skin cancer 0.1057748 0.8365365 0.106 NA NA
BRCA2 ponatinib uterine cancer 0.1060114 0.9908528 0.106 NA NA
BRAF rucaparib cancer 0.1061785 0.7668585 0.106 NA NA
ROS1 cabozantinib cancer 0.1061785 0.8621814 0.1062 NA NA
DNMT3A rucaparib colorectal cancer 0.1062445 0.7668585 0.106 NA NA
PDGFRA trametinib colorectal cancer 0.1062445 0.8606196 0.10624 NA NA
ABL1 ruxolitinib colorectal cancer 0.1062445 1.0000000 0.106 NA NA
BRAF rucaparib pancreatic cancer 0.1066232 0.7668585 0.107 NA NA
EGFR nilotinib multiple myeloma 0.1066371 0.8327971 0.107 NA NA
KRAS nilotinib multiple myeloma 0.1066371 0.8327971 0.107 NA NA
FLT3 tretinoin uterine cancer 0.1071234 0.8025128 0.1071 NA NA
PTCH1 tretinoin uterine cancer 0.1071234 0.8025128 0.1071 NA NA
TSC1 bosutinib monohydrate urinary bladder cancer 0.1071234 0.8544492 0.107 NA NA
FLT3 temozolomide esophageal cancer 0.1075377 0.8317711 0.1075 NA NA
TSC1 midostaurin pancreatic cancer 0.1075377 0.9940428 0.1075 NA NA
BRAF pazopanib pancreatic cancer 0.1075377 0.8564831 0.108 NA NA
BRAF ponatinib pancreatic cancer 0.1075377 0.9908528 0.108 NA NA
BRAF ruxolitinib pancreatic cancer 0.1075377 1.0000000 0.108 NA NA
DNMT3A dabrafenib esophageal cancer 0.1075377 0.8365365 0.108 NA NA
ERBB3 alectinib pancreatic cancer 0.1075377 0.7717115 0.108 NA NA
FLT3 bosutinib monohydrate colorectal cancer 0.1076482 0.8544492 0.108 NA NA
JAK2 bosutinib monohydrate colorectal cancer 0.1076482 0.8544492 0.108 NA NA
FLT3 vismodegib colorectal cancer 0.1076482 0.7479461 0.1076 NA NA
JAK2 vismodegib colorectal cancer 0.1076482 0.7479461 0.1076 NA NA
AKT1 ponatinib lung cancer 0.1077533 0.9908528 0.108 NA NA
ERBB3 nilotinib colorectal cancer 0.1079467 0.8327971 0.108 NA NA
FLT3 tretinoin colorectal cancer 0.1083040 0.8025128 0.1083 NA NA
JAK2 tretinoin colorectal cancer 0.1083040 0.8025128 0.1083 NA NA
DPYD midostaurin breast cancer 0.1083194 0.9940428 0.1083 NA NA
BRCA1 trametinib colorectal cancer 0.1083194 0.8606196 0.10832 NA NA
KIT temozolomide lung cancer 0.1083472 0.8317711 0.1083 NA NA
TSC1 trametinib lung cancer 0.1083472 0.8606196 0.10835 NA NA
KRAS bosutinib monohydrate esophageal cancer 0.1085264 0.8544492 0.109 NA NA
ABL1 bosutinib monohydrate esophageal cancer 0.1085264 0.8544492 0.109 NA NA
BRAF belinostat pancreatic cancer 0.1085264 0.9302048 0.109 NA NA
PDGFRA afatinib esophageal cancer 0.1085264 0.9638639 0.1085 NA NA
UGT1A1 afatinib esophageal cancer 0.1085264 0.9638639 0.1085 NA NA
TSC2 afatinib esophageal cancer 0.1085264 0.9638639 0.1085 NA NA
PTCH1 afatinib esophageal cancer 0.1085264 0.9638639 0.1085 NA NA
RET vismodegib colorectal cancer 0.1087465 0.7479461 0.1087 NA NA
FLT3 nilotinib colorectal cancer 0.1089958 0.8327971 0.109 NA NA
JAK2 nilotinib colorectal cancer 0.1089958 0.8327971 0.109 NA NA
FLT3 rucaparib leukemia 0.1092407 0.7668585 0.109 NA NA
ROS1 lapatinib lung cancer 0.1092407 0.9609381 0.109 NA NA
DPYD lapatinib lung cancer 0.1092407 0.9609381 0.109 NA NA
PDGFRB dasatinib lung cancer 0.1092407 0.9492569 0.109 NA NA
PDGFRB sunitinib lung cancer 0.1092407 0.7483136 0.109 NA NA
PDGFB ponatinib colorectal cancer 0.1092407 0.9908528 0.109 NA NA
PTCH1 rucaparib lung cancer 0.1093002 0.7668585 0.109 NA NA
FLT3 ponatinib colorectal cancer 0.1097267 0.9908528 0.110 NA NA
JAK2 ponatinib colorectal cancer 0.1097267 0.9908528 0.110 NA NA
FLT3 ruxolitinib leukemia 0.1097958 1.0000000 0.110 NA NA
FLT3 imatinib leukemia 0.1097958 0.6724569 0.110 NA NA
MET vismodegib esophageal cancer 0.1102215 0.7479461 0.1102 NA NA
FLT3 vismodegib leukemia 0.1103748 0.7479461 0.1104 NA NA
FLT3 alectinib leukemia 0.1103748 0.7717115 0.110 NA NA
FLT3 crizotinib leukemia 0.1103748 1.0000000 0.110 NA NA
TSC1 gefitinib colorectal cancer 0.1107257 0.8632872 0.111 NA NA
TSC1 gefitinib pancreatic cancer 0.1107652 0.8632872 0.111 NA NA
PDGFRA docetaxel pancreatic cancer 0.1107652 0.8289952 0.1108 NA NA
BRAF docetaxel pancreatic cancer 0.1107652 0.8289952 0.1108 NA NA
ERBB3 tretinoin pancreatic cancer 0.1107652 0.8025128 0.1108 NA NA
ERBB3 bosutinib monohydrate pancreatic cancer 0.1107652 0.8544492 0.111 NA NA
BRAF afatinib pancreatic cancer 0.1107652 0.9638639 0.1108 NA NA
BRAF vismodegib pancreatic cancer 0.1107652 0.7479461 0.1108 NA NA
PDGFRA pazopanib leukemia 0.1111233 0.8564831 0.111 NA NA
ERBB3 rucaparib lung cancer 0.1111558 0.7668585 0.111 NA NA
BRAF afatinib ovarian cancer 0.1113338 0.9638639 0.1113 NA NA
MET nilotinib lung cancer 0.1118049 0.8327971 0.112 NA NA
TSC1 temozolomide pancreatic cancer 0.1120393 0.8317711 0.1120 NA NA
BRAF nilotinib pancreatic cancer 0.1120393 0.8327971 0.112 NA NA
EGFR pazopanib ovarian cancer 0.1120393 0.8564831 0.112 NA NA
BRCA2 nilotinib lung cancer 0.1121385 0.8327971 0.112 NA NA
UGT1A1 pazopanib skin cancer 0.1121701 0.8564831 0.112 NA NA
KRAS pazopanib ovarian cancer 0.1123037 0.8564831 0.112 NA NA
FLT3 vismodegib lung cancer 0.1126194 0.7479461 0.1126 NA NA
ROS1 erlotinib lung cancer 0.1129661 0.9136623 0.113 NA NA
DPYD erlotinib lung cancer 0.1129661 0.9136623 0.113 NA NA
DNMT3A midostaurin esophageal cancer 0.1134364 0.9940428 0.1134 NA NA
TSC1 trametinib pancreatic cancer 0.1134364 0.8606196 0.11344 NA NA
ERBB3 gefitinib colorectal cancer 0.1135451 0.8632872 0.114 NA NA
PDGFB gefitinib colorectal cancer 0.1135451 0.8632872 0.114 NA NA
RET tretinoin lung cancer 0.1139807 0.8025128 0.1140 NA NA
MYD88 cabozantinib colorectal cancer 0.1144553 0.8621814 0.1145 NA NA
MYD88 ruxolitinib colorectal cancer 0.1144553 1.0000000 0.114 NA NA
PDGFRA rucaparib skin cancer 0.1144732 0.7668585 0.114 NA NA
TSC1 palbociclib pancreatic cancer 0.1149749 0.7711320 0.115 NA NA
MET rucaparib stomach cancer 0.1149749 0.7668585 0.115 NA NA
MET trametinib esophageal cancer 0.1151072 0.8606196 0.11511 NA NA
CYP19A1 belinostat breast cancer 0.1152568 0.9302048 0.115 NA NA
KIT ruxolitinib central nervous system cancer 0.1152568 1.0000000 0.115 NA NA
PML pazopanib colorectal cancer 0.1154935 0.8564831 0.115 NA NA
CYP19A1 temozolomide breast cancer 0.1161003 0.8317711 0.1161 NA NA
KRAS trametinib breast cancer 0.1161003 0.8606196 0.11610 NA NA
PDGFRA trametinib breast cancer 0.1161003 0.8606196 0.11610 NA NA
KIT dabrafenib colorectal cancer 0.1161003 0.8365365 0.116 NA NA
IDH2 dabrafenib colorectal cancer 0.1161003 0.8365365 0.116 NA NA
KIT alectinib central nervous system cancer 0.1161003 0.7717115 0.116 NA NA
UGT1A1 bosutinib monohydrate lung cancer 0.1164805 0.8544492 0.116 NA NA
PDGFRB alectinib colorectal cancer 0.1164928 0.7717115 0.116 NA NA
ALK gefitinib skin cancer 0.1168894 0.8632872 0.117 NA NA
RET cabozantinib ovarian cancer 0.1168894 0.8621814 0.1169 NA NA
KIT temozolomide central nervous system cancer 0.1169890 0.8317711 0.1170 NA NA
DPYD temozolomide central nervous system cancer 0.1169890 0.8317711 0.1170 NA NA
KIT pazopanib central nervous system cancer 0.1169890 0.8564831 0.117 NA NA
KRAS rucaparib urinary bladder cancer 0.1175249 0.7668585 0.118 NA NA
TSC1 ruxolitinib urinary bladder cancer 0.1175249 1.0000000 0.118 NA NA
KIT belinostat central nervous system cancer 0.1179267 0.9302048 0.118 NA NA
BRAF gefitinib ovarian cancer 0.1185025 0.8632872 0.119 NA NA
ESR1 midostaurin head and neck cancer 0.1185714 0.9940428 0.1186 NA NA
ESR1 ruxolitinib head and neck cancer 0.1185714 1.0000000 0.119 NA NA
PML ruxolitinib head and neck cancer 0.1185714 1.0000000 0.119 NA NA
PML alectinib head and neck cancer 0.1185714 0.7717115 0.119 NA NA
PDGFB sunitinib central nervous system cancer 0.1185714 0.7483136 0.119 NA NA
ROS1 imatinib central nervous system cancer 0.1185714 0.6724569 0.119 NA NA
KIT imatinib central nervous system cancer 0.1185714 0.6724569 0.119 NA NA
PDGFRB imatinib central nervous system cancer 0.1185714 0.6724569 0.119 NA NA
NPM1 imatinib central nervous system cancer 0.1185714 0.6724569 0.119 NA NA
RET nilotinib colorectal cancer 0.1187716 0.8327971 0.119 NA NA
BRCA2 tretinoin breast cancer 0.1188118 0.8025128 0.1188 NA NA
ROS1 trametinib lymphoma 0.1189176 0.8606196 0.11892 NA NA
KIT dabrafenib central nervous system cancer 0.1189176 0.8365365 0.119 NA NA
KIT alectinib lung cancer 0.1190235 0.7717115 0.119 NA NA
KIT nilotinib central nervous system cancer 0.1199661 0.8327971 0.120 NA NA
EGFR midostaurin stomach cancer 0.1206908 0.9940428 0.1207 NA NA
BRCA1 midostaurin stomach cancer 0.1206908 0.9940428 0.1207 NA NA
PDGFB trametinib head and neck cancer 0.1206908 0.8606196 0.12069 NA NA
PML trametinib head and neck cancer 0.1206908 0.8606196 0.12069 NA NA
ERBB2 dabrafenib stomach cancer 0.1206908 0.8365365 0.121 NA NA
EGFR imatinib lymphoma 0.1210776 0.6724569 0.121 NA NA
MET imatinib lymphoma 0.1210776 0.6724569 0.121 NA NA
BRCA1 imatinib lymphoma 0.1210776 0.6724569 0.121 NA NA
TSC2 imatinib lymphoma 0.1210776 0.6724569 0.121 NA NA
CYP19A1 imatinib lymphoma 0.1210776 0.6724569 0.121 NA NA
DNMT3A imatinib lymphoma 0.1210776 0.6724569 0.121 NA NA
PML imatinib lymphoma 0.1210776 0.6724569 0.121 NA NA
JAK2 imatinib lymphoma 0.1210776 0.6724569 0.121 NA NA
ERBB2 ruxolitinib urinary bladder cancer 0.1220648 1.0000000 0.122 NA NA
G6PD rucaparib skin cancer 0.1222576 0.7668585 0.122 NA NA
BRCA2 rucaparib skin cancer 0.1223074 0.7668585 0.122 NA NA
ROS1 bosutinib monohydrate breast cancer 0.1227507 0.8544492 0.123 NA NA
JAK2 bosutinib monohydrate lung cancer 0.1229145 0.8544492 0.123 NA NA
DPYD vismodegib colorectal cancer 0.1229267 0.7479461 0.1229 NA NA
UGT1A1 gefitinib stomach cancer 0.1230779 0.8632872 0.123 NA NA
CYP19A1 gefitinib stomach cancer 0.1230779 0.8632872 0.123 NA NA
MET docetaxel stomach cancer 0.1230779 0.8289952 0.1231 NA NA
KIT docetaxel stomach cancer 0.1230779 0.8289952 0.1231 NA NA
BRAF docetaxel stomach cancer 0.1230779 0.8289952 0.1231 NA NA
TSC2 docetaxel stomach cancer 0.1230779 0.8289952 0.1231 NA NA
IDH2 docetaxel stomach cancer 0.1230779 0.8289952 0.1231 NA NA
ESR1 docetaxel stomach cancer 0.1230779 0.8289952 0.1231 NA NA
PML docetaxel stomach cancer 0.1230779 0.8289952 0.1231 NA NA
UGT1A1 tretinoin stomach cancer 0.1230779 0.8025128 0.1231 NA NA
CYP19A1 tretinoin stomach cancer 0.1230779 0.8025128 0.1231 NA NA
KIT bosutinib monohydrate stomach cancer 0.1230779 0.8544492 0.123 NA NA
BRAF bosutinib monohydrate stomach cancer 0.1230779 0.8544492 0.123 NA NA
IDH2 bosutinib monohydrate stomach cancer 0.1230779 0.8544492 0.123 NA NA
ESR1 bosutinib monohydrate stomach cancer 0.1230779 0.8544492 0.123 NA NA

4.5 Drug screens: All CRISPR genes

Drug metadata:

drug_meta <- read.delim("./data_munging/drug_id_drug_name_table_10_12_2018.tsv", sep = "\t", header = FALSE)
colnames(drug_meta) <- c("CID", "Drug")
drug_meta$Drug <- tolower(drug_meta$Drug)

CCLE:

user system elapsed 1483.399 262.649 1901.698

ccle <- read.delim("./data_munging/data_drug_auc_ccle_10_12_2018.csv", sep = "\t", header  = TRUE, row.names = 1, check.names = FALSE)
ccle <- merge(drug_meta, ccle, by = "CID")
ccle_melt <- melt(ccle, id.vars = c("CID", "Drug"), measure.vars = colnames(ccle)[3:ncol(ccle)], variable.name = "accession_id", value.name = "AUC")
ccle_grid <- expand.grid("accession_id" = unique(ccle_melt$accession_id), "Hugo_Symbol" = as.character(unique(crispr_data$Hugo_Symbol)))
system.time({ ccle_data_allgenes <- WilcoxonByDrugAllGenes(ccle_melt, ccle_grid, "CCLE") })
saveRDS(ccle_data_allgenes, "./data_munging/rds/ccle_data_18Q3_allgenes.rds", compress = "xz")
ccle_data_allgenes <- readRDS("./data_munging/rds/ccle_data_18Q3_allgenes.rds")
ccle_data_allgenes <- ccle_data_allgenes[order(ccle_data_allgenes$p),]

knitr::kable(ccle_data_allgenes[1:1000, c("Hugo_Symbol", "Drug", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "CCLE: by-drug Wilcoxon test results for point mutations in genes targeted in CRISPR screen (* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
CCLE: by-drug Wilcoxon test results for point mutations in genes targeted in CRISPR screen (* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)
Hugo_Symbol Drug p p.adj p.format p.signif p.signif.adj
BRAF selumetinib 0.0000000 0.0008120 4.8e-08 **** ***
NRAS selumetinib 0.0000274 0.2300368 2.7e-05 **** NA
RABGAP1L irinotecan 0.0001104 0.8246221 0.00011 *** NA
PEX1 lapatinib 0.0001436 0.8066236 0.00014 *** NA
FOLH1 irinotecan 0.0001732 0.8246221 0.00017 *** NA
GAB1 lapatinib 0.0002666 0.8066236 0.00027 *** NA
SGTA erlotinib 0.0002996 0.8499467 0.00030 *** NA
PEX1 erlotinib 0.0003338 0.8499467 0.00033 *** NA
KNSTRN lapatinib 0.0003433 0.8066236 0.00034 *** NA
RAPGEFL1 lapatinib 0.0004253 0.8066236 0.00043 *** NA
LRP4 lapatinib 0.0004426 0.8066236 0.00044 *** NA
KRAS selumetinib 0.0004853 0.9529374 0.00049 *** NA
PM20D1 lapatinib 0.0004931 0.8066236 0.00049 *** NA
DTHD1 selumetinib 0.0005008 0.9529374 0.00050 *** NA
ZNF354A erlotinib 0.0005094 0.8499467 0.00051 *** NA
KLHL17 irinotecan 0.0005574 0.8246221 0.00056 *** NA
ZNF226 erlotinib 0.0005593 0.8499467 0.00056 *** NA
PREX1 lapatinib 0.0005712 0.8066236 0.00057 *** NA
LRRC37A2 irinotecan 0.0006426 0.8246221 0.00064 *** NA
SMTN selumetinib 0.0006605 0.9529374 0.00066 *** NA
IRF2BPL selumetinib 0.0006651 0.9529374 0.00067 *** NA
PCSK7 lapatinib 0.0006916 0.8066236 0.00069 *** NA
POP1 selumetinib 0.0006964 0.9529374 0.00070 *** NA
SLC44A3 irinotecan 0.0006970 0.8246221 0.00070 *** NA
SLC15A1 lapatinib 0.0007197 0.8066236 0.00072 *** NA
TGFBI lapatinib 0.0007397 0.8066236 0.00074 *** NA
TOPORS lapatinib 0.0007696 0.8066236 0.00077 *** NA
MIPOL1 lapatinib 0.0008036 0.8066236 0.00080 *** NA
LPO selumetinib 0.0009174 0.9529374 0.00092 *** NA
C20orf195 lapatinib 0.0009346 0.8066236 0.00093 *** NA
MAP10 erlotinib 0.0009792 0.8499467 0.00098 *** NA
PM20D1 erlotinib 0.0010281 0.8499467 0.00103 ** NA
DENND1B erlotinib 0.0010534 0.8499467 0.00105 ** NA
RTFDC1 lapatinib 0.0010911 0.8066236 0.00109 ** NA
ASB15 nilotinib 0.0010997 0.9993215 0.0011 ** NA
KIF11 irinotecan 0.0011053 0.8246221 0.00111 ** NA
ENAM lapatinib 0.0011374 0.8066236 0.00114 ** NA
FAM154B erlotinib 0.0011487 0.8499467 0.00115 ** NA
OR4M2 irinotecan 0.0011493 0.8246221 0.00115 ** NA
GZMH erlotinib 0.0011644 0.8499467 0.00116 ** NA
LRP4 erlotinib 0.0011988 0.8499467 0.00120 ** NA
PUS7 lapatinib 0.0012109 0.8066236 0.00121 ** NA
TUBA3E selumetinib 0.0012119 0.9529374 0.00121 ** NA
OR4K15 lapatinib 0.0012601 0.8066236 0.00126 ** NA
LGALS3BP lapatinib 0.0012852 0.8066236 0.00129 ** NA
REL erlotinib 0.0012883 0.8499467 0.00129 ** NA
CBFA2T3 erlotinib 0.0013360 0.8499467 0.00134 ** NA
PAN3 irinotecan 0.0013548 0.8246221 0.00135 ** NA
ZSCAN21 erlotinib 0.0013669 0.8499467 0.00137 ** NA
PRDM9 erlotinib 0.0013817 0.8499467 0.00138 ** NA
TRPM3 irinotecan 0.0013863 0.8246221 0.00139 ** NA
SGTA lapatinib 0.0013901 0.8066236 0.00139 ** NA
ERCC2 lapatinib 0.0014506 0.8066236 0.00145 ** NA
C1QTNF9 erlotinib 0.0014698 0.8499467 0.00147 ** NA
MS4A6A selumetinib 0.0014716 0.9529374 0.00147 ** NA
C1orf56 erlotinib 0.0014847 0.8499467 0.00148 ** NA
JPH2 erlotinib 0.0014979 0.8499467 0.00150 ** NA
NES lapatinib 0.0015102 0.8066236 0.00151 ** NA
KIAA1462 selumetinib 0.0015357 0.9529374 0.00154 ** NA
SLC35F3 lapatinib 0.0015924 0.8066236 0.00159 ** NA
MS4A8 erlotinib 0.0016519 0.8499467 0.00165 ** NA
SLITRK5 lapatinib 0.0016662 0.8066236 0.00167 ** NA
DLST selumetinib 0.0016934 0.9529374 0.00169 ** NA
GCAT lapatinib 0.0016991 0.8066236 0.00170 ** NA
LCK selumetinib 0.0017132 0.9529374 0.00171 ** NA
AGO4 lapatinib 0.0017146 0.8066236 0.00171 ** NA
SUN2 erlotinib 0.0017415 0.8499467 0.00174 ** NA
GIPC3 lapatinib 0.0017491 0.8066236 0.00175 ** NA
NCAPG2 irinotecan 0.0017741 0.8246221 0.00177 ** NA
INPP4B nilotinib 0.0017783 0.9993215 0.0018 ** NA
WDYHV1 selumetinib 0.0017802 0.9529374 0.00178 ** NA
FCRLA erlotinib 0.0018082 0.8499467 0.00181 ** NA
ABRA irinotecan 0.0018168 0.8246221 0.00182 ** NA
DFFA lapatinib 0.0018213 0.8066236 0.00182 ** NA
CBFA2T3 lapatinib 0.0018394 0.8066236 0.00184 ** NA
ITPR3 nilotinib 0.0018422 0.9993215 0.0018 ** NA
POU2F2 selumetinib 0.0018601 0.9529374 0.00186 ** NA
KCTD11 irinotecan 0.0019772 0.8246221 0.00198 ** NA
ANO3 erlotinib 0.0020105 0.8499467 0.00201 ** NA
HDAC7 selumetinib 0.0020609 0.9529374 0.00206 ** NA
ETV6 selumetinib 0.0021320 0.9529374 0.00213 ** NA
SLC2A9 irinotecan 0.0021647 0.8246221 0.00216 ** NA
ERCC2 erlotinib 0.0022218 0.8499467 0.00222 ** NA
WDYHV1 lapatinib 0.0022250 0.8066236 0.00223 ** NA
FAM35A lapatinib 0.0022812 0.8066236 0.00228 ** NA
GRAMD1C irinotecan 0.0023123 0.8246221 0.00231 ** NA
TPR lapatinib 0.0023145 0.8066236 0.00231 ** NA
ARHGEF2 erlotinib 0.0023552 0.8499467 0.00236 ** NA
MEOX2 erlotinib 0.0023721 0.8499467 0.00237 ** NA
PROM2 lapatinib 0.0023864 0.8066236 0.00239 ** NA
HADHA lapatinib 0.0024247 0.8066236 0.00242 ** NA
TP73 selumetinib 0.0024287 0.9529374 0.00243 ** NA
APOPT1 erlotinib 0.0024784 0.8499467 0.00248 ** NA
XPOT selumetinib 0.0025000 0.9529374 0.00250 ** NA
ABCE1 irinotecan 0.0025047 0.8246221 0.00250 ** NA
PPP4R2 erlotinib 0.0025121 0.8499467 0.00251 ** NA
CCDC137 lapatinib 0.0025383 0.8066236 0.00254 ** NA
ANKHD1 selumetinib 0.0025644 0.9529374 0.00256 ** NA
APBB1IP irinotecan 0.0026127 0.8246221 0.00261 ** NA
ADAMTSL2 erlotinib 0.0026349 0.8499467 0.00263 ** NA
SECISBP2 nilotinib 0.0027052 0.9993215 0.0027 ** NA
PPARGC1A irinotecan 0.0027202 0.8246221 0.00272 ** NA
MCRS1 selumetinib 0.0027255 0.9529374 0.00273 ** NA
RICTOR lapatinib 0.0027531 0.8066236 0.00275 ** NA
IRF2BP1 erlotinib 0.0027609 0.8499467 0.00276 ** NA
AZIN1 lapatinib 0.0027842 0.8066236 0.00278 ** NA
WDR45B erlotinib 0.0027981 0.8499467 0.00280 ** NA
ACSL6 lapatinib 0.0028179 0.8066236 0.00282 ** NA
TBC1D23 erlotinib 0.0028271 0.8499467 0.00283 ** NA
SIX4 erlotinib 0.0028336 0.8499467 0.00283 ** NA
RSPH10B lapatinib 0.0028698 0.8066236 0.00287 ** NA
CAPNS1 selumetinib 0.0028928 0.9529374 0.00289 ** NA
MDGA2 erlotinib 0.0029270 0.8499467 0.00293 ** NA
FERMT2 lapatinib 0.0030272 0.8066236 0.00303 ** NA
ACACB lapatinib 0.0030364 0.8066236 0.00304 ** NA
ZNF99 selumetinib 0.0030473 0.9529374 0.00305 ** NA
RARA selumetinib 0.0030492 0.9529374 0.00305 ** NA
SLC2A14 erlotinib 0.0030651 0.8499467 0.00307 ** NA
FSIP1 irinotecan 0.0030928 0.8246221 0.00309 ** NA
HTRA3 lapatinib 0.0031539 0.8066236 0.00315 ** NA
ECI1 lapatinib 0.0031886 0.8066236 0.00319 ** NA
PCDHA12 selumetinib 0.0032043 0.9529374 0.00320 ** NA
SLC16A6 irinotecan 0.0032476 0.8246221 0.00325 ** NA
BMP2K lapatinib 0.0032875 0.8066236 0.00329 ** NA
TMEM117 lapatinib 0.0033057 0.8066236 0.00331 ** NA
ANXA10 erlotinib 0.0033296 0.8499467 0.00333 ** NA
ZNF226 lapatinib 0.0033324 0.8066236 0.00333 ** NA
SPOCK3 lapatinib 0.0033562 0.8066236 0.00336 ** NA
TBC1D23 lapatinib 0.0033587 0.8066236 0.00336 ** NA
IDUA irinotecan 0.0033599 0.8246221 0.00336 ** NA
CDK5RAP1 lapatinib 0.0034196 0.8066236 0.00342 ** NA
BAZ1B irinotecan 0.0034370 0.8246221 0.00344 ** NA
HCRTR1 lapatinib 0.0034651 0.8066236 0.00347 ** NA
HSPD1 selumetinib 0.0034668 0.9529374 0.00347 ** NA
SMG5 selumetinib 0.0034715 0.9529374 0.00347 ** NA
AGO4 erlotinib 0.0034911 0.8499467 0.00349 ** NA
INTS4 irinotecan 0.0034962 0.8246221 0.00350 ** NA
HAL selumetinib 0.0035473 0.9529374 0.00355 ** NA
KATNAL1 selumetinib 0.0035604 0.9529374 0.00356 ** NA
CYP1A1 erlotinib 0.0036235 0.8499467 0.00362 ** NA
FANCF erlotinib 0.0036323 0.8499467 0.00363 ** NA
FREM1 erlotinib 0.0037088 0.8499467 0.00371 ** NA
DICER1 irinotecan 0.0037385 0.8246221 0.00374 ** NA
FLOT2 erlotinib 0.0037527 0.8499467 0.00375 ** NA
CCDC144A nilotinib 0.0037547 0.9993215 0.0038 ** NA
ESRP2 lapatinib 0.0037807 0.8066236 0.00378 ** NA
PPP3CA erlotinib 0.0037903 0.8499467 0.00379 ** NA
PCDH17 lapatinib 0.0038402 0.8066236 0.00384 ** NA
CERS3 lapatinib 0.0038458 0.8066236 0.00385 ** NA
ZNF461 irinotecan 0.0038504 0.8246221 0.00385 ** NA
NMT2 selumetinib 0.0038634 0.9529374 0.00386 ** NA
SHROOM3 irinotecan 0.0039148 0.8246221 0.00391 ** NA
VSIG8 erlotinib 0.0039542 0.8499467 0.00395 ** NA
FAM126B nilotinib 0.0039781 0.9993215 0.0040 ** NA
FRMD6 irinotecan 0.0039810 0.8246221 0.00398 ** NA
MAP2 lapatinib 0.0040094 0.8066236 0.00401 ** NA
CNGB3 selumetinib 0.0040417 0.9529374 0.00404 ** NA
LCP2 lapatinib 0.0040425 0.8066236 0.00404 ** NA
CD6 lapatinib 0.0040439 0.8066236 0.00404 ** NA
COL9A2 irinotecan 0.0040671 0.8246221 0.00407 ** NA
MUS81 irinotecan 0.0040752 0.8246221 0.00408 ** NA
IL16 lapatinib 0.0040892 0.8066236 0.00409 ** NA
COQ3 erlotinib 0.0041012 0.8499467 0.00410 ** NA
MGEA5 erlotinib 0.0041248 0.8499467 0.00412 ** NA
ZNF107 irinotecan 0.0041445 0.8246221 0.00414 ** NA
NUDT13 erlotinib 0.0041462 0.8499467 0.00415 ** NA
ROBO4 selumetinib 0.0041520 0.9529374 0.00415 ** NA
KLHL2 selumetinib 0.0041855 0.9529374 0.00419 ** NA
ZNF473 selumetinib 0.0041885 0.9529374 0.00419 ** NA
HIST1H1D irinotecan 0.0042434 0.8246221 0.00424 ** NA
CDKN2A selumetinib 0.0042499 0.9529374 0.00425 ** NA
DMTN selumetinib 0.0042656 0.9529374 0.00427 ** NA
ADHFE1 lapatinib 0.0042820 0.8066236 0.00428 ** NA
HELLS selumetinib 0.0043297 0.9529374 0.00433 ** NA
QPCTL lapatinib 0.0043378 0.8066236 0.00434 ** NA
USP48 irinotecan 0.0043688 0.8246221 0.00437 ** NA
SECISBP2 irinotecan 0.0043772 0.8246221 0.00438 ** NA
PCDH9 lapatinib 0.0044051 0.8066236 0.00441 ** NA
RHCE irinotecan 0.0044191 0.8246221 0.00442 ** NA
OR8B2 lapatinib 0.0044334 0.8066236 0.00443 ** NA
ARID4B erlotinib 0.0044434 0.8499467 0.00444 ** NA
ANGPTL6 lapatinib 0.0044757 0.8066236 0.00448 ** NA
MEIS1 erlotinib 0.0044837 0.8499467 0.00448 ** NA
SCN3A lapatinib 0.0044837 0.8066236 0.00448 ** NA
FIBP lapatinib 0.0044922 0.8066236 0.00449 ** NA
EYA3 irinotecan 0.0044959 0.8246221 0.00450 ** NA
HIST1H1D erlotinib 0.0044980 0.8499467 0.00450 ** NA
FARP2 selumetinib 0.0044980 0.9529374 0.00450 ** NA
OR51L1 lapatinib 0.0045055 0.8066236 0.00451 ** NA
PEX14 erlotinib 0.0045642 0.8499467 0.00456 ** NA
ARHGAP17 erlotinib 0.0045712 0.8499467 0.00457 ** NA
ACOX2 lapatinib 0.0045799 0.8066236 0.00458 ** NA
QPCTL selumetinib 0.0045992 0.9529374 0.00460 ** NA
CYP2B6 irinotecan 0.0046127 0.8246221 0.00461 ** NA
SULT4A1 lapatinib 0.0046981 0.8066236 0.00470 ** NA
BPIFB1 erlotinib 0.0047001 0.8499467 0.00470 ** NA
PNO1 lapatinib 0.0047293 0.8066236 0.00473 ** NA
FREM1 lapatinib 0.0047570 0.8066236 0.00476 ** NA
ASB15 irinotecan 0.0047887 0.8246221 0.00479 ** NA
SLC2A1 lapatinib 0.0048357 0.8066236 0.00484 ** NA
C2CD4A nilotinib 0.0048492 0.9993215 0.0048 ** NA
SLC16A7 selumetinib 0.0048970 0.9529374 0.00490 ** NA
HNRNPA3 lapatinib 0.0049062 0.8066236 0.00491 ** NA
PNLIPRP1 irinotecan 0.0049122 0.8246221 0.00491 ** NA
VWA8 irinotecan 0.0049243 0.8246221 0.00492 ** NA
XDH lapatinib 0.0049633 0.8066236 0.00496 ** NA
KCNMA1 selumetinib 0.0050099 0.9529374 0.00501 ** NA
SORBS3 selumetinib 0.0050481 0.9529374 0.00505 ** NA
MORF4L1 erlotinib 0.0050571 0.8499467 0.00506 ** NA
IGFBP2 selumetinib 0.0050839 0.9529374 0.00508 ** NA
CUL3 irinotecan 0.0050894 0.8246221 0.00509 ** NA
MCAT erlotinib 0.0051029 0.8499467 0.00510 ** NA
AIDA erlotinib 0.0051188 0.8499467 0.00512 ** NA
AP3M2 irinotecan 0.0051552 0.8246221 0.00516 ** NA
CHURC1 irinotecan 0.0051552 0.8246221 0.00516 ** NA
VWA1 nilotinib 0.0052464 0.9993215 0.0052 ** NA
ACTL8 erlotinib 0.0052644 0.8499467 0.00526 ** NA
TPRN irinotecan 0.0052646 0.8246221 0.00526 ** NA
PPP4R2 nilotinib 0.0052748 0.9993215 0.0053 ** NA
LUZP1 irinotecan 0.0052905 0.8246221 0.00529 ** NA
RP1 irinotecan 0.0052916 0.8246221 0.00529 ** NA
BBS7 lapatinib 0.0052944 0.8066236 0.00529 ** NA
ZNF614 selumetinib 0.0053238 0.9529374 0.00532 ** NA
PDZD3 erlotinib 0.0053256 0.8499467 0.00533 ** NA
WAPAL erlotinib 0.0053379 0.8499467 0.00534 ** NA
NPM3 selumetinib 0.0053447 0.9529374 0.00534 ** NA
DFFA erlotinib 0.0053706 0.8499467 0.00537 ** NA
ERVV-1 lapatinib 0.0053768 0.8066236 0.00538 ** NA
KCNK16 erlotinib 0.0054018 0.8499467 0.00540 ** NA
WDYHV1 erlotinib 0.0054342 0.8499467 0.00543 ** NA
HDAC1 lapatinib 0.0054570 0.8066236 0.00546 ** NA
TMEM117 erlotinib 0.0055783 0.8499467 0.00558 ** NA
LMBRD2 irinotecan 0.0055805 0.8246221 0.00558 ** NA
MIPOL1 erlotinib 0.0055888 0.8499467 0.00559 ** NA
SIX4 lapatinib 0.0055942 0.8066236 0.00559 ** NA
TSKU irinotecan 0.0056000 0.8246221 0.00560 ** NA
SYPL2 lapatinib 0.0056031 0.8066236 0.00560 ** NA
RUNX3 erlotinib 0.0056416 0.8499467 0.00564 ** NA
COL4A3BP lapatinib 0.0056619 0.8066236 0.00566 ** NA
C10orf55 lapatinib 0.0056868 0.8066236 0.00569 ** NA
SLC18A1 lapatinib 0.0056956 0.8066236 0.00570 ** NA
UPF1 selumetinib 0.0057067 0.9529374 0.00571 ** NA
LEMD1 lapatinib 0.0057296 0.8066236 0.00573 ** NA
KCNK7 selumetinib 0.0057569 0.9529374 0.00576 ** NA
PUS7 erlotinib 0.0057590 0.8499467 0.00576 ** NA
VCAN selumetinib 0.0057600 0.9529374 0.00576 ** NA
MYBPC3 lapatinib 0.0057618 0.8066236 0.00576 ** NA
RNMTL1 irinotecan 0.0057630 0.8246221 0.00576 ** NA
PLD3 selumetinib 0.0057946 0.9529374 0.00579 ** NA
FAM20A selumetinib 0.0058527 0.9529374 0.00585 ** NA
FAM135B irinotecan 0.0058751 0.8246221 0.00588 ** NA
POU1F1 irinotecan 0.0059007 0.8246221 0.00590 ** NA
NCKAP5 selumetinib 0.0059016 0.9529374 0.00590 ** NA
ZFYVE9 erlotinib 0.0059654 0.8499467 0.00597 ** NA
PSMA6 lapatinib 0.0059679 0.8066236 0.00597 ** NA
USP8 lapatinib 0.0060086 0.8066236 0.00601 ** NA
CNIH3 erlotinib 0.0060106 0.8499467 0.00601 ** NA
TOX4 erlotinib 0.0060256 0.8499467 0.00603 ** NA
BNIP2 erlotinib 0.0060659 0.8499467 0.00607 ** NA
BBS7 erlotinib 0.0060687 0.8499467 0.00607 ** NA
ZNF705A lapatinib 0.0060746 0.8066236 0.00607 ** NA
CREBZF selumetinib 0.0060769 0.9529374 0.00608 ** NA
ATP12A irinotecan 0.0060801 0.8246221 0.00608 ** NA
FUZ erlotinib 0.0060935 0.8499467 0.00609 ** NA
ESPL1 selumetinib 0.0061625 0.9529374 0.00616 ** NA
ZNF812 lapatinib 0.0061717 0.8066236 0.00617 ** NA
ZSCAN10 nilotinib 0.0061830 0.9993215 0.0062 ** NA
GAL3ST1 selumetinib 0.0061867 0.9529374 0.00619 ** NA
FCN2 erlotinib 0.0062034 0.8499467 0.00620 ** NA
AK4 irinotecan 0.0062043 0.8246221 0.00620 ** NA
TMEM100 lapatinib 0.0062056 0.8066236 0.00621 ** NA
MYBPC3 erlotinib 0.0062363 0.8499467 0.00624 ** NA
AKR1B10 erlotinib 0.0062569 0.8499467 0.00626 ** NA
GIPC3 erlotinib 0.0062802 0.8499467 0.00628 ** NA
SLC7A4 lapatinib 0.0062875 0.8066236 0.00629 ** NA
CUX2 selumetinib 0.0062938 0.9529374 0.00629 ** NA
TRPV2 irinotecan 0.0062967 0.8246221 0.00630 ** NA
CROCC nilotinib 0.0063141 0.9993215 0.0063 ** NA
CCNA1 lapatinib 0.0063613 0.8066236 0.00636 ** NA
NPAS2 selumetinib 0.0063920 0.9529374 0.00639 ** NA
NF2 erlotinib 0.0064062 0.8499467 0.00641 ** NA
TULP1 lapatinib 0.0064768 0.8066236 0.00648 ** NA
PCDHA10 nilotinib 0.0064790 0.9993215 0.0065 ** NA
ELF2 lapatinib 0.0064986 0.8066236 0.00650 ** NA
BUB1 irinotecan 0.0065029 0.8246221 0.00650 ** NA
DSC2 erlotinib 0.0065145 0.8499467 0.00651 ** NA
UBR2 nilotinib 0.0065316 0.9993215 0.0065 ** NA
CRTAC1 lapatinib 0.0065476 0.8066236 0.00655 ** NA
ACADS selumetinib 0.0065964 0.9529374 0.00660 ** NA
ALX4 lapatinib 0.0066202 0.8066236 0.00662 ** NA
SMG9 erlotinib 0.0066552 0.8499467 0.00666 ** NA
FANCF lapatinib 0.0066708 0.8066236 0.00667 ** NA
IL18RAP irinotecan 0.0066862 0.8246221 0.00669 ** NA
PCED1A selumetinib 0.0066987 0.9529374 0.00670 ** NA
DDX27 selumetinib 0.0067073 0.9529374 0.00671 ** NA
VPS37C nilotinib 0.0067406 0.9993215 0.0067 ** NA
DDX49 erlotinib 0.0067444 0.8499467 0.00674 ** NA
AGPAT3 erlotinib 0.0068057 0.8499467 0.00681 ** NA
MS4A8 lapatinib 0.0068101 0.8066236 0.00681 ** NA
WDR6 lapatinib 0.0068206 0.8066236 0.00682 ** NA
LCE2B nilotinib 0.0068310 0.9993215 0.0068 ** NA
PC lapatinib 0.0068372 0.8066236 0.00684 ** NA
CHAD erlotinib 0.0068391 0.8499467 0.00684 ** NA
DENND1B lapatinib 0.0068862 0.8066236 0.00689 ** NA
ASB15 erlotinib 0.0069235 0.8499467 0.00692 ** NA
CMA1 lapatinib 0.0069235 0.8066236 0.00692 ** NA
GMPS irinotecan 0.0069248 0.8246221 0.00692 ** NA
ROPN1L selumetinib 0.0069351 0.9529374 0.00694 ** NA
ANO3 lapatinib 0.0069452 0.8066236 0.00695 ** NA
OR6C65 irinotecan 0.0069823 0.8246221 0.00698 ** NA
PRR14 lapatinib 0.0070451 0.8066236 0.00705 ** NA
IK erlotinib 0.0070506 0.8499467 0.00705 ** NA
OR5T2 selumetinib 0.0070658 0.9529374 0.00707 ** NA
TAS2R41 nilotinib 0.0070946 0.9993215 0.0071 ** NA
RXFP2 erlotinib 0.0070967 0.8499467 0.00710 ** NA
TIGD2 irinotecan 0.0070969 0.8246221 0.00710 ** NA
CDK5R1 erlotinib 0.0071148 0.8499467 0.00711 ** NA
R3HDML lapatinib 0.0071148 0.8066236 0.00711 ** NA
MIB2 nilotinib 0.0071278 0.9993215 0.0071 ** NA
TCP1 lapatinib 0.0071350 0.8066236 0.00713 ** NA
RPS6KA2 nilotinib 0.0071558 0.9993215 0.0072 ** NA
PYGO1 lapatinib 0.0071848 0.8066236 0.00718 ** NA
ZNF444 lapatinib 0.0071848 0.8066236 0.00718 ** NA
AXDND1 irinotecan 0.0072029 0.8246221 0.00720 ** NA
CIRH1A nilotinib 0.0072063 0.9993215 0.0072 ** NA
TMX2 lapatinib 0.0072167 0.8066236 0.00722 ** NA
FAM63B nilotinib 0.0072215 0.9993215 0.0072 ** NA
CHD8 lapatinib 0.0072461 0.8066236 0.00725 ** NA
SH3GL1 irinotecan 0.0072694 0.8246221 0.00727 ** NA
HPS1 erlotinib 0.0073004 0.8499467 0.00730 ** NA
PCDHAC1 selumetinib 0.0073021 0.9529374 0.00730 ** NA
MCHR1 selumetinib 0.0073210 0.9529374 0.00732 ** NA
HIST1H1D nilotinib 0.0073222 0.9993215 0.0073 ** NA
NME8 irinotecan 0.0073559 0.8246221 0.00736 ** NA
A4GNT lapatinib 0.0073592 0.8066236 0.00736 ** NA
MECR erlotinib 0.0073739 0.8499467 0.00737 ** NA
SLC12A1 selumetinib 0.0073922 0.9529374 0.00739 ** NA
RASL11B erlotinib 0.0073936 0.8499467 0.00739 ** NA
VAV1 selumetinib 0.0074105 0.9529374 0.00741 ** NA
AKAP6 lapatinib 0.0074258 0.8066236 0.00743 ** NA
ZNF85 erlotinib 0.0074381 0.8499467 0.00744 ** NA
JAK1 irinotecan 0.0074451 0.8246221 0.00745 ** NA
PNO1 erlotinib 0.0074703 0.8499467 0.00747 ** NA
SEPSECS erlotinib 0.0074703 0.8499467 0.00747 ** NA
TBC1D30 lapatinib 0.0074748 0.8066236 0.00747 ** NA
PALLD selumetinib 0.0074748 0.9529374 0.00747 ** NA
C19orf47 selumetinib 0.0074838 0.9529374 0.00748 ** NA
PIGV irinotecan 0.0075085 0.8246221 0.00751 ** NA
CHRNA6 irinotecan 0.0075700 0.8246221 0.00757 ** NA
KLHL20 lapatinib 0.0075859 0.8066236 0.00759 ** NA
ATP13A5 selumetinib 0.0075926 0.9529374 0.00759 ** NA
GYPE lapatinib 0.0075933 0.8066236 0.00759 ** NA
NOL7 erlotinib 0.0076297 0.8499467 0.00763 ** NA
FOLR1 irinotecan 0.0076355 0.8246221 0.00764 ** NA
STX7 erlotinib 0.0076414 0.8499467 0.00764 ** NA
WBP11 irinotecan 0.0076943 0.8246221 0.00769 ** NA
SETD1A lapatinib 0.0077204 0.8066236 0.00772 ** NA
GHR selumetinib 0.0077319 0.9529374 0.00773 ** NA
PDCD6IP irinotecan 0.0077536 0.8246221 0.00775 ** NA
ZC2HC1A irinotecan 0.0077559 0.8246221 0.00776 ** NA
LHX5 erlotinib 0.0077696 0.8499467 0.00777 ** NA
ZSWIM1 lapatinib 0.0077696 0.8066236 0.00777 ** NA
SEMA5A lapatinib 0.0077944 0.8066236 0.00779 ** NA
SLC16A8 lapatinib 0.0078053 0.8066236 0.00781 ** NA
RGS20 erlotinib 0.0078504 0.8499467 0.00785 ** NA
UGT2B4 nilotinib 0.0078922 0.9993215 0.0079 ** NA
ANKS3 lapatinib 0.0078951 0.8066236 0.00790 ** NA
DNAJC8 nilotinib 0.0079155 0.9993215 0.0079 ** NA
UVRAG selumetinib 0.0079192 0.9529374 0.00792 ** NA
AKR1B10 lapatinib 0.0079255 0.8066236 0.00793 ** NA
FAM43A erlotinib 0.0079336 0.8499467 0.00793 ** NA
EPB41L5 erlotinib 0.0079422 0.8499467 0.00794 ** NA
ZNF160 lapatinib 0.0079771 0.8066236 0.00798 ** NA
ZMYM4 irinotecan 0.0079954 0.8246221 0.00800 ** NA
OR4K15 erlotinib 0.0080004 0.8499467 0.00800 ** NA
TRIM32 lapatinib 0.0080008 0.8066236 0.00800 ** NA
TLE3 lapatinib 0.0080073 0.8066236 0.00801 ** NA
PSMD2 lapatinib 0.0080171 0.8066236 0.00802 ** NA
LCP2 nilotinib 0.0080735 0.9993215 0.0081 ** NA
MLF2 erlotinib 0.0081067 0.8499467 0.00811 ** NA
FTSJ2 selumetinib 0.0081102 0.9529374 0.00811 ** NA
BARD1 erlotinib 0.0081120 0.8499467 0.00811 ** NA
CLDN8 lapatinib 0.0081241 0.8066236 0.00812 ** NA
RARS irinotecan 0.0081466 0.8246221 0.00815 ** NA
SIKE1 selumetinib 0.0081585 0.9529374 0.00816 ** NA
EEF2 selumetinib 0.0081729 0.9529374 0.00817 ** NA
ANKRD36 erlotinib 0.0081879 0.8499467 0.00819 ** NA
KCNQ1 erlotinib 0.0081884 0.8499467 0.00819 ** NA
SLC22A1 lapatinib 0.0082008 0.8066236 0.00820 ** NA
TAS2R5 irinotecan 0.0082033 0.8246221 0.00820 ** NA
ZNF823 irinotecan 0.0082307 0.8246221 0.00823 ** NA
TM9SF1 lapatinib 0.0082445 0.8066236 0.00824 ** NA
EFTUD1 irinotecan 0.0083442 0.8246221 0.00834 ** NA
TAOK1 irinotecan 0.0083660 0.8246221 0.00837 ** NA
NPY4R lapatinib 0.0084017 0.8066236 0.00840 ** NA
HDAC1 erlotinib 0.0084020 0.8499467 0.00840 ** NA
MIPOL1 selumetinib 0.0084204 0.9529374 0.00842 ** NA
COLEC11 nilotinib 0.0084280 0.9993215 0.0084 ** NA
MSMB selumetinib 0.0084504 0.9529374 0.00845 ** NA
ZNF317 lapatinib 0.0084512 0.8066236 0.00845 ** NA
TNKS1BP1 selumetinib 0.0084564 0.9529374 0.00846 ** NA
NEDD1 selumetinib 0.0084616 0.9529374 0.00846 ** NA
P2RY13 lapatinib 0.0084734 0.8066236 0.00847 ** NA
MRE11A irinotecan 0.0084883 0.8246221 0.00849 ** NA
MCM7 lapatinib 0.0085153 0.8066236 0.00852 ** NA
LCK erlotinib 0.0085223 0.8499467 0.00852 ** NA
SLC41A1 lapatinib 0.0085424 0.8066236 0.00854 ** NA
COLEC11 lapatinib 0.0085507 0.8066236 0.00855 ** NA
SLC36A3 erlotinib 0.0085524 0.8499467 0.00855 ** NA
SLC30A10 irinotecan 0.0086106 0.8246221 0.00861 ** NA
LRRC63 erlotinib 0.0086164 0.8499467 0.00862 ** NA
MLF2 lapatinib 0.0086793 0.8066236 0.00868 ** NA
ARHGAP29 nilotinib 0.0086939 0.9993215 0.0087 ** NA
DDX49 lapatinib 0.0087551 0.8066236 0.00876 ** NA
LRIF1 irinotecan 0.0087695 0.8246221 0.00877 ** NA
AP2A2 lapatinib 0.0087805 0.8066236 0.00878 ** NA
SERPINI1 irinotecan 0.0087947 0.8246221 0.00879 ** NA
SLC35E4 nilotinib 0.0087978 0.9993215 0.0088 ** NA
TOPORS erlotinib 0.0088286 0.8499467 0.00883 ** NA
ARID1B irinotecan 0.0088525 0.8246221 0.00885 ** NA
CALM3 selumetinib 0.0088548 0.9529374 0.00885 ** NA
TTC7B selumetinib 0.0088770 0.9529374 0.00888 ** NA
HCN2 erlotinib 0.0088904 0.8499467 0.00889 ** NA
ECI1 erlotinib 0.0088912 0.8499467 0.00889 ** NA
PHIP irinotecan 0.0089033 0.8246221 0.00890 ** NA
HHIPL2 erlotinib 0.0089162 0.8499467 0.00892 ** NA
SLU7 erlotinib 0.0089304 0.8499467 0.00893 ** NA
EXOC3L4 irinotecan 0.0089469 0.8246221 0.00895 ** NA
TUBA3C irinotecan 0.0089469 0.8246221 0.00895 ** NA
HS2ST1 nilotinib 0.0089560 0.9993215 0.0090 ** NA
GPR132 lapatinib 0.0089586 0.8066236 0.00896 ** NA
ENTPD8 irinotecan 0.0089671 0.8246221 0.00897 ** NA
NOTCH4 lapatinib 0.0090027 0.8066236 0.00900 ** NA
VAMP4 irinotecan 0.0090327 0.8246221 0.00903 ** NA
FBXW7 irinotecan 0.0090628 0.8246221 0.00906 ** NA
ARHGAP15 lapatinib 0.0090656 0.8066236 0.00907 ** NA
ATP5SL lapatinib 0.0090932 0.8066236 0.00909 ** NA
TGM7 selumetinib 0.0091052 0.9529374 0.00911 ** NA
GPALPP1 selumetinib 0.0091178 0.9529374 0.00912 ** NA
KIAA1919 irinotecan 0.0091606 0.8246221 0.00916 ** NA
PTAFR irinotecan 0.0091869 0.8246221 0.00919 ** NA
MTHFD2L irinotecan 0.0092013 0.8246221 0.00920 ** NA
PARD6B irinotecan 0.0092013 0.8246221 0.00920 ** NA
TPCN1 irinotecan 0.0092013 0.8246221 0.00920 ** NA
ZWILCH irinotecan 0.0092317 0.8246221 0.00923 ** NA
PTPN4 erlotinib 0.0092336 0.8499467 0.00923 ** NA
BSN irinotecan 0.0092519 0.8246221 0.00925 ** NA
OR2C1 erlotinib 0.0092524 0.8499467 0.00925 ** NA
VSX1 erlotinib 0.0092524 0.8499467 0.00925 ** NA
SEPT5 erlotinib 0.0092602 0.8499467 0.00926 ** NA
IRF2BP1 lapatinib 0.0092659 0.8066236 0.00927 ** NA
FAM155A irinotecan 0.0092866 0.8246221 0.00929 ** NA
WFDC3 nilotinib 0.0092868 0.9993215 0.0093 ** NA
VEZT erlotinib 0.0093021 0.8499467 0.00930 ** NA
CIR1 irinotecan 0.0093192 0.8246221 0.00932 ** NA
IL12RB2 selumetinib 0.0093355 0.9529374 0.00934 ** NA
ZNF444 erlotinib 0.0093441 0.8499467 0.00934 ** NA
KDM4E erlotinib 0.0093742 0.8499467 0.00937 ** NA
ABLIM2 lapatinib 0.0093826 0.8066236 0.00938 ** NA
OSBPL5 lapatinib 0.0093931 0.8066236 0.00939 ** NA
SLC5A6 erlotinib 0.0093984 0.8499467 0.00940 ** NA
TLE2 selumetinib 0.0094071 0.9529374 0.00941 ** NA
RUFY2 irinotecan 0.0094102 0.8246221 0.00941 ** NA
IQCA1 lapatinib 0.0094360 0.8066236 0.00944 ** NA
CADPS irinotecan 0.0094473 0.8246221 0.00945 ** NA
PMFBP1 lapatinib 0.0094664 0.8066236 0.00947 ** NA
C11orf49 erlotinib 0.0094872 0.8499467 0.00949 ** NA
ARL14EP lapatinib 0.0095009 0.8066236 0.00950 ** NA
ALX1 selumetinib 0.0095130 0.9529374 0.00951 ** NA
STXBP1 selumetinib 0.0095178 0.9529374 0.00952 ** NA
THRAP3 nilotinib 0.0095338 0.9993215 0.0095 ** NA
FBXL3 erlotinib 0.0095358 0.8499467 0.00954 ** NA
ELF3 lapatinib 0.0095609 0.8066236 0.00956 ** NA
C15orf41 erlotinib 0.0095770 0.8499467 0.00958 ** NA
GPR32 lapatinib 0.0095946 0.8066236 0.00959 ** NA
DNAJC27 nilotinib 0.0096506 0.9993215 0.0097 ** NA
PTK6 nilotinib 0.0096792 0.9993215 0.0097 ** NA
FAM170B lapatinib 0.0096798 0.8066236 0.00968 ** NA
SLCO5A1 irinotecan 0.0097204 0.8246221 0.00972 ** NA
C9orf64 irinotecan 0.0097239 0.8246221 0.00972 ** NA
ZNF100 irinotecan 0.0097611 0.8246221 0.00976 ** NA
APOBEC4 lapatinib 0.0097770 0.8066236 0.00978 ** NA
C1QTNF9 lapatinib 0.0097882 0.8066236 0.00979 ** NA
C1QTNF9B lapatinib 0.0098602 0.8066236 0.00986 ** NA
MATN1 lapatinib 0.0098602 0.8066236 0.00986 ** NA
EIF4E lapatinib 0.0098752 0.8066236 0.00988 ** NA
FBP1 irinotecan 0.0099039 0.8246221 0.00990 ** NA
TSPAN18 erlotinib 0.0099204 0.8499467 0.00992 ** NA
UNK selumetinib 0.0099205 0.9529374 0.00992 ** NA
LSM11 selumetinib 0.0099298 0.9529374 0.00993 ** NA
FNDC8 selumetinib 0.0099544 0.9529374 0.00995 ** NA
PRPF8 selumetinib 0.0099673 0.9529374 0.00997 ** NA
C16orf96 erlotinib 0.0100021 0.8499467 0.01000
NA
KIRREL2 lapatinib 0.0100311 0.8066236 0.01003
NA
GRM6 lapatinib 0.0100372 0.8066236 0.01004
NA
PACS1 selumetinib 0.0100379 0.9529374 0.01004
NA
MDGA2 lapatinib 0.0100642 0.8066236 0.01006
NA
PTPN5 lapatinib 0.0100833 0.8066236 0.01008
NA
TEX101 irinotecan 0.0100869 0.8246221 0.01009
NA
RIMS2 lapatinib 0.0101096 0.8066236 0.01011
NA
SLC16A14 selumetinib 0.0101231 0.9529374 0.01012
NA
TMEM30B erlotinib 0.0101259 0.8499467 0.01013
NA
MED21 erlotinib 0.0101297 0.8499467 0.01013
NA
SIKE1 erlotinib 0.0101297 0.8499467 0.01013
NA
DIAPH3 irinotecan 0.0101333 0.8246221 0.01013
NA
PLCL2 selumetinib 0.0101361 0.9529374 0.01014
NA
EEA1 nilotinib 0.0101538 0.9993215 0.0102
NA
NAA15 lapatinib 0.0101661 0.8066236 0.01017
NA
CDC14B irinotecan 0.0101754 0.8246221 0.01018
NA
NTPCR irinotecan 0.0101754 0.8246221 0.01018
NA
CXXC5 lapatinib 0.0101905 0.8066236 0.01019
NA
P4HA2 lapatinib 0.0101934 0.8066236 0.01019
NA
CYP4Z1 irinotecan 0.0101983 0.8246221 0.01020
NA
ZC3H11A irinotecan 0.0102131 0.8246221 0.01021
NA
HJURP erlotinib 0.0102419 0.8499467 0.01024
NA
NCL erlotinib 0.0102569 0.8499467 0.01026
NA
FBXL4 irinotecan 0.0102704 0.8246221 0.01027
NA
NPHS2 irinotecan 0.0102704 0.8246221 0.01027
NA
TJAP1 irinotecan 0.0102704 0.8246221 0.01027
NA
ZNF423 erlotinib 0.0102896 0.8499467 0.01029
NA
CHST11 erlotinib 0.0103178 0.8499467 0.01032
NA
PPP1R14A lapatinib 0.0103238 0.8066236 0.01032
NA
C14orf2 lapatinib 0.0103264 0.8066236 0.01033
NA
WWP2 lapatinib 0.0103793 0.8066236 0.01038
NA
ZNF473 erlotinib 0.0103970 0.8499467 0.01040
NA
PRDM15 irinotecan 0.0104000 0.8246221 0.01040
NA
LRRIQ1 irinotecan 0.0104193 0.8246221 0.01042
NA
DPP10 selumetinib 0.0104311 0.9529374 0.01043
NA
PBX1 irinotecan 0.0104362 0.8246221 0.01044
NA
LYVE1 selumetinib 0.0104373 0.9529374 0.01044
NA
CDK5R1 lapatinib 0.0104428 0.8066236 0.01044
NA
LRRC4B lapatinib 0.0104574 0.8066236 0.01046
NA
MFSD9 selumetinib 0.0104733 0.9529374 0.01047
NA
PER1 lapatinib 0.0104995 0.8066236 0.01050
NA
IHH erlotinib 0.0105015 0.8499467 0.01050
NA
KATNAL1 erlotinib 0.0105034 0.8499467 0.01050
NA
RAI1 irinotecan 0.0105253 0.8246221 0.01053
NA
SLC22A2 erlotinib 0.0105268 0.8499467 0.01053
NA
MRGPRX1 selumetinib 0.0105279 0.9529374 0.01053
NA
DDRGK1 nilotinib 0.0105448 0.9993215 0.0105
NA
NALCN lapatinib 0.0105860 0.8066236 0.01059
NA
THRAP3 erlotinib 0.0105866 0.8499467 0.01059
NA
SYVN1 irinotecan 0.0106002 0.8246221 0.01060
NA
PAX8 nilotinib 0.0106011 0.9993215 0.0106
NA
EHMT1 lapatinib 0.0106267 0.8066236 0.01063
NA
FECH erlotinib 0.0106280 0.8499467 0.01063
NA
PLEC irinotecan 0.0106310 0.8246221 0.01063
NA
LIPM selumetinib 0.0106324 0.9529374 0.01063
NA
SHC1 selumetinib 0.0106324 0.9529374 0.01063
NA
GSDMC selumetinib 0.0106467 0.9529374 0.01065
NA
CLEC6A irinotecan 0.0106539 0.8246221 0.01065
NA
GCM1 selumetinib 0.0106677 0.9529374 0.01067
NA
FRZB erlotinib 0.0106753 0.8499467 0.01068
NA
CYP27B1 irinotecan 0.0107095 0.8246221 0.01071
NA
HSP90AB1 lapatinib 0.0107152 0.8066236 0.01072
NA
HLA-C selumetinib 0.0107160 0.9529374 0.01072
NA
NIPBL irinotecan 0.0107665 0.8246221 0.01077
NA
PPAP2B erlotinib 0.0107808 0.8499467 0.01078
NA
KRAS irinotecan 0.0107870 0.8246221 0.01079
NA
TMPRSS9 irinotecan 0.0107902 0.8246221 0.01079
NA
ZNF430 selumetinib 0.0108018 0.9529374 0.01080
NA
WDR43 nilotinib 0.0108020 0.9993215 0.0108
NA
TGFBR1 erlotinib 0.0108184 0.8499467 0.01082
NA
CACYBP selumetinib 0.0108391 0.9529374 0.01084
NA
COMMD3 selumetinib 0.0108391 0.9529374 0.01084
NA
RBFOX2 erlotinib 0.0108516 0.8499467 0.01085
NA
PGK2 lapatinib 0.0108565 0.8066236 0.01086
NA
BMP2 selumetinib 0.0108566 0.9529374 0.01086
NA
CDK5RAP1 nilotinib 0.0109571 0.9993215 0.0110
NA
ALG11 erlotinib 0.0109633 0.8499467 0.01096
NA
C2CD4A lapatinib 0.0110089 0.8066236 0.01101
NA
NFATC4 nilotinib 0.0110135 0.9993215 0.0110
NA
PDLIM5 lapatinib 0.0110141 0.8066236 0.01101
NA
ADAM9 selumetinib 0.0110361 0.9529374 0.01104
NA
SPRR1A lapatinib 0.0110558 0.8066236 0.01106
NA
AVPR1B irinotecan 0.0110629 0.8246221 0.01106
NA
RIC8B erlotinib 0.0110847 0.8499467 0.01108
NA
OR6N2 lapatinib 0.0111010 0.8066236 0.01110
NA
ZNF117 selumetinib 0.0111208 0.9529374 0.01112
NA
CHCHD6 lapatinib 0.0111474 0.8066236 0.01115
NA
ASXL1 selumetinib 0.0111516 0.9529374 0.01115
NA
RRP12 irinotecan 0.0111562 0.8246221 0.01116
NA
ANKHD1 erlotinib 0.0111753 0.8499467 0.01118
NA
ANKRD36 lapatinib 0.0111890 0.8066236 0.01119
NA
KCNT2 irinotecan 0.0112552 0.8246221 0.01126
NA
HCFC2 nilotinib 0.0112632 0.9993215 0.0113
NA
TBX3 irinotecan 0.0113399 0.8246221 0.01134
NA
SULT4A1 erlotinib 0.0113683 0.8499467 0.01137
NA
DLG1 irinotecan 0.0114031 0.8246221 0.01140
NA
CLSTN3 selumetinib 0.0114122 0.9529374 0.01141
NA
CREB3L1 irinotecan 0.0114124 0.8246221 0.01141
NA
MAP4K3 irinotecan 0.0114208 0.8246221 0.01142
NA
ACTL8 lapatinib 0.0114490 0.8066236 0.01145
NA
ARMC6 lapatinib 0.0114611 0.8066236 0.01146
NA
WDR78 irinotecan 0.0114630 0.8246221 0.01146
NA
CCDC64 irinotecan 0.0114662 0.8246221 0.01147
NA
PPP1R14A erlotinib 0.0114693 0.8499467 0.01147
NA
KRT18 lapatinib 0.0114823 0.8066236 0.01148
NA
ITGA1 nilotinib 0.0114830 0.9993215 0.0115
NA
NOB1 irinotecan 0.0115086 0.8246221 0.01151
NA
TDRKH erlotinib 0.0115491 0.8499467 0.01155
NA
RASL10A lapatinib 0.0115693 0.8066236 0.01157
NA
HCLS1 irinotecan 0.0115698 0.8246221 0.01157
NA
BTBD7 erlotinib 0.0115756 0.8499467 0.01158
NA
SIGLEC10 lapatinib 0.0115927 0.8066236 0.01159
NA
EML5 irinotecan 0.0115964 0.8246221 0.01160
NA
STK32C erlotinib 0.0116002 0.8499467 0.01160
NA
PPP4R2 lapatinib 0.0116264 0.8066236 0.01163
NA
GALM erlotinib 0.0116311 0.8499467 0.01163
NA
IL1R1 selumetinib 0.0116316 0.9529374 0.01163
NA
KRT39 nilotinib 0.0116342 0.9993215 0.0116
NA
DUSP4 irinotecan 0.0116622 0.8246221 0.01166
NA
FAM43A selumetinib 0.0116715 0.9529374 0.01167
NA
HOXA2 lapatinib 0.0116726 0.8066236 0.01167
NA
IRX4 lapatinib 0.0117017 0.8066236 0.01170
NA
OR2A2 selumetinib 0.0117184 0.9529374 0.01172
NA
SPRR1A erlotinib 0.0117323 0.8499467 0.01173
NA
KCNQ2 erlotinib 0.0117367 0.8499467 0.01174
NA
THBS1 selumetinib 0.0117495 0.9529374 0.01175
NA
ADAM2 erlotinib 0.0117573 0.8499467 0.01176
NA
PKP4 irinotecan 0.0117676 0.8246221 0.01177
NA
SLC1A1 nilotinib 0.0117781 0.9993215 0.0118
NA
DHRS11 selumetinib 0.0117803 0.9529374 0.01178
NA
PIK3C3 selumetinib 0.0117982 0.9529374 0.01180
NA
TEAD3 lapatinib 0.0117983 0.8066236 0.01180
NA
PGAM2 selumetinib 0.0118036 0.9529374 0.01180
NA
ZNF615 selumetinib 0.0118059 0.9529374 0.01181
NA
LCT lapatinib 0.0118227 0.8066236 0.01182
NA
KIAA1467 lapatinib 0.0118403 0.8066236 0.01184
NA
ADAMTS12 irinotecan 0.0118405 0.8246221 0.01184
NA
PPP1R7 erlotinib 0.0118616 0.8499467 0.01186
NA
THOP1 irinotecan 0.0118674 0.8246221 0.01187
NA
DNM1 irinotecan 0.0118738 0.8246221 0.01187
NA
C16orf58 lapatinib 0.0118772 0.8066236 0.01188
NA
OSBPL8 irinotecan 0.0118793 0.8246221 0.01188
NA
RPS9 nilotinib 0.0119195 0.9993215 0.0119
NA
CD2 lapatinib 0.0119204 0.8066236 0.01192
NA
GCAT erlotinib 0.0119214 0.8499467 0.01192
NA
CNTN6 selumetinib 0.0119606 0.9529374 0.01196
NA
PIK3CG lapatinib 0.0119750 0.8066236 0.01198
NA
TSTA3 nilotinib 0.0119869 0.9993215 0.0120
NA
VSX1 lapatinib 0.0120312 0.8066236 0.01203
NA
SSFA2 lapatinib 0.0120699 0.8066236 0.01207
NA
PRDM5 erlotinib 0.0120942 0.8499467 0.01209
NA
SAR1B erlotinib 0.0121368 0.8499467 0.01214
NA
FUZ lapatinib 0.0121368 0.8066236 0.01214
NA
PRX lapatinib 0.0121584 0.8066236 0.01216
NA
ZMYM6 irinotecan 0.0121810 0.8246221 0.01218
NA
TTYH1 selumetinib 0.0122006 0.9529374 0.01220
NA
KEAP1 lapatinib 0.0122014 0.8066236 0.01220
NA
ANKRD36 selumetinib 0.0122099 0.9529374 0.01221
NA
NEURL2 erlotinib 0.0122149 0.8499467 0.01221
NA
LRRTM4 lapatinib 0.0122265 0.8066236 0.01223
NA
TRIP11 irinotecan 0.0122320 0.8246221 0.01223
NA
FAM109B lapatinib 0.0122402 0.8066236 0.01224
NA
B3GNT6 irinotecan 0.0122620 0.8246221 0.01226
NA
INSM1 nilotinib 0.0122810 0.9993215 0.0123
NA
HOXB7 selumetinib 0.0123136 0.9529374 0.01231
NA
WDR72 lapatinib 0.0123221 0.8066236 0.01232
NA
CACNB2 irinotecan 0.0123728 0.8246221 0.01237
NA
FNDC9 lapatinib 0.0123883 0.8066236 0.01239
NA
KRT16 lapatinib 0.0124363 0.8066236 0.01244
NA
SOX12 erlotinib 0.0124556 0.8499467 0.01246
NA
PEX5L nilotinib 0.0124777 0.9993215 0.0125
NA
OR5AP2 nilotinib 0.0124779 0.9993215 0.0125
NA
GNAI1 selumetinib 0.0125135 0.9529374 0.01251
NA
OR9G1 nilotinib 0.0125240 0.9993215 0.0125
NA
SDE2 selumetinib 0.0125667 0.9529374 0.01257
NA
WDR77 erlotinib 0.0125776 0.8499467 0.01258
NA
ZNF862 irinotecan 0.0125860 0.8246221 0.01259
NA
RECQL lapatinib 0.0126144 0.8066236 0.01261
NA
FAM90A1 erlotinib 0.0126148 0.8499467 0.01261
NA
TAMM41 irinotecan 0.0126412 0.8246221 0.01264
NA
TMEM100 erlotinib 0.0126412 0.8499467 0.01264
NA
CNIH3 lapatinib 0.0126593 0.8066236 0.01266
NA
HEXB lapatinib 0.0126593 0.8066236 0.01266
NA
MMP19 selumetinib 0.0127185 0.9529374 0.01272
NA
SRSF4 erlotinib 0.0127391 0.8499467 0.01274
NA
SPATC1L erlotinib 0.0127396 0.8499467 0.01274
NA
OR6Q1 irinotecan 0.0127543 0.8246221 0.01275
NA
ZNF705A erlotinib 0.0127667 0.8499467 0.01277
NA
KCNK13 irinotecan 0.0127840 0.8246221 0.01278
NA
HSP90AB1 erlotinib 0.0128173 0.8499467 0.01282
NA
ATG5 erlotinib 0.0128246 0.8499467 0.01282
NA
NME6 lapatinib 0.0128368 0.8066236 0.01284
NA
TTC4 erlotinib 0.0128384 0.8499467 0.01284
NA
RASL10B lapatinib 0.0128790 0.8066236 0.01288
NA
TMEM30B lapatinib 0.0128790 0.8066236 0.01288
NA
C16orf46 lapatinib 0.0128933 0.8066236 0.01289
NA
TRIM5 lapatinib 0.0129052 0.8066236 0.01291
NA
RLF irinotecan 0.0129398 0.8246221 0.01294
NA
C9orf9 lapatinib 0.0129457 0.8066236 0.01295
NA
CLP1 erlotinib 0.0129497 0.8499467 0.01295
NA
ZNF169 nilotinib 0.0129533 0.9993215 0.0130
NA
VPS51 selumetinib 0.0129669 0.9529374 0.01297
NA
ERBB3 lapatinib 0.0129696 0.8066236 0.01297
NA
PEX16 irinotecan 0.0129828 0.8246221 0.01298
NA
MRAP lapatinib 0.0130300 0.8066236 0.01303
NA
TDRD9 irinotecan 0.0130444 0.8246221 0.01304
NA
SEZ6L lapatinib 0.0130519 0.8066236 0.01305
NA
ADAM28 selumetinib 0.0130688 0.9529374 0.01307
NA
ELF2 erlotinib 0.0130759 0.8499467 0.01308
NA
TMEM194A selumetinib 0.0130782 0.9529374 0.01308
NA
GXYLT1 selumetinib 0.0130812 0.9529374 0.01308
NA
ZNF586 nilotinib 0.0130869 0.9993215 0.0131
NA
MAS1L lapatinib 0.0130910 0.8066236 0.01309
NA
MECR lapatinib 0.0130910 0.8066236 0.01309
NA
PITPNM2 lapatinib 0.0131196 0.8066236 0.01312
NA
LRRC63 lapatinib 0.0131290 0.8066236 0.01313
NA
RNPS1 lapatinib 0.0131290 0.8066236 0.01313
NA
WNT16 lapatinib 0.0131501 0.8066236 0.01315
NA
RSBN1 irinotecan 0.0131770 0.8246221 0.01318
NA
PLA2G4D erlotinib 0.0131927 0.8499467 0.01319
NA
NLRP12 erlotinib 0.0132001 0.8499467 0.01320
NA
SIRPB2 selumetinib 0.0132083 0.9529374 0.01321
NA
ZCCHC9 irinotecan 0.0132159 0.8246221 0.01322
NA
ELL2 lapatinib 0.0132165 0.8066236 0.01322
NA
CNTLN lapatinib 0.0132355 0.8066236 0.01324
NA
DEF6 selumetinib 0.0132814 0.9529374 0.01328
NA
BRICD5 selumetinib 0.0132987 0.9529374 0.01330
NA
TYSND1 lapatinib 0.0133153 0.8066236 0.01332
NA
FLT3 irinotecan 0.0133264 0.8246221 0.01333
NA
KIAA0020 selumetinib 0.0133363 0.9529374 0.01334
NA
TRPA1 irinotecan 0.0133784 0.8246221 0.01338
NA
WNT3 selumetinib 0.0133915 0.9529374 0.01339
NA
HIST1H2BM erlotinib 0.0134253 0.8499467 0.01343
NA
TIMP2 erlotinib 0.0134253 0.8499467 0.01343
NA
EIF2D selumetinib 0.0134257 0.9529374 0.01343
NA
COMMD5 selumetinib 0.0134305 0.9529374 0.01343
NA
NUDT12 lapatinib 0.0134392 0.8066236 0.01344
NA
RTN2 nilotinib 0.0134491 0.9993215 0.0134
NA
DERA erlotinib 0.0134610 0.8499467 0.01346
NA
VPS13A irinotecan 0.0134695 0.8246221 0.01347
NA
TTC30B lapatinib 0.0134923 0.8066236 0.01349
NA
LHX5 lapatinib 0.0135007 0.8066236 0.01350
NA
GPR37L1 erlotinib 0.0135356 0.8499467 0.01354
NA
CLEC7A lapatinib 0.0135480 0.8066236 0.01355
NA
CRIM1 lapatinib 0.0135501 0.8066236 0.01355
NA
TACC2 lapatinib 0.0135525 0.8066236 0.01355
NA
CYP4A11 lapatinib 0.0135766 0.8066236 0.01358
NA
KATNAL2 selumetinib 0.0136110 0.9529374 0.01361
NA
ACTL7B lapatinib 0.0136111 0.8066236 0.01361
NA
ZHX3 selumetinib 0.0136323 0.9529374 0.01363
NA
PHLDB2 lapatinib 0.0136456 0.8066236 0.01365
NA
NBN erlotinib 0.0136799 0.8499467 0.01368
NA
HIST1H1A selumetinib 0.0136807 0.9529374 0.01368
NA
MPND irinotecan 0.0136922 0.8246221 0.01369
NA
CD300E lapatinib 0.0137066 0.8066236 0.01371
NA
TTN irinotecan 0.0137217 0.8246221 0.01372
NA
CEP135 irinotecan 0.0137235 0.8246221 0.01372
NA
RAPGEFL1 erlotinib 0.0137328 0.8499467 0.01373
NA
FAM13A erlotinib 0.0137684 0.8499467 0.01377
NA
CDH1 selumetinib 0.0137714 0.9529374 0.01377
NA
CA1 lapatinib 0.0137792 0.8066236 0.01378
NA
PTPN12 selumetinib 0.0137799 0.9529374 0.01378
NA
TTPAL irinotecan 0.0138057 0.8246221 0.01381
NA
TRAF3IP2 selumetinib 0.0138221 0.9529374 0.01382
NA
PARD6G erlotinib 0.0138977 0.8499467 0.01390
NA
PNKP irinotecan 0.0139155 0.8246221 0.01392
NA
MRPL52 irinotecan 0.0139359 0.8246221 0.01394
NA
OR10G3 lapatinib 0.0139729 0.8066236 0.01397
NA
RREB1 lapatinib 0.0139889 0.8066236 0.01399
NA
ASXL1 lapatinib 0.0139893 0.8066236 0.01399
NA
GMPR lapatinib 0.0139937 0.8066236 0.01399
NA
HJURP lapatinib 0.0140138 0.8066236 0.01401
NA
XRN1 selumetinib 0.0140306 0.9529374 0.01403
NA
RAX selumetinib 0.0140412 0.9529374 0.01404
NA
SERINC4 irinotecan 0.0140484 0.8246221 0.01405
NA
SIPA1L1 erlotinib 0.0140664 0.8499467 0.01407
NA
ZACN erlotinib 0.0140814 0.8499467 0.01408
NA
NPM3 erlotinib 0.0141252 0.8499467 0.01413
NA
EPB41 selumetinib 0.0141326 0.9529374 0.01413
NA
MAP3K12 erlotinib 0.0141606 0.8499467 0.01416
NA
NRXN1 selumetinib 0.0142408 0.9529374 0.01424
NA
DNAH11 lapatinib 0.0142409 0.8066236 0.01424
NA
DCST2 lapatinib 0.0142476 0.8066236 0.01425
NA
ADPRH erlotinib 0.0142498 0.8499467 0.01425
NA
ANK2 erlotinib 0.0142622 0.8499467 0.01426
NA
PDIA5 selumetinib 0.0142686 0.9529374 0.01427
NA
SETD1A erlotinib 0.0142934 0.8499467 0.01429
NA
LRRC6 erlotinib 0.0142953 0.8499467 0.01430
NA
APLP1 erlotinib 0.0143098 0.8499467 0.01431
NA
PNMT selumetinib 0.0143120 0.9529374 0.01431
NA
PPP4R2 selumetinib 0.0143168 0.9529374 0.01432
NA
TCP10 lapatinib 0.0143266 0.8066236 0.01433
NA
GYG1 erlotinib 0.0143415 0.8499467 0.01434
NA
C1QL4 selumetinib 0.0143556 0.9529374 0.01436
NA
TFDP1 nilotinib 0.0143583 0.9993215 0.0144
NA
PGBD2 irinotecan 0.0143732 0.8246221 0.01437
NA
ZSCAN32 irinotecan 0.0143736 0.8246221 0.01437
NA
TSPAN19 selumetinib 0.0143738 0.9529374 0.01437
NA
CACNA1E erlotinib 0.0143860 0.8499467 0.01439
NA
OR10C1 selumetinib 0.0144043 0.9529374 0.01440
NA
EVC2 lapatinib 0.0144176 0.8066236 0.01442
NA
SLC18B1 irinotecan 0.0144334 0.8246221 0.01443
NA
PEX6 selumetinib 0.0144452 0.9529374 0.01445
NA
ACSL5 selumetinib 0.0144484 0.9529374 0.01445
NA
THAP8 erlotinib 0.0145357 0.8499467 0.01454
NA
ACCS irinotecan 0.0146088 0.8246221 0.01461
NA
PIGC irinotecan 0.0146088 0.8246221 0.01461
NA
CLCN7 selumetinib 0.0146240 0.9529374 0.01462
NA
FKRP selumetinib 0.0146452 0.9529374 0.01465
NA
ATG4C lapatinib 0.0146507 0.8066236 0.01465
NA
CORO6 nilotinib 0.0146570 0.9993215 0.0147
NA
ZNF611 erlotinib 0.0146703 0.8499467 0.01467
NA
NLN erlotinib 0.0146707 0.8499467 0.01467
NA
DNAJC27 selumetinib 0.0146881 0.9529374 0.01469
NA
MEDAG irinotecan 0.0146904 0.8246221 0.01469
NA
MPG nilotinib 0.0146915 0.9993215 0.0147
NA
ZAR1L lapatinib 0.0147179 0.8066236 0.01472
NA
NARF nilotinib 0.0147350 0.9993215 0.0147
NA
RC3H1 nilotinib 0.0147517 0.9993215 0.0148
NA
SCCPDH erlotinib 0.0147526 0.8499467 0.01475
NA
RGS22 lapatinib 0.0147530 0.8066236 0.01475
NA
SUOX selumetinib 0.0147661 0.9529374 0.01477
NA
N6AMT1 nilotinib 0.0147708 0.9993215 0.0148
NA
IMPACT erlotinib 0.0148181 0.8499467 0.01482
NA
CCDC172 nilotinib 0.0148220 0.9993215 0.0148
NA
CEP170 irinotecan 0.0148339 0.8246221 0.01483
NA
TBC1D23 nilotinib 0.0148353 0.9993215 0.0148
NA
NEUROD6 erlotinib 0.0148643 0.8499467 0.01486
NA
HCAR3 erlotinib 0.0148895 0.8499467 0.01489
NA
ESCO2 selumetinib 0.0149443 0.9529374 0.01494
NA
ZMYM4 nilotinib 0.0149504 0.9993215 0.0150
NA
GHR erlotinib 0.0149527 0.8499467 0.01495
NA
IRX1 lapatinib 0.0149683 0.8066236 0.01497
NA
CFB lapatinib 0.0149905 0.8066236 0.01499
NA
TPBGL erlotinib 0.0149975 0.8499467 0.01500
NA
TARBP1 irinotecan 0.0150028 0.8246221 0.01500
NA
ZSCAN10 irinotecan 0.0150090 0.8246221 0.01501
NA
AGPAT3 lapatinib 0.0150180 0.8066236 0.01502
NA
PRG4 irinotecan 0.0150285 0.8246221 0.01503
NA
OGDH erlotinib 0.0150506 0.8499467 0.01505
NA
PCDHGA11 selumetinib 0.0151325 0.9529374 0.01513
NA
FCHO2 erlotinib 0.0151449 0.8499467 0.01514
NA
DMRT1 selumetinib 0.0151540 0.9529374 0.01515
NA
C9orf72 nilotinib 0.0151544 0.9993215 0.0152
NA
GMPR selumetinib 0.0151690 0.9529374 0.01517
NA
UBTD1 selumetinib 0.0151690 0.9529374 0.01517
NA
PRKACB lapatinib 0.0151797 0.8066236 0.01518
NA
RNPS1 erlotinib 0.0152110 0.8499467 0.01521
NA
TTC12 lapatinib 0.0152345 0.8066236 0.01523
NA
FLOT2 selumetinib 0.0152519 0.9529374 0.01525
NA
NECAB3 nilotinib 0.0152563 0.9993215 0.0153
NA
DIO3 lapatinib 0.0152738 0.8066236 0.01527
NA
PKMYT1 selumetinib 0.0152850 0.9529374 0.01529
NA
MRPS31 nilotinib 0.0152873 0.9993215 0.0153
NA
ZIC2 lapatinib 0.0153063 0.8066236 0.01531
NA
TMEM64 nilotinib 0.0153114 0.9993215 0.0153
NA
HIPK1 selumetinib 0.0153276 0.9529374 0.01533
NA
MARCO irinotecan 0.0153347 0.8246221 0.01533
NA
RAPH1 irinotecan 0.0153475 0.8246221 0.01535
NA
CENPH lapatinib 0.0153519 0.8066236 0.01535
NA
CDRT1 nilotinib 0.0153716 0.9993215 0.0154
NA
ASB1 nilotinib 0.0153785 0.9993215 0.0154
NA
HEBP2 erlotinib 0.0153939 0.8499467 0.01539
NA
FAM188A lapatinib 0.0154116 0.8066236 0.01541
NA
FAM20C lapatinib 0.0154118 0.8066236 0.01541
NA
ASB5 irinotecan 0.0154242 0.8246221 0.01542
NA
STX7 lapatinib 0.0154507 0.8066236 0.01545
NA
WDR19 selumetinib 0.0154520 0.9529374 0.01545
NA
HMGCS2 lapatinib 0.0154526 0.8066236 0.01545
NA
TRPV1 lapatinib 0.0154526 0.8066236 0.01545
NA
DEGS1 irinotecan 0.0154806 0.8246221 0.01548
NA
DOPEY2 lapatinib 0.0154895 0.8066236 0.01549
NA
URB1 nilotinib 0.0154932 0.9993215 0.0155
NA
CBLN3 erlotinib 0.0154997 0.8499467 0.01550
NA
SLC25A38 selumetinib 0.0155055 0.9529374 0.01551
NA
STAR selumetinib 0.0155055 0.9529374 0.01551
NA
RRP36 selumetinib 0.0155331 0.9529374 0.01553
NA
LRRC6 irinotecan 0.0155505 0.8246221 0.01555
NA
SF3A3 lapatinib 0.0155595 0.8066236 0.01556
NA
SLC35B2 irinotecan 0.0155907 0.8246221 0.01559
NA
DNAH5 selumetinib 0.0155968 0.9529374 0.01560
NA
KIF13B nilotinib 0.0156001 0.9993215 0.0156
NA
EIF3E lapatinib 0.0156229 0.8066236 0.01562
NA
ABCC2 selumetinib 0.0156577 0.9529374 0.01566
NA
ABCG1 lapatinib 0.0156643 0.8066236 0.01566
NA
BTBD7 lapatinib 0.0156750 0.8066236 0.01568
NA
DDR1 selumetinib 0.0156790 0.9529374 0.01568
NA
CECR6 lapatinib 0.0156871 0.8066236 0.01569
NA
EIF4E erlotinib 0.0156890 0.8499467 0.01569
NA
HCAR3 lapatinib 0.0157117 0.8066236 0.01571
NA
ZNF197 erlotinib 0.0157370 0.8499467 0.01574
NA
PHOSPHO2 lapatinib 0.0157386 0.8066236 0.01574
NA
ADHFE1 erlotinib 0.0157404 0.8499467 0.01574
NA
FBXO22 irinotecan 0.0157522 0.8246221 0.01575
NA
FBN3 lapatinib 0.0157659 0.8066236 0.01577
NA
CACNA1E lapatinib 0.0157664 0.8066236 0.01577
NA
TULP1 erlotinib 0.0157705 0.8499467 0.01577
NA
AOAH selumetinib 0.0157764 0.9529374 0.01578
NA
CHUK selumetinib 0.0157777 0.9529374 0.01578
NA
EIF4G2 irinotecan 0.0158021 0.8246221 0.01580
NA
TRIM8 erlotinib 0.0158225 0.8499467 0.01582
NA
ERLIN2 irinotecan 0.0158328 0.8246221 0.01583
NA
TIAL1 erlotinib 0.0158427 0.8499467 0.01584
NA
FICD irinotecan 0.0158432 0.8246221 0.01584
NA
ABI2 selumetinib 0.0158444 0.9529374 0.01584
NA
RPS23 lapatinib 0.0159240 0.8066236 0.01592
NA
OR5B21 lapatinib 0.0159287 0.8066236 0.01593
NA
LCMT2 selumetinib 0.0159616 0.9529374 0.01596
NA
AK9 irinotecan 0.0159828 0.8246221 0.01598
NA
NCR1 selumetinib 0.0159951 0.9529374 0.01600
NA
FOXA1 erlotinib 0.0159965 0.8499467 0.01600
NA
KIAA0907 erlotinib 0.0159993 0.8499467 0.01600
NA
GBP4 irinotecan 0.0160280 0.8246221 0.01603
NA
C8orf58 nilotinib 0.0160765 0.9993215 0.0161
NA
WAPAL lapatinib 0.0160771 0.8066236 0.01608
NA
TMEM2 irinotecan 0.0160876 0.8246221 0.01609
NA
EVI5 nilotinib 0.0160908 0.9993215 0.0161
NA
FAM83A erlotinib 0.0161191 0.8499467 0.01612
NA
CACNA2D4 lapatinib 0.0161449 0.8066236 0.01614
NA
TYR nilotinib 0.0161517 0.9993215 0.0162
NA
ERMARD irinotecan 0.0161836 0.8246221 0.01618
NA
CHURC1 nilotinib 0.0161851 0.9993215 0.0162
NA
C10orf54 erlotinib 0.0161924 0.8499467 0.01619
NA
DUOX2 lapatinib 0.0161973 0.8066236 0.01620
NA
NFE2 erlotinib 0.0162000 0.8499467 0.01620
NA
ARFGEF1 irinotecan 0.0162138 0.8246221 0.01621
NA
MCAT lapatinib 0.0162317 0.8066236 0.01623
NA
PACRG irinotecan 0.0162328 0.8246221 0.01623
NA
OR1M1 erlotinib 0.0162440 0.8499467 0.01624
NA
ITGA4 lapatinib 0.0162448 0.8066236 0.01624
NA
SNX8 selumetinib 0.0162503 0.9529374 0.01625
NA
MAPK12 selumetinib 0.0163132 0.9529374 0.01631
NA
CREB3L1 nilotinib 0.0163246 0.9993215 0.0163
NA
RNF133 irinotecan 0.0163374 0.8246221 0.01634
NA
POLR2H lapatinib 0.0163504 0.8066236 0.01635
NA
NMRK1 erlotinib 0.0163547 0.8499467 0.01635
NA
SLC4A4 lapatinib 0.0163672 0.8066236 0.01637
NA
MAFK selumetinib 0.0163758 0.9529374 0.01638
NA
PUS7L irinotecan 0.0163841 0.8246221 0.01638
NA
BCAR3 nilotinib 0.0163909 0.9993215 0.0164
NA
CECR1 nilotinib 0.0163909 0.9993215 0.0164
NA
RHBDD1 selumetinib 0.0164012 0.9529374 0.01640
NA
OTUD7B irinotecan 0.0164336 0.8246221 0.01643
NA
GAL3ST4 nilotinib 0.0164621 0.9993215 0.0165
NA
ARHGAP44 selumetinib 0.0164722 0.9529374 0.01647
NA
RAB11FIP2 irinotecan 0.0164732 0.8246221 0.01647
NA
MBNL2 erlotinib 0.0164762 0.8499467 0.01648
NA
OR52B2 erlotinib 0.0165488 0.8499467 0.01655
NA
CABLES2 erlotinib 0.0165550 0.8499467 0.01655
NA
MBP irinotecan 0.0165570 0.8246221 0.01656
NA
KIF20B lapatinib 0.0165851 0.8066236 0.01659
NA
RAD9A lapatinib 0.0165856 0.8066236 0.01659
NA
STX12 irinotecan 0.0166049 0.8246221 0.01660
NA
YY1AP1 selumetinib 0.0166219 0.9529374 0.01662
NA
KRT71 irinotecan 0.0166489 0.8246221 0.01665
NA
ZNF683 nilotinib 0.0166491 0.9993215 0.0166
NA
CES1 irinotecan 0.0166759 0.8246221 0.01668
NA
SELE nilotinib 0.0166968 0.9993215 0.0167
NA
NOL7 lapatinib 0.0167684 0.8066236 0.01677
NA
ZNF653 lapatinib 0.0167728 0.8066236 0.01677
NA
SRSF6 irinotecan 0.0167771 0.8246221 0.01678
NA
P2RX4 irinotecan 0.0168067 0.8246221 0.01681
NA
FAM222A nilotinib 0.0168189 0.9993215 0.0168
NA
ELP6 lapatinib 0.0168219 0.8066236 0.01682
NA
CERCAM irinotecan 0.0168859 0.8246221 0.01689
NA
DARS2 lapatinib 0.0169008 0.8066236 0.01690
NA
BAZ2A lapatinib 0.0169024 0.8066236 0.01690
NA
DHRS4 erlotinib 0.0169202 0.8499467 0.01692
NA
WNT16 erlotinib 0.0169232 0.8499467 0.01692
NA
NRIP1 lapatinib 0.0169419 0.8066236 0.01694
NA
ZNF490 nilotinib 0.0169423 0.9993215 0.0169
NA
PER1 nilotinib 0.0169779 0.9993215 0.0170
NA
PNPLA6 irinotecan 0.0169895 0.8246221 0.01699
NA
KDM4A irinotecan 0.0170229 0.8246221 0.01702
NA
UBXN4 irinotecan 0.0170285 0.8246221 0.01703
NA
ADRA1B irinotecan 0.0170490 0.8246221 0.01705
NA
SLC6A5 nilotinib 0.0170583 0.9993215 0.0171
NA
NR5A1 erlotinib 0.0170785 0.8499467 0.01708
NA
GALNT18 erlotinib 0.0170799 0.8499467 0.01708
NA
NAT14 selumetinib 0.0170861 0.9529374 0.01709
NA
PARVG selumetinib 0.0170882 0.9529374 0.01709
NA
ARHGAP5 lapatinib 0.0170916 0.8066236 0.01709
NA
FAM109B erlotinib 0.0170964 0.8499467 0.01710
NA
NEUROD6 lapatinib 0.0171355 0.8066236 0.01714
NA
NHLRC2 lapatinib 0.0171458 0.8066236 0.01715
NA
DNAH11 erlotinib 0.0171489 0.8499467 0.01715
NA
TIAF1 erlotinib 0.0171535 0.8499467 0.01715
NA
ARSG nilotinib 0.0171649 0.9993215 0.0172
NA
MEF2C erlotinib 0.0171686 0.8499467 0.01717
NA
ACSF2 nilotinib 0.0171972 0.9993215 0.0172
NA
RAPGEFL1 nilotinib 0.0171972 0.9993215 0.0172
NA
TIPARP selumetinib 0.0172099 0.9529374 0.01721
NA
SLC15A1 erlotinib 0.0172199 0.8499467 0.01722
NA
TIAL1 lapatinib 0.0172248 0.8066236 0.01722
NA
GLI3 irinotecan 0.0172435 0.8246221 0.01724
NA
CEP104 nilotinib 0.0172545 0.9993215 0.0173
NA
SLC18A1 erlotinib 0.0172557 0.8499467 0.01726
NA
SLX4 lapatinib 0.0172586 0.8066236 0.01726
NA
BASP1 lapatinib 0.0172588 0.8066236 0.01726
NA
NETO2 irinotecan 0.0172617 0.8246221 0.01726
NA
CYP2D6 selumetinib 0.0172619 0.9529374 0.01726
NA
TENC1 lapatinib 0.0172752 0.8066236 0.01728
NA
IGLON5 erlotinib 0.0172824 0.8499467 0.01728
NA
MPL selumetinib 0.0172826 0.9529374 0.01728
NA
HIST1H4D selumetinib 0.0172887 0.9529374 0.01729
NA
DEFB124 lapatinib 0.0173015 0.8066236 0.01730
NA
CEACAM21 selumetinib 0.0173077 0.9529374 0.01731
NA

CTRP:

ctrp <- read.delim("./data_munging/data_drug_auc_ctrp_10_12_2018.csv", sep = "\t", header  = TRUE, row.names = 1, check.names = FALSE)
ctrp <- merge(drug_meta, ctrp, by = "CID")
ctrp_melt <- melt(ctrp, id.var  s = c("CID", "Drug"), measure.vars = colnames(ctrp)[3:ncol(ctrp)], variable.name = "accession_id", value.name = "AUC")
ctrp_grid <- expand.grid("accession_id" = unique(ctrp_melt$accession_id), "Hugo_Symbol" = as.character(unique(crispr_data$Hugo_Symbol)))
ctrp_data_allgenes <- WilcoxonByDrugAllGenes(ctrp_melt, ctrp_grid, "CTRP")
saveRDS(ctrp_data_allgenes, "./data_munging/rds/ctrp_data_18Q3_allgenes.rds", compress = "xz")
ctrp_data_allgenes <- readRDS("./data_munging/rds/ctrp_data_18Q3_allgenes.rds")
ctrp_data_allgenes <- ctrp_data_allgenes[order(ctrp_data_allgenes$p),]

knitr::kable(ctrp_data_allgenes[1:1000, c("Hugo_Symbol", "Drug", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "CTRP: by-drug Wilcoxon test results for point mutations in genes targeted in CRISPR screen (* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
CTRP: by-drug Wilcoxon test results for point mutations in genes targeted in CRISPR screen (* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)
Hugo_Symbol Drug p p.adj p.format p.signif p.signif.adj
BRAF vemurafenib 0.0000005 0.0083931 4.9e-07 **** **
PTEN afatinib 0.0000005 0.0084143 5.0e-07 **** **
KRT3 vandetanib 0.0000013 0.0216412 1.3e-06 ****
KRAS lapatinib 0.0000056 0.0953102 5.6e-06 **** NA
MYO1B vemurafenib 0.0000114 0.0968555 1.1e-05 **** NA
KRAS trametinib 0.0000123 0.1904129 1.2e-05 **** NA
KRT3 neratinib 0.0000141 0.2403292 1.4e-05 **** NA
IL12RB2 erlotinib 0.0000169 0.1520260 1.7e-05 **** NA
KRAS pazopanib 0.0000172 0.2934471 1.7e-05 **** NA
KRT3 erlotinib 0.0000178 0.1520260 1.8e-05 **** NA
KRT3 afatinib 0.0000181 0.1537573 1.8e-05 **** NA
KRT3 lapatinib 0.0000234 0.1991097 2.3e-05 **** NA
AXL vemurafenib 0.0000280 0.1368615 2.8e-05 **** NA
KRAS ibrutinib 0.0000293 0.4281528 2.9e-05 **** NA
KIF24 cabozantinib 0.0000316 0.1286957 3.2e-05 **** NA
MYD88 vemurafenib 0.0000321 0.1368615 3.2e-05 **** NA
SHC4 erlotinib 0.0000489 0.2780669 4.9e-05 **** NA
PRDM5 neratinib 0.0000510 0.4354491 5.1e-05 **** NA
SEC14L5 ibrutinib 0.0000517 0.4281528 5.2e-05 **** NA
BRINP3 cabozantinib 0.0000537 0.1286957 5.4e-05 **** NA
PTEN lapatinib 0.0000569 0.3228575 5.7e-05 **** NA
KRT3 gefitinib 0.0000607 0.8522633 6.1e-05 **** NA
EPHA1 temozolomide 0.0000773 0.8741265 7.7e-05 **** NA
GOLGA3 cabozantinib 0.0000815 0.1286957 8.1e-05 **** NA
WNK4 regorafenib 0.0000904 0.6564110 9e-05 **** NA
DDX59 cabozantinib 0.0000951 0.1286957 9.5e-05 **** NA
PLOD2 cabozantinib 0.0000974 0.1286957 9.7e-05 **** NA
AHCTF1 cabozantinib 0.0000976 0.1286957 9.8e-05 **** NA
COL11A2 sunitinib 0.0000988 0.6695527 9.9e-05 **** NA
DET1 gefitinib 0.0001000 0.8522633 0.00010 *** NA
ZBTB47 cabozantinib 0.0001022 0.1286957 0.00010 *** NA
GAB4 regorafenib 0.0001024 0.6564110 0.00010 *** NA
AHNAK cabozantinib 0.0001039 0.1286957 0.00010 *** NA
HADHA cabozantinib 0.0001054 0.1286957 0.00011 *** NA
TERT cabozantinib 0.0001056 0.1286957 0.00011 *** NA
ANK3 nilotinib 0.0001112 0.7820181 0.00011 *** NA
E2F7 sunitinib 0.0001191 0.6695527 0.00012 *** NA
PPP2R1A cabozantinib 0.0001203 0.1286957 0.00012 *** NA
MUC16 cabozantinib 0.0001209 0.1286957 0.00012 *** NA
MYT1 cabozantinib 0.0001213 0.1286957 0.00012 *** NA
SLC7A14 imatinib 0.0001217 0.8762527 0.00012 *** NA
PHF21B imatinib 0.0001249 0.8762527 0.00012 *** NA
SOCS4 cabozantinib 0.0001270 0.1286957 0.00013 *** NA
NLRC5 sunitinib 0.0001311 0.6695527 0.00013 *** NA
VPS13B cabozantinib 0.0001340 0.1286957 0.00013 *** NA
PRDM5 lapatinib 0.0001343 0.5312630 0.00013 *** NA
EMILIN3 cabozantinib 0.0001348 0.1286957 0.00013 *** NA
STIM2 vemurafenib 0.0001357 0.3867723 0.00014 *** NA
SBF2 cabozantinib 0.0001385 0.1286957 0.00014 *** NA
TTN pazopanib 0.0001407 0.9778540 0.00014 *** NA
VRK1 cabozantinib 0.0001426 0.1286957 0.00014 *** NA
CEP290 regorafenib 0.0001429 0.6564110 0.00014 *** NA
RBM5 cabozantinib 0.0001468 0.1286957 0.00015 *** NA
ICAM5 cabozantinib 0.0001556 0.1286957 0.00016 *** NA
CXXC5 lapatinib 0.0001559 0.5312630 0.00016 *** NA
ATAD5 erlotinib 0.0001579 0.4689421 0.00016 *** NA
SNX6 vemurafenib 0.0001604 0.3867723 0.00016 *** NA
TMTC3 fluorouracil 0.0001645 1.0000000 0.00016 *** NA
SSFA2 erlotinib 0.0001677 0.4689421 0.00017 *** NA
FAM193B cabozantinib 0.0001710 0.1286957 0.00017 *** NA
TACC2 cabozantinib 0.0001738 0.1286957 0.00017 *** NA
MKL1 cabozantinib 0.0001742 0.1286957 0.00017 *** NA
PTEN sunitinib 0.0001751 0.6695527 0.00018 *** NA
LRP11 vemurafenib 0.0001765 0.3867723 0.00018 *** NA
ZNF248 erlotinib 0.0001773 0.4689421 0.00018 *** NA
SNX14 cabozantinib 0.0001832 0.1296498 0.00018 *** NA
BRD7 vemurafenib 0.0001838 0.3867723 0.00018 *** NA
ERMARD erlotinib 0.0001923 0.4689421 0.00019 *** NA
KRT3 ibrutinib 0.0001957 0.9136837 0.00020 *** NA
CACNA1C cabozantinib 0.0001963 0.1312426 0.00020 *** NA
DHTKD1 vandetanib 0.0001986 0.8963224 0.00020 *** NA
PCYOX1L cabozantinib 0.0002009 0.1312426 0.00020 *** NA
KRAS selumetinib 0.0002012 0.9983774 0.00020 *** NA
BRAF selumetinib 0.0002081 0.9983774 0.00021 *** NA
SRCIN1 cabozantinib 0.0002116 0.1331394 0.00021 *** NA
PTEN neratinib 0.0002153 0.9827379 0.00022 *** NA
CACTIN cabozantinib 0.0002225 0.1350202 0.00022 *** NA
TP53 olaparib 0.0002233 0.9821538 0.00022 *** NA
KCTD3 vemurafenib 0.0002279 0.3867723 0.00023 *** NA
ZNF217 lapatinib 0.0002453 0.6963677 0.00025 *** NA
BRAF olaparib 0.0002505 0.9821538 0.00025 *** NA
ANKLE1 cabozantinib 0.0002608 0.1477637 0.00026 *** NA
ENOSF1 cabozantinib 0.0002609 0.1477637 0.00026 *** NA
GATA3 cabozantinib 0.0002714 0.1487444 0.00027 *** NA
SHC1 dasatinib 0.0002715 0.9816837 0.00027 *** NA
BRAF dabrafenib 0.0002722 0.9104067 0.00027 *** NA
EXT2 ibrutinib 0.0002723 0.9136837 0.00027 *** NA
TEP1 cabozantinib 0.0002862 0.1510065 0.00029 *** NA
ZNF467 cabozantinib 0.0002933 0.1510065 0.00029 *** NA
ZNF804B pazopanib 0.0002963 0.9778540 0.00030 *** NA
ANKLE1 sunitinib 0.0003252 0.6695527 0.00033 *** NA
GCC2 cabozantinib 0.0003302 0.1558899 0.00033 *** NA
CREBBP dasatinib 0.0003347 0.9816837 0.00033 *** NA
LRRC16A vemurafenib 0.0003411 0.3867723 0.00034 *** NA
ZNF335 cabozantinib 0.0003430 0.1558899 0.00034 *** NA
PYGO1 afatinib 0.0003533 0.8943727 0.00035 *** NA
PAQR8 neratinib 0.0003588 0.9827379 0.00036 *** NA
DMXL1 imatinib 0.0003594 0.8762527 0.00036 *** NA
KLHL40 cabozantinib 0.0003618 0.1558899 0.00036 *** NA
RTFDC1 afatinib 0.0003639 0.8943727 0.00036 *** NA
SCN1A fulvestrant 0.0003688 0.9869407 0.00037 *** NA
WNK4 vemurafenib 0.0003713 0.3867723 0.00037 *** NA
ASTN2 cabozantinib 0.0003714 0.1558899 0.00037 *** NA
NSA2 ibrutinib 0.0003777 0.9136837 0.00038 *** NA
MAK16 cabozantinib 0.0003884 0.1558899 0.00039 *** NA
DMRTA2 cabozantinib 0.0003898 0.1558899 0.00039 *** NA
URB2 cabozantinib 0.0003978 0.1558899 0.00040 *** NA
CLIP2 cabozantinib 0.0003980 0.1558899 0.00040 *** NA
ATP11A sunitinib 0.0004107 0.6695527 0.00041 *** NA
RUNX1 regorafenib 0.0004133 0.6564110 0.00041 *** NA
SLC29A4 nilotinib 0.0004156 0.7820181 0.00042 *** NA
SNX19 cabozantinib 0.0004184 0.1558899 0.00042 *** NA
ABCF1 regorafenib 0.0004243 0.6564110 0.00042 *** NA
MEP1A gefitinib 0.0004262 0.9513640 0.00043 *** NA
ARID3B gefitinib 0.0004268 0.9513640 0.00043 *** NA
KRAS sunitinib 0.0004277 0.6695527 0.00043 *** NA
NAIF1 cabozantinib 0.0004303 0.1558899 0.00043 *** NA
TTN olaparib 0.0004307 0.9821538 0.00043 *** NA
KRAS neratinib 0.0004366 0.9827379 0.00044 *** NA
JPH2 lapatinib 0.0004376 0.8488319 0.00044 *** NA
TSHZ2 vemurafenib 0.0004471 0.3867723 0.00045 *** NA
ZFP36L2 regorafenib 0.0004494 0.6564110 0.00045 *** NA
ACTL10 cabozantinib 0.0004521 0.1558899 0.00045 *** NA
TEK regorafenib 0.0004540 0.6564110 0.00045 *** NA
PCGF3 pazopanib 0.0004551 0.9778540 0.00046 *** NA
IFRD2 vemurafenib 0.0004566 0.3867723 0.00046 *** NA
SORL1 cabozantinib 0.0004583 0.1558899 0.00046 *** NA
RASEF afatinib 0.0004625 0.8943727 0.00046 *** NA
P2RX2 vemurafenib 0.0004626 0.3867723 0.00046 *** NA
CCDC122 vemurafenib 0.0004652 0.3867723 0.00047 *** NA
PPP3CB vandetanib 0.0004707 0.8963224 0.00047 *** NA
MSH6 cabozantinib 0.0004853 0.1558899 0.00049 *** NA
ANKEF1 regorafenib 0.0004913 0.6564110 0.00049 *** NA
SRPK1 cabozantinib 0.0004942 0.1558899 0.00049 *** NA
JAKMIP2 vemurafenib 0.0004957 0.3867723 0.00050 *** NA
AK8 neratinib 0.0004999 0.9827379 0.00050 *** NA
SEMA5A cabozantinib 0.0005006 0.1558899 0.00050 *** NA
GJA8 azd 0.0005022 0.9984655 0.00050 *** NA
C3 vemurafenib 0.0005049 0.3867723 0.00050 *** NA
KAT6A cabozantinib 0.0005081 0.1558899 0.00051 *** NA
HLA-B sunitinib 0.0005095 0.6695527 0.00051 *** NA
ST14 regorafenib 0.0005100 0.6564110 0.00051 *** NA
PCDH20 cabozantinib 0.0005176 0.1558899 0.00052 *** NA
C17orf70 cabozantinib 0.0005187 0.1558899 0.00052 *** NA
CIT vemurafenib 0.0005219 0.3867723 0.00052 *** NA
NUP107 cabozantinib 0.0005314 0.1558899 0.00053 *** NA
CLEC4E vandetanib 0.0005363 0.8963224 0.00054 *** NA
CXXC5 neratinib 0.0005366 0.9827379 0.00054 *** NA
HSPA13 cabozantinib 0.0005375 0.1558899 0.00054 *** NA
ZNF248 cabozantinib 0.0005408 0.1558899 0.00054 *** NA
HDAC3 cabozantinib 0.0005468 0.1558899 0.00055 *** NA
PRKAG2 crizotinib 0.0005484 0.9965659 0.00055 *** NA
DNAH14 nilotinib 0.0005496 0.7820181 0.00055 *** NA
PPP1R26 olaparib 0.0005576 0.9821538 0.00056 *** NA
UCP1 sunitinib 0.0005642 0.6695527 0.00056 *** NA
RAD23A gefitinib 0.0005652 0.9513640 0.00057 *** NA
TSHZ1 regorafenib 0.0005665 0.6564110 0.00057 *** NA
PCDHA10 neratinib 0.0005673 0.9827379 0.00057 *** NA
KMT2D cabozantinib 0.0005681 0.1558899 0.00057 *** NA
APC erlotinib 0.0005703 0.7436781 0.00057 *** NA
PAX1 imatinib 0.0005793 0.8762527 0.00058 *** NA
SGCG lapatinib 0.0005793 0.8488319 0.00058 *** NA
NELFA sunitinib 0.0005822 0.6695527 0.00058 *** NA
STK35 cabozantinib 0.0005881 0.1558899 0.00059 *** NA
SYNE4 cabozantinib 0.0005946 0.1558899 0.00059 *** NA
SLC4A8 cabozantinib 0.0005954 0.1558899 0.00060 *** NA
ARID3B erlotinib 0.0005962 0.7436781 0.00060 *** NA
RCC2 vemurafenib 0.0006048 0.3867723 0.00060 *** NA
LILRA1 ibrutinib 0.0006135 0.9136837 0.00061 *** NA
IQCE cabozantinib 0.0006141 0.1558899 0.00061 *** NA
EFCAB3 vemurafenib 0.0006144 0.3867723 0.00061 *** NA
APBA3 afatinib 0.0006175 0.8943727 0.00062 *** NA
RAB11FIP3 lapatinib 0.0006211 0.8488319 0.00062 *** NA
CBLN3 cabozantinib 0.0006239 0.1558899 0.00062 *** NA
SLC45A2 cabozantinib 0.0006261 0.1558899 0.00063 *** NA
KYNU gefitinib 0.0006263 0.9513640 0.00063 *** NA
CHEK2 erlotinib 0.0006283 0.7436781 0.00063 *** NA
VCAN azd 0.0006318 0.9984655 0.00063 *** NA
EGFR vemurafenib 0.0006405 0.3867723 0.00064 *** NA
TP53 crizotinib 0.0006495 0.9965659 0.00065 *** NA
MRGPRX1 erlotinib 0.0006522 0.7436781 0.00065 *** NA
DLX4 cabozantinib 0.0006567 0.1558899 0.00066 *** NA
ADNP cabozantinib 0.0006591 0.1558899 0.00066 *** NA
MAP7 vemurafenib 0.0006626 0.3867723 0.00066 *** NA
SLC35F2 cabozantinib 0.0006630 0.1558899 0.00066 *** NA
SH3BP5L crizotinib 0.0006657 0.9965659 0.00067 *** NA
DIMT1 vemurafenib 0.0006662 0.3867723 0.00067 *** NA
TNRC18 olaparib 0.0006714 0.9821538 0.00067 *** NA
HINFP cabozantinib 0.0006784 0.1558899 0.00068 *** NA
NME3 cabozantinib 0.0006809 0.1558899 0.00068 *** NA
ITGA6 cabozantinib 0.0006851 0.1558899 0.00069 *** NA
ZFP69B cabozantinib 0.0006856 0.1558899 0.00069 *** NA
MCM3AP nilotinib 0.0006880 0.7820181 0.00069 *** NA
RANBP3 cabozantinib 0.0006949 0.1558899 0.00069 *** NA
COL6A2 afatinib 0.0006970 0.8943727 0.00070 *** NA
RTFDC1 neratinib 0.0006971 0.9827379 0.00070 *** NA
ADAMTS13 erlotinib 0.0006981 0.7436781 0.00070 *** NA
OR6C75 regorafenib 0.0007051 0.6564110 0.00071 *** NA
ARID3B neratinib 0.0007102 0.9827379 0.00071 *** NA
OR2T27 imatinib 0.0007124 0.8762527 0.00071 *** NA
ZKSCAN3 cabozantinib 0.0007188 0.1558899 0.00072 *** NA
GABRR2 sunitinib 0.0007199 0.6695527 0.00072 *** NA
SEC14L2 vemurafenib 0.0007239 0.3867723 0.00072 *** NA
WDR11 vemurafenib 0.0007255 0.3867723 0.00073 *** NA
PAX8 regorafenib 0.0007275 0.6564110 0.00073 *** NA
BCLAF1 vandetanib 0.0007373 0.8963224 0.00074 *** NA
CCDC34 cabozantinib 0.0007377 0.1558899 0.00074 *** NA
FANCM cabozantinib 0.0007380 0.1558899 0.00074 *** NA
CCDC147 regorafenib 0.0007423 0.6564110 0.00074 *** NA
SOX11 cabozantinib 0.0007426 0.1558899 0.00074 *** NA
FAHD2B cabozantinib 0.0007434 0.1558899 0.00074 *** NA
CALCR olaparib 0.0007449 0.9821538 0.00074 *** NA
POLQ nilotinib 0.0007490 0.7820181 0.00075 *** NA
HEATR4 neratinib 0.0007513 0.9827379 0.00075 *** NA
UBAP2L regorafenib 0.0007520 0.6564110 0.00075 *** NA
CCDC101 olaparib 0.0007540 0.9821538 0.00075 *** NA
ZNF471 nilotinib 0.0007567 0.7820181 0.00076 *** NA
CRIM1 regorafenib 0.0007664 0.6564110 0.00077 *** NA
KIAA1586 cabozantinib 0.0007673 0.1558899 0.00077 *** NA
TP53 cabozantinib 0.0007688 0.1558899 0.00077 *** NA
SRRM1 olaparib 0.0007730 0.9821538 0.00077 *** NA
DUSP13 cabozantinib 0.0007746 0.1558899 0.00077 *** NA
DOCK2 vemurafenib 0.0007783 0.3867723 0.00078 *** NA
TMEM63A vemurafenib 0.0007807 0.3867723 0.00078 *** NA
GJA8 sunitinib 0.0007809 0.6695527 0.00078 *** NA
ZNF697 vemurafenib 0.0007878 0.3867723 0.00079 *** NA
FAT2 nilotinib 0.0007897 0.7820181 0.00079 *** NA
NME8 olaparib 0.0007906 0.9821538 0.00079 *** NA
CFI temozolomide 0.0007920 0.8741265 0.00079 *** NA
KRT83 vemurafenib 0.0007933 0.3867723 0.00079 *** NA
NTSR2 cabozantinib 0.0007941 0.1558899 0.00079 *** NA
MEFV cabozantinib 0.0007943 0.1558899 0.00079 *** NA
GPR110 temozolomide 0.0007944 0.8741265 0.00079 *** NA
LZTFL1 crizotinib 0.0007987 0.9965659 0.00080 *** NA
UVSSA olaparib 0.0008038 0.9821538 0.00080 *** NA
GPR128 dasatinib 0.0008067 0.9816837 0.00081 *** NA
TAF6 lapatinib 0.0008077 0.8488319 0.00081 *** NA
GPR110 regorafenib 0.0008117 0.6564110 0.00081 *** NA
NMUR1 cabozantinib 0.0008122 0.1558899 0.00081 *** NA
TRPV4 cabozantinib 0.0008139 0.1558899 0.00081 *** NA
PPP2R5E cabozantinib 0.0008178 0.1558899 0.00082 *** NA
PNLIPRP1 nilotinib 0.0008194 0.7820181 0.00082 *** NA
IKZF2 sunitinib 0.0008236 0.6695527 0.00082 *** NA
GRIK1 temozolomide 0.0008293 0.8741265 0.00083 *** NA
DHDDS cabozantinib 0.0008327 0.1558899 0.00083 *** NA
TRIM5 cabozantinib 0.0008355 0.1558899 0.00084 *** NA
STX17 cabozantinib 0.0008356 0.1558899 0.00084 *** NA
SYNDIG1 dasatinib 0.0008414 0.9816837 0.00084 *** NA
TNXB sunitinib 0.0008457 0.6695527 0.00085 *** NA
ENPP3 sunitinib 0.0008489 0.6695527 0.00085 *** NA
PAX2 vemurafenib 0.0008524 0.3867723 0.00085 *** NA
PWWP2B nilotinib 0.0008593 0.7820181 0.00086 *** NA
KPNB1 vemurafenib 0.0008621 0.3867723 0.00086 *** NA
TRPM6 vemurafenib 0.0008630 0.3867723 0.00086 *** NA
GPR4 cabozantinib 0.0008646 0.1558899 0.00086 *** NA
ZNF587 dasatinib 0.0008680 0.9816837 0.00087 *** NA
ZNF253 temozolomide 0.0008681 0.8741265 0.00087 *** NA
TGFB3 vemurafenib 0.0008700 0.3867723 0.00087 *** NA
TRIML1 cabozantinib 0.0008794 0.1558899 0.00088 *** NA
OR7D4 regorafenib 0.0008827 0.6564110 0.00088 *** NA
HOOK2 fulvestrant 0.0008831 0.9869407 0.00088 *** NA
MAP2K7 vemurafenib 0.0008832 0.3867723 0.00088 *** NA
NOL7 sunitinib 0.0008896 0.6695527 0.00089 *** NA
HAND2 cabozantinib 0.0008907 0.1558899 0.00089 *** NA
THSD7A temozolomide 0.0008907 0.8741265 0.00089 *** NA
TRA2B cabozantinib 0.0008965 0.1558899 0.00090 *** NA
RECQL vemurafenib 0.0008969 0.3867723 0.00090 *** NA
PROSER1 vandetanib 0.0008976 0.8963224 0.00090 *** NA
BRAF afatinib 0.0008985 0.8943727 0.00090 *** NA
ZFYVE16 vemurafenib 0.0009018 0.3867723 0.00090 *** NA
PLCL1 ibrutinib 0.0009043 0.9136837 0.00090 *** NA
SETD1A erlotinib 0.0009046 0.7436781 0.00090 *** NA
NCOA7 cabozantinib 0.0009047 0.1558899 0.00090 *** NA
MUC16 crizotinib 0.0009097 0.9965659 0.00091 *** NA
GPR128 vandetanib 0.0009125 0.8963224 0.00091 *** NA
RAD23A afatinib 0.0009161 0.8943727 0.00092 *** NA
NUAK2 cabozantinib 0.0009193 0.1558899 0.00092 *** NA
GPAT2 azd 0.0009198 0.9984655 0.00092 *** NA
ITGAL cabozantinib 0.0009198 0.1558899 0.00092 *** NA
TOPORS cabozantinib 0.0009234 0.1558899 0.00092 *** NA
IRX4 cabozantinib 0.0009248 0.1558899 0.00092 *** NA
FBXO42 vemurafenib 0.0009250 0.3867723 0.00092 *** NA
TRIM4 cabozantinib 0.0009261 0.1558899 0.00093 *** NA
NPR3 regorafenib 0.0009273 0.6564110 0.00093 *** NA
NGFR cabozantinib 0.0009365 0.1558899 0.00094 *** NA
CCDC68 lapatinib 0.0009373 0.8488319 0.00094 *** NA
POU6F2 gefitinib 0.0009381 0.9513640 0.00094 *** NA
ATP11A cabozantinib 0.0009410 0.1558899 0.00094 *** NA
DYNC1H1 cabozantinib 0.0009421 0.1558899 0.00094 *** NA
RAD23A neratinib 0.0009440 0.9827379 0.00094 *** NA
CFHR2 olaparib 0.0009453 0.9821538 0.00095 *** NA
SLC45A3 cabozantinib 0.0009465 0.1558899 0.00095 *** NA
CYBRD1 vemurafenib 0.0009509 0.3867723 0.00095 *** NA
ARMC4 nilotinib 0.0009519 0.7820181 0.00095 *** NA
SPRED1 afatinib 0.0009531 0.8943727 0.00095 *** NA
MUM1 cabozantinib 0.0009561 0.1558899 0.00096 *** NA
MBOAT2 erlotinib 0.0009582 0.7436781 0.00096 *** NA
TEKT2 cabozantinib 0.0009633 0.1558899 0.00096 *** NA
THNSL1 dabrafenib 0.0009636 0.9104067 0.00096 *** NA
DTX3L vandetanib 0.0009650 0.8963224 0.00096 *** NA
NELFA cabozantinib 0.0009689 0.1558899 0.00097 *** NA
TRIM72 nilotinib 0.0009704 0.7820181 0.00097 *** NA
TTC30A nilotinib 0.0009749 0.7820181 0.00097 *** NA
MYH7B sunitinib 0.0009751 0.6695527 0.00098 *** NA
GPRIN1 lapatinib 0.0009771 0.8488319 0.00098 *** NA
POLN regorafenib 0.0009782 0.6564110 0.00098 *** NA
VENTX cabozantinib 0.0009799 0.1558899 0.00098 *** NA
TMEM63B cabozantinib 0.0009927 0.1558899 0.00099 *** NA
ZFR cabozantinib 0.0009946 0.1558899 0.00099 *** NA
PIK3C2G cabozantinib 0.0009996 0.1558899 0.00100 *** NA
AP1G2 ruxolitinib 0.0010001 1.0000000 0.0010 ** NA
NOX5 cabozantinib 0.0010026 0.1558899 0.00100 ** NA
AK8 lapatinib 0.0010032 0.8488319 0.00100 ** NA
TGFB3 regorafenib 0.0010063 0.6564110 0.00101 ** NA
PPFIA4 cabozantinib 0.0010164 0.1558899 0.00102 ** NA
MPP2 erlotinib 0.0010171 0.7436781 0.00102 ** NA
CYB5R2 vemurafenib 0.0010234 0.3867723 0.00102 ** NA
CHTF18 cabozantinib 0.0010264 0.1558899 0.00103 ** NA
PPP1R21 regorafenib 0.0010295 0.6564110 0.00103 ** NA
ZIC4 cabozantinib 0.0010347 0.1558899 0.00103 ** NA
RHOA olaparib 0.0010354 0.9821538 0.00104 ** NA
SMARCAD1 vemurafenib 0.0010360 0.3867723 0.00104 ** NA
NOM1 cabozantinib 0.0010368 0.1558899 0.00104 ** NA
FOXK2 cabozantinib 0.0010369 0.1558899 0.00104 ** NA
NUP107 vemurafenib 0.0010385 0.3867723 0.00104 ** NA
ZNF706 erlotinib 0.0010390 0.7436781 0.00104 ** NA
FOLH1 erlotinib 0.0010411 0.7436781 0.00104 ** NA
CEP135 imatinib 0.0010435 0.8762527 0.00104 ** NA
ZNF597 dabrafenib 0.0010558 0.9104067 0.00106 ** NA
WDR4 vemurafenib 0.0010599 0.3867723 0.00106 ** NA
TMTC3 sunitinib 0.0010615 0.6695527 0.00106 ** NA
MGAT4B erlotinib 0.0010636 0.7436781 0.00106 ** NA
HCFC2 vemurafenib 0.0010638 0.3867723 0.00106 ** NA
ASB10 cabozantinib 0.0010660 0.1566523 0.00107 ** NA
DDX28 vemurafenib 0.0010708 0.3867723 0.00107 ** NA
CCDC175 cabozantinib 0.0010719 0.1566523 0.00107 ** NA
DLST selumetinib 0.0010725 0.9983774 0.00107 ** NA
TAF1C cabozantinib 0.0010752 0.1566523 0.00108 ** NA
PRDM5 ibrutinib 0.0010768 0.9136837 0.00108 ** NA
THSD7A cabozantinib 0.0010789 0.1566523 0.00108 ** NA
LIX1 vemurafenib 0.0010817 0.3867723 0.00108 ** NA
NKX6-2 selumetinib 0.0010842 0.9983774 0.00108 ** NA
CCDC68 crizotinib 0.0010920 0.9965659 0.00109 ** NA
PLEKHG4B gefitinib 0.0010977 0.9513640 0.00110 ** NA
COL16A1 cabozantinib 0.0011012 0.1583646 0.00110 ** NA
DOCK2 temozolomide 0.0011031 0.8741265 0.00110 ** NA
PIGW regorafenib 0.0011035 0.6564110 0.00110 ** NA
VAV1 temozolomide 0.0011041 0.8741265 0.00110 ** NA
ADCK1 vandetanib 0.0011052 0.8963224 0.00111 ** NA
PLBD2 imatinib 0.0011070 0.8762527 0.00111 ** NA
NTN4 vemurafenib 0.0011108 0.3867723 0.00111 ** NA
ARID3B lapatinib 0.0011156 0.8488319 0.00112 ** NA
ST6GAL2 sunitinib 0.0011178 0.6695527 0.00112 ** NA
STYK1 cabozantinib 0.0011203 0.1583646 0.00112 ** NA
ARHGEF15 dabrafenib 0.0011207 0.9104067 0.00112 ** NA
SCAP cabozantinib 0.0011210 0.1583646 0.00112 ** NA
NKD2 vandetanib 0.0011240 0.8963224 0.00112 ** NA
RTN3 regorafenib 0.0011257 0.6564110 0.00113 ** NA
TCF7L2 vemurafenib 0.0011266 0.3867723 0.00113 ** NA
NOC2L gefitinib 0.0011312 0.9513640 0.00113 ** NA
TRMT13 cabozantinib 0.0011328 0.1583646 0.00113 ** NA
PPP2R1A sunitinib 0.0011339 0.6695527 0.00113 ** NA
MYO7B cyclophosphamide 0.0011346 1.0000000 0.0011 ** NA
CHTF18 lapatinib 0.0011356 0.8488319 0.00114 ** NA
TNFRSF1B cabozantinib 0.0011373 0.1583646 0.00114 ** NA
SLCO6A1 regorafenib 0.0011379 0.6564110 0.00114 ** NA
PAQR8 lapatinib 0.0011436 0.8488319 0.00114 ** NA
STON1 imatinib 0.0011448 0.8762527 0.00114 ** NA
ZNF732 nilotinib 0.0011451 0.7820181 0.00115 ** NA
C10orf120 nilotinib 0.0011484 0.7820181 0.00115 ** NA
PHF20 regorafenib 0.0011590 0.6564110 0.00116 ** NA
NET1 cabozantinib 0.0011638 0.1607308 0.00116 ** NA
PI15 sunitinib 0.0011645 0.6695527 0.00116 ** NA
ABCA12 erlotinib 0.0011647 0.7436781 0.00116 ** NA
AKR1A1 vemurafenib 0.0011716 0.3867723 0.00117 ** NA
TRMT12 vemurafenib 0.0011757 0.3867723 0.00118 ** NA
TRIM16 cabozantinib 0.0011808 0.1614970 0.00118 ** NA
INSL3 vemurafenib 0.0011818 0.3867723 0.00118 ** NA
KAT5 erlotinib 0.0011830 0.7436781 0.00118 ** NA
LRP4 regorafenib 0.0011851 0.6564110 0.00119 ** NA
SCAF11 cabozantinib 0.0011883 0.1614970 0.00119 ** NA
CC2D2B vemurafenib 0.0011927 0.3867723 0.00119 ** NA
XKR3 regorafenib 0.0011928 0.6564110 0.00119 ** NA
MAML3 vemurafenib 0.0011979 0.3867723 0.00120 ** NA
TMC8 vemurafenib 0.0012013 0.3867723 0.00120 ** NA
PCM1 imatinib 0.0012057 0.8762527 0.00121 ** NA
ZNF436 pazopanib 0.0012094 0.9778540 0.00121 ** NA
MAP6 sunitinib 0.0012102 0.6695527 0.00121 ** NA
TROVE2 erlotinib 0.0012238 0.7436781 0.00122 ** NA
GPR156 cabozantinib 0.0012361 0.1618592 0.00124 ** NA
SLC22A8 temozolomide 0.0012363 0.8741265 0.00124 ** NA
METTL7A vandetanib 0.0012515 0.8963224 0.00125 ** NA
PDCD1LG2 sunitinib 0.0012562 0.6695527 0.00126 ** NA
PRPF4B cabozantinib 0.0012581 0.1618592 0.00126 ** NA
KRAS vandetanib 0.0012628 0.8963224 0.00126 ** NA
CPEB1 cabozantinib 0.0012639 0.1618592 0.00126 ** NA
SLC25A29 cabozantinib 0.0012651 0.1618592 0.00127 ** NA
ZNF653 fulvestrant 0.0012684 0.9869407 0.00127 ** NA
PHLPP2 cabozantinib 0.0012708 0.1618592 0.00127 ** NA
PRDM16 cabozantinib 0.0012722 0.1618592 0.00127 ** NA
ACRBP gefitinib 0.0012728 0.9513640 0.00127 ** NA
NUAK1 cabozantinib 0.0012775 0.1618592 0.00128 ** NA
PAPD4 vemurafenib 0.0012823 0.4051918 0.00128 ** NA
ST6GALNAC5 cabozantinib 0.0012833 0.1618592 0.00128 ** NA
ALOX5 vandetanib 0.0012929 0.8963224 0.00129 ** NA
XRCC5 erlotinib 0.0012930 0.7436781 0.00129 ** NA
RAPGEF1 cabozantinib 0.0012937 0.1618592 0.00129 ** NA
DNAAF3 lapatinib 0.0012952 0.8488319 0.00130 ** NA
FERMT2 regorafenib 0.0013000 0.6564110 0.00130 ** NA
MSI2 cabozantinib 0.0013033 0.1618592 0.00130 ** NA
DLL1 nilotinib 0.0013064 0.7820181 0.00131 ** NA
EPHB2 cabozantinib 0.0013085 0.1618592 0.00131 ** NA
MEP1A afatinib 0.0013090 0.8943727 0.00131 ** NA
MAP10 cabozantinib 0.0013109 0.1618592 0.00131 ** NA
ENPP2 regorafenib 0.0013138 0.6564110 0.00131 ** NA
RNF103 nilotinib 0.0013149 0.7820181 0.00131 ** NA
FPR3 cabozantinib 0.0013149 0.1618592 0.00131 ** NA
THOC1 vemurafenib 0.0013216 0.4054598 0.00132 ** NA
DNAH14 regorafenib 0.0013223 0.6564110 0.00132 ** NA
ZNF594 nilotinib 0.0013236 0.7820181 0.00132 ** NA
TMEM117 gefitinib 0.0013254 0.9513640 0.00133 ** NA
TMEM117 afatinib 0.0013255 0.8943727 0.00133 ** NA
RAPSN cabozantinib 0.0013283 0.1618592 0.00133 ** NA
ADORA2A erlotinib 0.0013283 0.7436781 0.00133 ** NA
ERVV-1 erlotinib 0.0013329 0.7436781 0.00133 ** NA
CDH4 cabozantinib 0.0013339 0.1618592 0.00133 ** NA
UBXN11 olaparib 0.0013350 0.9821538 0.00133 ** NA
GRIA1 sunitinib 0.0013445 0.6695527 0.00134 ** NA
PNMA2 cabozantinib 0.0013467 0.1622588 0.00135 ** NA
STARD4 vemurafenib 0.0013498 0.4054598 0.00135 ** NA
OPCML ibrutinib 0.0013513 0.9136837 0.00135 ** NA
GRK5 lapatinib 0.0013542 0.8488319 0.00135 ** NA
SSC5D vandetanib 0.0013593 0.8963224 0.00136 ** NA
ITGAD vandetanib 0.0013600 0.8963224 0.00136 ** NA
OR6T1 regorafenib 0.0013628 0.6564110 0.00136 ** NA
HSD17B12 regorafenib 0.0013669 0.6564110 0.00137 ** NA
GAPVD1 cabozantinib 0.0013683 0.1636954 0.00137 ** NA
RTN4RL2 vandetanib 0.0013687 0.8963224 0.00137 ** NA
PKMYT1 sunitinib 0.0013709 0.6695527 0.00137 ** NA
IGSF22 vemurafenib 0.0013745 0.4054598 0.00137 ** NA
SCEL imatinib 0.0013773 0.8762527 0.00138 ** NA
DNAH9 sunitinib 0.0013787 0.6695527 0.00138 ** NA
OR10Q1 sunitinib 0.0013790 0.6695527 0.00138 ** NA
CLEC10A ruxolitinib 0.0013845 1.0000000 0.0014 ** NA
PSD3 sunitinib 0.0013875 0.6695527 0.00139 ** NA
MAN1C1 sunitinib 0.0013898 0.6695527 0.00139 ** NA
LRP1B pazopanib 0.0013913 0.9778540 0.00139 ** NA
SWT1 cabozantinib 0.0013955 0.1657823 0.00140 ** NA
ADPRH erlotinib 0.0014017 0.7436781 0.00140 ** NA
MESP2 olaparib 0.0014045 0.9821538 0.00140 ** NA
SFRP2 sunitinib 0.0014061 0.6695527 0.00141 ** NA
EIF3M vemurafenib 0.0014077 0.4054598 0.00141 ** NA
PAK6 cabozantinib 0.0014086 0.1657823 0.00141 ** NA
SNX13 vemurafenib 0.0014153 0.4054598 0.00142 ** NA
SLC22A14 cabozantinib 0.0014154 0.1657823 0.00142 ** NA
RAD23A erlotinib 0.0014158 0.7436781 0.00142 ** NA
HDAC3 regorafenib 0.0014174 0.6564110 0.00142 ** NA
MGAT4B gefitinib 0.0014221 0.9513640 0.00142 ** NA
DCTN1 imatinib 0.0014230 0.8762527 0.00142 ** NA
PARP10 cabozantinib 0.0014248 0.1657823 0.00142 ** NA
POU6F2 neratinib 0.0014250 0.9827379 0.00143 ** NA
SLC43A3 vemurafenib 0.0014257 0.4054598 0.00143 ** NA
AGAP6 afatinib 0.0014276 0.8943727 0.00143 ** NA
EIF3B gefitinib 0.0014340 0.9513640 0.00143 ** NA
GMDS imatinib 0.0014387 0.8762527 0.00144 ** NA
ADPRH afatinib 0.0014476 0.8943727 0.00145 ** NA
NCAPG gefitinib 0.0014514 0.9513640 0.00145 ** NA
UVRAG erlotinib 0.0014553 0.7436781 0.00146 ** NA
GLIS1 lapatinib 0.0014554 0.8488319 0.00146 ** NA
EPHB6 regorafenib 0.0014568 0.6564110 0.00146 ** NA
PRKAG2 sunitinib 0.0014652 0.6695527 0.00147 ** NA
SF3A1 regorafenib 0.0014668 0.6564110 0.00147 ** NA
SNX32 cabozantinib 0.0014677 0.1686927 0.00147 ** NA
ZNF213 cabozantinib 0.0014697 0.1686927 0.00147 ** NA
STPG2 nilotinib 0.0014704 0.7820181 0.00147 ** NA
GORASP2 vemurafenib 0.0014712 0.4065722 0.00147 ** NA
MSL1 sunitinib 0.0014723 0.6695527 0.00147 ** NA
ZNF384 vemurafenib 0.0014772 0.4065722 0.00148 ** NA
POC5 erlotinib 0.0014781 0.7436781 0.00148 ** NA
FAM193B imatinib 0.0014870 0.8762527 0.00149 ** NA
CACNA1C sunitinib 0.0014910 0.6695527 0.00149 ** NA
TTC30A regorafenib 0.0014963 0.6564110 0.00150 ** NA
SCUBE2 erlotinib 0.0014976 0.7436781 0.00150 ** NA
ECI1 nilotinib 0.0014991 0.7820181 0.00150 ** NA
CNNM3 olaparib 0.0015004 0.9821538 0.00150 ** NA
TMEM223 lapatinib 0.0015046 0.8488319 0.00150 ** NA
HRC cabozantinib 0.0015095 0.1720979 0.00151 ** NA
OR6C4 lapatinib 0.0015103 0.8488319 0.00151 ** NA
FGF21 fulvestrant 0.0015129 0.9869407 0.00151 ** NA
CXXC5 erlotinib 0.0015136 0.7436781 0.00151 ** NA
AGPAT9 erlotinib 0.0015159 0.7436781 0.00152 ** NA
NCEH1 lapatinib 0.0015183 0.8488319 0.00152 ** NA
CCDC34 sunitinib 0.0015194 0.6695527 0.00152 ** NA
PHC2 gefitinib 0.0015331 0.9513640 0.00153 ** NA
FOXP4 vemurafenib 0.0015342 0.4100629 0.00153 ** NA
SLC18A1 sunitinib 0.0015351 0.6695527 0.00154 ** NA
FTCD regorafenib 0.0015373 0.6564110 0.00154 ** NA
HNRNPAB imatinib 0.0015405 0.8762527 0.00154 ** NA
RCC2 regorafenib 0.0015410 0.6564110 0.00154 ** NA
KLHL36 cabozantinib 0.0015436 0.1723805 0.00154 ** NA
SFRP2 crizotinib 0.0015448 0.9965659 0.00154 ** NA
C8orf82 crizotinib 0.0015462 0.9965659 0.00155 ** NA
RFC1 cabozantinib 0.0015473 0.1723805 0.00155 ** NA
SP4 pazopanib 0.0015517 0.9778540 0.00155 ** NA
DLL1 regorafenib 0.0015586 0.6564110 0.00156 ** NA
ARHGDIG cabozantinib 0.0015587 0.1723805 0.00156 ** NA
MUT vemurafenib 0.0015617 0.4100629 0.00156 ** NA
CCDC88A sunitinib 0.0015635 0.6695527 0.00156 ** NA
ANKRD9 lapatinib 0.0015673 0.8488319 0.00157 ** NA
RAD21L1 selumetinib 0.0015767 0.9983774 0.00158 ** NA
UNK cabozantinib 0.0015775 0.1723805 0.00158 ** NA
VPS53 cabozantinib 0.0015775 0.1723805 0.00158 ** NA
PLXNB2 regorafenib 0.0015778 0.6564110 0.00158 ** NA
BCL9L cabozantinib 0.0015807 0.1723805 0.00158 ** NA
IKZF4 erlotinib 0.0015820 0.7436781 0.00158 ** NA
MS4A8 dasatinib 0.0015833 0.9816837 0.00158 ** NA
ZC3H14 cabozantinib 0.0015872 0.1723805 0.00159 ** NA
PFDN1 lapatinib 0.0015881 0.8488319 0.00159 ** NA
CIZ1 sunitinib 0.0015897 0.6695527 0.00159 ** NA
FCGRT lapatinib 0.0015924 0.8488319 0.00159 ** NA
HOOK1 afatinib 0.0015929 0.8943727 0.00159 ** NA
SEC14L5 neratinib 0.0015945 0.9827379 0.00159 ** NA
GNPTAB temozolomide 0.0016008 0.8741265 0.00160 ** NA
PROSER1 erlotinib 0.0016047 0.7436781 0.00160 ** NA
ZSCAN18 temozolomide 0.0016048 0.8741265 0.00160 ** NA
MINPP1 regorafenib 0.0016062 0.6564110 0.00161 ** NA
C1orf56 erlotinib 0.0016067 0.7436781 0.00161 ** NA
ATP6V0A4 vemurafenib 0.0016088 0.4100629 0.00161 ** NA
PPIF vemurafenib 0.0016098 0.4100629 0.00161 ** NA
KRT83 olaparib 0.0016133 0.9821538 0.00161 ** NA
TTBK2 lapatinib 0.0016147 0.8488319 0.00161 ** NA
CYBRD1 cabozantinib 0.0016172 0.1723805 0.00162 ** NA
ARHGEF5 regorafenib 0.0016186 0.6564110 0.00162 ** NA
MYH6 vemurafenib 0.0016218 0.4100629 0.00162 ** NA
ZBTB21 cabozantinib 0.0016252 0.1723805 0.00163 ** NA
ZNF479 temozolomide 0.0016272 0.8741265 0.00163 ** NA
PPP2R2B temozolomide 0.0016278 0.8741265 0.00163 ** NA
ZSWIM3 cabozantinib 0.0016333 0.1723805 0.00163 ** NA
CDH15 neratinib 0.0016333 0.9827379 0.00163 ** NA
TTN cabozantinib 0.0016379 0.1723805 0.00164 ** NA
SDC3 cabozantinib 0.0016385 0.1723805 0.00164 ** NA
TRIM13 sunitinib 0.0016409 0.6695527 0.00164 ** NA
HRAS sunitinib 0.0016468 0.6695527 0.00165 ** NA
FOXO1 nilotinib 0.0016531 0.7820181 0.00165 ** NA
ADAMTSL4 nilotinib 0.0016534 0.7820181 0.00165 ** NA
AP4E1 sunitinib 0.0016541 0.6695527 0.00165 ** NA
ZNF662 vemurafenib 0.0016580 0.4100629 0.00166 ** NA
FOXL2 vemurafenib 0.0016581 0.4100629 0.00166 ** NA
CCDC77 cabozantinib 0.0016603 0.1723805 0.00166 ** NA
ELK4 cabozantinib 0.0016622 0.1723805 0.00166 ** NA
DPYSL2 erlotinib 0.0016629 0.7436781 0.00166 ** NA
PROSER1 afatinib 0.0016629 0.8943727 0.00166 ** NA
E2F7 cabozantinib 0.0016641 0.1723805 0.00166 ** NA
SLITRK5 gefitinib 0.0016647 0.9513640 0.00166 ** NA
ZNF839 gefitinib 0.0016733 0.9513640 0.00167 ** NA
DENND1A temozolomide 0.0016872 0.8741265 0.00169 ** NA
MBOAT2 gefitinib 0.0016898 0.9513640 0.00169 ** NA
MCM7 sunitinib 0.0016918 0.6695527 0.00169 ** NA
AOX1 cabozantinib 0.0016965 0.1746693 0.00170 ** NA
E2F3 azd 0.0016967 0.9984655 0.00170 ** NA
FOXP2 selumetinib 0.0016981 0.9983774 0.00170 ** NA
OR6C65 ibrutinib 0.0017090 0.9136837 0.00171 ** NA
BRPF1 vemurafenib 0.0017102 0.4130491 0.00171 ** NA
ACAD11 nilotinib 0.0017105 0.7820181 0.00171 ** NA
PRR14 neratinib 0.0017155 0.9827379 0.00172 ** NA
CSNK1G1 nilotinib 0.0017164 0.7820181 0.00172 ** NA
KRT20 sunitinib 0.0017185 0.6695527 0.00172 ** NA
INPP5A vemurafenib 0.0017186 0.4130491 0.00172 ** NA
APOB olaparib 0.0017210 0.9821538 0.00172 ** NA
ERG gefitinib 0.0017365 0.9513640 0.00174 ** NA
MYH10 cabozantinib 0.0017451 0.1771797 0.00175 ** NA
DNMT3A vandetanib 0.0017460 0.8963224 0.00175 ** NA
ZNF436 cabozantinib 0.0017465 0.1771797 0.00175 ** NA
CDK17 dasatinib 0.0017484 0.9816837 0.00175 ** NA
MEP1A lapatinib 0.0017510 0.8488319 0.00175 ** NA
ATM dasatinib 0.0017548 0.9816837 0.00175 ** NA
SLC7A2 dasatinib 0.0017586 0.9816837 0.00176 ** NA
PTPRG vemurafenib 0.0017601 0.4141788 0.00176 ** NA
ATAD5 gefitinib 0.0017649 0.9513640 0.00176 ** NA
EXT2 lapatinib 0.0017712 0.8488319 0.00177 ** NA
ANKH cabozantinib 0.0017714 0.1771797 0.00177 ** NA
CIT regorafenib 0.0017718 0.6627240 0.00177 ** NA
ETV1 erlotinib 0.0017720 0.7436781 0.00177 ** NA
FDXR cabozantinib 0.0017745 0.1771797 0.00177 ** NA
MYO15A erlotinib 0.0017761 0.7436781 0.00178 ** NA
VSX1 gefitinib 0.0017776 0.9513640 0.00178 ** NA
P4HTM crizotinib 0.0017781 0.9965659 0.00178 ** NA
ZNF600 cabozantinib 0.0017826 0.1771797 0.00178 ** NA
HAGHL cabozantinib 0.0017835 0.1771797 0.00178 ** NA
PAK6 sunitinib 0.0017919 0.6695527 0.00179 ** NA
ZFP36L2 temozolomide 0.0017933 0.8741265 0.00179 ** NA
SNTG2 nilotinib 0.0017952 0.7820181 0.00180 ** NA
ZNRF1 cabozantinib 0.0017964 0.1771956 0.00180 ** NA
SEMA7A afatinib 0.0017981 0.8943727 0.00180 ** NA
OR8B12 olaparib 0.0018015 0.9821538 0.00180 ** NA
ZFHX3 nilotinib 0.0018030 0.7820181 0.00180 ** NA
SSX2IP sunitinib 0.0018068 0.6695527 0.00181 ** NA
CBX2 ibrutinib 0.0018070 0.9136837 0.00181 ** NA
PNLIPRP3 pazopanib 0.0018078 0.9778540 0.00181 ** NA
IQSEC1 sunitinib 0.0018126 0.6695527 0.00181 ** NA
PYGO1 gefitinib 0.0018184 0.9513640 0.00182 ** NA
NFE2L2 cabozantinib 0.0018187 0.1771956 0.00182 ** NA
APLP2 cabozantinib 0.0018192 0.1771956 0.00182 ** NA
CRISPLD1 regorafenib 0.0018245 0.6627240 0.00182 ** NA
TLE2 lapatinib 0.0018257 0.8488319 0.00183 ** NA
RTFDC1 gefitinib 0.0018267 0.9513640 0.00183 ** NA
TTC30A vemurafenib 0.0018294 0.4141788 0.00183 ** NA
C9orf172 cabozantinib 0.0018347 0.1771956 0.00183 ** NA
ADCY9 imatinib 0.0018365 0.8762527 0.00184 ** NA
NOC2L afatinib 0.0018455 0.8943727 0.00185 ** NA
GPLD1 cabozantinib 0.0018483 0.1771956 0.00185 ** NA
STRC cabozantinib 0.0018517 0.1771956 0.00185 ** NA
NOA1 erlotinib 0.0018527 0.7436781 0.00185 ** NA
CSH1 regorafenib 0.0018561 0.6627240 0.00186 ** NA
PNN imatinib 0.0018586 0.8762527 0.00186 ** NA
TTF1 olaparib 0.0018671 0.9821538 0.00187 ** NA
CSN3 regorafenib 0.0018707 0.6627240 0.00187 ** NA
COPG1 cabozantinib 0.0018733 0.1771956 0.00187 ** NA
FES cabozantinib 0.0018754 0.1771956 0.00188 ** NA
RPUSD2 lapatinib 0.0018766 0.8488319 0.00188 ** NA
DLEC1 cabozantinib 0.0018775 0.1771956 0.00188 ** NA
ZNF441 neratinib 0.0018812 0.9827379 0.00188 ** NA
RBBP9 crizotinib 0.0018846 0.9965659 0.00188 ** NA
DDX21 erlotinib 0.0018930 0.7436781 0.00189 ** NA
ZNF629 imatinib 0.0018965 0.8762527 0.00190 ** NA
GJA8 pazopanib 0.0018996 0.9778540 0.00190 ** NA
ZNF570 cabozantinib 0.0019020 0.1776521 0.00190 ** NA
MRGPRX1 gefitinib 0.0019024 0.9513640 0.00190 ** NA
HSPA12A cabozantinib 0.0019033 0.1776521 0.00190 ** NA
TROAP sunitinib 0.0019042 0.6695527 0.00190 ** NA
CECR1 nilotinib 0.0019060 0.7820181 0.00191 ** NA
PTEN trametinib 0.0019075 0.9757752 0.0019 ** NA
MAP10 lapatinib 0.0019095 0.8488319 0.00191 ** NA
FAM19A4 pazopanib 0.0019105 0.9778540 0.00191 ** NA
ST3GAL3 regorafenib 0.0019135 0.6627240 0.00191 ** NA
DHTKD1 dasatinib 0.0019153 0.9816837 0.00192 ** NA
ARIH2 cabozantinib 0.0019265 0.1788415 0.00193 ** NA
GABBR2 ibrutinib 0.0019279 0.9136837 0.00193 ** NA
GPR98 temozolomide 0.0019318 0.8741265 0.00193 ** NA
GNAT3 vemurafenib 0.0019354 0.4141788 0.00194 ** NA
GPT olaparib 0.0019394 0.9821538 0.00194 ** NA
UPK3B olaparib 0.0019435 0.9821538 0.00194 ** NA
EYA1 lapatinib 0.0019444 0.8488319 0.00194 ** NA
SLC17A7 cabozantinib 0.0019453 0.1795979 0.00195 ** NA
GOLPH3L vemurafenib 0.0019460 0.4141788 0.00195 ** NA
STAP2 crizotinib 0.0019465 0.9965659 0.00195 ** NA
PPFIA2 vemurafenib 0.0019607 0.4141788 0.00196 ** NA
CTNND2 sunitinib 0.0019626 0.6695527 0.00196 ** NA
PIP4K2A vemurafenib 0.0019630 0.4141788 0.00196 ** NA
EP300 cabozantinib 0.0019685 0.1796467 0.00197 ** NA
ANKRD29 cabozantinib 0.0019708 0.1796467 0.00197 ** NA
FAM21A dasatinib 0.0019722 0.9816837 0.00197 ** NA
NLRP8 cabozantinib 0.0019775 0.1796467 0.00198 ** NA
GPRIN1 sunitinib 0.0019798 0.6695527 0.00198 ** NA
KLC2 imatinib 0.0019800 0.8762527 0.00198 ** NA
BCKDHA vemurafenib 0.0019820 0.4141788 0.00198 ** NA
OMP sunitinib 0.0019826 0.6695527 0.00198 ** NA
PRR23B nilotinib 0.0019847 0.7820181 0.00198 ** NA
PROSER1 neratinib 0.0019858 0.9827379 0.00199 ** NA
ARID3B vandetanib 0.0019899 0.8963224 0.00199 ** NA
SNX13 nilotinib 0.0019971 0.7820181 0.00200 ** NA
ZNF217 afatinib 0.0020075 0.8943727 0.00201 ** NA
VMO1 cabozantinib 0.0020084 0.1797062 0.00201 ** NA
FGF11 afatinib 0.0020143 0.8943727 0.00201 ** NA
KIAA1211 vemurafenib 0.0020156 0.4141788 0.00202 ** NA
ALMS1 olaparib 0.0020173 0.9821538 0.00202 ** NA
B3GALNT1 cabozantinib 0.0020202 0.1797062 0.00202 ** NA
ZNF683 temozolomide 0.0020232 0.8741265 0.00202 ** NA
DHTKD1 gefitinib 0.0020244 0.9513640 0.00202 ** NA
USP7 trametinib 0.0020279 0.9757752 0.0020 ** NA
CSNK1G3 nilotinib 0.0020289 0.7820181 0.00203 ** NA
CALCOCO1 cabozantinib 0.0020306 0.1797062 0.00203 ** NA
APC2 cabozantinib 0.0020307 0.1797062 0.00203 ** NA
MARCH10 cabozantinib 0.0020311 0.1797062 0.00203 ** NA
STK4 lapatinib 0.0020313 0.8488319 0.00203 ** NA
COL11A2 temozolomide 0.0020338 0.8741265 0.00203 ** NA
GMDS crizotinib 0.0020406 0.9965659 0.00204 ** NA
FAM212B lapatinib 0.0020421 0.8488319 0.00204 ** NA
PCDHGB7 imatinib 0.0020437 0.8762527 0.00204 ** NA
GTF3C6 lapatinib 0.0020445 0.8488319 0.00204 ** NA
RNF208 fulvestrant 0.0020451 0.9869407 0.00205 ** NA
DERL2 gefitinib 0.0020484 0.9513640 0.00205 ** NA
BRD2 dasatinib 0.0020569 0.9816837 0.00206 ** NA
INPPL1 cabozantinib 0.0020575 0.1807986 0.00206 ** NA
FGF11 ibrutinib 0.0020585 0.9136837 0.00206 ** NA
GRSF1 afatinib 0.0020590 0.8943727 0.00206 ** NA
TRIM69 gefitinib 0.0020618 0.9513640 0.00206 ** NA
PCLO pazopanib 0.0020734 0.9778540 0.00207 ** NA
GPRIN1 cabozantinib 0.0020767 0.1807986 0.00208 ** NA
TOMM70A vemurafenib 0.0020767 0.4141788 0.00208 ** NA
KRAS cabozantinib 0.0020791 0.1807986 0.00208 ** NA
CDC16 erlotinib 0.0020807 0.7436781 0.00208 ** NA
DTX3L gefitinib 0.0020815 0.9513640 0.00208 ** NA
KIF19 temozolomide 0.0020837 0.8741265 0.00208 ** NA
PI4KA vemurafenib 0.0020869 0.4141788 0.00209 ** NA
GLP2R cabozantinib 0.0020881 0.1807986 0.00209 ** NA
KRT3 fluorouracil 0.0020891 1.0000000 0.00209 ** NA
CROT sunitinib 0.0021046 0.6695527 0.00210 ** NA
LAD1 cabozantinib 0.0021069 0.1807986 0.00211 ** NA
ULK4 regorafenib 0.0021099 0.6627240 0.00211 ** NA
PYROXD2 cabozantinib 0.0021154 0.1807986 0.00212 ** NA
ZNF793 temozolomide 0.0021177 0.8741265 0.00212 ** NA
TENC1 cabozantinib 0.0021179 0.1807986 0.00212 ** NA
OCM vandetanib 0.0021279 0.8963224 0.00213 ** NA
PFDN1 vandetanib 0.0021279 0.8963224 0.00213 ** NA
OR6C75 nilotinib 0.0021282 0.7820181 0.00213 ** NA
SLC25A35 fluorouracil 0.0021296 1.0000000 0.00213 ** NA
RTKN2 pazopanib 0.0021300 0.9778540 0.00213 ** NA
FEZF1 nilotinib 0.0021379 0.7820181 0.00214 ** NA
TMEM260 cabozantinib 0.0021424 0.1815281 0.00214 ** NA
LRP1B olaparib 0.0021429 0.9821538 0.00214 ** NA
ARL16 vemurafenib 0.0021444 0.4141788 0.00214 ** NA
EXOC4 neratinib 0.0021494 0.9827379 0.00215 ** NA
WBP4 vemurafenib 0.0021505 0.4141788 0.00215 ** NA
GJA8 cabozantinib 0.0021511 0.1815281 0.00215 ** NA
COMP afatinib 0.0021546 0.8943727 0.00215 ** NA
TMEM252 crizotinib 0.0021547 0.9965659 0.00215 ** NA
ADD1 cabozantinib 0.0021585 0.1815281 0.00216 ** NA
ADCK1 dasatinib 0.0021625 0.9816837 0.00216 ** NA
NKD2 afatinib 0.0021625 0.8943727 0.00216 ** NA
GCKR sunitinib 0.0021651 0.6695527 0.00217 ** NA
TRIM41 lapatinib 0.0021660 0.8488319 0.00217 ** NA
HEATR6 olaparib 0.0021670 0.9821538 0.00217 ** NA
LRRC38 sunitinib 0.0021721 0.6695527 0.00217 ** NA
CPSF1 cabozantinib 0.0021771 0.1819554 0.00218 ** NA
MRPL37 gefitinib 0.0021799 0.9513640 0.00218 ** NA
TMEM102 cabozantinib 0.0021888 0.1819554 0.00219 ** NA
DMRT3 vemurafenib 0.0021910 0.4141788 0.00219 ** NA
IARS vemurafenib 0.0021957 0.4141788 0.00220 ** NA
EPHA7 olaparib 0.0021961 0.9821538 0.00220 ** NA
TPST2 cabozantinib 0.0021965 0.1819554 0.00220 ** NA
MDGA2 erlotinib 0.0021966 0.7436781 0.00220 ** NA
MGARP regorafenib 0.0022014 0.6627240 0.00220 ** NA
ZNF839 crizotinib 0.0022044 0.9965659 0.00220 ** NA
APOBEC3G vemurafenib 0.0022047 0.4141788 0.00220 ** NA
CTC1 cabozantinib 0.0022064 0.1819554 0.00221 ** NA
ROCK2 vemurafenib 0.0022127 0.4141788 0.00221 ** NA
SLC18A1 imatinib 0.0022150 0.8762527 0.00222 ** NA
FBXO30 imatinib 0.0022152 0.8762527 0.00222 ** NA
CCDC13 ibrutinib 0.0022180 0.9136837 0.00222 ** NA
SEMA3A sunitinib 0.0022200 0.6695527 0.00222 ** NA
ASXL3 nilotinib 0.0022231 0.7820181 0.00222 ** NA
GPR68 vemurafenib 0.0022246 0.4141788 0.00222 ** NA
RNF103 pazopanib 0.0022264 0.9778540 0.00223 ** NA
PRKAG2 azd 0.0022285 0.9984655 0.00223 ** NA
YTHDF2 azd 0.0022285 0.9984655 0.00223 ** NA
TRAPPC11 vemurafenib 0.0022307 0.4141788 0.00223 ** NA
OLFML2B cabozantinib 0.0022319 0.1829973 0.00223 ** NA
ZNF804B imatinib 0.0022366 0.8762527 0.00224 ** NA
SLC30A3 selumetinib 0.0022369 0.9983774 0.00224 ** NA
ZNF367 afatinib 0.0022401 0.8943727 0.00224 ** NA
GARS erlotinib 0.0022520 0.7436781 0.00225 ** NA
INTS10 olaparib 0.0022543 0.9821538 0.00225 ** NA
MSH5 cabozantinib 0.0022564 0.1829973 0.00226 ** NA
MED13 cabozantinib 0.0022577 0.1829973 0.00226 ** NA
TEX2 crizotinib 0.0022585 0.9965659 0.00226 ** NA
SLC43A1 regorafenib 0.0022588 0.6627240 0.00226 ** NA
OR51M1 pazopanib 0.0022598 0.9778540 0.00226 ** NA
FNDC8 selumetinib 0.0022628 0.9983774 0.00226 ** NA
SNTG2 vemurafenib 0.0022650 0.4141788 0.00227 ** NA
SEMA3G cabozantinib 0.0022656 0.1829973 0.00227 ** NA
CEP128 regorafenib 0.0022686 0.6627240 0.00227 ** NA
DERL2 erlotinib 0.0022686 0.7436781 0.00227 ** NA
SFMBT2 dasatinib 0.0022720 0.9816837 0.00227 ** NA
RASGRF2 cabozantinib 0.0022729 0.1829973 0.00227 ** NA
RAPGEF2 vemurafenib 0.0022743 0.4141788 0.00227 ** NA
FAM210A regorafenib 0.0022744 0.6627240 0.00227 ** NA
IDH3A temozolomide 0.0022761 0.8741265 0.00228 ** NA
TLE1 sunitinib 0.0022782 0.6695527 0.00228 ** NA
UNKL sunitinib 0.0022871 0.6695527 0.00229 ** NA
WDR24 temozolomide 0.0022957 0.8741265 0.00230 ** NA
NAALADL2 vemurafenib 0.0022958 0.4141788 0.00230 ** NA
ZNF45 neratinib 0.0022972 0.9827379 0.00230 ** NA
SLC6A6 vemurafenib 0.0023029 0.4141788 0.00230 ** NA
MMP14 imatinib 0.0023040 0.8762527 0.00230 ** NA
MYO18B ibrutinib 0.0023046 0.9136837 0.00230 ** NA
C7orf43 vemurafenib 0.0023058 0.4141788 0.00231 ** NA
TIMP4 vemurafenib 0.0023058 0.4141788 0.00231 ** NA
ALMS1 crizotinib 0.0023094 0.9965659 0.00231 ** NA
KCNN3 cabozantinib 0.0023228 0.1860116 0.00232 ** NA
TUBGCP4 imatinib 0.0023254 0.8762527 0.00233 ** NA
CXXC5 gefitinib 0.0023303 0.9513640 0.00233 ** NA
SERPINB2 dabrafenib 0.0023393 0.9104067 0.00234 ** NA
B3GAT1 dabrafenib 0.0023403 0.9104067 0.00234 ** NA
DNHD1 olaparib 0.0023421 0.9821538 0.00234 ** NA
CILP2 cabozantinib 0.0023427 0.1860116 0.00234 ** NA
WFDC8 sunitinib 0.0023480 0.6695527 0.00235 ** NA
DTX3L erlotinib 0.0023561 0.7436781 0.00236 ** NA
EXOC6B cabozantinib 0.0023595 0.1860116 0.00236 ** NA
TMEM117 erlotinib 0.0023630 0.7436781 0.00236 ** NA
FAM65C nilotinib 0.0023709 0.7820181 0.00237 ** NA
KIAA1045 cabozantinib 0.0023727 0.1860116 0.00237 ** NA
BDKRB2 temozolomide 0.0023771 0.8741265 0.00238 ** NA
ASUN nilotinib 0.0023774 0.7820181 0.00238 ** NA
RIMKLB cabozantinib 0.0023808 0.1860116 0.00238 ** NA
ARFGEF2 cabozantinib 0.0023810 0.1860116 0.00238 ** NA
ENPP6 sunitinib 0.0023824 0.6695527 0.00238 ** NA
CILP temozolomide 0.0023848 0.8741265 0.00238 ** NA
UGT1A10 cabozantinib 0.0023870 0.1860116 0.00239 ** NA
IGFLR1 lapatinib 0.0023995 0.8488319 0.00240 ** NA
ANK3 olaparib 0.0024019 0.9821538 0.00240 ** NA
OLFM4 vemurafenib 0.0024076 0.4207683 0.00241 ** NA
OLFML2B lapatinib 0.0024079 0.8488319 0.00241 ** NA
YTHDC1 temozolomide 0.0024118 0.8741265 0.00241 ** NA
IQCD nilotinib 0.0024140 0.7820181 0.00241 ** NA
GEN1 erlotinib 0.0024248 0.7436781 0.00242 ** NA
ARHGEF18 pazopanib 0.0024271 0.9778540 0.00243 ** NA
KCNA7 regorafenib 0.0024302 0.6627240 0.00243 ** NA
RIPK1 cabozantinib 0.0024317 0.1862158 0.00243 ** NA
SMG1 dasatinib 0.0024325 0.9816837 0.00243 ** NA
PLCE1 temozolomide 0.0024363 0.8741265 0.00244 ** NA
FGD4 cabozantinib 0.0024377 0.1862158 0.00244 ** NA
ANKRD55 lapatinib 0.0024385 0.8488319 0.00244 ** NA
GEMIN2 cabozantinib 0.0024400 0.1862158 0.00244 ** NA
TMEM106B cabozantinib 0.0024400 0.1862158 0.00244 ** NA
DRD5 vemurafenib 0.0024415 0.4207683 0.00244 ** NA
UBP1 vemurafenib 0.0024421 0.4207683 0.00244 ** NA
FOXG1 vemurafenib 0.0024587 0.4207683 0.00246 ** NA
PROSER1 gefitinib 0.0024607 0.9513640 0.00246 ** NA
KIAA1324 cabozantinib 0.0024649 0.1862158 0.00246 ** NA
MYH10 vemurafenib 0.0024658 0.4207683 0.00247 ** NA
ZNF320 cabozantinib 0.0024797 0.1862158 0.00248 ** NA
PAX6 regorafenib 0.0024809 0.6627240 0.00248 ** NA
ERAP2 selumetinib 0.0024816 0.9983774 0.00248 ** NA
ZNF596 erlotinib 0.0024851 0.7436781 0.00249 ** NA
NMRK1 vandetanib 0.0024864 0.8963224 0.00249 ** NA
EGFLAM fulvestrant 0.0024868 0.9869407 0.00249 ** NA
OSTF1 gefitinib 0.0024874 0.9513640 0.00249 ** NA
BRD1 regorafenib 0.0024881 0.6627240 0.00249 ** NA
CSN3 sunitinib 0.0024904 0.6695527 0.00249 ** NA
IL6ST nilotinib 0.0024911 0.7820181 0.00249 ** NA
CREBZF ibrutinib 0.0024957 0.9136837 0.00250 ** NA
THSD4 fulvestrant 0.0024981 0.9869407 0.00250 ** NA
MYRIP lapatinib 0.0025000 0.8488319 0.00250 ** NA
AGBL4 erlotinib 0.0025017 0.7436781 0.00250 ** NA
AQP9 cabozantinib 0.0025024 0.1862158 0.00250 ** NA
CDK11A lapatinib 0.0025100 0.8488319 0.00251 ** NA
USP50 lapatinib 0.0025106 0.8488319 0.00251 ** NA
SYCP1 regorafenib 0.0025109 0.6627240 0.00251 ** NA
COPA cabozantinib 0.0025218 0.1862158 0.00252 ** NA
ERMARD imatinib 0.0025219 0.8762527 0.00252 ** NA
MRPS30 cabozantinib 0.0025249 0.1862158 0.00252 ** NA
PFDN1 neratinib 0.0025267 0.9827379 0.00253 ** NA
RRP15 sunitinib 0.0025269 0.6695527 0.00253 ** NA
DSCR3 neratinib 0.0025290 0.9827379 0.00253 ** NA
ARHGAP24 belinostat 0.0025293 1.0000000 0.0025 ** NA
FREM1 cabozantinib 0.0025319 0.1862158 0.00253 ** NA
TAB1 afatinib 0.0025322 0.8943727 0.00253 ** NA
TMEM199 cabozantinib 0.0025357 0.1862158 0.00254 ** NA
PVRL3 fluorouracil 0.0025363 1.0000000 0.00254 ** NA
EHBP1L1 cabozantinib 0.0025428 0.1862158 0.00254 ** NA
NRAS ibrutinib 0.0025472 0.9136837 0.00255 ** NA
TSTD2 fluorouracil 0.0025476 1.0000000 0.00255 ** NA
GPR4 sunitinib 0.0025504 0.6695527 0.00255 ** NA
CA10 cabozantinib 0.0025505 0.1862158 0.00255 ** NA
POU6F2 erlotinib 0.0025505 0.7436781 0.00255 ** NA
KIF24 sunitinib 0.0025544 0.6695527 0.00255 ** NA
LINS cabozantinib 0.0025546 0.1862158 0.00255 ** NA
SYVN1 cabozantinib 0.0025615 0.1862158 0.00256 ** NA
C7 gefitinib 0.0025628 0.9513640 0.00256 ** NA
CTHRC1 temozolomide 0.0025750 0.8741265 0.00258 ** NA
GNAI2 neratinib 0.0025805 0.9827379 0.00258 ** NA
GFI1B vemurafenib 0.0025816 0.4245575 0.00258 ** NA
ADAMTS13 gefitinib 0.0025837 0.9513640 0.00258 ** NA
PRAMEF2 cabozantinib 0.0025863 0.1862158 0.00259 ** NA
RBBP8 dabrafenib 0.0025917 0.9104067 0.00259 ** NA
CLDN8 lapatinib 0.0025919 0.8488319 0.00259 ** NA
PFKFB3 erlotinib 0.0025944 0.7436781 0.00259 ** NA
FBXO25 olaparib 0.0025949 0.9821538 0.00259 ** NA
FAM3D vemurafenib 0.0025977 0.4245575 0.00260 ** NA
GMCL1 regorafenib 0.0025995 0.6627240 0.00260 ** NA
NCDN temozolomide 0.0026014 0.8741265 0.00260 ** NA
KRT14 cabozantinib 0.0026083 0.1862158 0.00261 ** NA
TBC1D10B olaparib 0.0026108 0.9821538 0.00261 ** NA
DRGX vandetanib 0.0026132 0.8963224 0.00261 ** NA
PPP2R1A regorafenib 0.0026137 0.6627240 0.00261 ** NA
CDK8 vemurafenib 0.0026171 0.4245575 0.00262 ** NA
GRIN3B fluorouracil 0.0026176 1.0000000 0.00262 ** NA
CXXC5 fluorouracil 0.0026180 1.0000000 0.00262 ** NA
CHKB afatinib 0.0026201 0.8943727 0.00262 ** NA
PPP2R4 cabozantinib 0.0026212 0.1862158 0.00262 ** NA
ALDH8A1 cabozantinib 0.0026230 0.1862158 0.00262 ** NA
CEP135 ibrutinib 0.0026234 0.9136837 0.00262 ** NA
CYLC2 imatinib 0.0026256 0.8762527 0.00263 ** NA
FAM171B cabozantinib 0.0026266 0.1862158 0.00263 ** NA
SRC sunitinib 0.0026281 0.6695527 0.00263 ** NA
CSGALNACT2 cabozantinib 0.0026321 0.1862158 0.00263 ** NA
PLEKHO1 trametinib 0.0026339 0.9757752 0.0026 ** NA
C17orf75 afatinib 0.0026346 0.8943727 0.00263 ** NA
NRBP1 imatinib 0.0026356 0.8762527 0.00264 ** NA
DPY19L3 cabozantinib 0.0026361 0.1862158 0.00264 ** NA
IZUMO2 cabozantinib 0.0026472 0.1862158 0.00265 ** NA
EGFL8 temozolomide 0.0026477 0.8741265 0.00265 ** NA
DUOXA2 afatinib 0.0026489 0.8943727 0.00265 ** NA
COL3A1 olaparib 0.0026507 0.9821538 0.00265 ** NA
SEMA4B olaparib 0.0026518 0.9821538 0.00265 ** NA
C14orf2 lapatinib 0.0026546 0.8488319 0.00265 ** NA
UVRAG neratinib 0.0026629 0.9827379 0.00266 ** NA
SLC38A6 vemurafenib 0.0026630 0.4245575 0.00266 ** NA
ARHGAP23 imatinib 0.0026635 0.8762527 0.00266 ** NA
F5 cabozantinib 0.0026636 0.1862158 0.00266 ** NA
FRY cabozantinib 0.0026637 0.1862158 0.00266 ** NA
TAS2R43 olaparib 0.0026686 0.9821538 0.00267 ** NA
IFT57 nilotinib 0.0026713 0.7820181 0.00267 ** NA
ZNF606 nilotinib 0.0026739 0.7820181 0.00267 ** NA
TAF4 olaparib 0.0026750 0.9821538 0.00267 ** NA
LRRIQ1 temozolomide 0.0026855 0.8741265 0.00269 ** NA
SERPINE1 trametinib 0.0026873 0.9757752 0.0027 ** NA
FAM181A ibrutinib 0.0026899 0.9136837 0.00269 ** NA
PDZD2 cabozantinib 0.0026910 0.1871701 0.00269 ** NA
P2RX5 gefitinib 0.0026913 0.9513640 0.00269 ** NA
ESPN temozolomide 0.0026994 0.8741265 0.00270 ** NA
PTEN gefitinib 0.0027031 0.9513640 0.00270 ** NA
ANKRD55 vemurafenib 0.0027078 0.4245575 0.00271 ** NA
NOLC1 fluorouracil 0.0027087 1.0000000 0.00271 ** NA
PLCE1 nilotinib 0.0027089 0.7820181 0.00271 ** NA
TRIM50 ibrutinib 0.0027094 0.9136837 0.00271 ** NA
TMEM117 lapatinib 0.0027102 0.8488319 0.00271 ** NA
CLN8 sunitinib 0.0027131 0.6695527 0.00271 ** NA
EVI5L nilotinib 0.0027179 0.7820181 0.00272 ** NA
FDFT1 nilotinib 0.0027203 0.7820181 0.00272 ** NA
NASP cabozantinib 0.0027220 0.1871701 0.00272 ** NA
OR1B1 ibrutinib 0.0027238 0.9136837 0.00272 ** NA
KIAA0825 temozolomide 0.0027299 0.8741265 0.00273 ** NA
TPTE regorafenib 0.0027309 0.6627240 0.00273 ** NA
SLC9A5 sunitinib 0.0027314 0.6695527 0.00273 ** NA
OR6T1 cabozantinib 0.0027327 0.1871701 0.00273 ** NA
MPP4 gefitinib 0.0027347 0.9513640 0.00273 ** NA
PLTP gefitinib 0.0027377 0.9513640 0.00274 ** NA
RAB40C vandetanib 0.0027387 0.8963224 0.00274 ** NA
ST6GAL2 olaparib 0.0027408 0.9821538 0.00274 ** NA
VPS13B regorafenib 0.0027418 0.6627240 0.00274 ** NA
SLC17A7 vemurafenib 0.0027425 0.4245575 0.00274 ** NA
PTCHD4 afatinib 0.0027480 0.8943727 0.00275 ** NA
GPR110 nilotinib 0.0027491 0.7820181 0.00275 ** NA
TAF4B lapatinib 0.0027497 0.8488319 0.00275 ** NA
RBFOX2 cabozantinib 0.0027501 0.1871701 0.00275 ** NA
KPNA3 imatinib 0.0027539 0.8762527 0.00275 ** NA
MBTPS1 dasatinib 0.0027583 0.9816837 0.00276 ** NA
STAP2 cabozantinib 0.0027583 0.1871701 0.00276 ** NA
LMX1B gefitinib 0.0027586 0.9513640 0.00276 ** NA
TP53BP2 vemurafenib 0.0027653 0.4245575 0.00277 ** NA
DNAJC6 cabozantinib 0.0027653 0.1871701 0.00277 ** NA
MAPK8 vemurafenib 0.0027765 0.4245575 0.00278 ** NA
LRIT2 cabozantinib 0.0027779 0.1871701 0.00278 ** NA
RAP1GAP imatinib 0.0027826 0.8762527 0.00278 ** NA
STAP2 sunitinib 0.0027832 0.6695527 0.00278 ** NA
ZNF217 temozolomide 0.0027869 0.8741265 0.00279 ** NA
C10orf120 vemurafenib 0.0027901 0.4245575 0.00279 ** NA
DMRT3 regorafenib 0.0027904 0.6627240 0.00279 ** NA
DNAJB9 cabozantinib 0.0027916 0.1871701 0.00279 ** NA
HID1 afatinib 0.0027956 0.8943727 0.00280 ** NA
ZFP69 gefitinib 0.0027964 0.9513640 0.00280 ** NA
OR6B2 regorafenib 0.0028042 0.6627240 0.00280 ** NA
PRDM11 trametinib 0.0028066 0.9757752 0.0028 ** NA
PTH1R erlotinib 0.0028070 0.7436781 0.00281 ** NA
AOC2 nilotinib 0.0028084 0.7820181 0.00281 ** NA
PLCH2 cabozantinib 0.0028130 0.1871701 0.00281 ** NA
RHD vemurafenib 0.0028157 0.4245575 0.00282 ** NA
KIF3C vemurafenib 0.0028158 0.4245575 0.00282 ** NA
MTBP sunitinib 0.0028197 0.6695527 0.00282 ** NA
SPIB cabozantinib 0.0028198 0.1871701 0.00282 ** NA
DLG4 cabozantinib 0.0028204 0.1871701 0.00282 ** NA
DPY19L1 neratinib 0.0028222 0.9827379 0.00282 ** NA
TFCP2L1 afatinib 0.0028254 0.8943727 0.00283 ** NA
LRRC7 selumetinib 0.0028301 0.9983774 0.00283 ** NA
TTLL2 gefitinib 0.0028314 0.9513640 0.00283 ** NA
RPE65 cabozantinib 0.0028419 0.1871701 0.00284 ** NA
UCP1 cabozantinib 0.0028457 0.1871701 0.00285 ** NA
DMXL1 regorafenib 0.0028461 0.6627240 0.00285 ** NA
DSCR3 lapatinib 0.0028493 0.8488319 0.00285 ** NA
HCFC2 cabozantinib 0.0028506 0.1871701 0.00285 ** NA
ITPKA vemurafenib 0.0028521 0.4245575 0.00285 ** NA
ARHGEF11 cabozantinib 0.0028532 0.1871701 0.00285 ** NA
ASPM cabozantinib 0.0028536 0.1871701 0.00285 ** NA
CCIN regorafenib 0.0028549 0.6627240 0.00285 ** NA
ATP8B1 afatinib 0.0028557 0.8943727 0.00286 ** NA
GLDC nilotinib 0.0028577 0.7820181 0.00286 ** NA
ATP10A vemurafenib 0.0028593 0.4245575 0.00286 ** NA
UBA2 vemurafenib 0.0028627 0.4245575 0.00286 ** NA
PDLIM4 neratinib 0.0028640 0.9827379 0.00286 ** NA
L3MBTL4 olaparib 0.0028679 0.9821538 0.00287 ** NA
TRPV4 sunitinib 0.0028708 0.6695527 0.00287 ** NA
ASAP1 cabozantinib 0.0028718 0.1873947 0.00287 ** NA
DHRS11 regorafenib 0.0028721 0.6627240 0.00287 ** NA
ZNF573 sunitinib 0.0028775 0.6695527 0.00288 ** NA
MORC2 cabozantinib 0.0028791 0.1873947 0.00288 ** NA
MGAM temozolomide 0.0028845 0.8741265 0.00288 ** NA
PMPCB pazopanib 0.0028882 0.9778540 0.00289 ** NA
TAF1L pazopanib 0.0028911 0.9778540 0.00289 ** NA
PHYKPL vemurafenib 0.0028913 0.4245575 0.00289 ** NA
ZBTB7C crizotinib 0.0028963 0.9965659 0.00290 ** NA
TPBGL dasatinib 0.0028968 0.9816837 0.00290 ** NA
PIK3R2 olaparib 0.0028987 0.9821538 0.00290 ** NA
DNMT3A lapatinib 0.0028992 0.8488319 0.00290 ** NA
MAP10 neratinib 0.0029011 0.9827379 0.00290 ** NA
ABCB6 cabozantinib 0.0029034 0.1882581 0.00290 ** NA
CNGB3 imatinib 0.0029078 0.8762527 0.00291 ** NA
AOX1 olaparib 0.0029089 0.9821538 0.00291 ** NA
A2ML1 pazopanib 0.0029116 0.9778540 0.00291 ** NA

GDSC:

gdsc <- read.delim("./data_munging/data_drug_auc_gdsc_10_12_2018.csv", sep = "\t", header  = TRUE, row.names = 1, check.names = FALSE)
gdsc <- merge(drug_meta, gdsc, by = "CID")
gdsc_melt <- melt(gdsc, id.vars = c("CID", "Drug"), measure.vars = colnames(gdsc)[3:ncol(gdsc)], variable.name = "accession_id", value.name = "AUC")
gdsc_grid <- expand.grid("accession_id" = unique(gdsc_melt$accession_id), "Hugo_Symbol" = as.character(unique(crispr_data$Hugo_Symbol)))
system.time({ gdsc_data_allgenes <- WilcoxonByDrugAllGenes(gdsc_melt, gdsc_grid, "GDSC") })
saveRDS(gdsc_data_allgenes, "./data_munging/rds/gdsc_data_18Q3_allgenes.rds", compress = "xz")
gdsc_data_allgenes <- readRDS("./data_munging/rds/gdsc_data_18Q3_allgenes.rds")
gdsc_data_allgenes <- gdsc_data_allgenes[order(gdsc_data_allgenes$p),]

knitr::kable(gdsc_data_allgenes[1:1000, c("Hugo_Symbol", "Drug", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "GDSC: by-drug Wilcoxon test results for point mutations in genes targeted in CRISPR screen (* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
GDSC: by-drug Wilcoxon test results for point mutations in genes targeted in CRISPR screen (* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)
Hugo_Symbol Drug p p.adj p.format p.signif p.signif.adj
KRAS trametinib 0.0000000 0.0001434 8.5e-09 **** ***
KRT3 gefitinib 0.0000006 0.0092957 5.6e-07 **** **
KRT3 afatinib 0.0000033 0.0544399 3.3e-06 **** NA
KRT3 docetaxel 0.0000230 0.3833031 2.3e-05 **** NA
LRRC16B tretinoin 0.0000319 0.3065581 3.2e-05 **** NA
GLI3 tretinoin 0.0000368 0.3065581 3.7e-05 **** NA
CCDC11 trametinib 0.0000772 0.6129716 7.7e-05 **** NA
ANKRD11 midostaurin 0.0000949 0.8485531 9.5e-05 **** NA
NF1 midostaurin 0.0001013 0.8485531 0.00010 *** NA
GRM7 gefitinib 0.0001055 0.8784133 0.00011 *** NA
BRAF dabrafenib 0.0001234 0.9305571 0.00012 *** NA
STK36 temozolomide 0.0001286 0.6902774 0.00013 *** NA
ZNF502 pazopanib 0.0001430 0.9978452 0.00014 *** NA
BRAF trametinib 0.0001576 0.6129716 0.00016 *** NA
CALD1 tretinoin 0.0001594 0.5222109 0.00016 *** NA
RETSAT gefitinib 0.0001619 0.8957015 0.00016 *** NA
APOB trametinib 0.0001645 0.6129716 0.00016 *** NA
SLC6A17 tretinoin 0.0001648 0.5222109 0.00016 *** NA
DPCR1 cabozantinib 0.0001688 0.8298252 0.00017 *** NA
ING1 alectinib 0.0001695 0.9168760 0.00017 *** NA
HCFC2 temozolomide 0.0001863 0.6902774 0.00019 *** NA
IVL ruxolitinib 0.0001893 0.9787856 0.00019 *** NA
DCHS1 cabozantinib 0.0001897 0.8298252 0.00019 *** NA
TTN trametinib 0.0002005 0.6129716 0.00020 *** NA
KAT6A tretinoin 0.0002041 0.5222109 0.00020 *** NA
PTEN belinostat 0.0002105 0.9983823 0.00021 *** NA
TNRC18 trametinib 0.0002193 0.6129716 0.00022 *** NA
ZNF304 tretinoin 0.0002225 0.5222109 0.00022 *** NA
MBNL1 cabozantinib 0.0002280 0.8298252 0.00023 *** NA
AZGP1 tretinoin 0.0002550 0.5222109 0.00026 *** NA
BICD1 tretinoin 0.0002627 0.5222109 0.00026 *** NA
PLEKHA5 temozolomide 0.0002708 0.6902774 0.00027 *** NA
SLC2A5 dabrafenib 0.0002882 0.9305571 0.00029 *** NA
SEC31B dabrafenib 0.0002925 0.9305571 0.00029 *** NA
TNC trametinib 0.0002990 0.7165039 0.00030 *** NA
TTLL11 alectinib 0.0003022 0.9168760 0.00030 *** NA
PRR14 gefitinib 0.0003066 0.8957015 0.00031 *** NA
SLC28A3 alectinib 0.0003397 0.9168760 0.00034 *** NA
CASP8 ruxolitinib 0.0003630 0.9787856 0.00036 *** NA
XIRP2 lapatinib 0.0003744 0.8107014 0.00037 *** NA
TNRC18 dabrafenib 0.0003745 0.9305571 0.00037 *** NA
GART alectinib 0.0003784 0.9168760 0.00038 *** NA
SZT2 pazopanib 0.0003837 0.9978452 0.00038 *** NA
PCDHB1 nilotinib 0.0003863 0.8055751 0.00039 *** NA
CDKN2A trametinib 0.0003927 0.7896655 0.00039 *** NA
ABCC12 tretinoin 0.0003991 0.5222109 0.00040 *** NA
DBF4 palbociclib 0.0004053 0.9551671 0.00041 *** NA
OTOG temozolomide 0.0004084 0.6902774 0.00041 *** NA
ANGPTL2 dabrafenib 0.0004196 0.9305571 0.00042 *** NA
UGT2A1 afatinib 0.0004220 0.9267832 0.00042 *** NA
KIAA0319 trametinib 0.0004237 0.7896655 0.00042 *** NA
GJA10 tretinoin 0.0004279 0.5222109 0.00043 *** NA
PCDHGB4 midostaurin 0.0004291 0.8795120 0.00043 *** NA
MYH8 tretinoin 0.0004310 0.5222109 0.00043 *** NA
UBR4 gefitinib 0.0004353 0.8957015 0.00044 *** NA
SEZ6L alectinib 0.0004383 0.9168760 0.00044 *** NA
SLC7A9 tretinoin 0.0004383 0.5222109 0.00044 *** NA
PCDHGB4 ponatinib 0.0004386 1.0000000 0.00044 *** NA
HECTD1 cabozantinib 0.0004417 0.8298252 0.00044 *** NA
MTF2 midostaurin 0.0004560 0.8795120 0.00046 *** NA
TP53 docetaxel 0.0004703 0.9106700 0.00047 *** NA
TWF2 midostaurin 0.0005002 0.8795120 0.00050 *** NA
PDGFRB cabozantinib 0.0005036 0.8298252 0.00050 *** NA
GSPT1 docetaxel 0.0005113 0.9106700 0.00051 *** NA
ZNF85 tretinoin 0.0005235 0.5222109 0.00052 *** NA
DOCK6 ruxolitinib 0.0005280 0.9787856 0.00053 *** NA
FOXA1 vismodegib 0.0005480 0.9623352 0.00055 *** NA
CAMK4 tretinoin 0.0005565 0.5222109 0.00056 *** NA
FGD6 tretinoin 0.0005638 0.5222109 0.00056 *** NA
SMEK2 tretinoin 0.0005725 0.5222109 0.00057 *** NA
PTH1R afatinib 0.0005796 0.9267832 0.00058 *** NA
DSEL tretinoin 0.0005844 0.5222109 0.00058 *** NA
GLG1 cabozantinib 0.0005860 0.8298252 0.00059 *** NA
ATG16L1 rucaparib 0.0005872 0.9990814 0.00059 *** NA
ESRP2 cabozantinib 0.0005887 0.8298252 0.00059 *** NA
LRP5 temozolomide 0.0006198 0.6902774 0.00062 *** NA
PABPC4 temozolomide 0.0006343 0.6902774 0.00063 *** NA
MDH1B dabrafenib 0.0006353 0.9305571 0.00064 *** NA
MUC16 docetaxel 0.0006486 0.9106700 0.00065 *** NA
ROBO2 erlotinib 0.0006603 0.7991878 0.00066 *** NA
SARS2 dabrafenib 0.0006646 0.9305571 0.00066 *** NA
CDKN2A docetaxel 0.0006721 0.9106700 0.00067 *** NA
LPAR5 docetaxel 0.0006722 0.9106700 0.00067 *** NA
NAPB temozolomide 0.0006842 0.6902774 0.00068 *** NA
TRMT44 afatinib 0.0007182 0.9267832 0.00072 *** NA
GABRA5 nilotinib 0.0007210 0.8055751 0.00072 *** NA
KBTBD12 docetaxel 0.0007266 0.9106700 0.00073 *** NA
RABL6 temozolomide 0.0007371 0.6902774 0.00074 *** NA
PRKCB bosutinib monohydrate 0.0007390 1.0000000 0.00074 *** NA
OR12D2 alectinib 0.0007538 0.9168760 0.00075 *** NA
CPAMD8 midostaurin 0.0007559 0.8795120 0.00076 *** NA
STAM temozolomide 0.0007729 0.6902774 0.00077 *** NA
NOTO ruxolitinib 0.0007812 0.9787856 0.00078 *** NA
PRDM15 cabozantinib 0.0007818 0.8298252 0.00078 *** NA
SNAP91 nilotinib 0.0007848 0.8055751 0.00078 *** NA
A2M cabozantinib 0.0008079 0.8298252 0.00081 *** NA
CYP2A6 docetaxel 0.0008086 0.9106700 0.00081 *** NA
MUC5B tretinoin 0.0008235 0.5222109 0.00082 *** NA
DOCK6 cabozantinib 0.0008245 0.8298252 0.00082 *** NA
KCNC4 nilotinib 0.0008246 0.8055751 0.00082 *** NA
GPA33 trametinib 0.0008408 0.9852344 0.00084 *** NA
ACAD11 tretinoin 0.0008461 0.5222109 0.00085 *** NA
ALPL gefitinib 0.0008712 0.8957015 0.00087 *** NA
HCFC2 vismodegib 0.0008896 0.9623352 0.00089 *** NA
GOLPH3L nilotinib 0.0008929 0.8055751 0.00089 *** NA
SNX14 nilotinib 0.0009023 0.8055751 0.00090 *** NA
CCDC17 temozolomide 0.0009029 0.6902774 0.00090 *** NA
XIRP2 rucaparib 0.0009195 0.9990814 0.00092 *** NA
OR6C70 cabozantinib 0.0009205 0.8298252 0.00092 *** NA
TCEA2 cabozantinib 0.0009677 0.8298252 0.00097 *** NA
FSTL4 tretinoin 0.0009720 0.5222109 0.00097 *** NA
ZNF846 pazopanib 0.0009734 0.9978452 0.00097 *** NA
MTMR7 tretinoin 0.0009774 0.5222109 0.00098 *** NA
OR2M5 vismodegib 0.0009854 0.9623352 0.00099 *** NA
GRID1 afatinib 0.0009931 0.9267832 0.00099 *** NA
OSR2 trametinib 0.0009981 0.9852344 0.00100 *** NA
KLHDC7A trametinib 0.0010019 0.9852344 0.00100 ** NA
ZKSCAN5 ponatinib 0.0010078 1.0000000 0.00101 ** NA
SLCO6A1 cabozantinib 0.0010088 0.8298252 0.00101 ** NA
GSPT1 nilotinib 0.0010113 0.8055751 0.00101 ** NA
KCNG2 tretinoin 0.0010395 0.5222109 0.00104 ** NA
SGCE midostaurin 0.0010401 0.8795120 0.00104 ** NA
GSC nilotinib 0.0010428 0.8055751 0.00104 ** NA
GNAI1 alectinib 0.0010441 0.9168760 0.00104 ** NA
TIAM2 trametinib 0.0010478 0.9852344 0.00105 ** NA
SLC25A39 tretinoin 0.0010508 0.5222109 0.00105 ** NA
VCPIP1 ponatinib 0.0010548 1.0000000 0.00105 ** NA
LILRB2 crizotinib 0.0010550 0.7869686 0.0011 ** NA
SEMA4A belinostat 0.0010554 0.9983823 0.00106 ** NA
PDHA2 palbociclib 0.0010572 0.9551671 0.00106 ** NA
ZNF202 dabrafenib 0.0010622 0.9305571 0.00106 ** NA
OR56A4 midostaurin 0.0010691 0.8795120 0.00107 ** NA
PCSK2 belinostat 0.0010719 0.9983823 0.00107 ** NA
XYLT1 tretinoin 0.0010746 0.5222109 0.00107 ** NA
MLLT4 tretinoin 0.0010936 0.5222109 0.00109 ** NA
IGSF9 docetaxel 0.0011031 0.9106700 0.00110 ** NA
KALRN dabrafenib 0.0011216 0.9305571 0.00112 ** NA
BFSP1 afatinib 0.0011233 0.9267832 0.00112 ** NA
TMEM82 cabozantinib 0.0011246 0.8298252 0.00112 ** NA
FAM198A dabrafenib 0.0011259 0.9305571 0.00113 ** NA
HCFC2 nilotinib 0.0011346 0.8055751 0.00113 ** NA
GZMH tretinoin 0.0011441 0.5222109 0.00114 ** NA
DNAH9 docetaxel 0.0011562 0.9106700 0.00116 ** NA
KDM4B temozolomide 0.0011595 0.6902774 0.00116 ** NA
MAP3K12 rucaparib 0.0011725 0.9990814 0.00117 ** NA
SUPT16H temozolomide 0.0011771 0.6902774 0.00118 ** NA
ACAD11 nilotinib 0.0011832 0.8055751 0.00118 ** NA
RPS6KA1 tretinoin 0.0011844 0.5222109 0.00118 ** NA
IL10RB gefitinib 0.0011848 0.8957015 0.00118 ** NA
EZH2 bosutinib monohydrate 0.0011913 1.0000000 0.00119 ** NA
PHLDB3 sunitinib 0.0012033 0.7819868 0.0012 ** NA
TRMT13 cabozantinib 0.0012095 0.8298252 0.00121 ** NA
POLR2A palbociclib 0.0012142 0.9551671 0.00121 ** NA
SEMA5A afatinib 0.0012154 0.9267832 0.00122 ** NA
OR5T2 trametinib 0.0012326 0.9852344 0.00123 ** NA
PYGO1 afatinib 0.0012345 0.9267832 0.00123 ** NA
GSPT1 temozolomide 0.0012353 0.6902774 0.00124 ** NA
RFPL4AL1 alectinib 0.0012390 0.9168760 0.00124 ** NA
WDR6 gefitinib 0.0012433 0.8957015 0.00124 ** NA
PIGN cabozantinib 0.0012484 0.8298252 0.00125 ** NA
PCSK7 afatinib 0.0012497 0.9267832 0.00125 ** NA
BMPER belinostat 0.0012548 0.9983823 0.00125 ** NA
OTOG nilotinib 0.0012594 0.8055751 0.00126 ** NA
DMBT1 cabozantinib 0.0012632 0.8298252 0.00126 ** NA
GJA10 vismodegib 0.0012708 0.9623352 0.00127 ** NA
ACIN1 trametinib 0.0012721 0.9852344 0.00127 ** NA
USP5 ruxolitinib 0.0012753 0.9787856 0.00128 ** NA
ZNF644 tretinoin 0.0012913 0.5222109 0.00129 ** NA
ACKR3 temozolomide 0.0012959 0.6902774 0.00130 ** NA
TRPM5 ponatinib 0.0012976 1.0000000 0.00130 ** NA
KRT9 temozolomide 0.0013003 0.6902774 0.00130 ** NA
NEGR1 gefitinib 0.0013015 0.8957015 0.00130 ** NA
FBXW10 palbociclib 0.0013029 0.9551671 0.00130 ** NA
EXOSC9 cabozantinib 0.0013032 0.8298252 0.00130 ** NA
CACNA1C docetaxel 0.0013040 0.9106700 0.00130 ** NA
SDAD1 nilotinib 0.0013062 0.8055751 0.00131 ** NA
ZNF528 temozolomide 0.0013101 0.6902774 0.00131 ** NA
IGSF9B nilotinib 0.0013195 0.8055751 0.00132 ** NA
PIK3C2B dabrafenib 0.0013202 0.9305571 0.00132 ** NA
TRPM5 cabozantinib 0.0013202 0.8298252 0.00132 ** NA
STK36 cabozantinib 0.0013279 0.8298252 0.00133 ** NA
MAP2 tretinoin 0.0013346 0.5222109 0.00133 ** NA
FBN3 gefitinib 0.0013395 0.8957015 0.00134 ** NA
SEC63 tretinoin 0.0013611 0.5222109 0.00136 ** NA
LRFN5 gefitinib 0.0013738 0.8957015 0.00137 ** NA
SERPIND1 alectinib 0.0013792 0.9168760 0.00138 ** NA
SPEG trametinib 0.0013912 0.9852344 0.00139 ** NA
GDF11 cabozantinib 0.0013978 0.8298252 0.00140 ** NA
SEL1L2 ruxolitinib 0.0013991 0.9787856 0.00140 ** NA
ERVV-1 afatinib 0.0014031 0.9267832 0.00140 ** NA
CDHR5 lapatinib 0.0014107 0.8107014 0.00141 ** NA
SLC2A10 cabozantinib 0.0014259 0.8298252 0.00143 ** NA
TTN cabozantinib 0.0014280 0.8298252 0.00143 ** NA
MUC16 cabozantinib 0.0014396 0.8298252 0.00144 ** NA
KIAA1244 tretinoin 0.0014413 0.5222109 0.00144 ** NA
HCFC2 docetaxel 0.0014446 0.9106700 0.00144 ** NA
FCHSD1 sunitinib 0.0014492 0.7819868 0.0014 ** NA
CNNM2 gefitinib 0.0014516 0.8957015 0.00145 ** NA
KCNT1 tretinoin 0.0014564 0.5222109 0.00146 ** NA
CNTNAP2 tretinoin 0.0014589 0.5222109 0.00146 ** NA
TRMT44 gefitinib 0.0014720 0.8957015 0.00147 ** NA
C5 tretinoin 0.0014839 0.5222109 0.00148 ** NA
ZNF785 tretinoin 0.0014923 0.5222109 0.00149 ** NA
CDH18 afatinib 0.0014976 0.9267832 0.00150 ** NA
RRAGD tretinoin 0.0014983 0.5222109 0.00150 ** NA
LAMA2 tretinoin 0.0015069 0.5222109 0.00151 ** NA
KCNAB1 tretinoin 0.0015148 0.5222109 0.00151 ** NA
A2ML1 tretinoin 0.0015364 0.5222109 0.00154 ** NA
ZNF93 trametinib 0.0015428 0.9852344 0.00154 ** NA
C19orf18 trametinib 0.0015539 0.9852344 0.00155 ** NA
C16orf71 trametinib 0.0015550 0.9852344 0.00155 ** NA
LAMC3 gefitinib 0.0015574 0.8957015 0.00156 ** NA
WWP2 bosutinib monohydrate 0.0015609 1.0000000 0.00156 ** NA
PAXBP1 cabozantinib 0.0015702 0.8298252 0.00157 ** NA
PHTF2 vismodegib 0.0015704 0.9623352 0.00157 ** NA
PTPRB midostaurin 0.0015720 0.8795120 0.00157 ** NA
CLEC4F cabozantinib 0.0015766 0.8298252 0.00158 ** NA
HCFC2 tretinoin 0.0015812 0.5222109 0.00158 ** NA
BICD1 nilotinib 0.0015833 0.8055751 0.00158 ** NA
PSIP1 ponatinib 0.0015943 1.0000000 0.00159 ** NA
SIGLEC5 alectinib 0.0016045 0.9168760 0.00160 ** NA
CCIN nilotinib 0.0016092 0.8055751 0.00161 ** NA
LPIN3 midostaurin 0.0016122 0.8795120 0.00161 ** NA
TAAR8 dabrafenib 0.0016175 0.9305571 0.00162 ** NA
POGK ruxolitinib 0.0016239 0.9787856 0.00162 ** NA
SCN8A temozolomide 0.0016278 0.6902774 0.00163 ** NA
RINL docetaxel 0.0016283 0.9106700 0.00163 ** NA
FAM207A nilotinib 0.0016338 0.8055751 0.00163 ** NA
FIGNL1 afatinib 0.0016356 0.9267832 0.00164 ** NA
TNC dabrafenib 0.0016383 0.9305571 0.00164 ** NA
NDUFS3 pazopanib 0.0016405 0.9978452 0.00164 ** NA
KIAA1683 ruxolitinib 0.0016411 0.9787856 0.00164 ** NA
CIITA tretinoin 0.0016484 0.5222109 0.00165 ** NA
DCLK2 nilotinib 0.0016547 0.8055751 0.00165 ** NA
ZNF391 dabrafenib 0.0016585 0.9305571 0.00166 ** NA
PCDHGC4 palbociclib 0.0016592 0.9551671 0.00166 ** NA
GLP2R nilotinib 0.0016642 0.8055751 0.00166 ** NA
ABLIM3 ponatinib 0.0016682 1.0000000 0.00167 ** NA
DAZAP1 tretinoin 0.0016683 0.5222109 0.00167 ** NA
RSPH10B2 tretinoin 0.0016799 0.5222109 0.00168 ** NA
UPF3A temozolomide 0.0016804 0.6902774 0.00168 ** NA
ZDHHC23 tretinoin 0.0016847 0.5222109 0.00168 ** NA
NUCB1 temozolomide 0.0016859 0.6902774 0.00169 ** NA
PTGIR alectinib 0.0016935 0.9168760 0.00169 ** NA
ELF5 tretinoin 0.0016961 0.5222109 0.00170 ** NA
COL4A3 tretinoin 0.0017038 0.5222109 0.00170 ** NA
ALS2CL temozolomide 0.0017044 0.6902774 0.00170 ** NA
PTPRU ponatinib 0.0017063 1.0000000 0.00171 ** NA
KRAS palbociclib 0.0017081 0.9551671 0.00171 ** NA
GABRP afatinib 0.0017226 0.9267832 0.00172 ** NA
FYCO1 gefitinib 0.0017341 0.8957015 0.00173 ** NA
NPAS3 afatinib 0.0017352 0.9267832 0.00174 ** NA
ITGB2 temozolomide 0.0017490 0.6902774 0.00175 ** NA
ZNF737 vismodegib 0.0017519 0.9623352 0.00175 ** NA
HKR1 midostaurin 0.0017579 0.8795120 0.00176 ** NA
MAP3K9 nilotinib 0.0017661 0.8055751 0.00177 ** NA
UPP2 temozolomide 0.0017737 0.6902774 0.00177 ** NA
FBN3 trametinib 0.0017748 0.9852344 0.00177 ** NA
TRMT10B alectinib 0.0017834 0.9168760 0.00178 ** NA
PDCD11 crizotinib 0.0017889 0.7869686 0.0018 ** NA
CCDC175 tretinoin 0.0017920 0.5222109 0.00179 ** NA
DSEL vismodegib 0.0018062 0.9623352 0.00181 ** NA
PRICKLE2 temozolomide 0.0018082 0.6902774 0.00181 ** NA
CSPG4 tretinoin 0.0018088 0.5222109 0.00181 ** NA
ABCG5 vismodegib 0.0018143 0.9623352 0.00181 ** NA
DPYSL2 gefitinib 0.0018158 0.8957015 0.00182 ** NA
CACNA1I gefitinib 0.0018318 0.8957015 0.00183 ** NA
HCFC2 ruxolitinib 0.0018327 0.9787856 0.00183 ** NA
CTAGE9 bosutinib monohydrate 0.0018332 1.0000000 0.00183 ** NA
ERVV-1 gefitinib 0.0018430 0.8957015 0.00184 ** NA
DSG2 palbociclib 0.0018458 0.9551671 0.00185 ** NA
SCRIB nilotinib 0.0018508 0.8055751 0.00185 ** NA
USP24 tretinoin 0.0018509 0.5222109 0.00185 ** NA
RASGRF2 nilotinib 0.0018627 0.8055751 0.00186 ** NA
SCIN pazopanib 0.0018732 0.9978452 0.00187 ** NA
ZNF320 tretinoin 0.0018740 0.5222109 0.00187 ** NA
APOBEC3B alectinib 0.0018822 0.9168760 0.00188 ** NA
RFPL4AL1 ruxolitinib 0.0018832 0.9787856 0.00188 ** NA
DNAH9 belinostat 0.0018840 0.9983823 0.00188 ** NA
UNC13D crizotinib 0.0018881 0.7869686 0.0019 ** NA
CDYL2 vismodegib 0.0018928 0.9623352 0.00189 ** NA
ZBTB10 docetaxel 0.0018952 0.9106700 0.00190 ** NA
PLA2R1 trametinib 0.0019052 0.9852344 0.00191 ** NA
STARD9 cabozantinib 0.0019131 0.8298252 0.00191 ** NA
ALPL afatinib 0.0019315 0.9267832 0.00193 ** NA
MYO5A afatinib 0.0019417 0.9267832 0.00194 ** NA
FBXO4 midostaurin 0.0019517 0.8795120 0.00195 ** NA
ZNF613 bosutinib monohydrate 0.0019531 1.0000000 0.00195 ** NA
MCF2L temozolomide 0.0019561 0.6902774 0.00196 ** NA
SH3PXD2B tretinoin 0.0019596 0.5222109 0.00196 ** NA
EMR3 nilotinib 0.0019609 0.8055751 0.00196 ** NA
EXOC6B vismodegib 0.0019609 0.9623352 0.00196 ** NA
CLSTN3 temozolomide 0.0019815 0.6902774 0.00198 ** NA
CHD8 tretinoin 0.0019977 0.5222109 0.00200 ** NA
ZNRF3 temozolomide 0.0020141 0.6902774 0.00201 ** NA
FER1L6 afatinib 0.0020174 0.9267832 0.00202 ** NA
ANKRD24 cabozantinib 0.0020209 0.8298252 0.00202 ** NA
RPH3AL afatinib 0.0020276 0.9267832 0.00203 ** NA
IQCH tretinoin 0.0020292 0.5222109 0.00203 ** NA
SPRY4 afatinib 0.0020307 0.9267832 0.00203 ** NA
FOCAD nilotinib 0.0020323 0.8055751 0.00203 ** NA
WIF1 tretinoin 0.0020387 0.5222109 0.00204 ** NA
VHL gefitinib 0.0020451 0.8957015 0.00205 ** NA
PCDHGA10 tretinoin 0.0020471 0.5222109 0.00205 ** NA
OLFM1 palbociclib 0.0020585 0.9551671 0.00206 ** NA
OR52J3 tretinoin 0.0020620 0.5222109 0.00206 ** NA
PC ruxolitinib 0.0020630 0.9787856 0.00206 ** NA
KIAA1045 alectinib 0.0020665 0.9168760 0.00207 ** NA
SNX3 palbociclib 0.0020699 0.9551671 0.00207 ** NA
SKIDA1 docetaxel 0.0020855 0.9106700 0.00209 ** NA
PIK3C3 rucaparib 0.0020895 0.9990814 0.00209 ** NA
GNPTG tretinoin 0.0020907 0.5222109 0.00209 ** NA
FOXA1 nilotinib 0.0021074 0.8055751 0.00211 ** NA
PHOX2B rucaparib 0.0021102 0.9990814 0.00211 ** NA
SORCS1 tretinoin 0.0021108 0.5222109 0.00211 ** NA
PRG4 afatinib 0.0021197 0.9267832 0.00212 ** NA
TECPR2 gefitinib 0.0021260 0.8957015 0.00213 ** NA
PRKRIR ruxolitinib 0.0021277 0.9787856 0.00213 ** NA
HKR1 sunitinib 0.0021396 0.7819868 0.0021 ** NA
GABRA5 vismodegib 0.0021417 0.9623352 0.00214 ** NA
HPS4 tretinoin 0.0021449 0.5222109 0.00214 ** NA
NOTCH3 palbociclib 0.0021467 0.9551671 0.00215 ** NA
SCN5A tretinoin 0.0021559 0.5222109 0.00216 ** NA
OR6P1 palbociclib 0.0021606 0.9551671 0.00216 ** NA
XIRP2 trametinib 0.0021617 0.9852344 0.00216 ** NA
PXDN trametinib 0.0021638 0.9852344 0.00216 ** NA
SLC25A18 docetaxel 0.0021651 0.9106700 0.00217 ** NA
AK8 vismodegib 0.0021681 0.9623352 0.00217 ** NA
MYO1B ruxolitinib 0.0021777 0.9787856 0.00218 ** NA
NSFL1C trametinib 0.0021790 0.9852344 0.00218 ** NA
ZBTB12 dabrafenib 0.0021808 0.9305571 0.00218 ** NA
HMGCR temozolomide 0.0021878 0.6902774 0.00219 ** NA
APLF tretinoin 0.0022027 0.5222109 0.00220 ** NA
ZBTB38 dabrafenib 0.0022028 0.9305571 0.00220 ** NA
TRA2B vismodegib 0.0022098 0.9623352 0.00221 ** NA
POM121 tretinoin 0.0022150 0.5222109 0.00222 ** NA
KRT75 afatinib 0.0022198 0.9267832 0.00222 ** NA
SCN4A nilotinib 0.0022199 0.8055751 0.00222 ** NA
AMHR2 tretinoin 0.0022367 0.5222109 0.00224 ** NA
MMP13 tretinoin 0.0022402 0.5222109 0.00224 ** NA
TIAM1 cabozantinib 0.0022451 0.8298252 0.00225 ** NA
C18orf63 temozolomide 0.0022496 0.6902774 0.00225 ** NA
KIAA0556 pazopanib 0.0022510 0.9978452 0.00225 ** NA
HAUS6 vismodegib 0.0022531 0.9623352 0.00225 ** NA
CCDC43 ruxolitinib 0.0022599 0.9787856 0.00226 ** NA
TMEM232 midostaurin 0.0022624 0.8795120 0.00226 ** NA
HAL palbociclib 0.0022696 0.9551671 0.00227 ** NA
PRRC2C tretinoin 0.0022705 0.5222109 0.00227 ** NA
MARK1 nilotinib 0.0022734 0.8055751 0.00227 ** NA
C1S trametinib 0.0022828 0.9852344 0.00228 ** NA
LPHN1 docetaxel 0.0022869 0.9106700 0.00229 ** NA
DNAAF1 tretinoin 0.0022911 0.5222109 0.00229 ** NA
KIAA1551 temozolomide 0.0022914 0.6902774 0.00229 ** NA
NLRP13 trametinib 0.0022947 0.9852344 0.00229 ** NA
CCR4 cabozantinib 0.0022978 0.8298252 0.00230 ** NA
TRIO tretinoin 0.0022997 0.5222109 0.00230 ** NA
CPT1B vismodegib 0.0023004 0.9623352 0.00230 ** NA
GTPBP10 temozolomide 0.0023042 0.6902774 0.00230 ** NA
FAM198A alectinib 0.0023090 0.9168760 0.00231 ** NA
TMEM194A alectinib 0.0023125 0.9168760 0.00231 ** NA
SMURF2 tretinoin 0.0023160 0.5222109 0.00232 ** NA
SFXN4 alectinib 0.0023208 0.9168760 0.00232 ** NA
CNNM1 temozolomide 0.0023212 0.6902774 0.00232 ** NA
CAMK4 cabozantinib 0.0023222 0.8298252 0.00232 ** NA
SAMD4B alectinib 0.0023392 0.9168760 0.00234 ** NA
ST8SIA2 afatinib 0.0023419 0.9267832 0.00234 ** NA
RTDR1 gefitinib 0.0023423 0.8957015 0.00234 ** NA
NID1 tretinoin 0.0023533 0.5222109 0.00235 ** NA
ZSCAN5B docetaxel 0.0023538 0.9106700 0.00235 ** NA
DOK1 docetaxel 0.0023570 0.9106700 0.00236 ** NA
PARK2 imatinib 0.0023597 0.7706799 0.0024 ** NA
PIK3CA docetaxel 0.0023604 0.9106700 0.00236 ** NA
ZNF441 temozolomide 0.0023649 0.6902774 0.00236 ** NA
PTH1R gefitinib 0.0023747 0.8957015 0.00237 ** NA
TNXB trametinib 0.0023752 0.9852344 0.00238 ** NA
HCFC2 dabrafenib 0.0023758 0.9305571 0.00238 ** NA
CYP51A1 bosutinib monohydrate 0.0023771 1.0000000 0.00238 ** NA
BMP2K afatinib 0.0023826 0.9267832 0.00238 ** NA
SH2D7 temozolomide 0.0023844 0.6902774 0.00238 ** NA
TFEB cabozantinib 0.0023871 0.8298252 0.00239 ** NA
BEGAIN tretinoin 0.0023880 0.5222109 0.00239 ** NA
PLEKHH2 nilotinib 0.0023899 0.8055751 0.00239 ** NA
PAXIP1 pazopanib 0.0023983 0.9978452 0.00240 ** NA
PTGDR2 alectinib 0.0023984 0.9168760 0.00240 ** NA
CD200R1L ponatinib 0.0024075 1.0000000 0.00241 ** NA
ZFP69B tretinoin 0.0024081 0.5222109 0.00241 ** NA
AASDH tretinoin 0.0024209 0.5222109 0.00242 ** NA
NLGN2 midostaurin 0.0024225 0.8795120 0.00242 ** NA
DLC1 gefitinib 0.0024260 0.8957015 0.00243 ** NA
GRID1 gefitinib 0.0024436 0.8957015 0.00244 ** NA
FAM171B gefitinib 0.0024570 0.8957015 0.00246 ** NA
ACVR1 cabozantinib 0.0024585 0.8298252 0.00246 ** NA
KIF2B gefitinib 0.0024656 0.8957015 0.00247 ** NA
PLCZ1 tretinoin 0.0024661 0.5222109 0.00247 ** NA
SSH2 nilotinib 0.0024686 0.8055751 0.00247 ** NA
SHC4 cabozantinib 0.0024767 0.8298252 0.00248 ** NA
DERL1 gefitinib 0.0024801 0.8957015 0.00248 ** NA
WIBG temozolomide 0.0024821 0.6902774 0.00248 ** NA
OSBPL1A ruxolitinib 0.0024889 0.9787856 0.00249 ** NA
ABCA12 gefitinib 0.0024950 0.8957015 0.00249 ** NA
MAP1B vismodegib 0.0024952 0.9623352 0.00250 ** NA
ATP9B trametinib 0.0024959 0.9852344 0.00250 ** NA
BCLAF1 docetaxel 0.0024960 0.9106700 0.00250 ** NA
RSL1D1 midostaurin 0.0024963 0.8795120 0.00250 ** NA
JAG1 tretinoin 0.0025001 0.5222109 0.00250 ** NA
GTPBP2 tretinoin 0.0025038 0.5222109 0.00250 ** NA
AQR midostaurin 0.0025065 0.8795120 0.00251 ** NA
ZNF556 bosutinib monohydrate 0.0025146 1.0000000 0.00251 ** NA
ACTR3B alectinib 0.0025215 0.9168760 0.00252 ** NA
ADAMDEC1 cabozantinib 0.0025226 0.8298252 0.00252 ** NA
TMEM8A tretinoin 0.0025233 0.5222109 0.00252 ** NA
GTSE1 palbociclib 0.0025280 0.9551671 0.00253 ** NA
TUBA3E trametinib 0.0025319 0.9852344 0.00253 ** NA
ANXA9 temozolomide 0.0025388 0.6902774 0.00254 ** NA
MDC1 cabozantinib 0.0025417 0.8298252 0.00254 ** NA
WDR53 nilotinib 0.0025683 0.8055751 0.00257 ** NA
CTNNA3 temozolomide 0.0025739 0.6902774 0.00257 ** NA
KDM2A tretinoin 0.0025772 0.5222109 0.00258 ** NA
POU4F2 temozolomide 0.0025813 0.6902774 0.00258 ** NA
METTL16 belinostat 0.0025825 0.9983823 0.00258 ** NA
PDGFD ponatinib 0.0025850 1.0000000 0.00258 ** NA
GSC dabrafenib 0.0025874 0.9305571 0.00259 ** NA
MYH2 midostaurin 0.0025880 0.8795120 0.00259 ** NA
NCKAP1L trametinib 0.0025885 0.9852344 0.00259 ** NA
FIGNL1 gefitinib 0.0025961 0.8957015 0.00260 ** NA
MAB21L2 vismodegib 0.0026191 0.9623352 0.00262 ** NA
ZNF280D rucaparib 0.0026326 0.9990814 0.00263 ** NA
TMEM174 ponatinib 0.0026364 1.0000000 0.00264 ** NA
STK36 ruxolitinib 0.0026417 0.9787856 0.00264 ** NA
PRR16 dabrafenib 0.0026430 0.9305571 0.00264 ** NA
DDX47 midostaurin 0.0026506 0.8795120 0.00265 ** NA
IL10RB afatinib 0.0026534 0.9267832 0.00265 ** NA
PLEKHH2 tretinoin 0.0026560 0.5222109 0.00266 ** NA
OR13F1 temozolomide 0.0026615 0.6902774 0.00266 ** NA
SNTG2 tretinoin 0.0026625 0.5222109 0.00266 ** NA
OSTF1 vismodegib 0.0026628 0.9623352 0.00266 ** NA
SLC12A6 tretinoin 0.0026644 0.5222109 0.00266 ** NA
UPF3A afatinib 0.0026671 0.9267832 0.00267 ** NA
SNAI2 gefitinib 0.0026711 0.8957015 0.00267 ** NA
PEX1 temozolomide 0.0026728 0.6902774 0.00267 ** NA
CCDC11 dabrafenib 0.0026752 0.9305571 0.00268 ** NA
NOP14 tretinoin 0.0026895 0.5222109 0.00269 ** NA
ANKRD55 ruxolitinib 0.0026905 0.9787856 0.00269 ** NA
FNDC9 gefitinib 0.0026953 0.8957015 0.00270 ** NA
ZNF555 temozolomide 0.0026957 0.6902774 0.00270 ** NA
STAC belinostat 0.0027013 0.9983823 0.00270 ** NA
KRT26 vismodegib 0.0027018 0.9623352 0.00270 ** NA
TECTA midostaurin 0.0027031 0.8795120 0.00270 ** NA
ZNF500 trametinib 0.0027055 0.9852344 0.00271 ** NA
CBLL1 vismodegib 0.0027060 0.9623352 0.00271 ** NA
QTRTD1 tretinoin 0.0027144 0.5222109 0.00271 ** NA
IVL temozolomide 0.0027149 0.6902774 0.00271 ** NA
DNAH10 midostaurin 0.0027294 0.8795120 0.00273 ** NA
ZNF345 nilotinib 0.0027464 0.8055751 0.00275 ** NA
LRIG2 sunitinib 0.0027470 0.7819868 0.0027 ** NA
GFRA2 midostaurin 0.0027471 0.8795120 0.00275 ** NA
ROCK2 cabozantinib 0.0027474 0.8298252 0.00275 ** NA
F11R gefitinib 0.0027558 0.8957015 0.00276 ** NA
FPR1 docetaxel 0.0027627 0.9106700 0.00276 ** NA
ZNF48 dabrafenib 0.0027673 0.9305571 0.00277 ** NA
NEB trametinib 0.0027840 0.9852344 0.00278 ** NA
ACACB cabozantinib 0.0028157 0.8298252 0.00282 ** NA
GFM2 tretinoin 0.0028289 0.5222109 0.00283 ** NA
RFWD2 tretinoin 0.0028289 0.5222109 0.00283 ** NA
TATDN2 gefitinib 0.0028397 0.8957015 0.00284 ** NA
PHKG1 sunitinib 0.0028448 0.7819868 0.0028 ** NA
TRAM1L1 erlotinib 0.0028483 0.7991878 0.00285 ** NA
CACNA1C palbociclib 0.0028535 0.9551671 0.00285 ** NA
MED23 palbociclib 0.0028551 0.9551671 0.00286 ** NA
PWWP2A pazopanib 0.0028564 0.9978452 0.00286 ** NA
SERPIND1 ruxolitinib 0.0028592 0.9787856 0.00286 ** NA
ZNF341 temozolomide 0.0028607 0.6902774 0.00286 ** NA
RSPO1 cabozantinib 0.0028623 0.8298252 0.00286 ** NA
TGFB1I1 cabozantinib 0.0028663 0.8298252 0.00287 ** NA
ZDHHC16 temozolomide 0.0028669 0.6902774 0.00287 ** NA
RIPK4 docetaxel 0.0028737 0.9106700 0.00287 ** NA
TMPPE docetaxel 0.0028753 0.9106700 0.00288 ** NA
IGDCC4 midostaurin 0.0028765 0.8795120 0.00288 ** NA
HKDC1 gefitinib 0.0028791 0.8957015 0.00288 ** NA
PHTF2 tretinoin 0.0028898 0.5222109 0.00289 ** NA
TLE2 trametinib 0.0028928 0.9852344 0.00289 ** NA
ANKRD11 ponatinib 0.0028964 1.0000000 0.00290 ** NA
ATP13A1 midostaurin 0.0028999 0.8795120 0.00290 ** NA
CAD tretinoin 0.0029012 0.5222109 0.00290 ** NA
GLUL rucaparib 0.0029129 0.9990814 0.00291 ** NA
H1FNT gefitinib 0.0029235 0.8957015 0.00292 ** NA
MEGF6 tretinoin 0.0029287 0.5222109 0.00293 ** NA
GSPT1 vismodegib 0.0029328 0.9623352 0.00293 ** NA
WSCD2 lapatinib 0.0029371 0.8107014 0.00294 ** NA
FAT2 tretinoin 0.0029698 0.5222109 0.00297 ** NA
CSRNP1 alectinib 0.0029742 0.9168760 0.00297 ** NA
FBN3 cabozantinib 0.0029871 0.8298252 0.00299 ** NA
TM9SF1 cabozantinib 0.0029940 0.8298252 0.00299 ** NA
MBLAC2 dabrafenib 0.0029963 0.9305571 0.00300 ** NA
APOBEC3F ruxolitinib 0.0030038 0.9787856 0.00300 ** NA
LARP1 afatinib 0.0030100 0.9267832 0.00301 ** NA
OSTF1 temozolomide 0.0030143 0.6902774 0.00301 ** NA
MFF ponatinib 0.0030414 1.0000000 0.00304 ** NA
FAM135B lapatinib 0.0030442 0.8107014 0.00304 ** NA
PRKD3 nilotinib 0.0030513 0.8055751 0.00305 ** NA
LRFN5 midostaurin 0.0030626 0.8795120 0.00306 ** NA
CDK14 rucaparib 0.0030667 0.9990814 0.00307 ** NA
SALL2 imatinib 0.0030780 0.7706799 0.0031 ** NA
GLDC afatinib 0.0030952 0.9267832 0.00310 ** NA
SLAMF9 midostaurin 0.0030968 0.8795120 0.00310 ** NA
GJA10 nilotinib 0.0031090 0.8055751 0.00311 ** NA
SFRP1 palbociclib 0.0031124 0.9551671 0.00311 ** NA
RTDR1 afatinib 0.0031141 0.9267832 0.00311 ** NA
HERC6 tretinoin 0.0031151 0.5222109 0.00312 ** NA
RHBDD3 palbociclib 0.0031156 0.9551671 0.00312 ** NA
ZSWIM6 midostaurin 0.0031161 0.8795120 0.00312 ** NA
RFX6 bosutinib monohydrate 0.0031182 1.0000000 0.00312 ** NA
STK31 pazopanib 0.0031215 0.9978452 0.00312 ** NA
CCT6A temozolomide 0.0031292 0.6902774 0.00313 ** NA
PLCB4 rucaparib 0.0031302 0.9990814 0.00313 ** NA
SCARF2 temozolomide 0.0031312 0.6902774 0.00313 ** NA
TAS2R60 nilotinib 0.0031337 0.8055751 0.00313 ** NA
KIF27 sunitinib 0.0031384 0.7819868 0.0031 ** NA
WIF1 cabozantinib 0.0031441 0.8298252 0.00314 ** NA
ZNF225 trametinib 0.0031448 0.9852344 0.00314 ** NA
SENP6 tretinoin 0.0031453 0.5222109 0.00315 ** NA
RETSAT afatinib 0.0031521 0.9267832 0.00315 ** NA
E2F2 dabrafenib 0.0031522 0.9305571 0.00315 ** NA
PLA1A tretinoin 0.0031562 0.5222109 0.00316 ** NA
C1orf168 tretinoin 0.0031568 0.5222109 0.00316 ** NA
CYP2C19 trametinib 0.0031592 0.9852344 0.00316 ** NA
DIP2C ruxolitinib 0.0031624 0.9787856 0.00316 ** NA
TOPORS afatinib 0.0031639 0.9267832 0.00316 ** NA
NPTX2 vismodegib 0.0031662 0.9623352 0.00317 ** NA
NFE2L3 cabozantinib 0.0031676 0.8298252 0.00317 ** NA
KIAA0319 docetaxel 0.0031700 0.9106700 0.00317 ** NA
KLHL42 dabrafenib 0.0031727 0.9305571 0.00317 ** NA
TMOD2 bosutinib monohydrate 0.0031763 1.0000000 0.00318 ** NA
RIMBP2 dasatinib 0.0031769 0.8707378 0.0032 ** NA
PAMR1 midostaurin 0.0031777 0.8795120 0.00318 ** NA
DNAI1 cabozantinib 0.0031781 0.8298252 0.00318 ** NA
CALCOCO1 tretinoin 0.0031845 0.5222109 0.00318 ** NA
SALL2 gefitinib 0.0031880 0.8957015 0.00319 ** NA
GPR98 palbociclib 0.0032017 0.9551671 0.00320 ** NA
PDGFRB tretinoin 0.0032063 0.5222109 0.00321 ** NA
CUL3 tretinoin 0.0032137 0.5222109 0.00321 ** NA
MS4A1 ruxolitinib 0.0032143 0.9787856 0.00321 ** NA
ANKRD30A lapatinib 0.0032293 0.8107014 0.00323 ** NA
RERE tretinoin 0.0032334 0.5222109 0.00323 ** NA
ARHGEF40 palbociclib 0.0032348 0.9551671 0.00323 ** NA
AGTPBP1 crizotinib 0.0032505 0.7869686 0.0033 ** NA
CEP55 tretinoin 0.0032556 0.5222109 0.00326 ** NA
DAO bosutinib monohydrate 0.0032606 1.0000000 0.00326 ** NA
KIAA1551 ruxolitinib 0.0032740 0.9787856 0.00327 ** NA
TNFSF18 tretinoin 0.0032850 0.5222109 0.00329 ** NA
SSH2 vismodegib 0.0032852 0.9623352 0.00329 ** NA
ENTPD7 cabozantinib 0.0032884 0.8298252 0.00329 ** NA
MAB21L1 docetaxel 0.0032911 0.9106700 0.00329 ** NA
ZC3HC1 ponatinib 0.0032913 1.0000000 0.00329 ** NA
ZNF345 vismodegib 0.0032958 0.9623352 0.00330 ** NA
TTC30A tretinoin 0.0032964 0.5222109 0.00330 ** NA
ZNF469 midostaurin 0.0033005 0.8795120 0.00330 ** NA
GZMH gefitinib 0.0033013 0.8957015 0.00330 ** NA
RCL1 temozolomide 0.0033031 0.6902774 0.00330 ** NA
MICAL2 tretinoin 0.0033065 0.5222109 0.00331 ** NA
CREM gefitinib 0.0033076 0.8957015 0.00331 ** NA
OAS2 alectinib 0.0033091 0.9168760 0.00331 ** NA
KNOP1 temozolomide 0.0033168 0.6902774 0.00332 ** NA
EPHA1 vismodegib 0.0033182 0.9623352 0.00332 ** NA
CPSF6 pazopanib 0.0033192 0.9978452 0.00332 ** NA
SRC alectinib 0.0033265 0.9168760 0.00333 ** NA
XPO1 tretinoin 0.0033296 0.5222109 0.00333 ** NA
CYP3A43 alectinib 0.0033312 0.9168760 0.00333 ** NA
ASB4 docetaxel 0.0033389 0.9106700 0.00334 ** NA
HTR4 tretinoin 0.0033443 0.5222109 0.00334 ** NA
LRIT2 tretinoin 0.0033443 0.5222109 0.00334 ** NA
STK11 cabozantinib 0.0033445 0.8298252 0.00334 ** NA
FERMT2 sunitinib 0.0033446 0.7819868 0.0033 ** NA
FBXL20 nilotinib 0.0033491 0.8055751 0.00335 ** NA
SLC29A3 cabozantinib 0.0033578 0.8298252 0.00336 ** NA
PCDHA11 tretinoin 0.0033650 0.5222109 0.00336 ** NA
ZNF583 temozolomide 0.0033751 0.6902774 0.00338 ** NA
TMEM174 midostaurin 0.0033796 0.8795120 0.00338 ** NA
CCIN bosutinib monohydrate 0.0033815 1.0000000 0.00338 ** NA
SYNCRIP nilotinib 0.0033909 0.8055751 0.00339 ** NA
OR52E6 vismodegib 0.0033939 0.9623352 0.00339 ** NA
SNAP91 tretinoin 0.0033941 0.5222109 0.00339 ** NA
SLC2A13 trametinib 0.0033949 0.9852344 0.00339 ** NA
ERCC4 gefitinib 0.0033983 0.8957015 0.00340 ** NA
SMARCC1 palbociclib 0.0034009 0.9551671 0.00340 ** NA
PREX1 belinostat 0.0034014 0.9983823 0.00340 ** NA
ALX3 pazopanib 0.0034042 0.9978452 0.00340 ** NA
DYRK2 midostaurin 0.0034044 0.8795120 0.00340 ** NA
TCFL5 cabozantinib 0.0034075 0.8298252 0.00341 ** NA
OR10A3 belinostat 0.0034122 0.9983823 0.00341 ** NA
PDIA3 temozolomide 0.0034192 0.6902774 0.00342 ** NA
PARP8 bosutinib monohydrate 0.0034240 1.0000000 0.00342 ** NA
MFSD6L palbociclib 0.0034259 0.9551671 0.00343 ** NA
RC3H1 tretinoin 0.0034274 0.5222109 0.00343 ** NA
FAM91A1 cabozantinib 0.0034309 0.8298252 0.00343 ** NA
TSR1 docetaxel 0.0034369 0.9106700 0.00344 ** NA
ST18 tretinoin 0.0034529 0.5222109 0.00345 ** NA
ADAM20 docetaxel 0.0034631 0.9106700 0.00346 ** NA
SFI1 nilotinib 0.0034720 0.8055751 0.00347 ** NA
TMEM185B docetaxel 0.0034753 0.9106700 0.00348 ** NA
PSMD11 docetaxel 0.0034760 0.9106700 0.00348 ** NA
SYTL2 cabozantinib 0.0034811 0.8298252 0.00348 ** NA
NEK9 temozolomide 0.0034824 0.6902774 0.00348 ** NA
GALNT10 ruxolitinib 0.0034830 0.9787856 0.00348 ** NA
TMCO3 cabozantinib 0.0034859 0.8298252 0.00349 ** NA
SLC17A3 alectinib 0.0034902 0.9168760 0.00349 ** NA
PRKRIR alectinib 0.0035037 0.9168760 0.00350 ** NA
MAMSTR temozolomide 0.0035106 0.6902774 0.00351 ** NA
NMUR1 gefitinib 0.0035119 0.8957015 0.00351 ** NA
NRG1 tretinoin 0.0035285 0.5222109 0.00353 ** NA
GNB1 ruxolitinib 0.0035419 0.9787856 0.00354 ** NA
MTMR12 dasatinib 0.0035438 0.8707378 0.0035 ** NA
GLG1 belinostat 0.0035444 0.9983823 0.00354 ** NA
LNPEP dabrafenib 0.0035456 0.9305571 0.00355 ** NA
KCNC4 vismodegib 0.0035459 0.9623352 0.00355 ** NA
ZNF530 docetaxel 0.0035471 0.9106700 0.00355 ** NA
VPS8 docetaxel 0.0035558 0.9106700 0.00356 ** NA
SDPR tretinoin 0.0035611 0.5222109 0.00356 ** NA
GZMH imatinib 0.0035651 0.7706799 0.0036 ** NA
ASNSD1 gefitinib 0.0035719 0.8957015 0.00357 ** NA
EPS8L2 temozolomide 0.0035724 0.6902774 0.00357 ** NA
DMPK nilotinib 0.0035782 0.8055751 0.00358 ** NA
ODF3L2 temozolomide 0.0035825 0.6902774 0.00358 ** NA
CAT tretinoin 0.0035862 0.5222109 0.00359 ** NA
DLGAP1 bosutinib monohydrate 0.0035863 1.0000000 0.00359 ** NA
CBLL1 tretinoin 0.0035927 0.5222109 0.00359 ** NA
OR10J3 cabozantinib 0.0036043 0.8298252 0.00360 ** NA
SLC22A12 cabozantinib 0.0036127 0.8298252 0.00361 ** NA
SMEK2 vismodegib 0.0036209 0.9623352 0.00362 ** NA
CNTNAP5 palbociclib 0.0036271 0.9551671 0.00363 ** NA
ZNF347 midostaurin 0.0036303 0.8795120 0.00363 ** NA
STXBP5 dabrafenib 0.0036311 0.9305571 0.00363 ** NA
SLC29A2 tretinoin 0.0036455 0.5222109 0.00365 ** NA
TF docetaxel 0.0036495 0.9106700 0.00365 ** NA
ZFHX3 tretinoin 0.0036551 0.5222109 0.00366 ** NA
ARHGAP19 nilotinib 0.0036563 0.8055751 0.00366 ** NA
GPR179 palbociclib 0.0036565 0.9551671 0.00366 ** NA
CTHRC1 cabozantinib 0.0036590 0.8298252 0.00366 ** NA
CELF2 ponatinib 0.0036630 1.0000000 0.00366 ** NA
DNAH9 trametinib 0.0036631 0.9852344 0.00366 ** NA
UBN1 gefitinib 0.0036686 0.8957015 0.00367 ** NA
ANKLE1 alectinib 0.0036707 0.9168760 0.00367 ** NA
RNF214 bosutinib monohydrate 0.0036712 1.0000000 0.00367 ** NA
MYH2 tretinoin 0.0036752 0.5222109 0.00368 ** NA
GGT5 tretinoin 0.0036979 0.5222109 0.00370 ** NA
TOP1 tretinoin 0.0036979 0.5222109 0.00370 ** NA
SH3D21 tretinoin 0.0037019 0.5222109 0.00370 ** NA
KLHL1 vismodegib 0.0037029 0.9623352 0.00370 ** NA
ROS1 cabozantinib 0.0037056 0.8298252 0.00371 ** NA
TIAL1 docetaxel 0.0037113 0.9106700 0.00371 ** NA
ACTC1 gefitinib 0.0037425 0.8957015 0.00374 ** NA
PLEKHH3 trametinib 0.0037429 0.9852344 0.00374 ** NA
ZNF304 temozolomide 0.0037465 0.6902774 0.00375 ** NA
TBK1 temozolomide 0.0037563 0.6902774 0.00376 ** NA
GPRC6A trametinib 0.0037567 0.9852344 0.00376 ** NA
EBF4 alectinib 0.0037585 0.9168760 0.00376 ** NA
TM6SF2 ponatinib 0.0037616 1.0000000 0.00376 ** NA
FANCD2 pazopanib 0.0037632 0.9978452 0.00376 ** NA
RAD54L dabrafenib 0.0037813 0.9305571 0.00378 ** NA
DOK3 gefitinib 0.0037934 0.8957015 0.00379 ** NA
PLEKHM1 temozolomide 0.0037978 0.6902774 0.00380 ** NA
SCN4A dabrafenib 0.0038145 0.9305571 0.00381 ** NA
TIMM44 dabrafenib 0.0038163 0.9305571 0.00382 ** NA
KIAA1467 midostaurin 0.0038174 0.8795120 0.00382 ** NA
METTL17 tretinoin 0.0038267 0.5222109 0.00383 ** NA
ZNF85 nilotinib 0.0038429 0.8055751 0.00384 ** NA
FMNL3 gefitinib 0.0038442 0.8957015 0.00384 ** NA
EXOC6B tretinoin 0.0038551 0.5222109 0.00386 ** NA
ENTHD1 tretinoin 0.0038569 0.5222109 0.00386 ** NA
GLP2R tretinoin 0.0038581 0.5222109 0.00386 ** NA
FERMT2 crizotinib 0.0038589 0.7869686 0.0039 ** NA
MPO belinostat 0.0038632 0.9983823 0.00386 ** NA
APOBEC3B nilotinib 0.0038803 0.8055751 0.00388 ** NA
FAM160A2 pazopanib 0.0038834 0.9978452 0.00388 ** NA
TBK1 tretinoin 0.0038873 0.5222109 0.00389 ** NA
MLKL alectinib 0.0038915 0.9168760 0.00389 ** NA
MAPK15 midostaurin 0.0038951 0.8795120 0.00390 ** NA
XIRP2 erlotinib 0.0038961 0.7991878 0.00390 ** NA
RUNDC1 ruxolitinib 0.0038966 0.9787856 0.00390 ** NA
GLDC temozolomide 0.0038975 0.6902774 0.00390 ** NA
ANGEL1 bosutinib monohydrate 0.0038991 1.0000000 0.00390 ** NA
NFE2L2 alectinib 0.0039010 0.9168760 0.00390 ** NA
PER3 pazopanib 0.0039077 0.9978452 0.00391 ** NA
XIRP2 gefitinib 0.0039079 0.8957015 0.00391 ** NA
FOXC2 tretinoin 0.0039092 0.5222109 0.00391 ** NA
RBM5 tretinoin 0.0039123 0.5222109 0.00391 ** NA
KLK14 docetaxel 0.0039190 0.9106700 0.00392 ** NA
GTDC1 ponatinib 0.0039200 1.0000000 0.00392 ** NA
TAF9 temozolomide 0.0039233 0.6902774 0.00392 ** NA
ATP1A1 dabrafenib 0.0039274 0.9305571 0.00393 ** NA
PPIL2 nilotinib 0.0039300 0.8055751 0.00393 ** NA
TANGO2 docetaxel 0.0039375 0.9106700 0.00394 ** NA
PRR14 afatinib 0.0039418 0.9267832 0.00394 ** NA
MX1 afatinib 0.0039427 0.9267832 0.00394 ** NA
SHPRH temozolomide 0.0039499 0.6902774 0.00395 ** NA
SKAP1 gefitinib 0.0039598 0.8957015 0.00396 ** NA
CCDC101 alectinib 0.0039649 0.9168760 0.00396 ** NA
EXTL3 alectinib 0.0039653 0.9168760 0.00397 ** NA
PDE6A bosutinib monohydrate 0.0039683 1.0000000 0.00397 ** NA
FNTB rucaparib 0.0039781 0.9990814 0.00398 ** NA
CYP1A1 ponatinib 0.0039820 1.0000000 0.00398 ** NA
LTBP1 alectinib 0.0039844 0.9168760 0.00398 ** NA
GALNT12 pazopanib 0.0039859 0.9978452 0.00399 ** NA
SLC26A2 tretinoin 0.0039861 0.5222109 0.00399 ** NA
PCDHAC1 ruxolitinib 0.0039908 0.9787856 0.00399 ** NA
TLN2 tretinoin 0.0040015 0.5222109 0.00400 ** NA
PCDHAC2 alectinib 0.0040065 0.9168760 0.00401 ** NA
ZFAT docetaxel 0.0040074 0.9106700 0.00401 ** NA
B3GNT4 cabozantinib 0.0040168 0.8298252 0.00402 ** NA
FZD10 temozolomide 0.0040175 0.6902774 0.00402 ** NA
EHMT1 temozolomide 0.0040248 0.6902774 0.00402 ** NA
NRAS imatinib 0.0040262 0.7706799 0.0040 ** NA
TMEM185B afatinib 0.0040348 0.9267832 0.00403 ** NA
OR5M11 alectinib 0.0040398 0.9168760 0.00404 ** NA
PAPD4 crizotinib 0.0040403 0.7869686 0.0040 ** NA
SGK3 cabozantinib 0.0040435 0.8298252 0.00404 ** NA
UGGT1 pazopanib 0.0040568 0.9978452 0.00406 ** NA
NGFR alectinib 0.0040600 0.9168760 0.00406 ** NA
ZBTB7A temozolomide 0.0040620 0.6902774 0.00406 ** NA
ZSWIM6 temozolomide 0.0040658 0.6902774 0.00407 ** NA
NR2C2 crizotinib 0.0040666 0.7869686 0.0041 ** NA
TBX10 temozolomide 0.0040676 0.6902774 0.00407 ** NA
ACVR1 tretinoin 0.0040744 0.5222109 0.00407 ** NA
KDM8 afatinib 0.0040752 0.9267832 0.00408 ** NA
CACNB1 tretinoin 0.0040781 0.5222109 0.00408 ** NA
CEP70 tretinoin 0.0040781 0.5222109 0.00408 ** NA
RBM26 dabrafenib 0.0040816 0.9305571 0.00408 ** NA
PIK3C2G tretinoin 0.0040835 0.5222109 0.00408 ** NA
TEKT3 nilotinib 0.0040859 0.8055751 0.00409 ** NA
ARHGAP19 docetaxel 0.0040892 0.9106700 0.00409 ** NA
HERPUD1 temozolomide 0.0040901 0.6902774 0.00409 ** NA
TFAP2A palbociclib 0.0040902 0.9551671 0.00409 ** NA
ATAD5 gefitinib 0.0040938 0.8957015 0.00409 ** NA
TRAF3 alectinib 0.0041005 0.9168760 0.00410 ** NA
HOXB1 tretinoin 0.0041060 0.5222109 0.00411 ** NA
KRT3 bosutinib monohydrate 0.0041080 1.0000000 0.00411 ** NA
PGLYRP4 nilotinib 0.0041112 0.8055751 0.00411 ** NA
TMEM129 cabozantinib 0.0041127 0.8298252 0.00411 ** NA
C2CD3 cabozantinib 0.0041201 0.8298252 0.00412 ** NA
HSP90AB1 ponatinib 0.0041202 1.0000000 0.00412 ** NA
WDR6 afatinib 0.0041203 0.9267832 0.00412 ** NA
GALNT14 rucaparib 0.0041209 0.9990814 0.00412 ** NA
CSMD1 palbociclib 0.0041270 0.9551671 0.00413 ** NA
GLB1L pazopanib 0.0041303 0.9978452 0.00413 ** NA
ASCL1 nilotinib 0.0041462 0.8055751 0.00415 ** NA
PGBD3 tretinoin 0.0041531 0.5241182 0.00415 ** NA
SPATA31A3 trametinib 0.0041610 0.9852344 0.00416 ** NA
FES nilotinib 0.0041648 0.8055751 0.00416 ** NA
RUVBL1 docetaxel 0.0041653 0.9106700 0.00417 ** NA
GGT5 nilotinib 0.0041751 0.8055751 0.00418 ** NA
C1orf185 cabozantinib 0.0041843 0.8298252 0.00418 ** NA
LETMD1 alectinib 0.0041904 0.9168760 0.00419 ** NA
MS4A6A crizotinib 0.0041960 0.7869686 0.0042 ** NA
PITRM1 nilotinib 0.0041977 0.8055751 0.00420 ** NA
CDK8 nilotinib 0.0042116 0.8055751 0.00421 ** NA
HKR1 ponatinib 0.0042168 1.0000000 0.00422 ** NA
FCHSD1 midostaurin 0.0042184 0.8795120 0.00422 ** NA
PCLO cabozantinib 0.0042190 0.8298252 0.00422 ** NA
OR6C70 afatinib 0.0042238 0.9267832 0.00422 ** NA
PCDHB8 nilotinib 0.0042246 0.8055751 0.00422 ** NA
ALPP palbociclib 0.0042301 0.9551671 0.00423 ** NA
PTRF ponatinib 0.0042344 1.0000000 0.00423 ** NA
HMGCR tretinoin 0.0042468 0.5241182 0.00425 ** NA
GLRB sunitinib 0.0042484 0.7819868 0.0042 ** NA
LRFN5 afatinib 0.0042568 0.9267832 0.00426 ** NA
GNB1 alectinib 0.0042631 0.9168760 0.00426 ** NA
SYCE2 midostaurin 0.0042640 0.8795120 0.00426 ** NA
TEX15 midostaurin 0.0042660 0.8795120 0.00427 ** NA
SNAI2 afatinib 0.0042691 0.9267832 0.00427 ** NA
SLC25A39 vismodegib 0.0042845 0.9623352 0.00428 ** NA
LRRK1 cabozantinib 0.0042924 0.8298252 0.00429 ** NA
ZNF786 sunitinib 0.0042925 0.7819868 0.0043 ** NA
ANPEP dabrafenib 0.0043005 0.9305571 0.00430 ** NA
CLUH temozolomide 0.0043014 0.6902774 0.00430 ** NA
SNX14 dabrafenib 0.0043102 0.9305571 0.00431 ** NA
GOLGA8B dasatinib 0.0043267 0.8707378 0.0043 ** NA
DFFB tretinoin 0.0043345 0.5241182 0.00433 ** NA
CAT nilotinib 0.0043388 0.8055751 0.00434 ** NA
APC trametinib 0.0043403 0.9852344 0.00434 ** NA
LCOR temozolomide 0.0043447 0.6902774 0.00434 ** NA
GGT7 tretinoin 0.0043524 0.5241182 0.00435 ** NA
FAM160A2 midostaurin 0.0043546 0.8795120 0.00435 ** NA
GJA10 temozolomide 0.0043584 0.6902774 0.00436 ** NA
ZNF470 tretinoin 0.0043619 0.5241182 0.00436 ** NA
SSFA2 ruxolitinib 0.0043628 0.9787856 0.00436 ** NA
FSIP2 ruxolitinib 0.0043677 0.9787856 0.00437 ** NA
ZNF112 gefitinib 0.0043740 0.8957015 0.00437 ** NA
FBLN7 alectinib 0.0043865 0.9168760 0.00439 ** NA
KRAS pazopanib 0.0043870 0.9978452 0.00439 ** NA
RBP4 alectinib 0.0043896 0.9168760 0.00439 ** NA
DCLK2 tretinoin 0.0043910 0.5241182 0.00439 ** NA
GLT1D1 tretinoin 0.0043989 0.5241182 0.00440 ** NA
FLT1 cabozantinib 0.0044037 0.8298252 0.00440 ** NA
MOCS2 tretinoin 0.0044042 0.5241182 0.00440 ** NA
ZNF844 midostaurin 0.0044044 0.8795120 0.00440 ** NA
TTN rucaparib 0.0044075 0.9990814 0.00441 ** NA
MACF1 tretinoin 0.0044088 0.5241182 0.00441 ** NA
FSIP2 docetaxel 0.0044132 0.9106700 0.00441 ** NA
RARA alectinib 0.0044172 0.9168760 0.00442 ** NA
PCDHB1 temozolomide 0.0044207 0.6902774 0.00442 ** NA
GINS3 trametinib 0.0044247 0.9852344 0.00442 ** NA
HAL trametinib 0.0044325 0.9852344 0.00443 ** NA
ZNF671 tretinoin 0.0044355 0.5241182 0.00444 ** NA
APOBEC3B rucaparib 0.0044389 0.9990814 0.00444 ** NA
CPD ruxolitinib 0.0044406 0.9787856 0.00444 ** NA
THEG nilotinib 0.0044599 0.8055751 0.00446 ** NA
SRP54 afatinib 0.0044687 0.9267832 0.00447 ** NA
LENG8 trametinib 0.0044770 0.9852344 0.00448 ** NA
TAF4 docetaxel 0.0044851 0.9106700 0.00449 ** NA
RYR3 gefitinib 0.0045044 0.8957015 0.00450 ** NA
FAM171A1 dasatinib 0.0045091 0.8707378 0.0045 ** NA
EPS8L2 alectinib 0.0045107 0.9168760 0.00451 ** NA
GGA3 palbociclib 0.0045148 0.9551671 0.00451 ** NA
ATPAF1 vismodegib 0.0045201 0.9623352 0.00452 ** NA
SLC44A3 belinostat 0.0045235 0.9983823 0.00452 ** NA
LINS rucaparib 0.0045241 0.9990814 0.00452 ** NA
NETO1 vismodegib 0.0045380 0.9623352 0.00454 ** NA
ATP5A1 palbociclib 0.0045397 0.9551671 0.00454 ** NA
ZNF131 cabozantinib 0.0045415 0.8298252 0.00454 ** NA
TMED7 alectinib 0.0045513 0.9168760 0.00455 ** NA
ABCA12 trametinib 0.0045515 0.9852344 0.00455 ** NA
SOX30 tretinoin 0.0045520 0.5318267 0.00455 ** NA
SDR16C5 bosutinib monohydrate 0.0045545 1.0000000 0.00455 ** NA
ZMYM5 trametinib 0.0045590 0.9852344 0.00456 ** NA
GRHL3 docetaxel 0.0045590 0.9106700 0.00456 ** NA
MTX1 temozolomide 0.0045648 0.6902774 0.00456 ** NA
OR4K1 ponatinib 0.0045701 1.0000000 0.00457 ** NA
WDR3 trametinib 0.0045726 0.9852344 0.00457 ** NA
SKIDA1 alectinib 0.0045811 0.9168760 0.00458 ** NA
SEMA4A afatinib 0.0045872 0.9267832 0.00459 ** NA
FBN1 cabozantinib 0.0045918 0.8298252 0.00459 ** NA
PM20D1 temozolomide 0.0045924 0.6902774 0.00459 ** NA
MEF2C palbociclib 0.0045937 0.9551671 0.00459 ** NA
CHN2 afatinib 0.0046015 0.9267832 0.00460 ** NA
CCDC142 alectinib 0.0046040 0.9168760 0.00460 ** NA
FEZF1 tretinoin 0.0046051 0.5318267 0.00461 ** NA
DST midostaurin 0.0046100 0.8795120 0.00461 ** NA
IGFN1 afatinib 0.0046119 0.9267832 0.00461 ** NA
NEUROD1 cabozantinib 0.0046142 0.8298252 0.00461 ** NA
TMEM151A cabozantinib 0.0046258 0.8298252 0.00463 ** NA
OPCML afatinib 0.0046279 0.9267832 0.00463 ** NA
WDR93 cabozantinib 0.0046329 0.8298252 0.00463 ** NA
ADAMTS9 alectinib 0.0046333 0.9168760 0.00463 ** NA
HDAC9 cabozantinib 0.0046438 0.8298252 0.00464 ** NA
ITPKC docetaxel 0.0046452 0.9106700 0.00465 ** NA
BLZF1 pazopanib 0.0046539 0.9978452 0.00465 ** NA
PCDHB2 lapatinib 0.0046634 0.8107014 0.00466 ** NA
RHOBTB3 cabozantinib 0.0046689 0.8298252 0.00467 ** NA
KLHL7 vismodegib 0.0046771 0.9623352 0.00468 ** NA
IGFN1 gefitinib 0.0046773 0.8957015 0.00468 ** NA
LGR6 temozolomide 0.0046792 0.6902774 0.00468 ** NA
GLYATL1 nilotinib 0.0046803 0.8055751 0.00468 ** NA
NCOA2 crizotinib 0.0046821 0.7869686 0.0047 ** NA
CUEDC1 ponatinib 0.0046975 1.0000000 0.00470 ** NA
MYO1F nilotinib 0.0047037 0.8055751 0.00470 ** NA
PQLC3 ponatinib 0.0047224 1.0000000 0.00472 ** NA
NUGGC dabrafenib 0.0047318 0.9305571 0.00473 ** NA
MYH10 sunitinib 0.0047341 0.7819868 0.0047 ** NA
DCST2 nilotinib 0.0047347 0.8055751 0.00473 ** NA
ATP13A5 temozolomide 0.0047421 0.6902774 0.00474 ** NA
AKAP12 temozolomide 0.0047464 0.6902774 0.00475 ** NA
KLHDC3 palbociclib 0.0047493 0.9551671 0.00475 ** NA
MLF1 tretinoin 0.0047538 0.5318267 0.00475 ** NA
YTHDC2 midostaurin 0.0047543 0.8795120 0.00475 ** NA
AGTPBP1 ponatinib 0.0047624 1.0000000 0.00476 ** NA
PLCZ1 sunitinib 0.0047635 0.7819868 0.0048 ** NA
MYT1L temozolomide 0.0047717 0.6902774 0.00477 ** NA
NPBWR1 midostaurin 0.0047740 0.8795120 0.00477 ** NA
JAG1 temozolomide 0.0047745 0.6902774 0.00477 ** NA
CSMD1 vismodegib 0.0047927 0.9623352 0.00479 ** NA
CDHR5 dasatinib 0.0048229 0.8707378 0.0048 ** NA
RABEP1 cabozantinib 0.0048293 0.8298252 0.00483 ** NA
ZNF500 dabrafenib 0.0048328 0.9305571 0.00483 ** NA
ZNF865 palbociclib 0.0048368 0.9551671 0.00484 ** NA
MTMR6 cabozantinib 0.0048455 0.8298252 0.00485 ** NA
OR2M7 bosutinib monohydrate 0.0048597 1.0000000 0.00486 ** NA
CPD gefitinib 0.0048657 0.8957015 0.00487 ** NA
THBS2 alectinib 0.0048736 0.9168760 0.00487 ** NA
ANKLE1 ruxolitinib 0.0048743 0.9787856 0.00487 ** NA
LRP5 sunitinib 0.0048761 0.7819868 0.0049 ** NA
TRPM7 tretinoin 0.0048796 0.5318267 0.00488 ** NA
ABCA3 tretinoin 0.0048850 0.5318267 0.00488 ** NA
ZC3H6 dasatinib 0.0048860 0.8707378 0.0049 ** NA
PFKFB3 afatinib 0.0048861 0.9267832 0.00489 ** NA
ANKS1B nilotinib 0.0048863 0.8055751 0.00489 ** NA
ANXA10 alectinib 0.0048901 0.9168760 0.00489 ** NA
PUS7L gefitinib 0.0049001 0.8957015 0.00490 ** NA
NUP35 alectinib 0.0049004 0.9168760 0.00490 ** NA
PTPRK tretinoin 0.0049046 0.5318267 0.00490 ** NA
MNS1 palbociclib 0.0049132 0.9551671 0.00491 ** NA
WSCD1 rucaparib 0.0049138 0.9990814 0.00491 ** NA
ANKRD65 cabozantinib 0.0049197 0.8298252 0.00492 ** NA
LPL vismodegib 0.0049280 0.9623352 0.00493 ** NA
FSD2 trametinib 0.0049306 0.9852344 0.00493 ** NA
RPL3 temozolomide 0.0049333 0.6902774 0.00493 ** NA
SUMF1 rucaparib 0.0049437 0.9990814 0.00494 ** NA
RNF38 trametinib 0.0049443 0.9852344 0.00494 ** NA
NLGN2 palbociclib 0.0049507 0.9551671 0.00495 ** NA
KRT31 sunitinib 0.0049648 0.7819868 0.0050 ** NA
SUPT3H temozolomide 0.0049775 0.6902774 0.00498 ** NA
RGR trametinib 0.0049804 0.9852344 0.00498 ** NA
RPL13A ponatinib 0.0049804 1.0000000 0.00498 ** NA
FADS6 midostaurin 0.0049816 0.8795120 0.00498 ** NA
PGLYRP1 tretinoin 0.0049953 0.5318267 0.00500 ** NA
NYAP1 palbociclib 0.0050106 0.9551671 0.00501 ** NA
TBC1D10B pazopanib 0.0050180 0.9978452 0.00502 ** NA
MFSD1 tretinoin 0.0050182 0.5318267 0.00502 ** NA
FCHSD1 ponatinib 0.0050184 1.0000000 0.00502 ** NA
CDH23 pazopanib 0.0050184 0.9978452 0.00502 ** NA
NSRP1 rucaparib 0.0050213 0.9990814 0.00502 ** NA
C2orf48 alectinib 0.0050241 0.9168760 0.00502 ** NA
GLYATL2 gefitinib 0.0050341 0.8957015 0.00503 ** NA
SLC45A4 cabozantinib 0.0050435 0.8298252 0.00504 ** NA
SLC15A1 gefitinib 0.0050458 0.8957015 0.00505 ** NA
ANKRD55 docetaxel 0.0050477 0.9106700 0.00505 ** NA
MORN1 gefitinib 0.0050496 0.8957015 0.00505 ** NA
MYLK4 tretinoin 0.0050508 0.5318267 0.00505 ** NA
DUS3L nilotinib 0.0050508 0.8055751 0.00505 ** NA
TEX14 nilotinib 0.0050508 0.8055751 0.00505 ** NA
AXIN2 cabozantinib 0.0050512 0.8298252 0.00505 ** NA
PALLD temozolomide 0.0050522 0.6902774 0.00505 ** NA
LIPM dabrafenib 0.0050527 0.9305571 0.00505 ** NA
SLC7A11 belinostat 0.0050530 0.9983823 0.00505 ** NA
SPRED1 rucaparib 0.0050537 0.9990814 0.00505 ** NA
NRXN3 rucaparib 0.0050580 0.9990814 0.00506 ** NA
ITPRIPL1 ponatinib 0.0050595 1.0000000 0.00506 ** NA
USP6NL midostaurin 0.0050614 0.8795120 0.00506 ** NA
CD40 bosutinib monohydrate 0.0050669 1.0000000 0.00507 ** NA
GOLGA2 lapatinib 0.0050730 0.8107014 0.00507 ** NA
PCDHGC4 cabozantinib 0.0050757 0.8298252 0.00508 ** NA
ZC3H15 tretinoin 0.0050788 0.5318267 0.00508 ** NA
TMEM126B vismodegib 0.0050928 0.9623352 0.00509 ** NA
LCE1A nilotinib 0.0050962 0.8055751 0.00510 ** NA
KIAA0825 cabozantinib 0.0051012 0.8298252 0.00510 ** NA
TDRKH bosutinib monohydrate 0.0051031 1.0000000 0.00510 ** NA
UVRAG afatinib 0.0051066 0.9267832 0.00511 ** NA
DUSP18 nilotinib 0.0051248 0.8055751 0.00512 ** NA
NAP1L1 sunitinib 0.0051289 0.7819868 0.0051 ** NA
FOXO1 pazopanib 0.0051311 0.9978452 0.00513 ** NA
GRSF1 afatinib 0.0051350 0.9267832 0.00513 ** NA
PIP4K2B temozolomide 0.0051431 0.6902774 0.00514 ** NA
FAM170A docetaxel 0.0051467 0.9106700 0.00515 ** NA
TRERF1 temozolomide 0.0051481 0.6902774 0.00515 ** NA
PCDHB1 tretinoin 0.0051580 0.5318267 0.00516 ** NA
TBC1D30 alectinib 0.0051609 0.9168760 0.00516 ** NA
YDJC nilotinib 0.0051622 0.8055751 0.00516 ** NA
MIER3 rucaparib 0.0051632 0.9990814 0.00516 ** NA
FANCI tretinoin 0.0051667 0.5318267 0.00517 ** NA
SLC22A16 sunitinib 0.0051720 0.7819868 0.0052 ** NA
FIBP temozolomide 0.0051771 0.6902774 0.00518 ** NA
MPRIP temozolomide 0.0051802 0.6902774 0.00518 ** NA
DDX60 tretinoin 0.0051829 0.5318267 0.00518 ** NA
RRBP1 tretinoin 0.0051871 0.5318267 0.00519 ** NA
TPCN2 crizotinib 0.0052050 0.7869686 0.0052 ** NA
CCDC114 cabozantinib 0.0052095 0.8298252 0.00521 ** NA
TAF9 vismodegib 0.0052159 0.9623352 0.00522 ** NA
FER1L6 gefitinib 0.0052195 0.8957015 0.00522 ** NA
FAAH dabrafenib 0.0052243 0.9305571 0.00522 ** NA
BSG cabozantinib 0.0052318 0.8298252 0.00523 ** NA
PNPLA1 pazopanib 0.0052343 0.9978452 0.00523 ** NA
PCDHGB4 sunitinib 0.0052393 0.7819868 0.0052 ** NA
OLFML1 temozolomide 0.0052458 0.6902774 0.00525 ** NA
FBXO15 tretinoin 0.0052478 0.5318267 0.00525 ** NA
COL17A1 cabozantinib 0.0052547 0.8298252 0.00525 ** NA
SLC17A4 nilotinib 0.0052581 0.8055751 0.00526 ** NA
KIF20A temozolomide 0.0052674 0.6902774 0.00527 ** NA
CYP2C9 rucaparib 0.0052723 0.9990814 0.00527 ** NA
PMPCB docetaxel 0.0052732 0.9106700 0.00527 ** NA
CR1 belinostat 0.0052768 0.9983823 0.00528 ** NA
LSM1 gefitinib 0.0052852 0.8957015 0.00529 ** NA
FNDC9 afatinib 0.0052854 0.9267832 0.00529 ** NA
RYR2 docetaxel 0.0052972 0.9106700 0.00530 ** NA
DNAJB7 temozolomide 0.0053054 0.6902774 0.00531 ** NA
LRIF1 bosutinib monohydrate 0.0053124 1.0000000 0.00531 ** NA
OR52D1 nilotinib 0.0053179 0.8055751 0.00532 ** NA
RABL3 tretinoin 0.0053246 0.5318267 0.00532 ** NA
CHST10 docetaxel 0.0053301 0.9106700 0.00533 ** NA
RASIP1 temozolomide 0.0053330 0.6902774 0.00533 ** NA
GPA33 docetaxel 0.0053355 0.9106700 0.00534 ** NA
EPS8L2 ruxolitinib 0.0053438 0.9787856 0.00534 ** NA
IRX4 erlotinib 0.0053489 0.7991878 0.00535 ** NA
AKR1B15 lapatinib 0.0053602 0.8107014 0.00536 ** NA
PEX1 docetaxel 0.0053660 0.9106700 0.00537 ** NA
DTHD1 gefitinib 0.0053703 0.8957015 0.00537 ** NA
PCDHB7 midostaurin 0.0053737 0.8795120 0.00537 ** NA
FBXO38 temozolomide 0.0053764 0.6902774 0.00538 ** NA
LYST crizotinib 0.0053766 0.7869686 0.0054 ** NA
REV3L midostaurin 0.0053955 0.8795120 0.00540 ** NA
COL7A1 tretinoin 0.0054001 0.5318267 0.00540 ** NA
SRGAP3 midostaurin 0.0054027 0.8795120 0.00540 ** NA
PQLC3 tretinoin 0.0054048 0.5318267 0.00540 ** NA
COL25A1 belinostat 0.0054054 0.9983823 0.00541 ** NA
SPTY2D1 tretinoin 0.0054103 0.5318267 0.00541 ** NA
TMEM26 midostaurin 0.0054202 0.8795120 0.00542 ** NA
PGLYRP1 vismodegib 0.0054230 0.9623352 0.00542 ** NA
TBXA2R ruxolitinib 0.0054246 0.9787856 0.00542 ** NA
MYZAP temozolomide 0.0054252 0.6902774 0.00543 ** NA
RUVBL1 pazopanib 0.0054301 0.9978452 0.00543 ** NA
TGFB1I1 belinostat 0.0054317 0.9983823 0.00543 ** NA
ZSWIM3 gefitinib 0.0054360 0.8957015 0.00544 ** NA

5 Gene expression

6 Dataset summaries

6.1 CRISPR: Mutation status counts

crispr_data_g2p_summ <- unique(crispr_data_g2p[, c("Hugo_Symbol", "N_Nonsilent_Mutant", "N_Nonsilent_Other")])
crispr_data_g2p_summ$Percent_Mutant <- crispr_data_g2p_summ$N_Nonsilent_Mutant / (crispr_data_g2p_summ$N_Nonsilent_Mutant + crispr_data_g2p_summ$N_Nonsilent_Other) * 100
rownames(crispr_data_g2p_summ) <- NULL
# write.table(crispr_data_g2p_summ, file = "~/Desktop/crispr_data_g2p_summ_20181003.tsv", quote = FALSE, sep = "\t")

knitr::kable(crispr_data_g2p_summ, caption = "CRISPR: Level A G2P genes mutation status summary") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
CRISPR: Level A G2P genes mutation status summary
Hugo_Symbol N_Nonsilent_Mutant N_Nonsilent_Other Percent_Mutant
ABL1 32 457 6.5439673
AKT1 11 476 2.2587269
ALK 38 451 7.7709611
BRAF 75 419 15.1821862
BRCA1 33 453 6.7901235
BRCA2 51 440 10.3869654
CYP19A1 8 477 1.6494845
DNMT3A 29 457 5.9670782
DPYD 29 458 5.9548255
EGFR 43 449 8.7398374
ERBB2 21 467 4.3032787
ERBB3 29 457 5.9670782
ESR1 14 471 2.8865979
FLT3 27 459 5.5555556
IDH2 6 479 1.2371134
JAK2 14 472 2.8806584
KIT 21 466 4.3121150
KRAS 94 395 19.2229039
MET 29 459 5.9426230
MGMT 7 478 1.4432990
MYD88 10 475 2.0618557
NPM1 6 479 1.2371134
PDGFB 6 479 1.2371134
PDGFRA 30 457 6.1601643
PDGFRB 28 459 5.7494867
PML 22 465 4.5174538
PTCH1 28 462 5.7142857
RET 20 465 4.1237113
ROS1 47 440 9.6509240
TPMT 4 481 0.8247423
TSC1 14 472 2.8806584
TSC2 37 451 7.5819672
UGT1A1 19 472 3.8696538

6.2 Drugscreen G2P evidence

6.2.1 By gene

g2p_druggene_p_tally <- g2p %>% group_by(Drug_Gene) %>% tally()
g2p_druggene_p_summ <- merge(g2p_druggene_p_tally, ccle_signif_g2p[, c("Drug_Gene", "p")], by = "Drug_Gene", all.x = TRUE)
g2p_druggene_p_summ <- merge(g2p_druggene_p_summ, ctrp_signif_g2p[, c("Drug_Gene", "p")], by = "Drug_Gene", all.x = TRUE, suffixes = c("_CCLE", "_CTRP"))
g2p_druggene_p_summ <- merge(g2p_druggene_p_summ, gdsc_signif_g2p[, c("Drug_Gene", "p")], by = "Drug_Gene", all.x = TRUE)
colnames(g2p_druggene_p_summ)[colnames(g2p_druggene_p_summ) == "p_CCLE"] <- "CCLE"
colnames(g2p_druggene_p_summ)[colnames(g2p_druggene_p_summ) == "p_CTRP"] <- "CTRP"
colnames(g2p_druggene_p_summ)[colnames(g2p_druggene_p_summ) == "p"] <- "GDSC"
g2p_druggene_p_summ_melt <- melt(g2p_druggene_p_summ, id.vars = c("Drug_Gene", "n"), measure.vars = c("CCLE", "CTRP", "GDSC"), variable.name = "Dataset", value.name = "p")

g2p_druggene_p_summ_plot <- ggplot(data = g2p_druggene_p_summ_melt, aes(x = p, y = n, shape = Dataset, color = Dataset)) +
  geom_point(size = 2) +
  scale_color_manual(values = c("green3", "darkslategray4", "darkturquoise")) +
  labs(x = "Gene-drug association p-value by mutation status", y = "Number of level A G2P associations")
g2p_druggene_p_summ_plot

# ggsave("./plots_18Q3/manuscript/g2p_druggene_p_summ_plot.png", g2p_druggene_p_summ_plot, device = "png", dpi = 450, width = 8, height = 4, units = "in")
ccle_druggene_mad_summ <- ccle_data_ptmuts %>% group_by(Drug_Gene, Mutation_Status_Nonsilent) %>% summarize(Mean_AUC = mean(AUC))
ccle_druggene_mad_summ <- dcast(ccle_druggene_mad_summ, Drug_Gene ~ Mutation_Status_Nonsilent)
ccle_druggene_mad_summ$MAD <- abs(ccle_druggene_mad_summ$Mutant - ccle_druggene_mad_summ$Other)
ccle_druggene_p_summ <- ccle_signif_g2p_ByDrug_all
ccle_druggene_p_summ$Drug_Gene <- paste0(ccle_druggene_p_summ$Drug, "_", ccle_druggene_p_summ$Hugo_Symbol)
ccle_druggene_summ <- merge(merge(g2p_druggene_p_tally, ccle_druggene_p_summ[, c("Drug_Gene", "p")], by = "Drug_Gene", all.y = TRUE), ccle_druggene_mad_summ, by = "Drug_Gene", all = TRUE)
ccle_druggene_summ$n <- ifelse(is.na(ccle_druggene_summ$n), 0, ccle_druggene_summ$n)
ccle_druggene_summ$InG2P <- ifelse(ccle_druggene_summ$n != 0, "Yes", "No")
ccle_druggene_summ$Dataset <- "CCLE"
ccle_p_ttest <- t.test(ccle_druggene_summ$p ~ ccle_druggene_summ$InG2P)
ccle_p_ttest_res <- paste0("t = ", round(ccle_p_ttest$statistic, 3), ", df = ", round(ccle_p_ttest$parameter, 3), ", p = ", round(ccle_p_ttest$p.value, 3))
ccle_mad_ttest <- t.test(ccle_druggene_summ$MAD ~ ccle_druggene_summ$InG2P)
ccle_mad_ttest_res <- paste0("t = ", round(ccle_mad_ttest$statistic, 3), ", df = ", round(ccle_mad_ttest$parameter, 3), ", p = ", round(ccle_mad_ttest$p.value, 3))

ctrp_druggene_mad_summ <- ctrp_data_ptmuts %>% group_by(Drug_Gene, Mutation_Status_Nonsilent) %>% summarize(Mean_AUC = mean(AUC))
ctrp_druggene_mad_summ <- dcast(ctrp_druggene_mad_summ, Drug_Gene ~ Mutation_Status_Nonsilent)
ctrp_druggene_mad_summ$MAD <- abs(ctrp_druggene_mad_summ$Mutant - ctrp_druggene_mad_summ$Other)
ctrp_druggene_p_summ <- ctrp_signif_g2p_ByDrug_all
ctrp_druggene_p_summ$Drug_Gene <- paste0(ctrp_druggene_p_summ$Drug, "_", ctrp_druggene_p_summ$Hugo_Symbol)
ctrp_druggene_summ <- merge(merge(g2p_druggene_p_tally, ctrp_druggene_p_summ[, c("Drug_Gene", "p")], by = "Drug_Gene", all.y = TRUE), ctrp_druggene_mad_summ, by = "Drug_Gene", all = TRUE)
ctrp_druggene_summ$n <- ifelse(is.na(ctrp_druggene_summ$n), 0, ctrp_druggene_summ$n)
ctrp_druggene_summ$InG2P <- ifelse(ctrp_druggene_summ$n != 0, "Yes", "No")
ctrp_druggene_summ$Dataset <- "CTRP"
ctrp_p_ttest <- t.test(ctrp_druggene_summ$p ~ ctrp_druggene_summ$InG2P)
ctrp_p_ttest_res <- paste0("t = ", round(ctrp_p_ttest$statistic, 3), ", df = ", round(ctrp_p_ttest$parameter, 3), ", p = ", round(ctrp_p_ttest$p.value, 3))
ctrp_mad_ttest <- t.test(ctrp_druggene_summ$MAD ~ ctrp_druggene_summ$InG2P)
ctrp_mad_ttest_res <- paste0("t = ", round(ctrp_mad_ttest$statistic, 3), ", df = ", round(ctrp_mad_ttest$parameter, 3), ", p = ", round(ctrp_mad_ttest$p.value, 3))

gdsc_druggene_mad_summ <- gdsc_data_ptmuts %>% group_by(Drug_Gene, Mutation_Status_Nonsilent) %>% summarize(Mean_AUC = mean(AUC))
gdsc_druggene_mad_summ <- dcast(gdsc_druggene_mad_summ, Drug_Gene ~ Mutation_Status_Nonsilent)
gdsc_druggene_mad_summ$MAD <- abs(gdsc_druggene_mad_summ$Mutant - gdsc_druggene_mad_summ$Other)
gdsc_druggene_p_summ <- gdsc_signif_g2p_ByDrug_all
gdsc_druggene_p_summ$Drug_Gene <- paste0(gdsc_druggene_p_summ$Drug, "_", gdsc_druggene_p_summ$Hugo_Symbol)
gdsc_druggene_summ <- merge(merge(g2p_druggene_p_tally, gdsc_druggene_p_summ[, c("Drug_Gene", "p")], by = "Drug_Gene", all.y = TRUE), gdsc_druggene_mad_summ, by = "Drug_Gene", all = TRUE)
gdsc_druggene_summ$n <- ifelse(is.na(gdsc_druggene_summ$n), 0, gdsc_druggene_summ$n)
gdsc_druggene_summ$InG2P <- ifelse(gdsc_druggene_summ$n != 0, "Yes", "No")
gdsc_druggene_summ$Dataset <- "GDSC"
gdsc_p_ttest <- t.test(gdsc_druggene_summ$p ~ gdsc_druggene_summ$InG2P)
gdsc_p_ttest_res <- paste0("t = ", round(gdsc_p_ttest$statistic, 3), ", df = ", round(gdsc_p_ttest$parameter, 3), ", p = ", round(gdsc_p_ttest$p.value, 3))
gdsc_mad_ttest <- t.test(gdsc_druggene_summ$MAD ~ gdsc_druggene_summ$InG2P)
gdsc_mad_ttest_res <- paste0("t = ", round(gdsc_mad_ttest$statistic, 3), ", df = ", round(gdsc_mad_ttest$parameter, 3), ", p = ", round(gdsc_mad_ttest$p.value, 3))

g2p_druggene_all_summ <- rbind(ccle_druggene_summ, ctrp_druggene_summ, gdsc_druggene_summ)
g2p_druggene_all_summ_text <- data.frame(Dataset = c("CCLE", "CTRP", "GDSC"), 
                                         Test_Results_p = c(ccle_p_ttest_res, ctrp_p_ttest_res, gdsc_p_ttest_res),
                                         Test_Results_MAD = c(ccle_mad_ttest_res, ctrp_mad_ttest_res, gdsc_mad_ttest_res))
## MAD
plot_mad_point <- ggplot(data = g2p_druggene_all_summ) +
  facet_wrap(~ Dataset, scales = "free_x") +
  geom_point(mapping = aes(color = InG2P, x = MAD, y = n), alpha = 0.5) +
  scale_y_continuous(breaks = seq(0, 110, by = 10), labels = seq(0, 110, by = 10)) +
  geom_text(data = g2p_druggene_all_summ_text, mapping = aes(x = c(0.75, 4, 0.19), y = 110, label = Test_Results_MAD)) +
  labs(x = "Gene-drug association difference in mean AUC between mutation groups", y = "Number of level A G2P associations", color = "Does the gene-drug combination have level A G2P indication?") +
  theme(legend.position = "none", plot.margin = unit(c(0.05, 0.5, 0.5, 0.5), "cm"), strip.background = element_blank(), strip.text.x = element_blank())

plot_mad_box <- ggplot(data = g2p_druggene_all_summ) +
  facet_wrap(~ Dataset, scales = "free_x") +
  geom_violin(mapping = aes(color = InG2P, y = MAD, x = InG2P), alpha = 0.5) +
  geom_boxplot(mapping = aes(color = InG2P, y = MAD, x = InG2P), alpha = 0.75, width = 0.25) +
  coord_flip() +
  labs(x = "Level A G2P\nassociation") +
  theme(legend.position = "none", axis.title.x = element_blank(), axis.text.x = element_blank(), axis.ticks.x = element_blank(), plot.margin = unit(c(0.5, 0.5, 0.05, 0.5), "cm"))

plot_mad_point <- ggplot_gtable(ggplot_build(plot_mad_point))
plot_mad_box <- ggplot_gtable(ggplot_build(plot_mad_box))
mad_maxWidth <-  grid::unit.pmax(plot_mad_point$widths, plot_mad_box$widths)
plot_mad_point$widths <- as.list(mad_maxWidth)
plot_mad_box$widths <- as.list(mad_maxWidth)

g2p_druggene_all_mad_summ_plot <- cowplot::plot_grid(plot_mad_box,
                   plot_mad_point,
                   nrow = 2,
                   rel_heights = c(1, 4))
g2p_druggene_all_mad_summ_plot

# ggsave("./plots_18Q3/manuscript/g2p_druggene_all_mad_summ_plot.png", g2p_druggene_all_mad_summ_plot, device = "png", dpi = 450, width = 12, height = 5, units = "in")

## P-value
plot_p_point <- ggplot(data = g2p_druggene_all_summ) +
  facet_wrap(~ Dataset, scales = "free_x") +
  geom_point(mapping = aes(label = Drug_Gene, color = InG2P, x = p, y = n), alpha = 0.5) +
  scale_y_continuous(breaks = seq(0, 110, by = 10), labels = seq(0, 110, by = 10)) +
  geom_text(data = g2p_druggene_all_summ_text, mapping = aes(x = 0.5, y = 110, label = Test_Results_p)) +
  labs(x = "Gene-drug association p-value between mutation groups", y = "Number of level A G2P associations", color = "Does the gene-drug combination have level A G2P indication?") +
  theme(legend.position = "none", plot.margin = unit(c(0.05, 0.5, 0.5, 0.5), "cm"), strip.background = element_blank(), strip.text.x = element_blank())

plot_p_box <- ggplot(data = g2p_druggene_all_summ) +
  facet_wrap(~ Dataset, scales = "free_x") +
  geom_violin(mapping = aes(color = InG2P, y = p, x = InG2P), alpha = 0.5) +
  geom_boxplot(mapping = aes(color = InG2P, y = p, x = InG2P), alpha = 0.75, width = 0.25) +
  coord_flip() +
  labs(x = "Level A G2P\nassociation") +
  theme(legend.position = "none", axis.title.x = element_blank(), axis.text.x = element_blank(), axis.ticks.x = element_blank(), plot.margin = unit(c(0.5, 0.5, 0.05, 0.5), "cm"))

plot_p_point <- ggplot_gtable(ggplot_build(plot_p_point))
plot_p_box <- ggplot_gtable(ggplot_build(plot_p_box))
p_maxWidth <-  grid::unit.pmax(plot_p_point$widths, plot_p_box$widths)
plot_p_point$widths <- as.list(p_maxWidth)
plot_p_box$widths <- as.list(p_maxWidth)

g2p_druggene_all_p_summ_plot <- cowplot::plot_grid(plot_p_box,
                   plot_p_point,
                   nrow = 2,
                   rel_heights = c(1, 4))
g2p_druggene_all_p_summ_plot

# ggsave("./plots_18Q3/manuscript/g2p_druggene_all_p_summ_plot.png", g2p_druggene_all_p_summ_plot, device = "png", dpi = 450, width = 12, height = 5, units = "in")
plot_p_point <- ggplot(data = g2p_druggene_all_summ) +
  facet_wrap(~ Dataset, scales = "free_x") +
  geom_point(mapping = aes(label = Drug_Gene, color = InG2P, x = p, y = n), alpha = 0.5) +
  scale_y_continuous(breaks = seq(0, 110, by = 10), labels = seq(0, 110, by = 10)) +
  geom_text(data = g2p_druggene_all_summ_text, mapping = aes(x = 0.5, y = 110, label = Test_Results_p)) +
  labs(x = "Gene-drug association p-value between mutation groups", y = "Number of level A G2P associations", color = "Does the gene-drug combination have level A G2P indication?") +
  theme(legend.position = "none", plot.margin = unit(c(0.05, 0.5, 0.5, 0.5), "cm"), strip.background = element_blank(), strip.text.x = element_blank())

plot_p_box <- ggplot(data = g2p_druggene_all_summ) +
  facet_wrap(~ Dataset, scales = "free_x") +
  geom_violin(mapping = aes(color = InG2P, y = p, x = InG2P), alpha = 0.5) +
  geom_boxplot(mapping = aes(color = InG2P, y = p, x = InG2P), alpha = 0.75, width = 0.25) +
  coord_flip() +
  labs(x = "Level A G2P\nassociation") +
  theme(legend.position = "none", axis.title.x = element_blank(), axis.text.x = element_blank(), axis.ticks.x = element_blank(), plot.margin = unit(c(0.5, 0.5, 0.05, 0.5), "cm"))

plot <- subplot(plot_p_box, plot_p_point, nrows = 2, titleX = TRUE, titleY = TRUE) %>% layout(margin = list(l = 75), xaxis5 = list(title = "Gene-drug association p-value between mutation groups"), yaxis = list(title = "Level A G2P\nassociation", domain = c(0.8, 1)), yaxis2 = list(title = "Number of level A G2P associations", domain = c(0, 0.79)))

saveWidgetFix(widget = plot, file = "./plots_18Q3/manuscript/g2p_druggene_all_p_summ_plot.html")

6.2.2 By lineage

g2p_druggenelin_p_tally <- g2p %>% group_by(Drug_Gene, group_general_lineage_name) %>% tally()

ccle_druggenelin_p_summ <- ccle_signif_g2p_lineage
ccle_druggenelin_p_summ$Drug_Gene <- paste0(ccle_druggenelin_p_summ$Drug, "_", ccle_druggenelin_p_summ$Hugo_Symbol)
ccle_druggenelin_summ <- merge(g2p_druggenelin_p_tally, ccle_druggenelin_p_summ[, c("Drug_Gene", "group_general_lineage_name", "p")], by = c("Drug_Gene", "group_general_lineage_name"), all.y = TRUE)
ccle_druggenelin_summ$n <- ifelse(is.na(ccle_druggenelin_summ$n), 0, ccle_druggenelin_summ$n)
ccle_druggenelin_summ$InG2P <- ifelse(ccle_druggenelin_summ$n != 0, "Yes", "No")
ccle_druggenelin_summ$Dataset <- "CCLE"

ctrp_druggenelin_p_summ <- ctrp_signif_g2p_lineage
ctrp_druggenelin_p_summ$Drug_Gene <- paste0(ctrp_druggenelin_p_summ$Drug, "_", ctrp_druggenelin_p_summ$Hugo_Symbol)
ctrp_druggenelin_summ <- merge(g2p_druggenelin_p_tally, ctrp_druggenelin_p_summ[, c("Drug_Gene", "group_general_lineage_name", "p")], by = c("Drug_Gene", "group_general_lineage_name"), all.y = TRUE)
ctrp_druggenelin_summ$n <- ifelse(is.na(ctrp_druggenelin_summ$n), 0, ctrp_druggenelin_summ$n)
ctrp_druggenelin_summ$InG2P <- ifelse(ctrp_druggenelin_summ$n != 0, "Yes", "No")
ctrp_druggenelin_summ$Dataset <- "CTRP"

gdsc_druggenelin_p_summ <- gdsc_signif_g2p_lineage
gdsc_druggenelin_p_summ$Drug_Gene <- paste0(gdsc_druggenelin_p_summ$Drug, "_", gdsc_druggenelin_p_summ$Hugo_Symbol)
gdsc_druggenelin_summ <- merge(g2p_druggenelin_p_tally, gdsc_druggenelin_p_summ[, c("Drug_Gene", "group_general_lineage_name", "p")], by = c("Drug_Gene", "group_general_lineage_name"), all.y = TRUE)
gdsc_druggenelin_summ$n <- ifelse(is.na(gdsc_druggenelin_summ$n), 0, gdsc_druggenelin_summ$n)
gdsc_druggenelin_summ$InG2P <- ifelse(gdsc_druggenelin_summ$n != 0, "Yes", "No")
gdsc_druggenelin_summ$Dataset <- "GDSC"

g2p_druggenelin_all_summ <- rbind(ccle_druggenelin_summ, ctrp_druggenelin_summ, gdsc_druggenelin_summ)
g2p_druggenelin_all_summ$InG2P <- factor(g2p_druggenelin_all_summ$InG2P)

# test <- filter(filter(g2p_druggenelin_all_summ, group_general_lineage_name == "breast cancer"), Dataset == "CCLE")
# test <- test[-39,]
lapply(as.character(unique(g2p_druggenelin_all_summ$group_general_lineage_name)), make_G2Plineage_plotly)

# test <- filter(g2p_druggenelin_all_summ, Dataset == "CCLE")
# test_summ <- test %>% count(group_general_lineage_name, InG2P)
# test2 <- filter(g2p_druggenelin_all_summ, Dataset == "CTRP")
# test2_summ <- test2 %>% count(group_general_lineage_name, InG2P)
# test3 <- filter(g2p_druggenelin_all_summ, Dataset == "GDSC")
# test3_summ <- test3 %>% count(group_general_lineage_name, InG2P)

6.3 Cell line overlap

crispr_ccl <- unique(select(crispr_data, Broad_ID, CCLE_Name))
ccle_ccl <- unique(select(ccle_data, Broad_ID, CCLE_Name, accession_id))
ctrp_ccl <- unique(select(ctrp_data, Broad_ID, CCLE_Name, accession_id))
gdsc_ccl <- unique(select(gdsc_data, Broad_ID, CCLE_Name, accession_id))

# all_ccl <- merge(ccle_ccl, ctrp_ccl, by = c("Broad_ID", "CCLE_Name", "accession_id"), all = TRUE)

7 Boxplots

Mutation status boxplots for genes identified in G2P.

7.1 Figure 1

Boxplots ordered by gene based on frequency of G2P associations.

7.1.1 CRISPR

crispr_data_g2p$Hugo_Symbol <- factor(crispr_data_g2p$Hugo_Symbol, levels = g2p_genes)
crispr_data_g2p_color <- as.character(crispr_data_g2p$Color_Nonsilent)
names(crispr_data_g2p_color) <- crispr_data_g2p$Mutation_Status_Nonsilent

crispr_label_text <- data.frame(p.signif.adj = crispr_signif_g2p_gene$p.signif.adj, p.signif = crispr_signif_g2p_gene$p.signif, Hugo_Symbol = crispr_signif_g2p_gene$Hugo_Symbol)
crispr_label_text <- filter(crispr_label_text, Hugo_Symbol %in% g2p_genes)
crispr_label_text$Hugo_Symbol <- factor(crispr_label_text$Hugo_Symbol, levels = g2p_genes)

crispr_data_g2p_plot <- ggplot(data = crispr_data_g2p, aes(x = Mutation_Status_Nonsilent, y = Score)) +
  facet_wrap(~ Hugo_Symbol, drop = FALSE, nrow = 1) +
  geom_hline(yintercept = 0, lty = 2, color = "darkgray") +
  geom_boxplot(mapping = aes(fill = Mutation_Status_Nonsilent), position = position_dodge(0.85)) +
  scale_fill_manual(values = crispr_data_g2p_color) +
  guides(color = FALSE) +
  geom_text(data = crispr_label_text, mapping = aes(x = 1.5, y = 2, label = p.signif), nudge_y = 0.1) +
  theme(strip.text.x = element_text(size = 10, angle = 45), legend.position = "top", axis.ticks.x = element_blank(), axis.text.x = element_blank(), axis.title.x = element_blank()) +
  labs(title = "CRISPR", fill = "Mutation Status", y = "CERES Score", x = "Mutation Status")
crispr_data_g2p_plot

# ggsave("./plots_18Q3/manuscript/crispr_data_g2p_plot.png", crispr_data_g2p_plot, device = "png", dpi = 450, width = 20, height = 5, units = "in")

7.1.2 CCLE

Plot code:

ccle_drugs <- as.character(unique(ccle_data_g2p_genesfilt$Drug))
ccle_g2p_drugboxplots <- lapply(ccle_drugs, makeDrugBoxplots, dataset = "CCLE")
ccle_g2p_drugboxplots_paths <- paste0(ccle_drugs, "_ccle_drugboxplots.png")
pwalk(list(ccle_g2p_drugboxplots_paths, ccle_g2p_drugboxplots), ggsave, path = "./plots_18Q3/manuscript/ccle_g2p_drugboxplots", dpi = 450, width = 20, height = 5, units = "in")

Data management:

ccle_g2p_drugboxplots <- paste0(list.files("./plots_18Q3/manuscript/ccle_g2p_drugboxplots", full.names = TRUE))
names(ccle_g2p_drugboxplots) <- str_replace_all(ccle_g2p_drugboxplots, c("_ccle_drugboxplots.png" = "", "./plots_18Q3/manuscript/ccle_g2p_drugboxplots/" = ""))
bsselect(ccle_g2p_drugboxplots, type = "img", live_search = TRUE, show_tick = TRUE, height = 100)

7.1.3 CTRP

Plot code:

ctrp_drugs <- as.character(unique(ctrp_data_g2p_genesfilt$Drug))
ctrp_g2p_drugboxplots <- lapply(ctrp_drugs, makeDrugBoxplots, dataset = "ctrp")
ctrp_g2p_drugboxplots_paths <- paste0(ctrp_drugs, "_ctrp_drugboxplots.png")
pwalk(list(ctrp_g2p_drugboxplots_paths, ctrp_g2p_drugboxplots), ggsave, path = "./plots_18Q3/manuscript/ctrp_g2p_drugboxplots", dpi = 450, width = 20, height = 5, units = "in")

Data management:

ctrp_g2p_drugboxplots <- paste0(list.files("./plots_18Q3/manuscript/ctrp_g2p_drugboxplots", full.names = TRUE))
names(ctrp_g2p_drugboxplots) <- str_replace_all(ctrp_g2p_drugboxplots, c("_ctrp_drugboxplots.png" = "", "./plots_18Q3/manuscript/ctrp_g2p_drugboxplots/" = ""))
bsselect(ctrp_g2p_drugboxplots, type = "img", live_search = TRUE, show_tick = TRUE, height = 100)

7.1.4 GDSC

Plot code:

gdsc_drugs <- as.character(unique(gdsc_data_g2p_genesfilt$Drug))
gdsc_g2p_drugboxplots <- lapply(gdsc_drugs, makeDrugBoxplots, dataset = "gdsc")
gdsc_g2p_drugboxplots_paths <- paste0(gdsc_drugs, "_gdsc_drugboxplots.png")
pwalk(list(gdsc_g2p_drugboxplots_paths, gdsc_g2p_drugboxplots), ggsave, path = "./plots_18Q3/manuscript/gdsc_g2p_drugboxplots", dpi = 450, width = 20, height = 5, units = "in")

Data management:

gdsc_g2p_drugboxplots <- paste0(list.files("./plots_18Q3/manuscript/gdsc_g2p_drugboxplots", full.names = TRUE))
names(gdsc_g2p_drugboxplots) <- str_replace_all(gdsc_g2p_drugboxplots, c("_gdsc_drugboxplots.png" = "", "./plots_18Q3/manuscript/gdsc_g2p_drugboxplots/" = ""))
bsselect(gdsc_g2p_drugboxplots, type = "img", live_search = TRUE, show_tick = TRUE, height = 100)

7.2 G2P level A gene-drug associations only

7.2.1 CCLE

ccle_g2p_order <- as.character(ccle_signif_g2p$Drug_Gene)
ccle_data_g2p$Drug_Gene_Ordered <- factor(ccle_data_g2p$Drug_Gene, levels = ccle_g2p_order, labels = sapply(strsplit(x = ccle_g2p_order, split = "_"), function(x) paste0(x[1], "\n", x[2])))
ccle_signif_g2p$Drug_Gene_Ordered <- factor(ccle_signif_g2p$Drug_Gene, levels = ccle_g2p_order, labels = sapply(strsplit(x = ccle_g2p_order, split = "_"), function(x) paste0(x[1], "\n", x[2])))
ccle_data_g2p_color <- as.character(ccle_data_g2p$Color_Nonsilent)
names(ccle_data_g2p_color) <- ccle_data_g2p$Mutation_Status_Nonsilent

ccle_label_text <- data.frame(p.signif.adj = ccle_signif_g2p$p.signif.adj, p.signif = ccle_signif_g2p$p.signif, Drug_Gene_Ordered = ccle_signif_g2p$Drug_Gene_Ordered)

ccle_data_g2p_plot <- ggplot(data = ccle_data_g2p, aes(x = Mutation_Status_Nonsilent, y = AUC)) +
  facet_wrap(~ Drug_Gene_Ordered, drop = FALSE, nrow = 1) +
  geom_hline(yintercept = 0, lty = 2, color = "darkgray") +
  geom_boxplot(mapping = aes(fill = Mutation_Status_Nonsilent), position = position_dodge(0.85), outlier.shape = 3, outlier.size = 0.5) +
  scale_fill_manual(values = ccle_data_g2p_color) +
  guides(color = FALSE) +
  geom_text(data = ccle_label_text, mapping = aes(x = 1.5, y = 7, label = p.signif), nudge_y = 0.1) +
  theme(legend.position = "top", axis.ticks.x = element_blank(), axis.text.x = element_blank(), axis.title.x = element_blank()) +
  labs(title = "CCLE", fill = "Mutation Status", y = "AUC", x = "Mutation Status")
ccle_data_g2p_plot

# ggsave("./plots_18Q3/manuscript/ccle_data_g2p_plot.png", ccle_data_g2p_plot, device = "png", dpi = 450, width = 12, height = 4, units = "in")

7.2.2 CTRP

ctrp_g2p_order <- as.character(ctrp_signif_g2p$Drug_Gene)
ctrp_data_g2p$Drug_Gene_Ordered <- factor(ctrp_data_g2p$Drug_Gene, levels = ctrp_g2p_order, labels = sapply(strsplit(x = ctrp_g2p_order, split = "_"), function(x) paste0(x[1], "\n", x[2])))
ctrp_signif_g2p$Drug_Gene_Ordered <- factor(ctrp_signif_g2p$Drug_Gene, levels = ctrp_g2p_order, labels = sapply(strsplit(x = ctrp_g2p_order, split = "_"), function(x) paste0(x[1], "\n", x[2])))
ctrp_data_g2p_color <- as.character(ctrp_data_g2p$Color_Nonsilent)
names(ctrp_data_g2p_color) <- ctrp_data_g2p$Mutation_Status_Nonsilent

ctrp_label_text <- data.frame(p.signif.adj = ctrp_signif_g2p$p.signif.adj, p.signif = ctrp_signif_g2p$p.signif, Drug_Gene_Ordered = ctrp_signif_g2p$Drug_Gene_Ordered)

ctrp_data_g2p_plot <- ggplot(data = ctrp_data_g2p, aes(x = Mutation_Status_Nonsilent, y = AUC)) +
  facet_wrap(~ Drug_Gene_Ordered, drop = FALSE, nrow = 3) +
  geom_hline(yintercept = 0, lty = 2, color = "darkgray") +
  geom_boxplot(mapping = aes(fill = Mutation_Status_Nonsilent), position = position_dodge(0.85), outlier.shape = 3, outlier.size = 0.5) +
  scale_fill_manual(values = ctrp_data_g2p_color) +
  guides(color = FALSE) +
  geom_text(data = ctrp_label_text, mapping = aes(x = 1.5, y = 22.5, label = p.signif), nudge_y = 0.1) +
  theme(legend.position = "top", axis.ticks.x = element_blank(), axis.text.x = element_blank(), axis.title.x = element_blank()) +
  labs(title = "CTRP", fill = "Mutation Status", y = "AUC", x = "Mutation Status")
ctrp_data_g2p_plot

# ggsave("./plots_18Q3/manuscript/ctrp_data_g2p_plot.png", ctrp_data_g2p_plot, device = "png", dpi = 450, width = 12, height = 7, units = "in")

7.2.3 GDSC

gdsc_g2p_order <- as.character(gdsc_signif_g2p$Drug_Gene)
gdsc_data_g2p$Drug_Gene_Ordered <- factor(gdsc_data_g2p$Drug_Gene, levels = gdsc_g2p_order, labels = sapply(strsplit(x = gdsc_g2p_order, split = "_"), function(x) paste0(x[1], "\n", x[2])))
gdsc_signif_g2p$Drug_Gene_Ordered <- factor(gdsc_signif_g2p$Drug_Gene, levels = gdsc_g2p_order, labels = sapply(strsplit(x = gdsc_g2p_order, split = "_"), function(x) paste0(x[1], "\n", x[2])))
gdsc_data_g2p_color <- as.character(gdsc_data_g2p$Color_Nonsilent)
names(gdsc_data_g2p_color) <- gdsc_data_g2p$Mutation_Status_Nonsilent

gdsc_label_text <- data.frame(p.signif.adj = gdsc_signif_g2p$p.signif.adj, p.signif = gdsc_signif_g2p$p.signif, Drug_Gene_Ordered = gdsc_signif_g2p$Drug_Gene_Ordered)

gdsc_data_g2p_plot <- ggplot(data = gdsc_data_g2p, aes(x = Mutation_Status_Nonsilent, y = AUC)) +
  facet_wrap(~ Drug_Gene_Ordered, drop = FALSE, nrow = 3) +
  geom_hline(yintercept = 0, lty = 2, color = "darkgray") +
  geom_boxplot(mapping = aes(fill = Mutation_Status_Nonsilent), position = position_dodge(0.85), outlier.shape = 3, outlier.size = 0.5) +
  scale_fill_manual(values = gdsc_data_g2p_color) +
  guides(color = FALSE) +
  geom_text(data = gdsc_label_text, mapping = aes(x = 1.5, y = 1, label = p.signif), nudge_y = 0.1) +
  theme(legend.position = "top", axis.ticks.x = element_blank(), axis.text.x = element_blank(), axis.title.x = element_blank()) +
  labs(title = "GDSC", fill = "Mutation Status", y = "AUC", x = "Mutation Status")
gdsc_data_g2p_plot

# ggsave("./plots_18Q3/manuscript/gdsc_data_g2p_plot.png", gdsc_data_g2p_plot, device = "png", dpi = 450, width = 12, height = 7, units = "in")

8 CRISPR: Point mutation mapping

Match specific point mutations.

g2p_indications <- filter(read.delim("./data_munging/data_mutation_associations_appended.csv", sep = "\t", header = TRUE), Evidence.Level == "A")
maf_g2p_indications <- filter(maf_raw, Genome_Change %in% g2p_indications$MutationName)
crispr_g2p_indications <- merge(crispr_data_ptmuts, maf_g2p_indications, by = c("Hugo_Symbol", "CCLE_Name", "Broad_ID"), all.x = TRUE)
crispr_g2p_indications$Mutation_Status_Nonsilent <- ifelse(is.na(crispr_g2p_indications$Mutation_Status_Nonsilent), "Other", crispr_g2p_indications$Mutation_Status_Nonsilent)
dup_g2p_indications <- filter(crispr_g2p_indications[, c("Hugo_Symbol", "CCLE_Name", "Broad_ID")] %>% group_by(Hugo_Symbol, CCLE_Name, Broad_ID) %>% tally(), n > 1)
crispr_g2p_indications <- merge(crispr_g2p_indications, dup_g2p_indications, by = c("Hugo_Symbol", "CCLE_Name", "Broad_ID"), all.x = TRUE)
crispr_g2p_indications$Genome_Change <- factor(crispr_g2p_indications$Genome_Change, levels = unique(crispr_g2p_indications$Genome_Change))
crispr_g2p_indications_nonNA <- filter(crispr_g2p_indications, is.na(n))

crispr_g2p_indications_plot <- ggplot(crispr_g2p_indications, aes(x = Hugo_Symbol, y = Score)) +
  geom_hline(yintercept = 0, lty = 2, color = "darkgray") +
  geom_boxplot(alpha = 0.5, color = "lightgray", outlier.shape = NA) +
  geom_jitter(width = 0.3, mapping = aes(color = Mutation_Status_Nonsilent), size = 1) +
  theme_light() +
  theme(legend.title = element_blank()) +
  labs(x = "Gene", y = "CERES Score")
crispr_g2p_indications_plot

crispr_g2p_indications_muts_plot <- ggplot(crispr_g2p_indications, aes(x = Protein_Change, y = Score)) +
  facet_grid(~ Hugo_Symbol, scales = "free_x", space = "free") +
  geom_hline(yintercept = 0, lty = 2, color = "darkgray") +
  geom_boxplot(alpha = 0.5, color = "lightgray", outlier.shape = NA) +
  geom_jitter(width = 0.1, mapping = aes(color = Mutation_Status_Nonsilent), size = 1) +
  theme_light() +
  theme(legend.title = element_blank(), axis.text.x = element_text(angle = 90, hjust = 1)) +
  labs(x = "Gene", y = "CERES Score")
crispr_g2p_indications_muts_plot

# ggsave("./plots_18Q3/manuscript/crispr_g2p_indications_plot_test.png", crispr_g2p_indications_plot, width = 12, height = 5, units = "in")
# ggsave("./plots_18Q3/manuscript/crispr_g2p_indications_muts_plot_test.png", crispr_g2p_indications_muts_plot, width = 20, height = 5, units = "in")

9 References

Barretina, J., Caponigro, G., Stransky, N., Venkatesan, K., Margolin, A. A., Kim, S., … Garraway, L. A. (2012). The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature, 483(7391), 603–607. https://doi.org/10.1038/nature11003

Broad Institute Cancer Dependency Map; Cancer Data Science (2018): Cancer Dependency Map, CRISPR Avana dataset 18Q3 (Avana_public_18Q3). figshare. Fileset. doi:10.6084/m9.figshare.6931364.v1

Consortium, T. C. C. L. E., & Consortium, T. G. of D. S. in C. (2015). Pharmacogenomic agreement between two cancer cell line data sets. Nature, 528(7580), 84–87. https://doi.org/10.1038/nature15736

Data Science, Cancer (2018): DEMETER2 data. figshare. Fileset. doi:10.6084/m9.figshare.6025238.v2

Doench, J. G., Fusi, N., Sullender, M., Hegde, M., Vaimberg, E. W., Donovan, K. F., … Root, D. E. (2016). Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9. Nature Biotechnology, 34(2), 184–191. https://doi.org/10.1038/nbt.3437

Meyers, R. M., Bryan, J. G., McFarland, J. M., Weir, B. A., Sizemore, A. E., Xu, H., … Tsherniak, A. (2017). Computational correction of copy-number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells. Nature Genetics, 49(12), 1779–1784. https://doi.org/10.1038/ng.3984

McFarland, J. M., Ho, Z. V., Kugener, G., Dempster, J. M., Montgomery, P. G., Bryan, J. G., … Tsherniak, A. (2018). Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration. https://doi.org/10.1101/305656

10 Session information

print(sessionInfo())
## R version 3.5.0 (2018-04-23)
## Platform: x86_64-apple-darwin15.6.0 (64-bit)
## Running under: macOS  10.14
## 
## Matrix products: default
## BLAS: /Library/Frameworks/R.framework/Versions/3.5/Resources/lib/libRblas.0.dylib
## LAPACK: /Library/Frameworks/R.framework/Versions/3.5/Resources/lib/libRlapack.dylib
## 
## locale:
## [1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8
## 
## attached base packages:
## [1] stats     graphics  grDevices utils     datasets  methods   base     
## 
## other attached packages:
##  [1] bindrcpp_0.2.2    forcats_0.3.0     stringr_1.3.1    
##  [4] dplyr_0.7.6       purrr_0.2.5       readr_1.1.1      
##  [7] tidyr_0.8.1       tibble_1.4.2      tidyverse_1.2.1  
## [10] scales_1.0.0      reshape2_1.4.3    plotly_4.8.0     
## [13] kableExtra_0.9.0  htmlwidgets_1.2   ggsignif_0.4.0   
## [16] ggpubr_0.1.7.999  magrittr_1.5      ggplot2_3.0.0    
## [19] data.table_1.11.4 bsselectR_0.1.0  
## 
## loaded via a namespace (and not attached):
##  [1] Rcpp_0.12.18      lubridate_1.7.4   lattice_0.20-35  
##  [4] assertthat_0.2.0  rprojroot_1.3-2   digest_0.6.15    
##  [7] mime_0.5          R6_2.2.2          cellranger_1.1.0 
## [10] plyr_1.8.4        backports_1.1.2   evaluate_0.11    
## [13] httr_1.3.1        highr_0.7         pillar_1.3.0     
## [16] rlang_0.2.1       lazyeval_0.2.1    readxl_1.1.0     
## [19] rstudioapi_0.7    rmarkdown_1.10    labeling_0.3     
## [22] munsell_0.5.0     shiny_1.1.0       broom_0.5.0      
## [25] compiler_3.5.0    httpuv_1.4.5      modelr_0.1.2     
## [28] pkgconfig_2.0.1   htmltools_0.3.6   tidyselect_0.2.4 
## [31] viridisLite_0.3.0 crayon_1.3.4      withr_2.1.2      
## [34] later_0.7.3       grid_3.5.0        xtable_1.8-2     
## [37] nlme_3.1-137      jsonlite_1.5.9000 gtable_0.2.0     
## [40] cli_1.0.0         stringi_1.2.4     promises_1.0.1   
## [43] xml2_1.2.0        cowplot_0.9.3     tools_3.5.0      
## [46] glue_1.3.0        hms_0.4.2         crosstalk_1.0.0  
## [49] parallel_3.5.0    yaml_2.1.19       colorspace_1.3-2 
## [52] rvest_0.3.2       knitr_1.20        bindr_0.1.1      
## [55] haven_1.1.2